Moonil Kang, Ting Fang Alvin Ang, Sherral A Devine, Richard Sherva, Shubhabrata Mukherjee, Emily H Trittschuh, Laura E Gibbons, Phoebe Scollard, Michael Lee, Seo-Eun Choi, Brandon Klinedinst, Connie Nakano, Logan C Dumitrescu, Alaina Durant, Timothy J Hohman, Michael L Cuccaro, Andrew J Saykin, Walter A Kukull, David A Bennett, Li-San Wang, Richard P Mayeux, Jonathan L Haines, Margaret A Pericak-Vance, Gerard D Schellenberg, Paul K Crane, Rhoda Au, Kathryn L Lunetta, Jesse B Mez, Lindsay A Farrer
BACKGROUND: More than 75 common variant loci account for only a portion of the heritability for Alzheimer's disease (AD). A more complete understanding of the genetic basis of AD can be deduced by exploring associations with AD-related endophenotypes. METHODS: We conducted genome-wide scans for cognitive domain performance using harmonized and co-calibrated scores derived by confirmatory factor analyses for executive function, language, and memory. We analyzed 103,796 longitudinal observations from 23,066 members of community-based (FHS, ACT, and ROSMAP) and clinic-based (ADRCs and ADNI) cohorts using generalized linear mixed models including terms for SNP, age, SNP × age interaction, sex, education, and five ancestry principal components...
June 22, 2023: Molecular Neurodegeneration