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Journal of Orthopaedic Surgery and Research

Francesco Oliva, Nicola Maffulli, Clarissa Gissi, Francesca Veronesi, Lucia Calciano, Milena Fini, Silvia Brogini, Marialucia Gallorini, Cristina Antonetti Lamorgese Passeri, Roberta Bernardini, Rosella Cicconi, Maurizio Mattei, Anna Concetta Berardi
BACKGROUND: This pilot study aimed to ascertain whether the local application of ascorbic acid (AA), of T3 , and of rat (r) bone marrow mesenchymal stem cells (BMSCs), alone or in all possible combinations, promoted healing after an Achilles tendon injury in a rat model. METHODS: An Achilles tendon defect was produced in 24 6-8-week-old male inbred Lewis rats. The animals were then randomly divided into eight groups of three rats each. The tendon defect was filled with 50 μL of phosphate-buffered saline (PBS) containing (1) 50 μg/mL AA (AA group), (2) 10-7  M T3 (T3 group), (3) 4 × 106 rBMSCs (rBMSC group), (4) 50 μg/mL AA + 10-7  M T3 (AA + T3 group), (5) 4 × 106 rBMSCs + 50 μg/mL AA (rBMSC + AA group), (6) 4 × 106 rBMSCs + 10-7  M T3 (rBMSC + T3 group), (7) 4 × 106 rBMSCS + 50 μg/mL AA + 10-7  M T3 (rBMSC + AA + T3 group), and (8) PBS only (control group: CTRL)...
February 18, 2019: Journal of Orthopaedic Surgery and Research
Xuan Wu, Yunpeng Zhang, Yixiao Xing, Bin Zhao, Cong Zhou, Yong Wen, Xin Xu
BACKGROUND: Type 2 diabetes mellitus (T2DM) and hyperlipidemia are negatively related to bone regeneration. The aim of this study was to evaluate the effect of high-fat and high-glucose microenvironment on bone regeneration and to detect the expression of runt-related transcription factor 2 (Runx2) and transcriptional co-activator with PDZ-binding domain (TAZ) during this process. METHODS: After establishing a high-fat and high-glucose mouse model, a 1 mm × 1...
February 18, 2019: Journal of Orthopaedic Surgery and Research
Sungwook Choi, Jong-Hwan Bae, Yong Suk Kwon, Hyunseong Kang
BACKGROUND: Reverse total shoulder arthroplasty (RTSA) is a treatment option for patients with severe osteoarthritis, rotator cuff arthropathy, or massive rotator cuff tear with pseudoparalysis. We are to deduce not only the early functional outcomes and complications of cementless RTSA during the learning curve period but also complication-based, and operation time-based learning curve of RTSA. METHODS: Between March 2010 and February 2014, we retrospectively evaluated 38 shoulders (6 male, 32 female)...
February 18, 2019: Journal of Orthopaedic Surgery and Research
Yasen Cao, Yong Zhang, Lixin Huang, Xiaowei Huang
BACKGROUND: Tibial shaft fractures account for approximately 15% of long bone fractures. Locked plates with minimally invasive plate osteosynthesis techniques are used widely by surgeons. The purpose of this study is to investigate the impact of factors meaning the plate length, fibula integrity, and placement of the plate on the stability of tibial shaft fracture fixation. METHODS: A finite element model of the tibial shaft fracture was built. An axial force of 2500 N was applied to simulate the axial compressive load on an adult knee during single-limb stance...
February 15, 2019: Journal of Orthopaedic Surgery and Research
Akinori Okuda, Naoki Maegawa, Hiroaki Matsumori, Tomohiko Kura, Yasushi Mizutani, Hideki Shigematsu, Eiichiro Iwata, Masato Tanaka, Keisuke Masuda, Yusuke Yamamoto, Yusuke Tada, Yohei Kogeichi, Keisuke Takano, Hideki Asai, Yasuyuki Kawai, Yasuyuki Urisono, Kenji Kawamura, Hidetada Fukushima, Yasuhito Tanaka
BACKGROUND: Unstable sacral fractures are high-energy injuries and comprise polytrauma. Internal fixation to enable withstanding vertical loads is required to get up early from the bed after an unstable sacral fracture. We developed a new minimally invasive surgical (MIS) procedure for unstable pelvic ring fractures and reported it in Japanese in 2010. We presented our minimally invasive surgical technique of crab-shaped fixation for the treatment of unstable pelvic ring fractures and report on its short-term outcomes...
February 15, 2019: Journal of Orthopaedic Surgery and Research
Abulimiti Amuti, Hui-Yong Ding, Li-Guo Liu
AbstractIn the original publication of this article [1], the spelling of the first author's name A. Ablimit was incorrect.
February 15, 2019: Journal of Orthopaedic Surgery and Research
Nick C Leegwater, Sander M van der Meer, Inger N Sierevelt, Hugo Spruijt, Peter A Nolte
BACKGROUND: The aim of this study was to define deep tissue temperature during cryotherapy in postoperative hip fracture patients, by using measured skin temperature as input parameter for a simple numerical model. Second, an association was investigated between pain and tissue temperature distribution, to assess cryotherapy-induced analgesia of soft tissue-derived pain. METHODS: Data from 35 participants in an ongoing trial was used. In three subjects who consented on optional measurements, skin temperature was measured in 3 days during and after cryotherapy...
February 14, 2019: Journal of Orthopaedic Surgery and Research
Yi-Ming Ren, Yuan-Hui Duan, Yun-Bo Sun, Tao Yang, Wei-Yu Hou, Meng-Qiang Tian
OBJECTIVE: Labral repair and biceps tenotomy and tenodesis are routine operations for type II superior labrum anterior posterior (SLAP) lesion of the shoulder, but evidence of their superiority is lacking. We conducted this systematic review and meta-analysis to compare the clinical outcomes of arthroscopic repair versus biceps tenotomy and tenodesis intervention. METHODS: The eight studies were acquired from PubMed, Medline, Embase, CNKI, and Cochrane Library. The data were extracted by two of the coauthors independently and were analyzed by RevMan 5...
February 13, 2019: Journal of Orthopaedic Surgery and Research
Felix Porschke, Marc Schnetzke, Stefan Studier-Fischer, Paul Alfred Gruetzner, Thorsten Guehring
BACKGROUND: Considering the epidemiology of acromioclavicular (AC) dislocation related to young and active patients, the impact on working capacity is highly relevant. The purpose of this study was to determine the capacity of work and time to return to work (RTW) after AC joint stabilization. We hypothesized that manual working patients show more restrictions returning to work. METHODS: In this retrospective case series, pre- and posttraumatic working capacity of 54 patients (FU-rate 80...
February 12, 2019: Journal of Orthopaedic Surgery and Research
Teng-Fei Lou, Gen Wen, Chun-Yang Wang, Yi-Min Chai, Pei Han, Xiao-Fan Yin
BACKGROUND: We described the use of the technique of L-shaped corticotomy with bone flap sliding to treat chronic osteomyelitis of the tibia in eight patients and presented the preliminary results. METHODS: L-shaped corticotomy with bone flap sliding was performed in eight patients between 2007 and 2014. All patients had chronic tibial osteomyelitis involving the anterior tibial cortex with intact and healthy posterior cortex. The size of bone defects following sequestrectomy and radical debridement was 8...
February 12, 2019: Journal of Orthopaedic Surgery and Research
Wei Sun, Cheng Xue, Xian-Ye Tang, Hu Feng, Feng Yuan, Kai-Jin Guo, Jie Zhao
BACKGROUND: Lumbar spinal stenosis, often accompanied by degenerative spondylolisthesis, is one of the most common conditions in the elderly. Decompression and fusion is a well-accepted treatment for single-segment lumbar spinal stenosis with degenerative spondylolisthesis; however, the treatment for multi-segment lumbar spinal stenosis with single-segment degenerative spondylolisthesis (MLSS) remains controversial. The objective of this study is to compare the effectiveness of selective decompression and fusion to multi-segmental decompression and fusion for MLSS...
February 12, 2019: Journal of Orthopaedic Surgery and Research
Duraisamy Shriram, Go Yamako, Etsuo Chosa, Yee Han Dave Lee, Karupppasamy Subburaj
BACKGROUND: Patients undergoing total or partial arthroscopic meniscectomy for treating traumatic meniscal tears are at greater risk of developing knee osteoarthritis (OA) due to increased mechanical load. The purpose of this study was to evaluate the effects of a valgus unloader brace in the medial meniscectomized knee joint during the gait cycle. METHODS: A three-dimensional finite element model of the knee joint was developed using the substructures segmented from magnetic resonance images...
February 12, 2019: Journal of Orthopaedic Surgery and Research
Suzannah M Schmidt-Malan, Kerryl E Greenwood-Quaintance, Lawrence J Berglund, Jayawant Mandrekar, Robin Patel
BACKGROUND: Polymethylmethacrylate (PMMA) is used for local antimicrobial delivery in orthopedic infection. Oritavancin is a long half-life lipoglycopeptide with broad activity against Gram-positive bacteria. Herein, we addressed if 7.5% w/w oritavancin mixed into PMMA affects PMMA strength and whether it elutes from PMMA, compared to vancomycin. METHODS: Elution was assessed by placing an oritavancin- or vancomycin-loaded bead in a flow system with human plasma...
February 12, 2019: Journal of Orthopaedic Surgery and Research
John Tristan Cassidy, Eamonn Coveney, Diarmoud Molony
INTRODUCTION: While locking plates have markedly improved fixation of proximal humerus fractures, a cohort of fractures remains difficult to treat. This cohort has been identified as fractures with marked medial comminution and varus deformity. Loss of reduction and fixation failure are the most frequently reported complications for this cohort. We report the use of an orthogonal 1/3 tubular plate to augment the proximal humerus locking plate. METHODS: The subject underwent osteosynthesis for a four-part proximal humerus fracture with medial comminution...
February 11, 2019: Journal of Orthopaedic Surgery and Research
Xingchen Yao, Ziyu Xu, Xinru Du
BACKGROUND: Multiple myeloma (MM) is a blood system malignant tumor, which often leads to osteolytic bone destruction, and the vertebral column is the primary site of involvement. However, the efficacy and prognosis of percutaneous kyphoplasty/vertebroplasty (PKP/PVP) for simple vertebral pathological fractures in patients with multiple myeloma are not yet unified. The primary objective of this study was to investigate the efficacy and prognosis of PKP/PVP in the treatment of multiple myeloma patients with vertebral pathological fractures...
February 11, 2019: Journal of Orthopaedic Surgery and Research
Hongwu Zhuo, Jian Li
BACKGROUND: To compare the clinical outcomes of one-stage and two-stage procedures for the management of patients with rotator cuff tear and concomitant shoulder stiffness. METHODS: From December 2013 to June 2016, we recruited 42 consecutive patients with rotator cuff tear and concomitant shoulder stiffness. Twenty-two patients underwent a one-stage procedure, including arthroscopic capsule release and concomitant rotator cuff repair, within 2 weeks of the diagnosis...
February 7, 2019: Journal of Orthopaedic Surgery and Research
Jen-Chung Liao
BACKGROUND: Platelet-rich plasma (PRP) is autologous in origin and contains a high concentration of platelets which is a source of various growth factors. Previous studies have suggested that PRP has a positive effect in accelerating fusion by an autologous bone graft in a lumbar fusion. The role of PRP on artificial bone grafts in spinal fusion remains controversial. In this study, positive effect on spinal fusion by PRP was hypothesized; in vitro and in vivo studies were designed to test this hypothesis...
February 6, 2019: Journal of Orthopaedic Surgery and Research
Yue Luo, Zhouyuan Yang, Releken Yeersheng, Donghai Li, Pengde Kang
BACKGROUND: Total hip arthroplasty for adult patients with a history of infection of the hip in childhood could be a more technically demanding procedure due to complicated anatomy and the possibility of reinfection. Here, we conducted a mid-term analysis of clinical outcomes in such patients after primary cementless total hip arthroplasty (THA). METHODS: We reviewed 101 patients (101 hips; 51 men; mean age, 52.3 years) who underwent cementless THA between 2008 and 2015, at a mean of 24 years (range, 11-43) since the resolution of childhood hip infection...
February 1, 2019: Journal of Orthopaedic Surgery and Research
Yang Ruen Zheng, Yung Chang Lu, Chung Ting Liu
BACKGROUND: Clavicle fractures are common clinical problems, accounting for approximately 10% of all fractures. Neer's type II fractures disrupt the integrity of the coracoclavicular ligament and, therefore, are inherently unstable, requiring an extended period time to achieve bone union and being associated with a high rate of non- or malunion. Restoration of the stability of the distal clavicle is an important factor to decrease the rate of non- or malunion. As such, the aim of our study was to describe our technique of indirect osteosynthesis, using a minimally invasive closed-loop double endobutton (TightRope) technique for fixation of unstable (Neer's type II) distal clavicle factures, and to evaluate the short-term clinical outcomes...
January 31, 2019: Journal of Orthopaedic Surgery and Research
Zhuoyang Li, Yijun Zhang
BACKGROUND: To conduct a meta-analysis to compare the curative effect of treating the full thickness tear of the rotator cuff using the arthroscopic bone marrow stimulation (BMS) technology and provide the evidence for its extensive clinical application. METHODS: A systematic literature search was conducted to evaluate the studies on comparison of the curative effect of routine surgery with or without BMS on rotator cuff tear in the major medical databases. The literature was screened according to the inclusion and exclusion standards, and the quality assessment was conducted, then Review Manager 5...
January 29, 2019: Journal of Orthopaedic Surgery and Research
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