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CNS & Neurological Disorders Drug Targets

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https://read.qxmd.com/read/30963986/targeting-macrophage-for-the-treatment-of-amyotrophic-lateral-sclerosis
#1
Lian Li, Jie Liu, Hua She
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease that specifically affects motor neurons in the brain and in the spinal cord. Patients with amyotrophic lateral sclerosis usually die from respiratory failure within 3 to 5 years from when the symptoms first appear. Currently, there is no cure for amyotrophic lateral sclerosis. Accumulating evidence suggests that dismantling of neuromuscular junction is an early event in the pathogenesis of amyotrophic lateral sclerosis. It is starting to realized that macrophage malfunction contributes to the disruption of neuromuscular junction...
April 8, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30892167/computational-protein-protein-docking-revealing-the-therapeutic-potential-of-kunitz-type-venom-against-hkv1-2-binding-sites
#2
Rida Khalid, Nighat Noureen, Mohammad Amjad Kamal, Sidra Batool
Kunitz-type venoms are bioactive proteins isolated from a wide variety of venomous animals. These venoms are involved in protease inhibitory activity or potassium channel blocking activity. Therefore they are reported as an important source for lead drug candidates towards protease or channel associated diseases like neurological, metabolic and cardiovascular disorders. This study aimed to check the inhibitory action of Kunitz-type venoms against potassium channels using computational tools. Among potassium channels, Human Voltage-Gated Potassium Channel 1...
March 19, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30892166/bioavailability-and-pharmaco-therapeutic-potential-of-luteolin-in-overcoming-alzheimer-s-disease
#3
Fahad Ali, Yasir Siddique
Luteolin is a naturally occurring, yellow crystalline flavonoid found in numerous dietary supplements we frequently have in our meals. Studies in last 2 decades have revealed its therapeutic potential to reduce the Alzheimer's disease (AD) symptoms in various in vitro and in vivo studies. The anti-Alzheimer's potential of luteolin is attributed to its ability to suppress Aβ as well as tau aggregation or promote their disaggregation, down-regulate the expression of COX-2, NOS, MMP-9, TNF-α, interleukins and chemokines, reduce oxidative stress by scavenging ROS, modulate the activities of transcription factors CREB, cJun, Nrf-1, NF-κB, p38, p53, AP-1 and β-catenine and inhibiting the activities of various protein kinases...
March 19, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30868971/attenuating-effect-of-portulaca-oleracea-extract-in-chronic-constriction-injury-induced-neuropathic-pain-in-rats-an-evidence-of-anti-oxidative-and-anti-inflammatory-properties
#4
Fatemeh Forouzanfar, Hossein Hosseinzadeh, Mohammad Bagher Khorrami, Samira Asgharzade, Hassan Rakhshandeh
Neuropathic pain responds poorly to drug treatments. The present study investigated the therapeutic effect of Portulaca oleracea, in chronic constriction injury (CCI)-induced neuropathic pain in rats. Neuropathic pain was performed by putting four loose ligatures around the sciatic nerve. CCI resulted in the development of heat hyperalgesia, mechanical allodynia and cold allodynia accompanied by an increase in the contents of TNF-α, IL1β, malondialdehyde, with a reduction in total thiol content. Administration of Portulaca oleracea (100 and 200 mg/kg intraperitoneal) for 14 days in CCI rats significantly alleviated pain-related behaviors, oxidative damage and inflammatory cytokines in a dose-dependent manner...
March 13, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30868970/hydrolyzed-rutin-decreases-worsening-of-anaplasia-in-glioblastoma-relapse
#5
Carlos Tadeu Parisi de Oliveira, Renato Colenci, Cesar Cozar Pacheco, Patrick Moro Mariano, Paula Ribeiro do Prado, Gustavo Pignatari Rosas Mamprin, Maycon Giovani Santana, Alessandra Gambero, Patrícia de Oliveira Carvalho, Denise Gonçalves Priolli
BACKGROUND: Gliomas are aggressive and resilient tumors. Progression to advanced stages of malignancy, characterized by cell anaplasia, necrosis, and reduced response to conventional surgery or therapeutic adjuvant, are critical challenges in glioma therapy. Relapse of the disease poses a considerable challenge for management. Hence, new compounds are required to improve therapeutic response. As hydrolyzed rutin (HR), a compound modified via rutin deglycosylation, as well as some flavonoids demonstrated antiproliferative effect for glioblastoma, these are considered potential epigenetic drugs...
March 13, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30868969/the-associations-between-central-nervous-system-diseases-and-haemostatic-disorders
#6
Maria Podsiedlik, Magdalena Markowicz-Piasecka, Elżbieta Mikiciuk-Olasik, Joanna Sikora
The aim of this review is to examine the relationship between the occurrence of central nervous system (CNS) diseases, the medicines used in their treatment and the blood coagulation process. The paper mainly focuses on the effects of antidepressant and antipsychotic drugs. Special attention has been paid to the influence of drugs on platelets, the vascular endothelium, plasma coagulation and fibrinolysis, regarding coagulation.
March 13, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30868968/safety-and-efficacy-of-levetiracetam-for-the-management-of-levodopa-induced-dyskinesia-in-patients-with-parkinson-s-disease-a-systematic-review
#7
Mahmoud Ahmed Ebada, Souad Alkanj, Mohamed Ebada, Ahmed H Abdelkarim, Ahmed Diab, Mohamed Abd Elalem Aziz, Ahmed Magdy Soliman, Notila Fayed, Eshak I Bahbah, Ahmed Negida
BACKGROUND: Levetiracetam, a novel antiepileptic drug, has shown antidyskinetic effects in experimental animal models of Parkinson's disease (PD). The tolerability and efficacy of levetiracetam in reducing the levodopa-induced dyskinesia (LID) in PD patients has not been established. Therefore, this study aims to synthesize evidence from published prospective clinical trials about the efficacy of levetiracetam for the management of LID in PD patients. METHODS: We followed the PRISMA statement guidelines during the preparation of this systematic review...
March 13, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30864513/neuronal-deletion-of-pten-results-in-cerebellar-motor-learning-dysfunction-and-alterations-in-intracellular-signaling
#8
Suzanne O Nolan, Taylor S Jefferson, Conner D Reynolds, Gregory D Smith, Andrew J Holley, Samantha L Hodges, Joaquin N Lugo
BACKGROUND: Loss of the Pten (phosphatase and tensin homolog) gene has been demonstrated to result in hyperactivation of the mammalian target of rapamycin (mTOR) pathway, a signaling pathway common to many disease etiologies, including tuberous sclerosis complex, Fragile X syndrome, and schizophrenia. Previous studies have focused on the impact of hyperactivation of the mTOR pathway in hippocampus and cortex and behaviors among those structures, but little is known about the relationship of Pten and mTOR signaling in the development and function of the cerebellum...
March 12, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30864514/clinical-characteristics-and-possible-drug-targets-in-autosomal-dominant-spinocerebellar-ataxias
#9
Laszlo Szpisjak, Denes Zadori, Peter Klivenyi, Laszlo Vecsei
BACKGROUND & OBJECTIVE: The autosomal dominant spinocerebellar ataxias (SCAs) belong to a large and expanding group of neurodegenerative disorders. SCAs comprise more than 40 subtypes characterized by progressive ataxia as a common feature. The most prevalent diseases among SCAs are caused by CAG repeat expansions in the coding-region of the causative gene resulting in polyglutamine (polyQ) tract formation in the encoded protein. Unfortunately, there is no approved therapy to treat cerebellar motor dysfunction in SCA patients...
March 11, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30848219/enhancement-of-hippocampal-plasticity-by-physical-exercise-as-a-polypill-for-stress-and-depression-a-review
#10
Ang Li, Suk-Yu Yau, Sergio Machado, Pingjie Wang, Ti-Fei Yuan, Kwok-Fai So
Generation of newborn neurons that form functional synaptic connections in the dentate gyrus of adult mammals, known as adult hippocampal neurogenesis, has been suggested to play critical roles in regulating mood, as well as certain forms of hippocampus-dependent learning and memory. Environmental stress suppresses structural plasticity including adult neurogenesis and dendritic remodeling in the hippocampus, whereas physical exercise exerts opposite effects. Here, we review recent discoveries on the potential mechanisms concerning how physical exercise mitigates the stress-related depressive disorder, with a focus on the perspective of modulation on hippocampal neurogenesis, dendritic remodeling and synaptic plasticity...
March 7, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30827269/ultramicronized-palmitoylethanolamide-um-pea-as-add-on-treatment-in-fibromyalgia-syndrome-fms-retrospective-observational-study-on-407-patients
#11
V Schweiger, A Martini, P Bellamoli, K Donadello, C Schievano, G Del Balzo, P Sarzi-Puttini, M Parolini, E Polati
BACKGROUND: fibromyalgia syndrome is a chronic multifaceted disease characterized by widespread pain, muscle stiffness, fatigue, unrefreshing sleep and cognitive disorders. To date, no medication has been shown to significantly improve pain, associated symptoms and Quality of Life in fibromyalgic patients. METHODS: In this retrospective observational study, we analyzed data regarding 407 patients with diagnosis of fibromyalgia syndrome who between 2013 and 2016 have been prescribed orally ultramicronized palmitoylethanolamide tablets (Normast® Epitech Group SpA, Saccolongo, Italy) regardless of the concomitant pharmacological therapy (add-on treatment)...
February 27, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30747083/grape-seed-proanthocyanidins-protect-n2a-cells-against-ischemic-injury-via-endoplasmic-reticulum-stress-and-mitochondrial-associated-pathways
#12
Kun Fu, Liqiang Chen, Lifeng Miao, Yan Guo, Wei Zhang, Yunan Bai
BACKGROUND/OBJECTIVE: Grape seed proanthocyanidins (GSPs) are a group of polyphenolic bioflavonoids, which possess a variety of biological functions and pharmacological properties. We studied the neuroprotective effects of GSP against oxygen-glucose deprivation/reoxygenation (OGD/R) injury and the potential mechanisms in mouse neuroblastoma N2a cells. METHODS: OGD/R was conducted in N2a cells. Cell viability was evaluated by CCK-8 and LDH release assay. Apoptosis was assessed by TUNEL staining and flow cytometry...
February 11, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30714535/noncoding-rnas-and-intracerebral-hemorrhage
#13
Lingzhi Li, Pingping Wang, Haiping Zhao, Yumin Luo
Intracerebral hemorrhage (ICH) is the most devastating subtype of stroke, for which there are few effective interventions. Computed tomography is accepted as the gold standard for diagnosis, whereas surgical evacuation is the main treatment for ICH. However, in emergency rooms, time is limited and information regarding a patient's clinical status or tolerance is typically not available. Many studies over the last decade have investigated the fundamental mechanisms of ICH and especially hematoma, which not only cause physical damage but also release toxins that have detrimental effects...
February 3, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30714534/fire-needle-acupuncture-regulates-wnt-erk-multiple-pathways-to-promote-neural-stem-cells-differentiating-into-neurons-in-rats-with-spinal-cord-injury
#14
Jiachun Xu, Suli Cheng, Zhaohua Jiao, Zhiheng Zhao, Zhimin Cai, Nan Su, Baohong Liu, Zhen Zhou, Yan Li
NSCs therapy is considered as one of the most potential methods for Spinal cord injury (SCI). We build the SCI model rats to investigate the theraputic effect of fire needle acupunture in improving locomotor function of SCI rats and its possible mechanism. BBB scalewas used for the motor ability of rats. The expression of Nestin, NSE, Gal-C, and GFAP were detected by immunohistochemistry. Wnt, GSK3β, β-catenin, ERK1/2, cyclinD1, and ngn1 was detected by western blot and PCR. The BBB score of both model group (1...
February 3, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30714533/causes-and-consequences-of-microrna-dysregulation-following-cerebral-ischemia-reperfusion-injury
#15
Fatemeh Forouzanfar, Mana Shojapour, Samira Asgharzade, Elham Amini
Stroke continues to be a major cause of death and disability worldwide. In this respect, the most important mechanisms underlying stroke pathophysiology are inflammatory pathways, oxidative stress, as well as apoptosis. Accordingly, miRNAs are considered as non-coding endogenous RNA molecules interacting with their target mRNAs to inhibit mRNA translation or reduce its transcription. Studies in this domain have similarly shown that miRNAs are strongly associated with coronary artery disease and correspondingly contribute to the brain ischemia molecular processes...
February 3, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30706796/short-term-ultramicronized-palmitoylethanolamide-therapy-in-patients-with-myasthenia-gravis-a-pilot-study-to-possible-future-implications-of-treatment
#16
Emanuela Onesti, Vittorio Frasca, Marco Ceccanti, Giorgio Tartaglia, Maria Cristina Gori, Chiara Cambieri, Laura Libonati, Eleonora Palma, Maurizio Inghilleri
BACKGROUND: The cannabinoid system may be involved in the humoral mechanisms at the neuromuscular junction. Ultramicronized-palmythoylethanolamide (µm-PEA) has recently been shown to reduce the desensitization of Acetylcholine (ACh)-evoked currents in denervated patients modifying the stability of ACh receptor (AChR) function. OBJECTIVE: To analyze the possible beneficial effects of µm-PEA in patients with myasthenia gravis (MG) on muscular fatigue and neurophysiological changes...
January 31, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30648527/behavioral-experimental-paradigms-for-the-evaluation-of-drug-s-influence-on-cognitive-functions-interpretation-of-associative-spatial-non-spatial-and-working-memory
#17
Saima Zameer, Mohd Akhtar, Divya Vohora
BACKGROUND: Currently, a large number of people throughout the world are affected by neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease which appear with a lapse in recall, attention and altered cognitive functions. Learning and memory, the fundamental indices defining cognitive functions, are the complex psychological processes governing acquisition, consolidation, and retrieval of stored information. These processes are synchronized by the coordination of various parts of the brain including hippocampus, striatum and amygdala...
January 12, 2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30821218/message-from-the-editor-in-chief
#18
Cesar V Borlongan
No abstract text is available yet for this article.
2019: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30588889/bibliometrics-of-cns-neurological-disorders-drug-targets-an-international-evolution-along-time
#19
Mirna Rossi Barbosa Medeiros, Ana Carolina de Mello Alves Rodrigues, Mariana Rocha Alves, Roberto Cesar Faria E Silva, Lais Francielle Francisca Felício, Lara S F Carneiro, Daniel Ferreira Fagundes, Sérgio Machado, Renato Sobral Monteiro
To investigate trends in the scientific evolution of the journal CNS & Neurological Disorders - Drug Targets in the neuroscience scope, we compared the contribution of publications between this journal and others from different geographical regions of the world. To track research output we conducted a bibliometric analysis of neuroscience research based on the SCimago Journal and Country Rank® from 2003 to 2017. Journal rankings were verified according to the following inclusion criteria: journals publishing the neuroscience scope and sub-areas; geographical location and journal trajectory...
December 27, 2018: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/30582486/mitochondrial-dysfunctions-in-blood-platelets-of-patients-with-manic-episode-of-bipolar-disorder
#20
Jana Hroudová, Zdeněk Fišar, Hana Hansíková, Lucie Kališová, Eva Kitzlerová, Martina Zvěřová, Alena Lambertová, Jiří Raboch
OBJECTIVES: The bipolar affective disorder (BAD) pathophysiology is multifactorial and has not been fully clarified. METHOD: We measured selected mitochondrial parameters in peripheral blood components. The analyses were performed for patients suffering from a manic episode during remission and were compared to those performed for healthy controls. BAD was clinically evaluated using well-established diagnostic scales and questionnaires. Mitochondrial respiration was examined in intact and permeabilized blood platelets using high-resolution respirometry...
December 24, 2018: CNS & Neurological Disorders Drug Targets
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