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Recent Patents on Anti-cancer Drug Discovery

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https://read.qxmd.com/read/30760193/enzyme-and-transporter-kinetics-for-cpt-11-irinotecan-and-sn-38-an-insight-on-tumor-tissue-compartment-pharmacokinetics-using-pbpk
#1
Yingfang Fan, Najia Mansoor, Tasneem Ahmad, Zhuo X Wu, Rafeeq A Khan, Martin Czejka, Syed Sharib, Mansoor Ahmed, Zhe S Chen, Dong H Yang
BACKGROUND: Computational tools are becoming more and more powerful and comprehensive as compared to past decades in facilitating pharmaceutical, pharmacological and clinical practice. Anticancer agents are used either as monotherapy or in combination therapy to treat malignant conditions of the body. A single anti neoplastic agent may be used in different types of malignancies at different doses according to the stage of the disease. OBJECTIVE: To study the behavior of CPT-11 (Irinotecan) and its metabolite SN-38 in tumor tissue compartment through the Whole Body-Physiologically Pharmacokinetics (WB-PBPK) and to determine the activity of metabolic enzymes and transporters participating in the disposition of CPT-11 and SN-38 working in their physiological environment inside the human body...
February 12, 2019: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30663573/from-antimicrobial-to-anticancer-peptides-the-transformation-of-peptides
#2
Yuan Qin, Zuo D Qin, Jing Chen, Che G Cai, Ling Li, Lu Y Feng, Zheng Wang, Gregory J Duns, Nong Y He, Zhe S Chen, Xiao F Luo
BACKGROUND: Antimicrobial peptides play an important role in the innate immune system. Possessing broad-spectrum antibacterial activity, antimicrobial peptides can quickly treat and kill various targets, including gram-negative bacteria, gram-positive bacteria, fungi, and tumor cells. OBJECTIVE: An overview of the state of play with regard to the research trend of antimicrobial peptides in recent years and the situation of targeting tumor cells, and to make statistical analysis of the patents related to anticancer peptides published in recent years, is important both from toxicological and medical tumor therapy point of view...
January 19, 2019: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30652649/purinergic-p2x7-receptor-a-cation-channel-sensitive-to-tumor-microenvironment
#3
Giorgia Scarpellino, Tullio Genova, Luca Munaron
BACKGROUND: Purinergic signalling is involved in several physiological and pathophysiological processes. P2X7 receptor (P2X7R) is a calcium-permeable ion channel that is gaining interest as a potential therapeutic target for the treatment of different diseases including inflammation, pain, psychiatric disorders and cancer. P2X7R is ubiquitously expressed and sensitive to high ATP levels, usually found in tumor microenvironment. P2X7R regulates several cell functions, from migration to cell death, but its selective contribution to tumor progression remains controversial...
January 16, 2019: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30652648/tocotrienols-and-cancer-from-the-state-of-the-art-to-promising-novel-patents
#4
Fabrizio Fontana, Michela Raimondi, Monica Marzagalli, Roberta M Moretti, Marina Montagnani Marelli, Patrizia Limonta
BACKGROUND: Tocotrienols (TTs) are vitamin E derivatives naturally occurring in several plants and vegetable oils. Like Tocopherols (TPs), they comprise four isoforms, α, β, γ and δ, but unlike TPs, they present an unsaturated isoprenoid chain. Recent studies indicate that TTs provide important health benefits, including neuroprotective, anti-inflammatory, anti-oxidant, cholesterol lowering and immunomodulatory effects. Moreover, they have been found to possess unique anti-cancer properties...
January 15, 2019: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30636617/new-anti-cancer-strategies-in-testicular-germ-cell-tumors
#5
Paolo Chieffi, Marco D Martino, Francesco Esposito
BACKGROUND: The most common solid malignancy of young men aged 20 to 34 years is testicular germ cell tumor. In addition, the incidence of these tumors has significatively increased throughout the last years. Testicular germ cell tumors are classified into seminoma and nonseminoma germ cell tumors, which take in yolk sac tumor, embryonal cell carcinoma, choriocarcinoma, and teratoma. There are noteworthy differences about therapy and prognosis of seminomas and nonseminoma germ cell tumors, even though both share characteristics of the primordial germ cells...
January 11, 2019: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30636615/chimeric-antigen-receptor-t-cell-immunotherapy-for-tumor-a-review-of-patent-literatures
#6
Manxue Fu, Liling Tang
BACKGROUND: Chimeric Antigen Receptor (CAR) T cell immunotherapy, as an innovative method for tumor immunotherapy, acquires unprecedented clinical outcomes. Genetic modification not only provides T cells with the antigen-binding function but also endows T cells better immunological functions both in solid and hematological cancer. However, the CAR T cell therapy is not perfect because of several reasons, such as tumor immune microenvironment, and autologous limiting factors of CAR T cells...
January 11, 2019: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30636616/contemporary-formulations-for-drug-delivery-of-anticancer-bioactive-compounds
#7
Darinka Gjorgieva Ackova, Katarina Smilkov, Darko Bosnakovski
BACKGROUND: The immense development in the field of anticancer research has led to an increase in the research of bioactive compounds with anticancer potential. It has been known that many bioactive natural compounds have low insolubility (and low bioavailability) as their main drawback when it comes to the formulation and drug delivery to specific sites. OBJECTIVE: As many attempts have been made to overcome this issue, this review gives a summary of the current accomplishments regarding the development of new Drug Delivery Systems (DDSs) represented by Nanoparticles (NPs) and exosomes...
January 10, 2019: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30605063/tobacco-smoking-risk-to-develop-addiction-chronic-obstructive-pulmonary-disease-and-lung-cancer
#8
Alessia Santoro, Giulia Prinzi, Palma Lamonaca, Vittorio Cardaci, Massimo Fini, Patrizia Russo
BACKGROUND: The morbidity and mortality associated with tobacco smoking is well established. Nicotine is the addictive component of tobacco. Nicotine, through non-neuronal 7nicotinic receptor, induces cell proliferation, neo-angiogenesis, epithelial to mesenchymal transition, and inhibits drug-induced apoptosis. OBJECTIVE: To understand the genetic, molecular and cellular biology of addiction, chronic obstructive pulmonary disease and lung cancer. METHODS: The search for papers to be included in the review was performed during the months of July-September 2018 in the following databases: PubMed (http://www...
January 2, 2019: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30599110/lentiviral-mediated-overexpression-of-microrna-141-promotes-cell-proliferation-and-inhibits-apoptosis-in-human-esophageal-squamous-cell-carcinoma
#9
Jun-He Zhang, Hai-Bin Xia
BACKGROUND: Esophageal Carcinoma (EC) is the eighth most common cancer worldwide. Numerous studies have highlighted a vital role of microRNAs (miRNAs) in the development of EC. However, the mechanism of microRNA (miRNA)-141 in Esophageal Squamous Cell Carcinoma (ESCC) remains unknown. OBJECTIVE: In this study, we explored the effects of miRNA-141 on EC cell proliferation, apoptosis, xenograft tumour growth and their possible mechanisms. METHODS: A lentivirus-vector-expressing miRNA-141 was constructed, and a TE-1 cell line of ESCC with a stable expression of miRNA-141 was transfected and screened...
December 31, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30569876/death-associated-protein-kinase-1-as-a-promising-drug-target-in-cancer-and-alzheimer-s-disease
#10
Dongmei Chen, Xiao Z Zhou, Tae H Lee
BACKGROUND: Death-Associated Protein Kinase 1 (DAPK1) plays an important role in apoptosis, tumor suppression and neurodegeneration including Alzheimer's Disease (AD). OBJECTIVE: This review will describe the diverse roles of DAPK1 in the development of cancer and AD, and the current status of drug development targeting DAPK1-based therapies. METHODS: Reports of DAPK1 regulation, function and substrates were analyzed using genetic DAPK manipulation and chemical DAPK modulators...
December 18, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30451116/cucurbitacins-as-anticancer-agents-a-patent-review
#11
Hidayat Hussain, Ivan R Green, Muhammad Saleem, Khanzadi Fatima Khattak, Muhammad Irshad, Maroof Ali
BACKGROUND: Cucurbitacins belong to a group of tetracyclic triterpenoids that display a wide range of biological effects. In the past, numerous cucurbitacins have been isolated from natural sources and many active compounds have been synthesized using the privileged scaffold in order to enhance its anticancer effects. OBJECTIVE: This review covers patents on the therapeutic effects of natural cucurbitacins and their synthetic analogs published during the past decade...
November 19, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30474536/high-throughput-strategy-accelerates-the-progress-of-marine-anticancer-peptide-drug-development
#12
Peng Lyu, Hang Fai Kwok
No abstract text is available yet for this article.
November 14, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30381087/nanostructured-systems-in-advanced-drug-targeting-for-the-cancer-treatment-recent-patents
#13
Maricruz Anaya-Ruiz, Cindy Bandala, Gerardo Landeta, Patricia Martínez-Morales, Jose Lino Zumaquero-Rios, Jorge Sarracent-Pérez, Martin Perez-Santos
BACKGROUND: Cancer is one of the leading causes of death in the world and it is necessary to develop new strategies for its treatment because most therapies have limited access to many types of tumors, as well as low therapeutic efficacy and high toxicity. OBJECTIVE: The present review aims to provide to identify recent patents of drug delivery nanostructured systems that may have application in improving cancer treatment. METHOD: Recent patents regarding the drug delivery nanostructured systems for cancer treatment were obtained from the patent databases of the six main patent offices of the world: United States Patent and Trademark Office, European Patent Office, World Intellectual Property Organization, Japan Patent Office, State Intellectual Property Office of China and Korean Intellectual Property Office...
October 31, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30370857/novel-small-molecule-inhibitors-of-programmed-cell-death-pd-1-and-its-ligand-pd-l1-in-cancer-immunotherapy-a-review-update-of-patent-literature
#14
Spandana Rajendra Kopalli, Tae-Bong Kang, Kwang-Ho Lee, Sushruta Koppula
BACKGROUND: In the last few decades, cancer immunotherapy has been extensively researched, and novel checkpoint signaling mechanisms involving programmed death (PD)-1 and PD-ligand 1 (PD-L1) receptors have been targeted. The PD-1/PD-L1 binding and interaction play a critical role in the development of malignancies. OBJECTIVE: The present review focuses on recent patents on the pharmacological and biological cancer-regulating properties of PD-1/PD-L1 inhibitors involved in immunotherapeutic cancer drug development...
October 29, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30173649/recent-advances-in-developing-novel-anti-cancer-drugs-targeting-tumor-hypoxic-and-acidic-microenvironments
#15
Weidong Li, Xueying Sun
BACKGROUND: Solid tumors often contain hypoxic microenvironments due to abnormal vasculatures and outweighing demands of oxygen. Cancer cells rely on anaerobic respiration, leading to sequential acidic microenvironments. Hypoxic and acidic microenvironments cause genetic instability and activate signaling pathways, contributing to cancer progression and drug therapy resistance, and have become targets for developing novel anti-cancer agents. OBJECTIVE: This article reviews recent advances in the development of novel anti-cancer drugs targeting hypoxic and acidic microenvironments...
August 30, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30091418/journey-describing-the-cytotoxic-potential-of-withanolides-a-patent-review
#16
Hidayat Hussain, Rene Csuk, Ivan R Green, Najeeb Ur Rehman, Ghulam Abbas, Wahid Hussain
Withanolides are C-28 ergostane steroids known to demonstrate some very interesting therapeutic properties. Numerous withanolides have been isolated from a variety of different plant species and can be employed to treat various types of cancers. Withanolides are indeed capable of demonstrating excellent anticancer, anti-inflammatory, and neuroprotective activities. Additionally, libraries of prepared withaferin A analogs incorporating an acyl, sulphate, amide and aldehyde functionality have demonstrated the most potential response potentials...
August 8, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30039764/semi-synthetic-derivatives-of-heliomycin-with-an-antiproliferative-potency
#17
A E Shchekotikhin, Georgy Y Nadysev, Alexander S Tikhomirov, Lyubov G Dezhenkova
BACKGROUND: Heliomycin (resistomycin), an antibiotic with broad spectra of biological activities including antimicrobial, antifungal, antiviral, and antiproliferative. However, an extremely low solubility in aqueous media and in the majority of organic solvents limits its practical application. OBJECTIVE: Due to a high practical potential of heliomycin new routes of structural modification are strongly required to improve its solubility. CONCLUSION: The patent claims a series of 4-aminomethyl derivatives of heliomycin as well as a pharmaceutical composition based on it...
July 23, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/30027855/amplified-crosstalk-between-estrogen-binding-and-gfr-signaling-mediated-pathways-of-er-activation-drives-responses-in-tumors-treated-with-endocrine-disruptors
#18
Zsuzsanna Suba
BACKGROUND: The pharmaceutical development of endocrine disruptors could not achieve appropriate advances in the field of anticancer fight. OBJECTIVE: Considerations on the principles of currently used endocrine therapies. METHODS: Comparison of the results of genetic studies being performed on breast cancer cells treated with estrogens, synthetic estrogens and antiestrogens. RESULTS: In breast cancer cells, increased estrogen concentrations amplify ER-signaling via a synergistic upregulation of both liganded and unliganded ER-activations and increased aromatase expression...
July 20, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/29807523/targeting-metabolism-to-counteract-tumor-angiogenesis-a-review-of-patent-literature
#19
Sara Petrillo, Emanuela Tolosano, Luca Munaron, Tullio Genova
Massive vessel recruitment is required to sustain rapid tumor growth by delivering oxygen and nutrients. Current strategies to counteract angiogenesis are mostly aimed at reducing tumor vessel density. However, many of these drugs have been shown to trigger hypoxia, thus exacerbating tumor aggressiveness. Promising results come from a completely different approach based on the "normalization" of the endothelial layer and the consequent improvement of the vascular function. Since endothelial metabolism has proved essential in the regulation of the angiogenic switch, many recent patents focus on agents able to inhibit specific metabolic pathways in tumor-associated endothelial cells (TECs) in order to provide vessel normalization...
May 27, 2018: Recent Patents on Anti-cancer Drug Discovery
https://read.qxmd.com/read/29708076/recent-progress-of-marine-polypeptides-as-anticancer-agents
#20
Lanhong Zheng, Yixin Xu, Xiukun Lin, Zhixin Yuan, Minghua Liu, Shousong Cao, Fuming Zhang, Robert J Linhardt
BACKGROUND: Marine environment constitutes an almost infinite resource for novel anticancer drugs discovery. The biodiversity of marine organisms provides a rich source for the discovery and development of novel anticancer peptides in the treatment of human cancer. Marine peptides represent a new opportunity to obtain lead compounds in biomedical field, particularly for cancer therapy. OBJECTIVE: Providing an insight of the recent progress of patented marine peptides and presenting information about the structures and mechanistic mode of anticancer activities of these marine peptides...
April 29, 2018: Recent Patents on Anti-cancer Drug Discovery
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