journal
https://read.qxmd.com/read/38873903/the-impact-of-systemic-isotretinoin-treatment-on-the-tear-film-meibomian-glands-and-corneal-endothelium
#1
JOURNAL ARTICLE
Kamile Demir, Feyzahan Uzun
PURPOSE: The study aims to investigate changes in tear function, meibomian glands and corneal endothelium in patients receiving systemic isotretinoin therapy. MATERIALS AND METHODS: This prospective study included 38 eyes from 38 patients (23 females and 15 males) treated with systemic isotretinoin (0.5-1 mg/kg/day) following the diagnosis of acne vulgaris. All patients underwent a comprehensive ophthalmologic examination at baseline, 1st month, and third month of treatment...
June 14, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38806172/ocular-effects-of-eye-cosmetic-formulations
#2
JOURNAL ARTICLE
Shruti Vinod Sabhahit, Mahesh Babu, Dixitha V
OBJECTIVE: To study the ocular effects seen among eye cosmetic wearers in the Indian Population. METHODS: This cross-sectional study was conducted on female participants who had fulfilled the inclusion and exclusion criteria. A detailed history was obtained and thorough ophthalmic evaluation was done. Mann Whitney U test was used. Statistical analysis was done using IBM SPSS. p  < .05 was taken as the level of statistical significance. RESULTS: Among a total of 225 participants in our study, the mean age was 24...
June 5, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38810268/evaluation-of-eye-irritation-potential-of-experimental-cosmetic-formulations-containing-glycolic-acid-salicylic-acid-and-ethanol-using-the-bovine-corneal-opacity-and-permeability-assay
#3
JOURNAL ARTICLE
R Labib, K Cantrell, G-E Costin, A L Milac, H Raabe, S Gettings
Objective: Prototype cosmetic formulations containing short-chain acids and alcohols intended to be applied in the proximity of the eyes are sometimes evaluated for ocular irritation potential using the validated Bovine Corneal Opacity and Permeability Assay (OECD TG 437). We evaluated the eye irritation potential of nine experimental cosmetic formulations designed and prepared by Avon Products International to differ only in the concentrations of Ethanol, Glycolic Acid and Salicylic Acid. Methods: We analyzed the data generated using the BCOP assay...
May 29, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38810266/the-impact-of-low-dose-methotrexate-on-erectile-dysfunction-sex-hormone-profile-and-spermiogram-in-male-patients-with-psoriasis-a-prospective-study
#4
JOURNAL ARTICLE
Hatice Atas, Tuğcan Yüksek, Ahmet Nihat Karakoyunlu, Selda Pelin Kartal, Gamze Taş Aygar
UNLABELLED: Purpose Psoriasis, affecting approximately 2% of the world's population, often necessitates systemic treatments, with methotrexate (MTX) as a cornerstone therapy. Despite documented systemic side effects of MTX, concerns about its impact on male reproductive health persist. We aim to investigate low-dose MTX effect on hormonal, cellular and functional ability of male reproductive system. MATERIALS AND METHODS: Our prospective study on 40 male psoriasis patients receiving low-dose MTX (<15mg/week) comprehensively investigates its effects on erectile function, sex hormones, and spermiogram parameters...
May 29, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38781033/efficacy-and-safety-of-self-made-wenyangjianpi-qushi-decoction-combined-with-mometasone-furoate-cream-in-the-treatment-of-atopic-dermatitis-of-spleen-deficiency-and-dampness-accumulation-type
#5
JOURNAL ARTICLE
Jinhui Tan, Yuting Fan, Luhui Liu, Lixia Deng, Xianzhou Li, Lifang Lan, Yuling Zeng
Introduction : This work was to explore the efficacy and safety of self-made WenyangJianpi-qushi Decoction plus mometasone furoate cream in atopic dermatitis (AD) of spleen deficiency and dampness accumulation type. Material and method : 120 patients with this kind of atopic dermatitis were grouped: The Observation group (disease health education + basic treatment + mometasone furoate cream + self-made Decoction) and The Control group (disease health education + basic treatment + mometasone furoate cream), 60 cases in each group...
May 23, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38695323/correction
#6
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
May 2, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38608452/enhanced-sun-protection-factor-of-octocrylene-with-green-tea-and-bhringraj-extracts
#7
JOURNAL ARTICLE
Pasupathi M, Natarajan B, Kumar T
The overexposure of human skin to ultraviolet radiation (UVR) can trigger photodamage, UV burn, pigmentation, erythema, and enhance the chance of dermal carcinoma. UVR causes DNA damage, leading to dermal cancer. Daily sunscreen application protects the skin from the adverse effects of sun rays, particularly UVB (290-320 nm) and UVA (320-400 nm). The ozone layer filters UVC (200-290 nm) radiation upon entry into the Earth's atmosphere. UVB causes sunburn, photo damage, and induces mutagenic changes in nucleic acids...
April 12, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38608451/evaluation-of-isotretinoin-effects-on-depression-sleep-apnea-and-sleep-quality
#8
JOURNAL ARTICLE
Ozge Mine Orenay, Berkay Temel, Arcan Kivanc Capci, Zulal Inci Bal, Nermin Karaosmanoglu
Background: Isotretinoin is used to treat severe acne, treatment-resistant moderate acne, and acne that leads to scarring or psychological distress. It has many side effects and is also associated with depression, sleep apnea, and sleep disturbances. Objectives: In this study, we aimed to evaluate the effects of isotretinoin on depression, sleep apnea, and sleep quality. Methods: A total of 42 patients diagnosed with acne and started isotretinoin treatment were included in the study. In order to compare the effects of isotretinoin, patients were asked to fill out a questionnaire containing the Beck Depression Inventory (BDI), the Berlin Questionnaire (BQ), and the Pittsburg Sleep Quality Index (PSQI) at baseline and third months of treatment...
April 12, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38452360/time-to-treat-the-climate-and-nature-crisis-as-one-indivisible-global-health-emergency
#9
EDITORIAL
Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski
No abstract text is available yet for this article.
March 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38258428/clinical-features-and-biomarker-differences-of-severe-intrinsic-and-extrinsic-atopic-dermatitis
#10
JOURNAL ARTICLE
Zhong Liu, Zeqi Shi, Yunhua Deng
OBJECTIVES: Atopic dermatitis (AD) can be classified into intrinsic AD(IAD) and extrinsic AD(EAD). However, the differences in clinical features and pathogenesis between these two subtypes of AD are currently unclear. This study aimed to analyse the differences in clinical features and peripheral blood biomarkers between Chinese patients with severe IAD and EAD in order to elucidate the physiopathogenesis of AD. MATERIALS AND METHODS: A total of 316 hospitalised patients definitively diagnosed with severe AD were included in this study...
March 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38284163/understanding-the-impact-of-risankizumab-on-keratinocyte-derived-il-23a-in-a-novel-organotypic-3d-skin-model-containing-il-23a-responsive-and-il-17a-producing-%C3%AE-%C3%AE-t-cells
#11
JOURNAL ARTICLE
Laura Huth, Philipp M Amann, Yvonne Marquardt, Manuela Jansen, Jens Malte Baron, Sebastian Huth
PURPOSE: To study the effects of the anti-IL-23A antibody risankizumab on the IL-36γ/IL-23A/IL-17A signalling cascade we used a newly developed 3D skin model consisting of primary human keratinocytes, fibroblasts and γδ-T-cells. METHODS: In this in vitro study we developed new full-thickness 3D skin models containing normal human epidermal keratinocytes (NHEK), normal human dermal fibroblasts (NHDF) and IL-23A responsive and IL-17A producing γδ-T-cells...
January 29, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38235962/evaluation-of-corneal-endothelial-cell-morphology-off-and-on-treatment-by-specular-microscopy-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder
#12
JOURNAL ARTICLE
Hakan Koc, Bedia Sultan Önal, Esra Hoşoğlu
PURPOSE: To determine the structure and properties of corneal endothelial cells in children and adolescents with ADHD who received methylphenidate treatment at least six months. METHOD: The prospective, observational study included 33 eyes of 33 patients diagnosed with ADHD who received methylphenidate treatment for at least six months, 33 eyes of 33 patients newly diagnosed with ADHD who did not start medication treatment, and 33 eyes of 33 healthy individuals...
January 18, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38179974/the-efficacy-of-hddpiw-jsb-solution-on-docetaxel-induced-alopecia-of-rats
#13
JOURNAL ARTICLE
Bilgin Demir, Buket Demirci, Canten Tataroglu, Sabri Barutca, Duygu Barutca
OBJECTIVE: Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn't have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of newly developed HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model. MATERIAL AND METHODS: Docetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX...
January 5, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38174703/biochemical-and-histopathological-evaluation-of-systemic-and-ocular-toxicity-of-favipiravir-in-rats
#14
JOURNAL ARTICLE
Delil Özcan, Fatih Özçelik, Renad Mammadov, Mehmet Aktaş, Fikret Altındağ, Abdurrahman Alpaslan Alkan, Murat Karapapak, Durdu Altuner, Halis Süleyman
Purpose: Favipiravir used against COVID-19 is an antiviral drug that causes adverse reactions such as hyperuricemia, liver damage and hematopoetic toxicity. The aim of the study was to investigate the systemic and ocular side-effects of favipiravir in rats, for the first time. Materials and Methods: A total of 18 albino male Wistar rats were used in the study. The rats were divided into 3 groups as the healthy group (HG), the group given 50 mg/kg/day favipiravir (FAV50), and the group given 200 mg/kg/day favipiravir (FAV200)...
January 4, 2024: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38127818/potential-inhibition-of-12-o-tetradecanoylphorbol-13-acetate-induced-inflammation-hyperproliferation-and-hyperplasiogenic-responses-by-celecoxib-in-mouse-skin
#15
JOURNAL ARTICLE
Shakilur Rahman, Rizwanul Haque, Sheikh Raisuddin
Purpose: Skin exposure to noxious agents leads to cutaneous lesion marked by an increase in inflammation, cellular proliferation, and hyperplasiogenic reactions. Studies have demonstrated that these damages breach the skin integrity resulting in the etiology of various cutaneous disorders like atopic dermatitis, eczema, psoriasis, and development of non-melanoma skin cancer. Celecoxib, a cyclooxygenase- 2 (COX-2) inhibitor, is an effective treatment for a variety of inflammatory diseases. Its importance in the therapy of skin problems, however, remains underappreciated...
December 21, 2023: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/38099874/ocular-irritation-reversibility-assessment-of-a-laundry-detergent-using-the-porcine-corneal-opacity-reversibility-assay-porcora-a-focused-study
#16
JOURNAL ARTICLE
Puneet Vij, Ashley Brinkman, Rachael M Koch, George DeGeorge, Matthew Wolter
Consumer product manufacturers utilise a spectrum of alternative ocular irritation assays, as these tests do not require the use of live animals. Despite their usefulness, no regulatory-accepted assay assesses the reversibility of ocular damage, a key criterion of GHS ocular classification, like the rabbit eye test (i.e., Draize Rabbit Eye Test [DRET]) . The Porcine Corneal Opacity Reversibility Assay (PorCORA), an ex vivo intact corneal tissue culture model, predicts the reversibility of damage by ocular irritants...
December 15, 2023: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/37933164/time-to-treat-the-climate-and-nature-crisis-as-one-indivisible-global-health-emergency
#17
EDITORIAL
Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Gregory E Erhabor, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski
No abstract text is available yet for this article.
November 6, 2023: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/37916307/a-systematic-review-of-heavy-metals-contamination-in-cosmetics
#18
REVIEW
Opoku Gyamfi, James Aboko, Edward Ankapong, Jemima Tiwaa Marfo, Nana Yaa Awuah-Boateng, Kofi Sarpong, Emmanuel Dartey
Background: Globally, the consumption and use of cosmetics have increased exponentially. The presence of hazardous metals raises worries about their potential long-term impacts on human health. Objective: This review's primary goal is to shed light on the presence and ranges of heavy metal concentrations in diverse cosmetic samples as well as the instrumental techniques used by various authors to analyse the hazardous metals in the articles under evaluation. Methodology: This analysis concentrated on 16 publications that measured the levels of heavy metals like lead, cadmium, iron, nickel, chromium, and mercury in various cosmetic samples that were published between the years 2012 and 2020...
November 2, 2023: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/37909927/literature-analysis-of-cutaneous-adverse-reactions-induced-by-tislelizumab
#19
JOURNAL ARTICLE
Qingli Guo, Lili Jin, Tingting Zhang, Ruihao Gao, Kaili Zou, Min Fu, Hengtai Bi, Junyao Zhang, Min Zhang
OBJECTIVE: Tislelizumab may induce immune-related adverse events, especially adverse skin events. Early detection and timely intervention of cutaneous adverse events are crucial to improve patients' quality of life and reduce the disruption of therapeutic regimens. This study aimed to determine the clinical characteristics of cutaneous adverse reactions to tislelizumab and offer a reference for its rational clinical use. METHODS: Case reports of cutaneous adverse reactions induced by tislelizumab were collected from the relevant databases (up to 31 March 2023)...
November 1, 2023: Cutaneous and Ocular Toxicology
https://read.qxmd.com/read/37908111/toxicity-of-superparamagnetic-iron-oxide-nanoparticles-on-retinoblastoma-mitochondria
#20
JOURNAL ARTICLE
Enayatollah Seydi, Ghazaleh Tahmasebi, Abdollah Arjmand, Jalal Pourahmad
PURPOSE: Retinoblastoma (RB) is one of the most important cancers in children with a higher rate of prevalence in developing countries. Despite different approaches to the treatment of RB, it seems necessary to discover a new approach to its treatment. Today, mitochondria are recognised as an important target in the treatment of cancer. Superparamagnetic iron oxide nanoparticles (SPIONs) have been studied by researchers due to their important biological effects. METHODS: In this study, the effects of SPIONs on mitochondria isolated from Y79 retinoblastoma cells were investigated...
October 31, 2023: Cutaneous and Ocular Toxicology
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