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Journals Anti-cancer Agents in Medicina...

Anti-cancer Agents in Medicinal Chemistry

https://read.qxmd.com/read/38529608/liposomal-nano-based-drug-delivery-systems-for-breast-cancer-therapy-recent-advances-and-progresses
#1
JOURNAL ARTICLE
Mostafa Yazdan, Seyed Morteza Naghib, M R Mozafari
Breast cancer is a highly prevalent disease on a global scale, with a 30% incidence rate among women and a 14% mortality rate. Developing countries bear a disproportionate share of the disease burden, while countries with greater technological advancements exhibit a higher incidence. A mere 7% of women under the age of 40 are diagnosed with breast cancer, and the prevalence of this ailment is significantly diminished among those aged 35 and younger. Chemotherapy, radiation therapy, and surgical intervention comprise the treatment protocol...
March 25, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38500290/bee-venom-toxic-effect-on-mda-mb-231-breast-cancer-cells-and-caenorhabditis-elegans
#2
JOURNAL ARTICLE
Yáskara Veruska Ribeiro Barros, Amanda Onduras de Andrade, Larissa Pereira Dantas da Silva, Lucas Aleixo Leal Pedroza, Iverson Conrado Bezerra, Iago Dillion Lima Cavalcanti, Mariane Cajuba de Britto Lira Nogueira, Kristiana Cerqueira Mousinho, Angelo Roberto Antoniolli, Luiz Carlos Alves, José Luiz de Lima Filho, Alexandre Varão Moura, Álex Aparecido Rosini Silva, Andréia de Melo Porcari, Priscila Gubert
INTRODUCTION: Bee venom has therapeutics and pharmacological properties. Further toxicological studies on animal models are necessary due to the severe allergic reactions caused by this product. METHOD: Here, Caenorhabditis elegans was used as an in vivo toxicity model, while breast cancer cells were used to evaluate the pharmacological benefits. The bee venom utilized in this research was collected from Apis mellifera species found in Northeast Brazil. The cytotoxicity caused by bee venom was measured by MTT assay on MDA-MB-231 and J774 A...
March 15, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38482619/investigating-the-effects-of-dorema-hyrcanum-root-extracts-on-selective-induction-of-programmed-cell-death-in-glioblastoma-ovarian-cancer-and-breast-cancer-cell-lines
#3
JOURNAL ARTICLE
Mahsa Hatami, Shamim Sahranavard, Fereshteh Bagheri, Zahra Shahsavari, Siamak Salami
BACKGROUND: Despite remarkable advances, cancer has remained the second cause of death, which shows that more potent novel compounds should be found. Ethnobotanical compounds have a long history of treating diseases, and several approved chemotherapeutic compounds were isolated from plants. OBJECTIVE: The research aimed to evaluate the cytotoxic effects of Dorema hyrcanum root extract on ovarian, breast, and glioblastoma cells while examining its selectivity towards normal cells...
March 12, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38465430/ginsenoside-rb1-inhibits-the-proliferation-of-lung-cancer-cells-by-inducing-the-mitochondrial-mediated-apoptosis-pathway
#4
JOURNAL ARTICLE
Lin Feng, Xinze Liu, Kaijing Sun, Ying Sun, Wei Wu, Changbao Chen, Xin Jin, Xilin Wan
BACKGROUND: Lung cancer is one of the more common malignant tumors posing a great threat to human life, and it is very urgent to find safe and effective therapeutic drugs. The antitumor effect of ginsenosides has been reported to be a treatment with a strong effect and a high safety profile. OBJECTIVE: This paper aimed to investigate the inhibitory effect of ginsenoside Rb1 on 95D and NCI-H460 lung cancer cells and its pathway to promote apoptosis. METHODS: We performed the CCK-8 assay, fluorescence staining assay, flow cytometry, scratch healing assay, and Transwell assay to detect the effects of different concentrations of ginsenoside Rb1 on the antitumor activity of 95D and NCI-H460 cells and Western Blot detected the mechanism of antitumor effect...
March 7, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38465429/tabersonine-induces-the-apoptosis-of-human-hepatocellular-carcinoma-in-vitro-and-in-vivo
#5
JOURNAL ARTICLE
Xuan Li, Xudan Li, Lianghua Chen, Yuan Deng, Zhizhong Zheng, Yanlin Ming
BACKGROUND: Tabersonine, a natural indole alkaloid derived from Apocynaceae plants, exhibits antiinflammatory and acetylcholinesterase inhibitory activities, among other pharmacological effects. However, its anti-tumor properties and the underlying molecular mechanisms remain underexplored. OBJECTIVE: The present study aims to investigate the anti-tumor effects of tabersonine and its mechanisms in inducing apoptosis in hepatocellular carcinoma. METHODS: The inhibitory effects of tabersonine on the viability and proliferation of liver cancer cells were evaluated using MTT assay and colony formation assay...
March 7, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38415470/hyperoxic-hypoxic-paradox-breast-cancer-microenvironment-and-an-innovative-treatment-strategy
#6
JOURNAL ARTICLE
Suman Kumar Ray, Sukhes Mukherjee
A small therapeutic range of oxygen is required for effective metabolism. As a result, hypoxia (low oxygen concentration) is one of the most potent inducers of gene expression, metabolic alterations, and regenerative processes, such as angiogenesis, stem cell proliferation, migration, and differentiation. The cellular response is controlled by sensing the increased oxygen levels (hyperoxia) or hypoxia via specific chemoreceptor cells. Surprisingly, changes in free oxygen concentration instead of absolute oxygen levels may be regarded as a deficiency of oxygen at the cellular level...
February 26, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38415491/phytol-and-%C3%AE-bisabolol-synergy-induces-autophagy-and-apoptosis-in-a549-cells-and-additional-molecular-insights-through-comprehensive-proteome-analysis-via-nano-lc-ms-ms
#7
JOURNAL ARTICLE
Chandramohan Kiruthiga, Kambati Niharika, Kasi Pandima Devi
BACKGROUND: Non-Small Cell Lung Cancer (NSCLC) is a malignancy with a significant prevalence and aggressive nature, posing a considerable challenge in terms of therapeutic interventions. Autophagy and apoptosis, two intricate cellular processes, are integral to NSCLC pathophysiology, each affecting the other through shared signaling pathways. Phytol (Phy) and α -bisabolol (Bis) have shown promise as potential anticancer agents individually, but their combined effects in NSCLC have not been extensively investigated...
February 23, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38409708/recent-advances-in-chemistry-mechanism-and-applications-of-quantum-dots-in-photodynamic-and-photothermal-therapy
#8
JOURNAL ARTICLE
Faride Ranjbari, Farzaneh Fathi
Semiconductor quantum dots (QD) are a kind of nanoparticle with unique optical properties that have attracted a lot of attention in recent years. In this paper, the characteristics of these nanoparticles and their applications in nanophototherapy have been reviewed. Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has gained special importance because of its high accuracy and local treatment due to the activation of the drug at the tumor site. PDT is a new way of cancer treatment that is performed by activating light-sensitive compounds named photosensitizers (PS) by light...
February 22, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38385488/anticancer-activity-of-sargassum-fluitans-extracts-in-different-cancer-cells
#9
JOURNAL ARTICLE
José Arnold González-Garrido, Javier Alejandro Gómez-García, Oswaldo Ignacio Hernández-Abreu, Ivonne María Olivares-Corichi, Fernando Pereyra-Vergara, José Rubén García-Sánchez
BACKGROUND: The arrival of large quantities of Sargassum in the Mexican Caribbean Sea has generated major environmental, health and economic problems. Although Sargassum has been used in the generation of some commercial products, few studies have described its possible applications as a source of compounds with anticancer activity. OBJECTIVE: This study aimed to evaluate the antiproliferative effects of different Sargassum extracts on various cancer cell lines...
February 21, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38362678/1-3-diaryl-triazenes-incorporating-disulfonamides-show-both-antiproliferative-activity-and-effective-inhibition-of-tumor-associated-carbonic-anhydrases-ix-and-xii
#10
JOURNAL ARTICLE
Nebih Lolak, Suleyman Akocak, Andrea Petreni, Yakup Budak, Esra Bozgeyik, Meliha Burcu Gurdere, Mustafa Ceylan, Claudiu T Supuran
AIM: The aim of this study was to synthesize a library of novel di-sulfa drugs containing 1,3- diaryltriazene derivatives TS (1-13) by conjugation of diazonium salts of primary sulfonamides with sulfa drugs to investigate the cytotoxic effect of these new compounds in different cancer types and to determine their inhibitory activity against tumor-associated carbonic anhydrases IX and XII. MATERIALS AND METHODS: A carbonic anhydrase inhibitory activity of the obtained compounds was evaluated against four selected human carbonic anhydrase isoforms (hCA I, hCA II, hCA IX and hCA XII) by a stoppedflow CO2 hydrase assay...
February 15, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38347773/indirubin-an-active-component-of-indigo-naturalis-exhibits-inhibitory-effects-on-leukemia-cells-via-targeting-hsp90aa1-and-pi3k-akt-pathway
#11
JOURNAL ARTICLE
Yuanzhi Yao, Xiaoying Li, Xiaoqin Yang, Hai Mou, Lin Wei
BACKGROUND: This research intended to predict the active ingredients and key target genes of Indigo Naturalis in treating human chronic myeloid leukemia (CML) using network pharmacology and conduct the invitro verification. METHODS: The active components of Indigo Naturalis and the corresponding targets and leukemia-associated genes were gathered through public databases. The core targets and pathways of Indigo Naturalis were predicted through protein-protein interaction (PPI) network, gene ontology (GO) function, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses...
February 12, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38321904/anti-proliferative-morphological-and-molecular-docking-studies-of-new-thiophene-derivatives-and-their-strategy-in-ionic-liquids-immobilized-reactions
#12
JOURNAL ARTICLE
Rafat M Mohareb, Sayeed Mukhtar, Humaira Parveen, Mahmoud A Abdelaziz, Ensaf S Alwan
BACKGROUND: A number of research were conducted on the pyran and thiophene derivatives, which were attributed to have a wide range of biological activities, including anti-plasmodial, as well as acting as caspase, hepatitis C and cancer inhibitors. OBJECTIVE: The multicomponent reactions of the 5-acetyl-2-amino-4-(phenylamino)-thiophene-3-carbonitrile produced biologically active target molecules like pyran and their fused derivatives. Comparison between regular catalytic multi-component reactions and solvent-free ionic liquids immobilized multicomponent was studied...
February 6, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38305294/cordyceps-militaris-a-comprehensive-study-on-laboratory-cultivation-and-anticancer-potential-in-dalton-s-ascites-lymphoma-tumor-model
#13
JOURNAL ARTICLE
Diksha Dutta, Namram Sushindrajit Singh, Rohit Aggarwal, Akalesh Kumar Verma
BACKGROUND: Cancer, a predominant cause of mortality, poses a formidable challenge in our pursuit of elevating life expectancy. Throughout history, individuals have sought natural remedies with minimal side effects as an appealing substitute for chemotherapeutic drugs. One such remedy is Cordyceps militaris, a renowned medicinal mushroom deeply entrenched in Asian ethnomedicine. Revered for its rejuvenating and curative attributes, it relied upon for ages. OBJECTIVE: The mushroom's soaring demand outpaced natural availability, necessitating controlled laboratory cultivation as the core focus and exploring the potential of methanolic extracts from harvested Cordyceps militaris fruiting bodies against Dalton's Lymphoma Ascites (DLA) cells in vitro, with a specific emphasis on its anticancer traits...
February 2, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38367265/drug-repositioning-for-ovarian-cancer-treatment-an-update
#14
JOURNAL ARTICLE
Maria Maddalena Cavalluzzi, Maurizio Viale, Natalie Paola Rotondo, Valeria Ferraro, Giovanni Lentini
Ovarian cancer (OC) is one of the most prevalent malignancies in female reproductive organs, and its 5-year survival is below 45%. Despite the advances in surgical and chemotherapeutic options, OC treatment is still a challenge, and new anticancer agents are urgently needed. Drug repositioning has gained significant attention in drug discovery, representing a smart way to identify new clinical applications for drugs whose human safety and pharmacokinetics have already been established, with great time and cost savings in pharmaceutical development endeavors...
February 1, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38367264/thiosemicarbazone-benzene-sulfonamide-derivatives-as-human-carbonic-anhydrases-inhibitors-synthesis-characterization-and-in-silico-studies
#15
JOURNAL ARTICLE
Muhammed Trawally, Kübra Demir-Yazıcı, Andrea Angeli, Kerem Kaya, Atilla Akdemir, Claudiu T Supuran, Özlen Güzel-Akdemir
INTRODUCTION: Carbonic anhydrases (CAs) are widespread metalloenzymes with the core function of catalyzing the interconversion of CO2 and HCO3-. Targeting these enzymes using selective inhibitors has emerged as a promising approach for the development of novel therapeutic agents against multiple diseases. METHOD: A series of novel thiosemicarbazones-containing derivatives were synthesized, characterized, and tested for their inhibitory activity against pharmaceutically important human CA I (hCA I), II (hCA II), IX (hCA IX), and XII (hCA XII) using the single tail approach...
February 1, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38299417/cervical-cancer-therapeutics-an-in-depth-significance-of-herbal-and-chemical-approaches-of-nanoparticles
#16
JOURNAL ARTICLE
Istuti Saraswat, Anjana Goel
Cervical cancer emerges as a prominent health issue, demanding attention on a global level for women's well-being, which frequently calls for more specialized and efficient treatment alternatives. Traditional therapies may have limited tumour targeting and adverse side effects. Recent breakthroughs have induced a transformative shift in the strategies employed against cervical cancer. biocompatible herbal nanoparticles and metallic particles made of gold, silver, and iron have become promising friends in the effort to fight against this serious disease and understand the possibility of these nanoparticles for targeted medication administration...
January 31, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38288815/an-expedition-on-synthetic-methodology-of-fda-approved-anticancer-drugs-2018-2021
#17
JOURNAL ARTICLE
Vishakha S, Navneesh N, Balak Das Kurmi, Ghanshyam Das Gupta, Sant Kumar Verma, Ankit Jain, Preeti Patel
New drugs being established in the market every year produce specified structures for selective biological targeting. With medicinal insights into molecular recognition, these begot molecules open new rooms for designing potential new drug molecules. In this review, we report the compilation and analysis of a total of 56 drugs including 33 organic small molecules (Mobocertinib, Infigratinib, Sotorasib, Trilaciclib, Umbralisib, Tepotinib, Relugolix, Pralsetinib, Decitabine, Ripretinib, Selpercatinib, Capmatinib, Pemigatinib, Tucatinib, Selumetinib, Tazemetostat, Avapritinib, Zanubrutinib, Entrectinib, Pexidartinib, Darolutamide, Selinexor, Alpelisib, Erdafitinib, Gilteritinib, Larotrectinib, Glasdegib, Lorlatinib, Talazoparib, Dacomitinib, Duvelisib, Ivosidenib, Apalutamide), 6 metal complexes (Edotreotide Gallium Ga-68, fluoroestradiol F-18, Cu 64 dotatate, Gallium 68 PSMA-11, Piflufolastat F-18, 177Lu (lutetium)), 16 macromolecules as monoclonal antibody conjugates (Brentuximabvedotin, Amivantamab-vmjw, Loncastuximabtesirine, Dostarlimab, Margetuximab, Naxitamab, Belantamabmafodotin, Tafasitamab, Inebilizumab, SacituzumabGovitecan, Isatuximab, Trastuzumab, Enfortumabvedotin, Polatuzumab, Cemiplimab, Mogamulizumab) and 1 peptide enzyme (Erwiniachrysanthemi-derived asparaginase) approved by the U...
January 29, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38288814/novel-n-3-ethynyl-phenyl-6-7-bis-2-methoxyethoxy-quinazoline-4-amine-derivatives-synthesis-characterization-anti-cancer-activity-in-silico-and-dft-studies
#18
JOURNAL ARTICLE
Amitananda Dash, Guruswamy Vaddamanu, Raja Karreddula, Surya Surendra Babu Manubolu, Pavana Kumari G, Naveen Mulakayala
BACKGROUND: Cancer is one of the most common reasons for mortality in the world. A continuous effort to develop effective anti-cancer drugs with minimum side effects has become necessary. The use of small-molecule drugs has revolutionized cancer research by inhibiting cancer cell survival and proliferation. Quinazolines are a class of bioactive heterocyclic compounds with active pharmacophores in several anti-cancer drugs. Such small molecule inhibitors obstruct the significant signals responsible for cancer cell development, thus blocking these cell signals to prevent cancer development and spread...
January 25, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38279753/an-insight-into-the-effect-of-schiff-base-and-their-d-and-f-block-metal-complexes-on-various-cancer-cell-lines-as-anticancer-agents-a-review
#19
JOURNAL ARTICLE
Presenjit, Shubhra Chaturvedi, Akanksha Singh, Divya Gautam, Kaman Singh, Anil Kumar Mishra
Over the last few decades, an alarming rise in the percentage of individuals with cancer and those with multi-resistant illnesses has forced researchers to explore possibilities for novel therapeutic approaches. Numerous medications currently exist to treat various disorders, and the development of small molecules as anticancer agents has considerable potential. However, the widespread prevalence of resistance to multiple drugs in cancer indicates that it is necessary to discover novel and promising compounds with ideal characteristics that could overcome the multidrug resistance issue...
January 25, 2024: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/38275051/design-synthesis-in-vitro-and-in-vivo-evaluation-of-new-imidazo-1-2-a-pyridine-derivatives-as-cyclooxygenase-2-inhibitors
#20
JOURNAL ARTICLE
Nahid Ahmadi, Mona Khoramjouy, Mahsa Azami Movahed, Salimeh Amidi, Mehrdad Faizi, Afshin Zarghi
BACKGROUND: Cyclooxygenase-2 (COX-2), the key enzyme in the arachidonic acid conversion to prostaglandins, is one of the enzymes associated with different pathophysiological conditions, such as inflammation, cancers, Alzheimer's, and Parkinson's disease. Therefore, COX-2 inhibitors have emerged as potential therapeutic agents in these diseases. OBJECTIVE: The objective of this study was to design and synthesize novel imidazo[1,2-a]pyridine derivatives utilizing rational design methods with the specific aim of developing new potent COX-2 inhibitors...
January 24, 2024: Anti-cancer Agents in Medicinal Chemistry
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