journal
Journals CNS & Neurological Disorders D...

CNS & Neurological Disorders Drug Targets

https://read.qxmd.com/read/38008941/intestinal-barrier-function-and-neurodegenerative-disease
#21
JOURNAL ARTICLE
Shijing Wu, Liangfang Yang, Yiwei Fu, Zhimin Liao, De Cai, Zhou Liu
Neurodegenerative diseases are caused by the loss of neurons and/or their myelin sheaths, which deteriorate over time and become dysfunctional. Alzheimer's disease, Parkinson's disease, and multiple sclerosis are among the most prominent neurodegenerative diseases that affect millions of older adults worldwide. Despite extensive research over several decades, controversies still surround the etiology of neurodegenerative diseases, and many of them remain incurable. Meanwhile, an increasing number of new mechanistic studies related to the microbiota-gut-brain axis have emerged, among which the relationship between the function of the intestinal barrier and neurodegenerative diseases has received widespread attention...
November 24, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37990896/transdermal-therapeutic-systems-for-the-treatment-of-alzheimer-s-disease-a-patent-review
#22
JOURNAL ARTICLE
Letícia Basso, Silvia Cristina Fagundes, Tatiana Staudt, Karini da Rosa, Elizane Langaro, Hamid Omidian, Charise Dallazem Bertol
BACKGROUND: Two classes of medications are used to treat Alzheimer's disease (AD); donepezil, galantamine, and rivastigmine are acetylcholinesterase inhibitors, and memantine is a non-competitive antagonist of the N-methyl-D-aspartate receptor. Although these are typically taken orally, there are transdermal therapeutic systems (TTSs) commercially available for rivastigmine and donepezil. The transdermal route has been preferable for guardians/caregivers due to ease of use, reduced side effects, and improved adherence to therapy...
November 16, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37921148/metabolic-disorder-therapeutics-and-their-effects-on-memory
#23
JOURNAL ARTICLE
Punita Agarwal, Faiz Khan, Sugato Banerjee
Diabetes is one of the major metabolic disorders of this era. It not only impacts a person's lifestyle but also has a long-term impact on the brain. It has a detrimental effect on a person's health when combined with hypertension and hyperlipidaemia. Several studies have suggested that the incidence of dementia is higher in people with metabolic syndrome. Investigations are underway to determine whether antidiabetic, hypolipidemic, hypercholesteraemic, anti-hypertensive, and other combination medicines can minimize the incidence of cognitive impairment...
October 25, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37885113/circadian-rhythms-and-sleep-disorders-associated-to-major-depressive-disorder-pathophysiology-and-therapeutic-opportunities
#24
JOURNAL ARTICLE
Luana M Manosso, Luciano A Duarte, Nicoly S Martinello, Gisiane B Mathia, Gislaine Z Réus
Major depressive disorder (MDD) is a complex mood disorder. While much progress has been made in understanding the pathophysiology of MDD, no single mechanism can explain all facets of this disorder. Several studies show that disturbances in biological rhythms can lead to the development of MDD. Indeed, insomnia or hypersomnia are symptoms included in the MDD diagnostic criteria. Clinical studies and meta-analyses showed a strong relationship between MDD and sleep disorders. Sleep disorder and MDD are associated with activation in the hypothalamicpituitary-adrenal (HPA) axis and inflammation...
October 25, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37916625/the-essential-role-of-astrocytes-in-neurodegeneration-and-neuroprotection
#25
JOURNAL ARTICLE
Federico López Couselo, Julieta Saba, Lila Carniglia, Daniela Durand, Mercedes Lasaga, Carla Caruso
Astrocytes are glial cells that perform several fundamental physiological functions within the brain. They can control neuronal activity and levels of ions and neurotransmitters, and release several factors that modulate the brain environment. Over the past few decades, our knowledge of astrocytes and their functions has rapidly evolved. Neurodegenerative diseases are characterized by selective degeneration of neurons, increased glial activation, and glial dysfunction. Given the significant role played by astrocytes, there is growing interest in their potential therapeutic role...
October 24, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37855362/length-of-survival-outcome-and-potential-predictors-in-poor-grade-aneurysmal-subarachnoid-hemorrhage-patients-treated-with-microsurgical-clipping
#26
JOURNAL ARTICLE
Xanthoula Lambrianou, Christos Tzerefos, Christina Arvaniti, Anastasia Tasiou, Kostas N Fountas
BACKGROUND: Poor-grade aneurysmal subarachnoid hemorrhage (aSAH) has been associated with severe morbidity and high mortality. It has been demonstrated that early intervention is of paramount importance. The aim of our study is to evaluate the functional outcome and the overall survival of early microsurgically treated patients. MATERIAL AND METHODS: Poor-grade aSAH patients admitted at our institution over fifteen years (January 2008 - December 2022) were included in our retrospective study...
October 19, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37846576/the-effectiveness-of-transcranial-magnetic-stimulation-in-treating-apraxia
#27
JOURNAL ARTICLE
Asma Ruwaili, Rida Fatima, Amal Hussain, Mohammad Uzair, Turki Abualait, Kaleem Imdad, Shahid Bashir
Apraxia can be detected when engaging in mental motor envisioning exercises. The nonverbal skills of manufacturing, representation, strategizing, arithmetic, visual sensitivity, and motor skills are all related to apraxia. Limb apraxia also negatively affects communication gestures and linguistic skills. The impairment of brain regions related to motion patterns is the primary cause of apraxia. People with apraxia may struggle to complete a variety of tasks because they are unable to focus on various movements...
October 13, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37842902/exerkines-a-crosstalk-between-lactate-production-exercise-and-mental-health
#28
JOURNAL ARTICLE
Alberto Souza Sá Filho, Silvio Roberto Barsanulfo, Sara Socorro Faria, Pedro Augusto Inacio, Farahnaz Ayatizadeh, Sérgio Machado
Muscle skeletal striated cells secrete a wide range of proteins called myokines or "exerkines", which in turn perform autocrine, paracrine, or endocrine functions. For being able to act in the communication between skeletal muscle, adipose tissue, and mainly the brain, exerkines play a prominent role and potential influence on health promotion. Furthermore, we detected in the literature that one of these potential therapeutic substances derived from muscle contraction is a molecule derived from glycolytic metabolism that in the past was largely marginalized, the lactate...
October 12, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37861051/artificial-intelligence-in-the-management-of-neurodegenerative-disorders
#29
JOURNAL ARTICLE
Sanchit Dhankar, Somdutt Mujwar, Nitika Garg, Samrat Chauhan, Prerna Sharma, Satish Kumar Sharma, Mohammad Amjad Kamal, Dr Nidhi Rani, Suresh Kumar, Monika Saini
Neurodegenerative disorders are characterized by a gradual but irreversible loss of neurological function. The ability to detect and treat these conditions successfully is crucial for ensuring the best possible quality of life for people who suffer from them. The development of effective new methods for managing and treating neurodegenerative illnesses has been made possible by recent developments in computer technology. In this overview, we take a look at the prospects for applying computational approaches, such as drug design, AI, ML, and DL, to the treatment of neurodegenerative diseases...
October 11, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37815179/pre-clinical-aspects-and-contemporary-treatments-of-parkinson-s-disease
#30
JOURNAL ARTICLE
Partosh Chhabra, Rishabh, Shivani Singla, Sunayna Choudhary, Shivam Kohli, Nitin Bansal, Seema Bansal
BACKGROUND: After Alzheimer's disease, the second slot for the most common neurodegenerative disease, is occupied by Parkinson's disease. The symptoms of Parkinson's are classified as motor symptoms and non-motor symptoms. Motor symptoms involve rigidity, tremors, bradykinesia, and postural instability. Non-motor symptoms consist of cognitive dysfunction, salivation, lacrimation, etc. Objectives: The objectives of this study are to find out the most recent treatment options for Parkinson's disease...
October 6, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37855297/memory-reflections-of-the-microbiota-gut-and-oligodendrocyte-axis
#31
JOURNAL ARTICLE
Suman Kumar Ray, Sukhes Mukherjee
Memory is the persisting consequence of cognitive activities instigated by and engrossed on exterior information from the environment and commenced by an intensive on internal mental representations. Establishing a gut-brain axis (GBA) in health and disease has recently brought the gut, the main portal of communication with the external environment, to the forefront of this interaction. Dietary stimuli have long been linked to brain development, behavioral responses, and memory reflections. Vagus nerve, immune system, bacterial metabolites and products are just a few of the linkages that make up the GBA, a bidirectional arrangement of signaling pathways that connects the neurological system with the gastrointestinal tract...
October 5, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37855296/the-landscape-of-randomized-clinical-trial-meta-analyses-on-statins-for-aneurysmal-subarachnoid-hemorrhage-a-scoping-review
#32
JOURNAL ARTICLE
Panagiotis Skouras, Theodosis Kalamatianos, Mariam Markouli, Angelos Karagiannis, Lampis C Stavrinou
INTRODUCTION: Aneurysmal subarachnoid hemorrhage (aSAH) is a type of non-traumatic SAH that can have detrimental effects on the central nervous system, resulting in severe disability or death. METHODS: Early nimodipine is currently the only strongly recommended pharmacological treatment that has shown efficacy in improving neurological/functional outcomes in aSAH patients. Whether statin treatment is of benefit to aSAH patients is an issue that has generated considerable interest and debate...
October 4, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37817521/role-of-astrogliosis-in-the-pathogenesis-of-parkinson-s-disease-insights-into-astrocytic-nrf2-pathway-as-a-potential-therapeutic-target
#33
JOURNAL ARTICLE
Bharat Bhushan, Niraj Kumar Singh
Recently, Parkinson's disease (PD) has become a remarkable burden on families and society with an acceleration of population aging having several pathological hallmarks such as dopaminergic neuronal loss of the substantia nigra pars compacta, α-synucleinopathy, neuroinflammation, autophagy, last but not the least astrogliosis. Astrocyte, star-shaped glial cells perform notable physiological functions in the brain through several molecular and cellular mechanisms including nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway...
October 4, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37779395/montelukast-ameliorates-scopolamine-induced-alzheimer-s-disease-role-on-cholinergic-neurotransmission-antioxidant-defence-system-neuroinflammation-and-expression-of-bdnf
#34
JOURNAL ARTICLE
Bhavana Yerraguravagari, Naga Pavani Penchikala, Aravinda Sai Kolusu, Grandhi Sandeep Ganesh, Prasad Konduri, Kumar V S Nemmani, Pavan Kumar Samudrala
BACKGROUND: Alzheimer's disease (AD) is an overwhelming neurodegenerative disease with progressive loss of memory. AD is characterized by the deposition of the senile plaques mainly composed of β-amyloid (Aβ) fragment, BDNF decline, Cholinergic system overactivity and neuroinflammation. Montelukast (MTK), a leukotriene receptor antagonist, showed astounding neuroprotective effects in a variety of neurodegenerative disorders. OBJECTIVE: This study aims to investigate the ameliorative effects of Montelukast in the scopolamineinduced Alzheimer's disease (AD) model in rats and evaluate its activity against neuroinflammation...
September 27, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37855295/phosphodiesterase-2-and-its-isoform-a-as-therapeutic-targets-in-the-central-nervous-system-disorders
#35
JOURNAL ARTICLE
Sanjay K Metkar, Yuqing Yan, Yue Lu, Jianming Lu, Xiongwei Zhu, Fu Du, Ying Xu
Cyclic adenosine monophosphates (cAMP) and cyclic guanosine monophosphate (cGMP) are two essential second messengers, which are hydrolyzed by phosphodiesterase's (PDEs), such as PDE-2. Pharmacological inhibition of PDE-2 (PDE2A) in the central nervous system improves cAMP and cGMP signaling, which controls downstream proteins related to neuropsychiatric, neurodegenerative, and neurodevelopmental disorders. Considering that there are no specific treatments for these disorders, PDE-2 inhibitors' development has gained more attention in the recent decade...
September 25, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37702162/role-of-bdnf-signaling-in-the-neuroprotective-and-memory-enhancing-effects-of-flavonoids-in-alzheimer-s-disease
#36
JOURNAL ARTICLE
Meysam Amidfar, Michelle Lima Garcez, Gholamreza Askari, Mohammad Bagherniya, Fariborz Khorvash, Sahar Golpour Hamedani, Jade de Oliveira
INTRODUCTION: Foods rich in flavonoids are associated with a reduced risk of various chronic diseases, including Alzheimer's disease (AD). In fact, growing evidence suggests that consuming flavonoid-rich foods can beneficially affect normal cognitive function. Animal models have shown that many flavonoids prevent the development of AD-like pathology and improve cognitive deficits. RESULT: Flavonoid-rich foods, such as green tea and blueberries, must exert their effect through the direct interaction of absorbed flavonoids and their metabolites with cellular and molecular targets...
September 12, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37670711/deciphering-the-role-of-peroxisome-proliferator-activated-receptor-%C3%AE-and-phosphodiesterase-type-5-targets-in-alzheimer-s-disease
#37
JOURNAL ARTICLE
Parnika M Sose, Pravin P Kale, Gaurav M Doshi
The most prevalent cause of dementia is Alzheimer's disease (AD). Although the global AD rate is on a constant rise, medical research is yet to find a cure for this neurological condition. Current available therapeutic drugs for AD treatment only provide symptomatic alleviation. Therefore, it is essential to establish effective AD treatment strategies in addressing clinical needs. The development of disease-modifying treatments for use in the disease's early stages and the advancement of symptomatic drugs principally used in the disease's later stages are priorities in AD research...
September 4, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37592793/mycotoxins-and-amyotrophic-lateral-sclerosis-food-exposure-nutritional-implications-and-dietary-solutions
#38
JOURNAL ARTICLE
Umberto Manera, Enrico Matteoni, Antonio Canosa, Stefano Callegaro, Federico Casale, Daniela Marchis, Rosario Vasta, Cristina Moglia, Adriano Chiò, Andrea Calvo
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder determined by a combination of both genetic and environmental factors. Despite wide investigations, the role of chronic exposure to environmental pollutants is still rather unknown. Among natural toxins, the mycotoxins have received major attention only in the last few years, due to both technical and scientific achievements that allowed to disentangle many important features of the complex fungal biology. Whereas the effects of acute and high-dose mycotoxin exposure are well known, the potential effects of chronic and low-dose exposure on neurodegeneration have not been broadly elucidated...
August 17, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37592792/neuroprotection-of-sex-bias-a-protective-response-to-traumatic-brain-injury-in-the-females
#39
JOURNAL ARTICLE
Mohammad I Yatoo, Ghaith A Bahader, Shafayat A Beigh, Adil M Khan, Antonisamy William James, Maleha R Asmi, Zahoor A Shah
Traumatic brain injury (TBI) is a major healthcare problem and a common cause of mortality and morbidity. Clinical and preclinical research suggests sex-related differences in short- and long-term outcomes following TBI; however, males have been the main focus of TBI research. Females show a protective response against TBI. Female animals in preclinical studies and women in clinical trials have shown comparatively better outcomes against mild, moderate, or severe TBI. This reflects a favorable protective nature of the females compared to the males, primarily attributed to various protective mechanisms that provide better prognosis and recovery in the females after TBI...
August 17, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37587820/the-number-of-antiseizure-medications-taken-and-not-the-lipid-profile-was-associated-with-seizure-control-in-adult-patients-with-epilepsy
#40
JOURNAL ARTICLE
Vania Aparecida Leandro-Merhi, Glória Maria de Almeida Souza Tedrus, Giovanna Gigolotti Jacober de Moraes, Michele Novaes Ravelli
Previous studies show changes in lipid metabolism in epilepsy. The aim of this study was to investigate the association between lipid profile and clinical variables in adult patients with epilepsy (APE). Seventy-two APE participated in this pilot study at an outpatient neurology service. The lipid profile (total cholesterol, low-density lipoprotein (LDL) cholesterol, very-low-density lipoproteins (VLDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides), age at disease onset, disease duration, seizures frequency, and the number of antiseizure medications (ASM) used were investigated...
August 16, 2023: CNS & Neurological Disorders Drug Targets
journal
journal
41296
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.