journal
Journals CNS & Neurological Disorders D...

CNS & Neurological Disorders Drug Targets

https://read.qxmd.com/read/38500273/gastrointestinal-issues-in-depression-anxiety-and-neurodegenerative-diseases-a-systematic-review-on-pathways-and-clinical-targets-implications
#1
JOURNAL ARTICLE
Ian Richard Lucena Andriolo, Bruna Longo, Dayse Machado de Melo, Márcia Maria de Souza, Rui Daniel Prediger, Luisa Mota da Silva
INTRODUCTION: Multiple illnesses commonly involve both the Central Nervous System (CNS) and the Gastrointestinal Tract (GI) simultaneously. Consistent evidence suggests that neurological disorders impair GI tract function and worsen the symptomatology and pathophysiology of digestive disorders. On the other hand, it has been proposed that early functional changes in the GI tract contribute to the genesis of several CNS illnesses. Additionally, the role played by the gut in these diseases can be seen as a paradigm for how the gut and the brain interact...
March 18, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38409689/emerging-treatments-for-subarachnoid-hemorrhage
#2
JOURNAL ARTICLE
Matthew C Findlay, Mrinmoy Kundu, Jayson R Nelson, Kyril L Cole, Candace Winterton, Samuel Tenhoeve, Brandon Lucke-Wold
The current landscape of therapeutic strategies for subarachnoid hemorrhage (SAH), a significant adverse neurological event commonly resulting from the rupture of intracranial aneurysms, is rapidly evolving. Through an in-depth exploration of the natural history of SAH, historical treatment approaches, and emerging management modalities, the present work aims to provide a broad overview of the shifting paradigms in SAH care. By synthesizing the historical management protocols with contemporary therapeutic advancements, patient-specific treatment plans can be individualized and optimized to deliver outstanding care for the best possible SAH-related outcomes...
February 22, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38375844/t-lymphocyte-interferon-gamma-response-to-anaplasmataceae-related-major-surface-proteins-and-ankyrin-a-in-fibromyalgia
#3
JOURNAL ARTICLE
Basant K Puri, Rosemarie Preyer, Gary S Lee, Armin Schwarzbach
BACKGROUND: The aetiology of fibromyalgia is unknown; its symptoms may be related to a T-lymphocyte-mediated response to infectious organisms. OBJECTIVES: First, to test the hypothesis that fibromyalgia is associated with increased interferon (IFN)-γ-secreting T-lymphocytes after stimulation with Anaplasmataceae-related major surface proteins (MSFs) and the macromolecular translocation type IV secretion system effector ankyrin repeat domain-containing protein A (AnkA)...
February 16, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38351689/designing-and-formulation-of-nanocarriers-for-alzheimer-s-and-parkinson-s-early-detection-and-therapy
#4
JOURNAL ARTICLE
Jakleen Abujamai, Rukhsana Satar, Shakeel Ahmed Ansari
The potential of nanotechnology in advancing the diagnosis and treatment of neurodegenerative diseases is explored in this comprehensive literature review. Through an examination of various studies that utilize nanotechnology models. The aim of this paper is to evaluate whether these models can be considered a significant breakthrough in the field of neurodegeneration. The findings of these studies suggest that nanotechnology has the capacity to improve existing therapeutic approaches, create novel and safe compounds, and develop more precise imaging techniques and diagnostic methods for neurodegenerative diseases...
February 13, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38351688/unraveling-the-emerging-niche-role-of-extracellular-vesicles-evs-in-traumatic-brain-injury-tbi
#5
JOURNAL ARTICLE
Sumel Ashique, Radheshyam Pal, Himanshu Sharma, Neeraj Mishra, Ashish Garg
Extracellular vesicles or exosomes, often known as EVs, have acquired significant attention in the investigations of traumatic brain injury (TBI) and have a distinct advantage in actively researching the fundamental mechanisms underlying various clinical symptoms and diagnosing the wide range of traumatic brain injury cases. The mesenchymal stem cells (MSCs) can produce and release exosomes, which offer therapeutic benefits. Exosomes are tiny membranous vesicles produced by various cellular entities originating from endosomes...
February 13, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38299273/the-possible-protective-effect-of-taurine-on-bisphenol-induced-structural-changes-on-the-cerebral-cortex-of-rats-histological-and-immunohistochemical-study
#6
JOURNAL ARTICLE
Samah Kandeel, Marwa M Abd-Elsalam, Sherief Abd-Elsalam, Heba Hassan Elkaliny
INTRODUCTION: Bisphenol A (BPA) is a chemical compound that has been used in many industries, such as paints and dental sealants. Taurine is a semi-essential amino acid with antioxidant, anti-inflammatory, and anti-apoptotic actions. AIM: This study aimed to evaluate the possible protective effect of taurine on BPA-induced structural changes in the cerebral cortex of rats using histological and immunohistochemical methods. MATERIALS AND METHODS: 35 Wistar rats (180-200 gm) were divided into control: 10 rats; Group I: 5 rats received corn oil (0...
January 30, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38288843/application-of-nanocomposites-and-nanoparticles-in-treating-neurodegenerative-disorders
#7
JOURNAL ARTICLE
Javeria Fatima, Yasir Hasan Siddique
Neurodegenerative diseases represent a formidable global health challenge, affecting millions and imposing substantial burdens on healthcare systems worldwide. Conditions, like Alzheimer's, Parkinson's, and Huntington's diseases, among others, share common characteristics, such as neuronal loss, misfolded protein aggregation, and nervous system dysfunction. One of the major obstacles in treating these diseases is the presence of the blood-brain barrier, limiting the delivery of therapeutic agents to the central nervous system...
January 29, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38279762/lrrk2-communicative-role-in-the-treatment-of-parkinson-s-disease-and-ulcerative-colitis-overlapping
#8
JOURNAL ARTICLE
Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Amirhossein Niknejad, Hedieh Sadat Shamsnia, Maryam Shayan, Leila Mohaghegh Shalmani, Saeideh Momtaz, Nima Rezaei, Amir Hossein Abdolghaffari
BACKGROUND: Involvement of gastrointestinal inflammation in Parkinson's disease (PD) pathogenesis and movement have progressively emerged. Inflammation is involved in the etiology of both PD and inflammatory bowel disease (IBD). Transformations in leucine-rich recurrent kinase 2 (LRRK2) are among the best hereditary supporters of IBD and PD. Elevated levels of LRRK2 have been reported in stimulated colonic tissue from IBD patients and peripheral invulnerable cells from irregular PD patients; thus, it is thought that LRRK2 directs inflammatory cycles...
January 25, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38279761/potential-neuroprotective-role-of-neurotrophin-in-traumatic-brain-injury
#9
JOURNAL ARTICLE
Rei Shian Yap, Jaya Kumar, Seong Lin Teoh
Traumatic brain injury (TBI) is a major global health issue that affects millions of people every year. It is caused by any form of external force, resulting in temporary or permanent impairments in the brain. The pathophysiological process following TBI usually involves excitotoxicity, mitochondrial dysfunction, oxidative stress, inflammation, ischemia, and apoptotic cell death. It is challenging to find treatment for TBI due to its heterogeneous nature, and no therapeutic interventions have been approved thus far...
January 25, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38279763/non-coding-rnas-as-key-regulators-of-the-notch-signaling-pathway-in-glioblastoma-diagnostic-prognostic-and-therapeutic-targets
#10
JOURNAL ARTICLE
Seyed Hossein Shahcheraghi, Elmira Roshani Asl, Malihe Lotfi, Jamshid Ayatollahi, Seyed Hossein Khaleghinejad, Alaa A Aljabali, Hamid A Bakshi, Mohamed El-Tanani, Nitin Charbe, Ángel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Rohit Goyal, Altijana Hromić-Jahjefendić, Vladimir N Uversky, Marzieh Lotfi, Murtaza M Tambuwala
Glioblastoma multiforme (GBM) is a highly invasive brain malignancy originating from astrocytes, accounting for approximately 30% of central nervous system malignancies. Despite advancements in therapeutic strategies including surgery, chemotherapy, and radiopharmaceutical drugs, the prognosis for GBM patients remains dismal. The aggressive nature of GBM necessitates the identification of molecular targets and the exploration of effective treatments to inhibit its proliferation. The Notch signaling pathway, which plays a critical role in cellular homeostasis, becomes deregulated in GBM, leading to increased expression of pathway target genes such as MYC, Hes1, and Hey1, thereby promoting cellular proliferation and differentiation...
January 24, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38243987/pharmacotherapy-in-sah-clinical-trial-lessons
#11
JOURNAL ARTICLE
Sotirios Apostolakis, Pantelis Stavrinou
Subarachnoid Haemorrhage (SAH) is a medical emergency with potentially devastating outcomes. It is without doubt that over the past decades, there has been a radical change in the approach towards patients with SAH, both in terms of the surgical as well as of the pharmacological treatments offered. The present review aims to outline the principal data regarding the best practice in the pharmacotherapy of SAH, as well as to sum up the emerging evidence from the latest clinical trials. To date, nimodipine is the only evidence-based treatment of vasospasm...
January 15, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38243986/role-of-imaging-genetics-in-alzheimer-s-disease-a-systematic-review-and-current-update
#12
JOURNAL ARTICLE
Aakash Chhetri, Kashish Goel, Abhilash Ludhiadch, Paramdeep Singh, Anjana Munshi
BACKGROUND: Alzheimer's disease is a neurodegenerative disorder characterized by severe cognitive, behavioral, and psychological symptoms, such as dementia, cognitive decline, apathy, and depression. There are no accurate methods to diagnose the disease or proper therapeutic interventions to treat AD. Therefore, there is a need for novel diagnostic methods and markers to identify AD efficiently before its onset. Recently, there has been a rise in the use of imaging techniques like Magnetic Resonance Imaging (MRI) and functional Magnetic Resonance Imaging (fMRI) as diagnostic approaches in detecting the structural and functional changes in the brain, which help in the early and accurate diagnosis of AD...
January 12, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38213169/intrathecal-baclofen-infusion-botulinum-toxin-combined-treatment-efficacy-in-the-management-of-spasticity-due-to-cerebral-palsy
#13
JOURNAL ARTICLE
Riccardo Marvulli, Giuseppa Lagioia, Giancarlo Ianieri, Lucrezia Dell'Olio, Alessandra Zonno, Mariagrazia Riccardi, Rosa Bianca Sinisi, Laura Belinda Rizzo, Giacomo Farì, Marisa Megna, Maurizio Ranieri
BACKGROUND: Cerebral Palsy (CP) is a group of permanent, but not unchanging, disorders of movement and/or posture and motor function, which are due to a non-progressive interference, lesion, or abnormality of the developing/immature brain. One clinical presentation is muscle spasticity, which leads to a significant impact on the individual's functionality and quality of life. Spasticity treatment is multidisciplinary and includes pharmacological and physical intervention; intrathecal baclofen shows a positive effect in severe spasticity and suboptimal response to oral drugs, while local injection of Botulinum toxin type A (BTXA) improves muscle tone, motion and pain...
January 11, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38213168/gfap-and-uchl1-in-non-traumatic-sah-the-story-thus-far-a-systematic-review-of-the-literature
#14
JOURNAL ARTICLE
Filippos Psochias, Georgios Mavrovounis, George Stranjalis, Theodosis Kalamatianos
OBJECTIVE: Non-traumatic subarachnoid hemorrhage (SAH) is associated with a high percentage of misdiagnosis and poor prognosis. Biomarkers could be useful in the identification, treatment/management guidance, and outcome improvement of SAH patients. The current systematic review aims to investigate the potential role of biomarkers GFAP (Glial Fibrillary Acidic Protein) and UCH-L1 (Ubiquitin C-Terminal Hydrolase L1) in the diagnosis and prognosis of non-traumatic SAH. METHODS: A systematic search of PubMed, Scopus, and Web of Science databases was conducted from their inception through February 2023...
January 11, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38192128/anti-seizure-medications-challenges-and-opportunities
#15
JOURNAL ARTICLE
Neha Tandon, Milica Radosavljevic, Danijela Vucevic, Miroslav Radenkovic, Jasna Jancic, Janko Samardzic
Epilepsy is a chronic neurological condition characterized by unprovoked, recurrent seizures. There are several types of epilepsy, and the cause of the condition can vary. Some cases of epilepsy have a genetic component, while others may be caused by brain injuries, infections, or other underlying conditions. Treatment for epilepsy typically involves anti-seizure medications (ASMs), although different approaches, such as surgery or a special diet, may be considered in specific cases. The treatment aims to effectively manage and potentially eliminate seizures while minimizing any accompanying side effects...
January 8, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/37005520/neurological-complications-caused-by-human-immunodeficiency-virus-hiv-and-associated-opportunistic-co-infections-a-review-on-their-diagnosis-and-therapeutic-insights
#16
REVIEW
Sivaraman Balaji, Rohan Chakraborty, Sumit Aggarwal
Neurocognitive disorders associated with human immunodeficiency virus (HIV) infected individuals increase the risk of mortality and morbidity that remain a prevalent clinical complication even in the antiretroviral therapy era. It is estimated that a considerable number of people in the HIV community are developing neurological complications at their early stages of infection. The daily lives of people with chronic HIV infections are greatly affected by cognitive declines such as loss of attention, learning, and executive functions, and other adverse conditions like neuronal injury and dementia...
2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/36803746/nicotine-abuse-and-neurodegeneration-novel-pharmacogenetic-targets-to-aid-quitting-and-reduce-the-risk-of-dementia
#17
JOURNAL ARTICLE
Fatimah Almahasneh, Romany H Gerges, Ejlal Abu-El-Rub, Ramada R Khasawneh
Nicotine dependence has deleterious neurological impacts. Previous studies found an association between cigarette smoking and accelerating age-related thinning of the brain's cortex and subsequent cognitive decline. Smoking is considered the third most common risk factor for dementia, which prompted the inclusion of smoking cessation in dementia prevention strategies. Traditional pharmacologic options for smoking cessation include nicotine transdermal patches, bupropion and varenicline. However, based on smokers' genetic makeup, pharmacogenetics can be used to develop novel therapies to replace these traditional approaches...
2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38151851/nordihydroguaiaretic-acid-affects-undifferentiated-and-differentiated-neuroblastoma-cells-differently-through-mechanisms-that-impact-on-cell-viability
#18
JOURNAL ARTICLE
Patricia Ferrera, César Espino De la Fuente-Muñoz, Clorinda Arias
AIM: We aimed to investigate the mechanisms involved in the neurotoxic effects of NDGA on differentiated and undifferentiated human neuroblastoma cells (MSN), assessing cell viability, changes in the actin cytoskeleton, cell migration and the expression of the 5-LOX enzyme and the inhibitor of cell cycle progression p21WAF1/CIP1. BACKGROUND: High expression and activity of the lipoxygenase enzyme (LOX) have been detected in several tumors, including neuroblastoma samples, suggesting the use of LOX inhibitors as potential therapy molecules...
December 26, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38018200/natural-compounds-as-inhibitors-of-a%C3%AE-peptide-and-tau-aggregation
#19
JOURNAL ARTICLE
Kadja Luana Chagas Monteiro, Thiago Mendonça de Aquino, Edeildo Ferreira da Silva-Júnior
Neurodegenerative conditions like Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) encompass disorders characterized by the degeneration of neurons in specific circumstances. The quest for novel agents to influence these diseases, particularly AD, has unearthed various natural compounds displaying multifaceted activities and diverse pharmacological mechanisms. Given the ongoing extensive study of pathways associated with the accumulation of neurofibrillary aggregates and amyloid plaques, this paper aims to comprehensively review around 130 studies exploring natural products...
November 28, 2023: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38013445/vasospasm-in-pediatric-subarachnoid-hemorrhage
#20
JOURNAL ARTICLE
Ioannis Mavridis, Efstratios-Stylianos Pyrgelis, Eleni Agapiou, Jeries Assi
Cerebral vasospasm (CV) is a common severe complication of subarachnoid hemorrhage (SAH), a severe type of intracranial bleeding that is uncommon in children. The purpose of this article is to review the current literature regarding this potentially devastating complication. CV may be asymptomatic and is less common in children compared to adults. Several molecular phenomena, including inflammatory ones, contribute to its pathophysiology. Better collateral circulation and higher cerebral blood flow are protective factors in children...
November 27, 2023: CNS & Neurological Disorders Drug Targets
journal
journal
41296
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.