Journals Endocrine, Metabolic & Immune ...

Endocrine, Metabolic & Immune Disorders Drug Targets
Mehtap Evran, Gizem Pire, İsa Burak Güney
OBJECTIVE: Patients with impaired glucose metabolism have increased thyroid volume and a higher prevalence of nodules. Yet, some studies show that there is an improvement in these thyroid parameters after diabetes treatment. Our observational study aimed to reveal the effect of treatment on thyroid function, thyroid volume, and the presence of nodules in newly diagnosed type 2 diabetes mellitus (T2DM) patients who were started on metformin treatment. METHODS: Euthyroid and subclinically hypothyroid patients with a serum TSH level of <10 mU/L, who were newly diagnosed with T2DM and started on metformin as an antidiabetic treatment and not used any thyroid medication previously, were included in our study...
April 26, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Kai-Sheng Liao, Ying-Ray Lee, Wen-Ying Chao, Yen-Ju Huang, Hui-Chen Chung, Shu-Hsin Chen, Yi-Zhen Li, Pei-Wen Zhao, Hong-Yi Chang
BACKGROUND: Honokiol is a natural polyphenolic compound extracted from Magnolia officinali, which is commonly used material in Chinese herbal medicine, has a variety of biological functions, including anti-tumor, anti-oxidant, anti-inflammation, anti-microbial and anti-allergy. Although honokiol has numerous beneficial effects on human diseases, the underlying mechanisms of tumor metastasis are still unclear. Previously, we reported that honokiol suppresses thyroid cancer cell proliferation with cytotoxicity through cell cycle arrest, apoptosis, and dysregulation of intracellular hemostasis...
April 24, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Oğuz Akkuş, Fatih Şen, Ramazan Yasdıbaş, Alper Tunga Ötegen, İrem Hüzmeli, Gamze Akkuş
BACKGROUND: The effects of thyroid hormone on patients hospitalized in coronary intensive care units are still controversial. We retrospectively examined thyroid hormone levels and their impact on cardiovascular morbidity in patients admitted to coronary intensive care units. MATERIAL AND METHODS: A total of 208 (Female/Male; 47.1%/52.9%) patients without any history of thyroid disease were enrolled and screened. Patients with specific heart disease and existing thyroid hormone parameters were included in the study...
April 23, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Juan Du, Enhua Shen
BACKGROUND: Hepatocellular carcinoma (HCC) is a globally prevalent malignancy accompanied by high incidence, poor outcomes, and high mortality. Anthocyanins can inhibit tumor proliferation, migration, invasion, and promote apoptosis. Moreover, autophagy-related genes (ARGs) may play vital roles in HCC progression. This study aimed to decipher the mechanisms through which anthocyanins influence HCC via ARGs and to establish a novel prognostic model. METHODS: Based on data from public databases, differential analysis and the Venn algorithm were employed to detect intersecting genes among differentially expressed genes (DEGs), anthocyanin- related targets, and ARGs...
April 8, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Anita Sakarwal, Karishma Sen, Heera Ram, Suman Chowdhury, Priya Kashyap, Sunil Dutt Shukla, Anil Panwar
BACKGROUND: Small molecule phytocompounds can potentially ameliorate degenerative changes in cerebral tissues. Thus, the current study aimed to evaluate the neuroprotective efficacy of phytocompounds of methanolic shoots extract of Calligonum polygonoides L. (MSECP) in hypercholesterolemia-associated neurodegenerations. METHODS: Phytochemical screening of the extract was made by LCMS/MS and validated by a repository of the chemical library. The hypercholesterolemia was induced through the intraperitoneal administration of poloxamer-407 with a high-fat diet...
April 2, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Luigi Santacroce, Lucrezia Bottalico, Ioannis Alexandros Charitos, Kastriot Haxhirexha, Skender Topi, Emilio Jirillo
Longevity has been associated with healthy lifestyles, including some dietary regimens, such as the Mediterranean diet (MedDiet) and the Blue Zone (BZ) diets. MedDiet relies on a large consumption of fruit, vegetables, cereals, and extra-virgin olive oil, with less red meat and fat intake. Four major BZ have been recognized in the world, namely, Ogliastra in Sardinia (Italy), Ikaria (Greece), the Peninsula of Nicoya (Costa Rica), and Okinawa (Japan). Extreme longevity in these areas has been associated with correct lifestyles and dietary regimens...
April 2, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Anran Liang, Tingting Feng, Xiang Gao, Bowen Zhao, Song Chen
BACKGROUND: The dysregulation of the innate immune system plays a crucial role in the development of Diabetic Retinopathy (DR). To gain an insight into the underlying mechanism of DR, it is essential to identify specific biomarkers associated with immune cell infiltration. METHODS: In this study, we retrieved the GSE94019 and GSE60436 datasets from the Gene Expression Omnibus (GEO) database. By utilizing CIBERSORT, MCPcounter, and xCell algorithms, we conducted a comprehensive analysis of the immune cell infiltration landscape in DR...
March 19, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Monica Montagnani, Maria Assunta Potenza, Massimo Corsalini, Giuseppe Barile, Ioannis Alexandros Charitos, Andrea de Giacomo, Emilio Jirillo, Marica Colella, Luigi Santacroce
Panax ginseng is one of the most important remedies in ancient Eastern medicine. In the modern Western world, its reputation started to grow towards the end of the XIX century, but the rather approximate understanding of action mechanisms did not provide sufficient information for an appropriate use. Nowadays, Panax ginseng is frequently used in some pathological conditions, but the comprehension of its potential beneficial effects is still incomplete. The purpose of this study is to highlight the most recent knowledge on mechanisms and effects of ginseng active ingredients on the intestinal microbiota...
March 19, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Mario G Balzanelli, Reza Rastanesh, Pietro Distratis, Rita Lazzaro, Francesco Inchingolo, Raffaele Del Prete, Van H Pham, Sergey K Aityan, Toai Tran Cong, Kieu C D Nguyen, Ciro Gargiulo Isacco
Coronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding replicase and structural proteins for the virus...
March 11, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Zi-Jun Lin, Lian-Ping He, Cui-Ping Li
Gestational Diabetes Mellitus (GDM) is a common endocrine condition associated with adverse pregnancy outcomes. In recent years, a growing number of risk factors associated with gestational diabetes mellitus have been defined. GDM poses a serious threat to maternal health. The etiology is complex and multifactorial and can be divided into inherent and modifiable factors. The inherent factors have been described in other literature, while the modifiable factors are mainly the risk of lifestyle habits. In this study, we performed a narrative review of the progress of risk factors associated with gestational diabetes mellitus...
March 7, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Laura Molteni, Giuseppe Marelli, Giona Castagna, Luciano Brambilla, Maurizio Acerbis, Fabio Alberghina, Antonio Carpani, Erika Chiavenna, Maria Grazia Ferlini, Carmen Impellizzeri, Roberto Paredi, Alberto Rigamonti, Giuseppe Rivolta, Olga Eugenia Disoteo
BACKGROUND: Compared to Immediate-Release (IR) metformin, Extended-Release (ER) metformin reduces side effects and pill burden while improving adherence; however, there is little real-life data on patient satisfaction with this innovative formulation to guide physicians toward a more holistic approach. OBJECTIVE: Our goal is to train general practitioners on holistic patient management, with the aim of increasing patient satisfaction and treatment adherence, reducing side effects, and improving quality of life in patients with poor tolerance to metformin-IR...
February 28, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Mehdi Kushkestani, Mahsa Moghadassi, Labros Sidossis
Although the Mediterranean Diet (MedDiet) may appear simple and locally inspired based on the provided definitions, mounting evidence reveals that adopting a dietary pattern aligned with MedDiet principles can yield numerous health benefits. Also, the MedDiet stands as the gold standard in preventive medicine, so it is not a simplistic diet centered around specific ingredients or cooking methods; instead, it emerges from a distinctive way of life (lifestyle) inherent to the Mediterranean region. This lifestyle encapsulates essential components of a balanced diet and life, including frugality and moderation in food consumption, the utilization of seasonal and traditional products, a focus on locally sourced, eco-friendly, and biodiverse items, personal engagement in culinary preparation, the emphasis on conviviality and social activities during meal consumption, regular engagement in physical activity, adequate hydration, and sufficient rest...
February 28, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Javad Razaviyan, Majid Sirati-Sabet, Ali Tafti, Razie Hadavi, Saeed Karima, Masoumeh Rajabibazl, Samira Mohammadi-Yeganeh
BACKGROUND: The most aggressive form of breast cancer (BC) is Triple-Negative BC (TNBC), with the poorest prognosis, accounting for nearly 15% of all cases. Since there is no effective treatment, novel strategies, especially targeted therapies, are essential to treat TNBC. Exosomes are nano-sized microvesicles derived from cells and transport various intracellular cargoes, including microRNAs (miRNAs). MiRNAs, small non-coding RNA, are an influential factor in the development of cancerous transformations in cells...
February 28, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Elizalde-Barrera Cesar Ivan, Estrada-Garcia Teresa, Lopez-Saucedo Catalina, Rubio-Guerra Alberto Francisco, Ramirez-Velasco Diana Elena
BACKGROUND: Obesity-linked insulin resistance (IR) is an important risk factor for metabolic diseases, and anthropometric indices are commonly used for risk assessment. AIM: The study aimed to assess possible differences between women and men in the predictive value and association of nine obesity indices with IR, as assessed by HOMA-IR, in a nondiabetic adult population. METHODS: The cross-sectional study included individuals recruited from a hospital in Mexico City...
February 23, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Shayesteh Khalili, Anahita Zakeri, Farzad Hadaegh, Seyed Saeed Tamehri Zadeh
BACKGROUND: Adrenal Hypoplasia Congenita (AHC) is a rare subtype of primary adrenal insufficiency (PAI) that can go undiagnosed easily. In this article, we report two brothers with hypogonadotropic hypogonadism and novel mutations in the NR0B1 gene who were misdiagnosed and mismanaged as having congenital adrenal hypoplasia (CAH) for several years. CASE PRESENTATION: Herein, we describe two brothers with similar histories; first, they were diagnosed with CAH and treated for that; however, after several years, they showed symptoms of lack of testosterone despite receiving CAH treatment...
February 21, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Stephanie Farah, Leah Nasr, Jocelyne Eid Fares
BACKGROUND: A far more common disease than Cushing's syndrome is subclinical hypercortisolism or mild autonomous cortisol secretion (MACS), with an overall prevalence of 0.2-2%. OBJECTIVE: This review aims to shed light on the prevalence, screening and diagnostic criteria, comorbidities, and management of Mild Autonomous Cortisol Secretion (MACS). METHODS: Studies eligible targeted MACS regarding prevalence, screening, comorbidities, management, and clinical outcome...
February 16, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Bindu Kumari, Usha Kumari, Dhananjay Kumar Singh, Gulam Mohammad Husain, Dinesh Kumar Patel, Anshul Shakya, Ravi Bhushan Singh, Gyan Prakash Modi, Gireesh Kumar Singh
BACKGROUNDS: Postbiotics produced by gut microbiota have exhibited diverse pharmacological activities. Valeric acid, a postbiotic material produced by gut microbiota and some plant species like valerian, has been explored to have diverse pharmacological activities. METHODS: This narrative review aims to summarise the beneficial role of valeric acid for different health conditions along with its underlying mechanism. In order to get ample scientific evidence, various databases like Science Direct, PubMed, Scopus, Google Scholar and Google were exhaustively explored to collect relevant information...
February 16, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Yiling Cui, Ningyi Song, Ling Hou
BACKGROUND: This study reported a case of micropenis caused by a novel hemizygous mutation in the ADGRG2 gene, which aimed to expand the understanding of sexual dysplasia caused by ADGRG2 gene mutation. CASE PRESENTATION: We present the clinical data and genetic test results of a patient with micropenis admitted in September, 2022, to the Tongji Hospital. The patient was a 9-year-10- month-old male whose chief complaint was the presence of a short penis over a period of three years...
February 15, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
María Miguélez González, Alba Galdón Sanz-Pastor, Roberto Áñez Gómez, Noemi Brox Torrecilla, Diego Muñoz Moreno, Laura González Fernández, Alejandra Maricel Rivas, Aurelio López Guerra, Rosa Álvarez, José Ángel Arranz, Iván Márquez Rodas, Vicente Escudero, María Sanjurjo, Javier Martín Vallejo, Miguel Martín, Olga González Albarrán
OBJECTIVE: The purpose of this study was to identify predictive and risk factors for the development of immune-related endocrinopathies and to analyze the incidence and characteristics of immune-related endocrinopathies in our population Design: A retrospective, single-centre cohort carried out at Gregorio Marañón Hospital between January 2018 -December 2019. METHODS: A total of 163 patients were enrolled. In January 2018 and December 2019, we treated patients who underwent ICI treatment in the Medical Oncology Department of General University Hospital Gregorio Marañón, a tertiary care public hospital in Madrid, as part of an observational, retrospective, single-center cohort study...
February 14, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Xiaomei Lv, Yujun An
BACKGROUND: Gestational diabetes mellitus (GDM) is considered a risk factor for heart metabolic disorder in future mothers and offspring. Ferroptosis is a new type of programmed cell death, which may participate in the occurrence and development of GDM. OBJECTIVE: This study aims to identify ferroptosis-related genes in GDM by bioinformatics methods and to explore their clinical diagnostic value. METHODS: The dataset GSE103552 was analyzed using the Gene Expression Omnibus (GEO) database to screen for differentially expressed genes (DEGs) in GDM...
February 12, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
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