Journals Endocrine, Metabolic & Immune ...

Endocrine, Metabolic & Immune Disorders Drug Targets
Elena Castellano, Roberto Attanasio, Alberto Boriano, Laura Gianotti, Giorgio Borretta
OBJECTIVE: Primary Hyperparathyroidism (PHPT) is a common disease, frequently diagnosed in post-menopausal women, among whom Osteoporosis (OP) is a common finding. To date, no study has specifically evaluated the asymptomatic PHPT (aPHPT) patients without OP, in particular post-menopausal women who are exposed to an increased risk of developing OP. DESIGN: This study involved a retrospective cross-sectional evaluation. PATIENTS: From our database of 500 consecutive patients diagnosed with PHPT, 178 postmenopausal aPHPT were retrieved...
May 7, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Meeramol C Chellappan, V Soumya, Shriraam Mahadevan, M K Kathiravan, J Saravanan, Soniya Naik
Type 2 diabetes mellitus is a long-term medical illness in which the body either becomes resistant to insulin or fails to produce it sufficiently. Mostly, combinatorial therapy is required to control blood glucose levels. However, combinatorial therapy has detrimental side effects. The prevalence of the cases and subsequent increases in medical costs of the same intimidate human health globally. While there have been a lot of studies focused on developing diabetic regimens that work to lower blood glucose levels, their effectiveness is short-lived because of unfavorable side effects, such as weight gain and hypoglycemia...
April 30, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Benedetta Rivolta, Benedetta Masserini, Irene Bernardi, Antonella Camera, Federico Liboà, Sebastiano Bruno Solerte, Chiara Cerabolini, Nadia Cerutti
BACKGROUND: T1DM patients have a higher prevalence of eating disorders than the general population, and up to 30-40% of young T1DM patients suffer from an eating disorder, including diabulimia. Eating disorders worsen glycemic control and make insulin therapy management more difficult. Closed loop systems (HCLS) allow major therapeutic flexibility; however, proper carbohydrate (CHO) counting remains a fundamental feature for insulin dose adjustments. CASE REPORT: A 30-year-old female patient affected by T1DM (with a past medical history of drug abuse and depressive syndrome) presented with inadequate glycemic control and prandial boli management...
April 30, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Deepak Kumar, Govind Singh, Tarun, Meenakshi Dhanawat, Sumeet Gupta, Mohamed A Morsy, Anroop B Nair, Asmaa I Matouk
BACKGROUND: Alzheimer's disease is a neurological dysfunction of the brain caused by neurodegeneration and oxidative stress. Some viruses, such as herpes viruses, HSV-1, and HSV-2, are causative agents of Alzheimer's disease and result in β-amyloid peptide and tau protein accumulation in the brain. Some antiviral drugs, such as valacyclovir, acyclovir, and foscarnet, reduce amyloid-beta and P-tau. Pavetta indica leaves are also reported for their antiviral properties. The current study aimed to find out the significance of using Pavetta indica methanolic extract and acyclovir against Alzheimer's disease induced by streptozotocin...
April 27, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Francesco Di Marco, Claudio Cusini, Anna Ferrulli, Giovanni Mauri, Livio Luzi
BACKGROUND: Currently, parathyroidectomy is the standard treatment for Primary Hyperparathyroidism (PHPT). Surgical treatment is often effective, although not free of complications and relapses. Minimally invasive techniques, such as Microwave Ablation (MWA) and Radiofrequency Ablation (RFA), are an alternative to surgery in selected patients. We have, herein, reported on the successful use of RFA in a patient with post-surgical persistent hyperparathyroidism. CASE PRESENTATION: A 54-year-old woman was referred to our Center for mild hypercalcemia with exams revealing Primary Hyperparathyroidism (PHPT)...
April 26, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Sally A Elekhtiar, Maha Mohamed Abo Gazia, Azza I Helal, Hala Mahfouz, Nesma M El-Kemary, Sherief Abd-Elsalam, Samar Elksass, Hend A Alkabes, Maged El-Kemary, Marwa M Abd-Elsalam
BACKGROUND: Diabetic wound represents a serious issue with a substantial impact and an exceptionally complex pathology affecting patients' mental health and quality of life. So, we have developed a novel 3D organo-hydrogel nanocomposite of polydopamine/TiO2 nanoparticles and cu (PDA-TiO2@Cu) and examined its efficacy in diabetic wound healing. METHODS: Forty-five adult male albino rats were divided into normal control rats (non-diabetic rats with non-treated skin wounds), diabetic control rats (diabetic rats with non-treated skin wounds), and organo-hydrogel-treated rats (diabetic wounds treated with topically applied organo- hydrogel once daily)...
April 26, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Alberto Ragni, Giulia Bendotti, Emilia Biamonte, Beatrice Cavigiolo, Enrico Gabellieri, Paola Leporati, Edoardo Luigi Maria Mollero, Marco Gallo
BACKGROUND: Pituitary apoplexy (PA) can arise from haemorrhage or ischaemia of pituitary tissue and is characterized by abrupt onset of headache, visual impairment and hypopituitarism. COVID-19 may be associated with various degrees of vascular complications and, recently, its relationship with PA has been suggested. Cases Presentation Case 1: A 64-year-old male with type 2 diabetes, hypertension and coronary heart disease was admitted to the ER, after several days of asymptomatic COVID-19 infection, with symptoms of PA of a known non-functioning pituitary macroadenoma...
April 26, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Praveen Halagali, Aparna Inamdar, Jagroop Singh, Amit Anand, Poulami Sadhu, Rashmi Pathak, Himanshu Sharma, Deepak Biswas
Comprehensive and effective care techniques have become essential due to the global epidemic dimensions of metabolic disorders, including diabetes, obesity, and cardiovascular ailments. Recent research highlights the potential of dietary supplements, herbal extracts, and phytochemicals in treating metabolic diseases. This abstract conveys the current state of the science in this field by highlighting these findings' underlying mechanisms and potential therapeutic applications. Plant-based diets contain naturally occurring bioactive molecules termed phytochemicals, which have shown promise in treating various metabolic illnesses...
April 26, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Mehtap Evran, Gizem Pire, İsa Burak Güney
OBJECTIVE: Patients with impaired glucose metabolism have increased thyroid volume and a higher prevalence of nodules. Yet, some studies show that there is an improvement in these thyroid parameters after diabetes treatment. Our observational study aimed to reveal the effect of treatment on thyroid function, thyroid volume, and the presence of nodules in newly diagnosed type 2 diabetes mellitus (T2DM) patients who were started on metformin treatment. METHODS: Euthyroid and subclinically hypothyroid patients with a serum TSH level of <10 mU/L, who were newly diagnosed with T2DM and started on metformin as an antidiabetic treatment and not used any thyroid medication previously, were included in our study...
April 26, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Kai-Sheng Liao, Ying-Ray Lee, Wen-Ying Chao, Yen-Ju Huang, Hui-Chen Chung, Shu-Hsin Chen, Yi-Zhen Li, Pei-Wen Zhao, Hong-Yi Chang
BACKGROUND: Honokiol is a natural polyphenolic compound extracted from Magnolia officinali, which is commonly used material in Chinese herbal medicine, has a variety of biological functions, including anti-tumor, anti-oxidant, anti-inflammation, anti-microbial and anti-allergy. Although honokiol has numerous beneficial effects on human diseases, the underlying mechanisms of tumor metastasis are still unclear. Previously, we reported that honokiol suppresses thyroid cancer cell proliferation with cytotoxicity through cell cycle arrest, apoptosis, and dysregulation of intracellular hemostasis...
April 24, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Oğuz Akkuş, Fatih Şen, Ramazan Yasdıbaş, Alper Tunga Ötegen, İrem Hüzmeli, Gamze Akkuş
BACKGROUND: The effects of thyroid hormone on patients hospitalized in coronary intensive care units are still controversial. We retrospectively examined thyroid hormone levels and their impact on cardiovascular morbidity in patients admitted to coronary intensive care units. MATERIAL AND METHODS: A total of 208 (Female/Male; 47.1%/52.9%) patients without any history of thyroid disease were enrolled and screened. Patients with specific heart disease and existing thyroid hormone parameters were included in the study...
April 23, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Juan Du, Enhua Shen
BACKGROUND: Hepatocellular carcinoma (HCC) is a globally prevalent malignancy accompanied by high incidence, poor outcomes, and high mortality. Anthocyanins can inhibit tumor proliferation, migration, invasion, and promote apoptosis. Moreover, autophagy-related genes (ARGs) may play vital roles in HCC progression. This study aimed to decipher the mechanisms through which anthocyanins influence HCC via ARGs and to establish a novel prognostic model. METHODS: Based on data from public databases, differential analysis and the Venn algorithm were employed to detect intersecting genes among differentially expressed genes (DEGs), anthocyanin- related targets, and ARGs...
April 8, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Anita Sakarwal, Karishma Sen, Heera Ram, Suman Chowdhury, Priya Kashyap, Sunil Dutt Shukla, Anil Panwar
BACKGROUND: Small molecule phytocompounds can potentially ameliorate degenerative changes in cerebral tissues. Thus, the current study aimed to evaluate the neuroprotective efficacy of phytocompounds of methanolic shoots extract of Calligonum polygonoides L. (MSECP) in hypercholesterolemia-associated neurodegenerations. METHODS: Phytochemical screening of the extract was made by LCMS/MS and validated by a repository of the chemical library. The hypercholesterolemia was induced through the intraperitoneal administration of poloxamer-407 with a high-fat diet...
April 2, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Luigi Santacroce, Lucrezia Bottalico, Ioannis Alexandros Charitos, Kastriot Haxhirexha, Skender Topi, Emilio Jirillo
Longevity has been associated with healthy lifestyles, including some dietary regimens, such as the Mediterranean diet (MedDiet) and the Blue Zone (BZ) diets. MedDiet relies on a large consumption of fruit, vegetables, cereals, and extra-virgin olive oil, with less red meat and fat intake. Four major BZ have been recognized in the world, namely, Ogliastra in Sardinia (Italy), Ikaria (Greece), the Peninsula of Nicoya (Costa Rica), and Okinawa (Japan). Extreme longevity in these areas has been associated with correct lifestyles and dietary regimens...
April 2, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Anran Liang, Tingting Feng, Xiang Gao, Bowen Zhao, Song Chen
BACKGROUND: The dysregulation of the innate immune system plays a crucial role in the development of Diabetic Retinopathy (DR). To gain an insight into the underlying mechanism of DR, it is essential to identify specific biomarkers associated with immune cell infiltration. METHODS: In this study, we retrieved the GSE94019 and GSE60436 datasets from the Gene Expression Omnibus (GEO) database. By utilizing CIBERSORT, MCPcounter, and xCell algorithms, we conducted a comprehensive analysis of the immune cell infiltration landscape in DR...
March 19, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Monica Montagnani, Maria Assunta Potenza, Massimo Corsalini, Giuseppe Barile, Ioannis Alexandros Charitos, Andrea de Giacomo, Emilio Jirillo, Marica Colella, Luigi Santacroce
Panax ginseng is one of the most important remedies in ancient Eastern medicine. In the modern Western world, its reputation started to grow towards the end of the XIX century, but the rather approximate understanding of action mechanisms did not provide sufficient information for an appropriate use. Nowadays, Panax ginseng is frequently used in some pathological conditions, but the comprehension of its potential beneficial effects is still incomplete. The purpose of this study is to highlight the most recent knowledge on mechanisms and effects of ginseng active ingredients on the intestinal microbiota...
March 19, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Mario G Balzanelli, Reza Rastanesh, Pietro Distratis, Rita Lazzaro, Francesco Inchingolo, Raffaele Del Prete, Van H Pham, Sergey K Aityan, Toai Tran Cong, Kieu C D Nguyen, Ciro Gargiulo Isacco
Coronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding replicase and structural proteins for the virus...
March 11, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Zi-Jun Lin, Lian-Ping He, Cui-Ping Li
Gestational Diabetes Mellitus (GDM) is a common endocrine condition associated with adverse pregnancy outcomes. In recent years, a growing number of risk factors associated with gestational diabetes mellitus have been defined. GDM poses a serious threat to maternal health. The etiology is complex and multifactorial and can be divided into inherent and modifiable factors. The inherent factors have been described in other literature, while the modifiable factors are mainly the risk of lifestyle habits. In this study, we performed a narrative review of the progress of risk factors associated with gestational diabetes mellitus...
March 7, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Laura Molteni, Giuseppe Marelli, Giona Castagna, Luciano Brambilla, Maurizio Acerbis, Fabio Alberghina, Antonio Carpani, Erika Chiavenna, Maria Grazia Ferlini, Carmen Impellizzeri, Roberto Paredi, Alberto Rigamonti, Giuseppe Rivolta, Olga Eugenia Disoteo
BACKGROUND: Compared to Immediate-Release (IR) metformin, Extended-Release (ER) metformin reduces side effects and pill burden while improving adherence; however, there is little real-life data on patient satisfaction with this innovative formulation to guide physicians toward a more holistic approach. OBJECTIVE: Our goal is to train general practitioners on holistic patient management, with the aim of increasing patient satisfaction and treatment adherence, reducing side effects, and improving quality of life in patients with poor tolerance to metformin-IR...
February 28, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
Mehdi Kushkestani, Mahsa Moghadassi, Labros Sidossis
Although the Mediterranean Diet (MedDiet) may appear simple and locally inspired based on the provided definitions, mounting evidence reveals that adopting a dietary pattern aligned with MedDiet principles can yield numerous health benefits. Also, the MedDiet stands as the gold standard in preventive medicine, so it is not a simplistic diet centered around specific ingredients or cooking methods; instead, it emerges from a distinctive way of life (lifestyle) inherent to the Mediterranean region. This lifestyle encapsulates essential components of a balanced diet and life, including frugality and moderation in food consumption, the utilization of seasonal and traditional products, a focus on locally sourced, eco-friendly, and biodiverse items, personal engagement in culinary preparation, the emphasis on conviviality and social activities during meal consumption, regular engagement in physical activity, adequate hydration, and sufficient rest...
February 28, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
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