Didem Kazan, Evren Odyakmaz-Demirsoy, Rebiay Kıran, Aysun Şikar-Aktürk, Nilgün Sayman, Dilek Bayramgürler
INTRODUCTION: Due to their ubiquitous use, isothiazolinones caused allergic contact dermatitis epidemics and their use was restricted by legal regulations. OBJECTIVES: We aimed to evaluate demographic data, clinical findings, and patch test features of patients with methylisothiazolinone (MI) and/or methylchloroisothiazolinone(MCI) sensitivity in our study. METHODS: This study is a bidirectional and cross-sectional study, between July 2020 and September 2021...
May 26, 2023: Cutaneous and Ocular Toxicology
Nur Demir, Belma Kayhan, Selin Gamze Sumen, Murat Sonmez, Nejla Tukenmez Dikmen
Purpose: The study aimed to investigate the electrophysiological effects of hyperbaric oxygen treatment (HBOT) on the retina after ten sessions in healthy eyes. Methods: This prospective, interventional study evaluated forty eyes of twenty patients who were treated with HBOT of ten sessions with the diagnosis of an extraocular health problem. All patients underwent a complete ophthalmologic examination, including assessments of best-corrected visual acuity (BCVA), slit-lamp and pupil-dilated fundus examinations, full-field electroretinography (ffERG) measurements before and after HBOT within 24 hours of the 10th session...
May 23, 2023: Cutaneous and Ocular Toxicology
Utku Limon, Işılay Özsoy Saygın, Tuğba Aydoğan Gezginaslan, Erdinç Bozkurt, Sinan Bulut, Betül Ilkay Sezgin Akçay
PURPOSE: To evaluate the effects of fluorescein dye on corneal endothelial morphology (CEM) after fundus fluorescein angiography (FFA) in patients with diabetic macular edema (DME). METHODS: In this retrospective study, patients were divided into 2 groups, non-proliferative diabetic retinopathy (Group-1, NPDR) and proliferative diabetic retinopathy (Group-2, PDR). CEM properties including endothelial cell density (ECD), coefficient of variation of cell area (CV), average cell area (AVG), percentage of hexagonal cells (HEX), and central corneal thickness (CCT) measured before FFA and at week 1 and month 1 after FFA were collected from patients' charts...
May 18, 2023: Cutaneous and Ocular Toxicology
Pingwei Wang, Dongge Liu, Jiajing Cui, Shuqi Yan, Yujun Liang, Qianqian Chen, Yanping Liu, Shuping Ren, Peng Chen
UNLABELLED: Objective Ultraviolet-B (UVB) radiation is an important factor in causing skin damage. The study is to explore whether 1,25-Dihydroxvitamin D3(1,25(OH)2 D3 ) will attenuate the damage of human immortalized keratinocytes (HaCaT) cells caused by UVB and relevant underlying mechanisms. METHODS: CCK-8 was employed to determine the UVB irradiation intensity and 1,25(OH)2 D3 concentration. Western blot was used to detect the expression of NF-κB, Caspase9, Caspase3, Bax, Bcl2, FADD, CytC, Beclin-1; Flowcytometry was applied to measure the production of ROS...
May 2, 2023: Cutaneous and Ocular Toxicology
Qianqian Fan, Huan Chen, Yang Hu, Bin Zhao
PURPOSE: Immune checkpoint inhibitors (ICIs) have emerged as a novel class of drugs carrying a potential risk of uveitis. Due to the rarity, current knowledge on this safety issue is still incomplete. This study employed the post-marketing surveillance data to comprehensively describe and assess the uveitis events after the use of ICIs. METHODS: Data between 2004 and 2021 were downloaded from the Food and Drug Administration Adverse Event Reporting System (FAERS), and the uveitis events reported for ICIs were identified and included in this study...
May 2, 2023: Cutaneous and Ocular Toxicology
Fikret Ucar, Ekrem Kadioglu
OBJECTIVE: To evaluate the effect of ketorolac-soaked contact lenses (CLs) on postoperative pain after photorefractive keratectomy (PRK) and their potential side effects including conjunctival hyperemia and delayed epithelial healing. METHODS: This is a prospective, randomized, double-blind, contralateral eye study. A total of 310 eyes of 155 patients who underwent PRK in both eyes were included in the study. After photoablation, a 0.4% ketorolac-soaked bandage CL was placed over the cornea in Group 1, while a drug-free soft bandage CL was placed over the cornea in Group 2...
April 12, 2023: Cutaneous and Ocular Toxicology
Ayşe Gölgeli Bedir, Latif Emrah Yanmaz
The purpose of the current study was to evaluate the effect of Triticum vulgare (TVE) alone, or combined with therapeutic ultrasound (TUS) on wound healing in a diabetic rat model. A total of 72 male Wistar rats were randomly divided into four groups: Group Control, wounded rats without treatment; Group TUS, wounded rats with TUS application; Group TVE, wounded rats treated with TVE; and Group TVE + TUS, wounded rats treated with TVE + TUS. Wound healing was assessed using wound area calculation and thermographic, biochemical, histopathologic, immunohistochemical, and immunofluorescence analyses on post-wounding days 7, 14, and 21...
April 12, 2023: Cutaneous and Ocular Toxicology
Isis Mendoza-Aldabisis, Nelly López-Valdez, María Eugenia Cervantes-Valencia, Teresa Imelda Fortoul
UNLABELLED: Air pollution is a public health problem caused by predatory human activities and the indiscriminate burning of fossil fuels that liberate particulate matter (PM) into the atmosphere. Vanadium (V) adheres to them and reach the bloodstream and different organs such as the eye when inhaled. Another way to reach the eye is by direct contact, and the cornea is the first layer exposed. Ciliary neurotrophic factor (CNTF) is secreted by the corneal nerves and some of its functions include self-renewal maintenance and wound healing by the activation of STAT3...
February 8, 2023: Cutaneous and Ocular Toxicology
Stewart Lebrun, Sara Chavez, Linda Nguyen, Roxanne Chan
PURPOSE: OptiSafeTM (OS) is a shelf stable, nonanimal test for ocular irritation. A recent database search found that half of the OS false positive (FP) materials were associated with reactive oxygen chemistries but were not eye irritants in vivo (based on historical rabbit studies by other groups). We hypothesized that naturally occurring tear antioxidants protect the eye from reactive chemistries in vivo and that specific tear chemistries might help explain why some materials are FP for nonanimal tests but are reported as nonirritants in the live animal...
January 20, 2023: Cutaneous and Ocular Toxicology
Nergis Akbaş, Emin Murat Akbaş, Zeynep Süleyman, Betül Çiçek, Ahmet Gökhan Ağgül, Behzad Mokhtare, Halis Süleyman
PURPOSE: Ribociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been connected to a number of serious dermatologic complications. This study explored the effects of ATP on ribociclib-induced skin damage. MATERIALS AND METHODS: Using a rat model, ATP 25 mg/kg was injected intraperitoneally in the ATP + Ribociclib (ATR) group ( n  = 6)...
January 19, 2023: Cutaneous and Ocular Toxicology
Ahmet Alp Bilgic, Huri Sabur, Mutlu Acar, Filiz Canpolat
Objective To evaluate the effects of lipid-containing Rohto Dry Aid eye drops and sodium hyaluronate eye drops on the ocular surface and in vivo confocal microscopy (IVCM) findings in patients using systemic isotretinoin. Methods This retrospective study included 71 patients using systemic isotretinoin for acne vulgaris. Ocular surface and tear functions were evaluated with the tear break-up time (TBUT), corneal fluorescein staining (CFS), and the ocular surface disease index questionnaire (OSDI). Meibography was used for the staging of meibomian gland dysfunction (MGD) while IVCM was used for the analysis of corneal micro-structural changes...
January 12, 2023: Cutaneous and Ocular Toxicology
Nilay Duman, Reşat Duman, Ayhan Vurmaz
BACKGROUND: Literature on the effects of second-generation H1-antihistamines on angiogenesis is limited. OBJECTIVES: To investigate the effects of cetirizine, desloratadine, and rupatadine (second-generation H1-antihistamines commonly used in dermatology clinics) on angiogenesis in an in vivo chick chorioallantoic membrane (CAM) model. METHODS: The study was approved by the local ethics committee on animal experimentation. Forty fertilized specific pathogen free eggs were incubated and kept under appropriate temperature and humidity control...
December 5, 2022: Cutaneous and Ocular Toxicology
Buğra Karasu, Enes Kesim, Mert Kaskal, Ali Rıza Cenk Celebi
PURPOSE: To evaluate the efficacy and safety of topical dexamethasone (DEX) eye drops in combination with a single perioperative subtenon triamcinolone acetonide (sTA) injection versus conventional topical DEX eye drops in the prevention of ocular inflammation and cystoid macular edema following cataract surgery. MATERIALS AND METHODS: Medical records of 245 eyes of 245 patients who underwent uncomplicated cataract surgery were analyzed in this retrospective controlled clinical study...
December 2022: Cutaneous and Ocular Toxicology
Yalda Arast, Aida Jabbarzadeh, Farahnaz Tanbakosazan, Abdollah Arjmand, Amir Vazirizadeh, Jalal Pourahmad
INTRODUCTION: Melanoma is known as an aggressive and highly lethal cancer. The poor prognosis and resistance to treatment are characteristics of melanoma. In melanoma cells, apoptosis signaling which relies heavily on the acute activity of mitochondria and reactive oxygen species (ROS) formation is suppressed. Studies have shown that compounds isolated from marine herbs and animals, have been shown to have cytotoxic consequences on cancerous cells in prior research. This study was designed to evaluate the apoptotic effect of methanolic extract of Persian Gulf shell-less marine mollusk (Peronia peronii) on skin mitochondria isolated from animal model of melanoma...
November 26, 2022: Cutaneous and Ocular Toxicology
Mustafa Tosun, Erman Bozali, Duygu Yalınbaş Yeter, Anıl Selim Apa
PURPOSE: To evaluate dry eye parameters, corneal topographic features, corneal densitometric changes, and anterior segment parameters in patients receiving systemic isotretinoin treatment. METHODS: This prospective cross-sectional study included 66 eyes of 33 patients who were started on oral isotretinoin therapy for severe acne vulgaris. All patients were evaluated in terms of ocular surface tests such as tear break-up time (TBUT) and Schirmer-1 and were asked to fill in the ocular surface disease index (OSDI) questionnaire...
November 26, 2022: Cutaneous and Ocular Toxicology
Saeed Karimi, Hosein Nouri, Sahar Mahmoudinejad-Azar, Seyed-Hossein Abtahi
Smoking remains a major public health concern, with more than a billion smokers worldwide. Tobacco smoke contains thousands of substances, many of which are proven harmful; environmental tobacco smoke (ETS) exposure and smoking have links with numerous diseases and can affect various parts of the human eye by promoting oxidative stress and inflammatory processes. Many studies have explored the implications of smoking and ETS exposure in ocular pathologies. This article reviews the available knowledge on such implications and provides pathomechanistic insights where applicable...
November 11, 2022: Cutaneous and Ocular Toxicology
(no author information available yet)
No abstract text is available yet for this article.
October 28, 2022: Cutaneous and Ocular Toxicology
Gabriele Roccuzzo, Tommaso Tibaldi, Francesco Cavallo, Carola Aquino, Teresa Rolle, Pietro Quaglino, Simone Ribero
Systemic retinoids are among the most prescribed drugs in dermatology, thanks to their activity as proliferation modulators and keratinization normalizers. Common side effects such as blood lipid disorders, xerosis and photosensitivity are well established and usually dose dependent. Conversely, retinoid-associated ocular disturbances have been reported, yet with differences in terms of frequency and manifestations. As data regarding a potential correlation with refractive errors are heterogenous and have not been previously thoroughly addressed, we performed a systematic review of the literature with the aim of comprehensively evaluating the current evidence regarding retinoid-associated myopia in dermatologic patients...
October 19, 2022: Cutaneous and Ocular Toxicology
Adem Soydan, Fatih Ulaş, Abdulgani Kaymaz, Güvenç Toprak, Enes Uyar, Serdal Çelebi
PURPOSE: To evaluate the acute effects of the water drinking test (WDT) on the eye using optical coherence tomography angiography (OCTA) on healthy young male subjects. METHODS: The study included 25 eyes of 25 male subjects. Selected parameters of the retinal vasculature were measured, including macular flow indices, foveal avascular zone, and vessel densities (VDs) of the macula using OCTA. The measurements were taken on the first day without drinking water at 0 min, 30 min and 60 min, then repeated on the second day before drinking water at 0 min, and after drinking water at 30 min and 60 min...
October 7, 2022: Cutaneous and Ocular Toxicology
Kenji Goto, Keiichi Hiramoto, Kiyoko Maruyama, Kazuya Ooi
Skin dryness is a symptom of rheumatoid arthritis (RA). However, the mechanisms through which dry skin is induced in RA are unclear. Accordingly, in this study, we characterized substances related to pruritus and pain and then evaluated whether oral administration of zaltoprofen (ZLT) alleviated the symptom of dry skin induced by RA in model mice. DBA/1JJmsSlc collagen-induced arthritis model mice were treated with ZLT, and transepidermal water loss (TEWL), capacitance, and inflammation-, pruritus-, and pain-related markers were assessed...
September 28, 2022: Cutaneous and Ocular Toxicology
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.