journal
https://read.qxmd.com/read/38429802/a-novel-network-pharmacology-strategy-to-decode-mechanism-of-wuling-powder-in-treating-liver-cirrhosis
#21
JOURNAL ARTICLE
Qinwen Liu, Xiaowei Li, Yi Li, Qian Luo, Qiling Fan, Aiping Lu, Daogang Guan, Jiahui Li
BACKGROUND: Liver cirrhosis is a chronic liver disease with hepatocyte necrosis and lesion. As one of the TCM formulas Wuling Powder (WLP) is widely used in the treatment of liver cirrhosis. However, it's key functional components and action mechanism still remain unclear. We attempted to explore the Key Group of Effective Components (KGEC) of WLP in the treatment of Liver cirrhosis through integrative pharmacology combined with experiments. METHODS: The components and potential target genes of WLP were extracted from published databases...
March 1, 2024: Chinese Medicine
https://read.qxmd.com/read/38419127/the-combination-of-tanshinone-iia-and-astragaloside-iv-attenuates-myocardial-ischemia-reperfusion-injury-by-inhibiting-the-sting-pathway
#22
JOURNAL ARTICLE
Pan Zhai, Qianyun Chen, Xunxun Wang, Xiaohu Ouyang, Mengling Yang, Yalan Dong, Junyi Li, Yiming Li, Shanshan Luo, Yue Liu, Xiang Cheng, Rui Zhu, Desheng Hu
BACKGROUND: Astragaloside IV (As-IV) and Tanshinone IIA (Ta-IIA) are the main ingredients of traditional Chinese medicinal Astragalus membranaceus (Fisch.) Bunge and Salvia miltiorrhiza Bunge, respectively, both of which have been employed in the treatment of cardiovascular diseases. Nevertheless, the efficacy of the combination (Co) of Ta-IIA and As-IV for cardiovascular diseases remain unclear and warrant further investigation. This study aimed to investigate the efficacy and the underlying molecular mechanism of Co in treating myocardial ischemia-reperfusion injury (MIRI)...
February 28, 2024: Chinese Medicine
https://read.qxmd.com/read/38419106/a-review-on-traditional-chinese-medicine-natural-products-and-acupuncture-intervention-for-alzheimer-s-disease-based-on-the-neuroinflammatory
#23
REVIEW
Zhihan Chen, Xinrui Wang, Simin Du, Qi Liu, Zhifang Xu, Yi Guo, Xiaowei Lin
Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. It is clinically characterized by cognitive impairment, memory impairment and behavioral change. Chinese herbal medicine and acupuncture are important components of traditional Chinese medicine (TCM), and are commonly used in clinical treatment of AD. This paper systematically summarizes the research progress of traditional Chinese medicine natural products and acupuncture treatment of AD, which combined with existing clinical and preclinical evidence, based on a comprehensive review of neuroinflammation, and discusses the efficacy and potential mechanisms of traditional Chinese medicine natural products and acupuncture treatment of AD...
February 28, 2024: Chinese Medicine
https://read.qxmd.com/read/38419104/determination-of-its1-haplotypes-of-fritillariae-cirrhosae-bulbus-by-amplicon-sequencing
#24
JOURNAL ARTICLE
Hoi-Yan Wu, Ka-Lok Wong, Sean Tsz-Sum Law, Wenyang Nong, Kwun-Tin Chan, Jerome Ho-Lam Hui, Ge Lin, Wing-Han Chan, Pang-Chui Shaw
BACKGROUND: Fritillariae Cirrhosae Bulbus is an antitussive and expectorant Chinese medicinal material derived from the dried bulbs of six Fritillaria species. In the 2015 edition of the Chinese Pharmacopoeia, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) is the officially listed method for their authenfication. Specifically, the ~ 300-bp ITS1 amplicon of only Fritillariae Cirrhosae Bulbus but not other Fritillaria species can be cleaved into two smaller fragments with restriction enzyme SmaI...
February 28, 2024: Chinese Medicine
https://read.qxmd.com/read/38413976/bufei-yishen-formula-protects-the-airway-epithelial-barrier-and-ameliorates-copd-by-enhancing-autophagy-through-the-sirt1-ampk-foxo3-signaling-pathway
#25
JOURNAL ARTICLE
Lidan Jia, Xuefang Liu, Xinguang Liu, Qingzhou Guan, Yange Tian, Jiansheng Li, Peng Zhao
OBJECT: Bufei Yishen formula (BYF), a traditional Chinese medicine alleviates COPD symptoms and suppresses airway epithelial inflammation. In this study, we determined whether BYF protects the airway epithelial barrier from destruction in COPD rats. METHODS: The protective effects of BYF on the airway epithelial barrier were examined in a rat COPD model. BEAS-2B epithelial cells were exposed to cigarette smoke extract (CSE) to determine the effect of BYF on epithelial barrier function...
February 28, 2024: Chinese Medicine
https://read.qxmd.com/read/38403669/skp-alleviates-the-ferroptosis-in-diabetic-kidney-disease-through-suppression-of-hif-1%C3%AE-ho-1-pathway-based-on-network-pharmacology-analysis-and-experimental-validation
#26
JOURNAL ARTICLE
Yangtian Yan, Ningning Yuan, Yuchi Chen, Yun Ma, Ali Chen, Fujing Wang, Shihua Yan, Zhuo'en He, Jinyue He, Chi Zhang, Hao Wang, Mingqing Wang, Jianxin Diao, Wei Xiao
BACKGROUND: Diabetic kidney disease (DKD) represents a microvascular complication of diabetes mellitus. Shenkang Pills (SKP), a traditional Chinese medicine formula, has been widely used in the treatment of DKD and has obvious antioxidant effect. Ferroptosis, a novel mode of cell death due to iron overload, has been shown to be associated with DKD. Nevertheless, the precise effects and underlying mechanisms of SKP on ferroptosis in diabetic kidney disease remain unclear. METHODS: The active components of SKP were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database...
February 25, 2024: Chinese Medicine
https://read.qxmd.com/read/38402401/optimized-new-shengmai-powder-modulation-of-camp-rap1a-signaling-pathway-attenuates-myocardial-fibrosis-in-heart-failure
#27
JOURNAL ARTICLE
Zeyu Zhang, Zhe Xu, Shuai Wang, Zhuangzhuang Jia, Zhou Zhou, Ci Wang, Shanshan Lin, Yiting Feng, Xianliang Wang, Jingyuan Mao
BACKGROUND: Optimized New Shengmai Powder (ONSMP) is a traditional Chinese medicine formula with significant anti-heart failure and myocardial fibrosis effects, but the specific molecular biological mechanisms are not fully understood. METHODS: In this study, we first used network pharmacology to analyze the ONSMP's active ingredients, core signaling pathways, and core targets. Second, calculate the affinity and binding modes of the ONSMP components to the core targets using molecular docking...
February 24, 2024: Chinese Medicine
https://read.qxmd.com/read/38383512/exploring-the-chemical-components-of-kuanchang-shu-granule-and-its-protective-effects-of-postoperative-ileus-in-rats-by-regulating-akt-hsp90aa1-enos-pathway
#28
JOURNAL ARTICLE
Wen-Qian Duan, Ming-Chen Cai, Qi-Qi Ma, Peng Huang, Jia-Hui Zhang, Tian-Fu Wei, Dong Shang, Ai-Jing Leng, Jia-Lin Qu
BACKGROUND: Postoperative ileus (POI) is a common obstruction of intestinal content passage caused by almost all abdominal operations that seriously strokes the quality of life of patients. Kuanchang-Shu granule (KCSG), a classic modified prescription based on "Da-Cheng-Qi Decoction", has obtained satisfactory efficacy in the clinical therapeutics of POI. However, its material basis and holistic molecular mechanism against POI have not been revealed. METHODS: The chemical ingredients of KCSG were first characterized by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS)...
February 21, 2024: Chinese Medicine
https://read.qxmd.com/read/38369521/immunopotentiating-effects-of-herb-partitioned-moxibustion-on-the-spleens-of-cyclophosphamide-induced-immunosuppressed-rats
#29
JOURNAL ARTICLE
Luojie Xiong, Yuefeng Tian, Xiaoshan Xu, Huifang Wang, Wei Li, Chuntao Zhai
BACKGROUND: To investigate the effec of the herb-partitioned moxibustion on T-lymphocyte activity in immunosuppressed rats through differential modulation of the immune checkpoint molecules CD28 and CTLA-4. METHODS: Forty-eight Sprague‒Dawley rats were randomly divided into the normal group (NG), the cyclophosphamide model group (CTX), the herb-partitioned moxibustion group (HPM), the CD28 inhibitor + herb-partitioned moxibustion group (aCD28 + HPM), the CTLA-4 inhibitor + herb-partitioned moxibustion group (aCTLA-4 + HPM), and the levamisole group (LEV) (8 rats per group)...
February 18, 2024: Chinese Medicine
https://read.qxmd.com/read/38365794/total-flavonoids-of-astragalus-protects-glomerular-filtration-barrier-in-diabetic-kidney-disease
#30
JOURNAL ARTICLE
Pei-Yu Liu, Kin-Fong Hong, Ya-Di Liu, Zhong-Yan Sun, Ting-Ting Zhao, Xu-Ling Li, Chi-Chou Lao, Shu-Feng Tan, Hai-Ying Zhang, Yong-Hua Zhao, Ying Xie, You-Hua Xu
BACKGROUND: Diabetic kidney disease (DKD) is a prevalent complication of diabetes and the leading cause of end-stage renal disease. Recent evidence suggests that total flavonoids of Astragalus (TFA) has promising effects on diabetes; however, its influence on DKD and the underlying mechanism remains unclear. METHODS: In this study, we induced the DKD model using streptozotocin (STZ) in male C57BL/6J mice and utilized glomerular endothelial cell (GEC) lines for in vitro investigations...
February 16, 2024: Chinese Medicine
https://read.qxmd.com/read/38360724/natural-products-in-osteoarthritis-treatment-bridging-basic-research-to-clinical-applications
#31
REVIEW
Shunzheng Fang, Bin Zhang, Wei Xiang, Liujie Zheng, Xiaodong Wang, Song Li, Tongyi Zhang, Daibo Feng, Yunquan Gong, Jinhui Wu, Jing Yuan, Yaran Wu, Yizhen Zhu, Enli Liu, Zhenhong Ni
Osteoarthritis (OA) is the most prevalent degenerative musculoskeletal disease, severely impacting the function of patients and potentially leading to disability, especially among the elderly population. Natural products (NPs), obtained from components or metabolites of plants, animals, microorganisms etc., have gained significant attention as important conservative treatments for various diseases. Recently, NPs have been well studied in preclinical and clinical researches, showing promising potential in the treatment of OA...
February 15, 2024: Chinese Medicine
https://read.qxmd.com/read/38360696/paclitaxel-combined-with-compound-k-inducing-pyroptosis-of-non-small-cell-lung-cancer-cells-by-regulating-treg-th17-balance
#32
JOURNAL ARTICLE
Hongzheng Wang, Min Huang, Mengyuan Zhu, Chi Su, Yijian Zhang, Hongyu Chen, Yuexin Jiang, Haidi Wang, Qinglong Guo, Shuai Zhang
BACKGROUND: Immune checkpoint inhibitors, which have attracted much attention in recent years, have achieved good efficacy, but their use is limited by the high incidence of acquired drug resistance. Therefore, there is an urgent need to develop new immunotherapy drugs. Compound taxus chinensis capsule (CTC) is an oral paclitaxel compound drug, clinical results showed it can change the number of regulatory T cells and T helper cell 17 in peripheral blood. Regulating the balance between regulatory T cells and T helper cell 17 is considered to be an effective anticancer strategy...
February 15, 2024: Chinese Medicine
https://read.qxmd.com/read/38355571/tanreqing-injection-inhibits-dengue-virus-encephalitis-by-suppressing-the-activation-of-nlrp3-inflammasome
#33
JOURNAL ARTICLE
Hefei Huang, Xuemei He, Lingzhu Shi, Jingtao Yu, Zibin Lu, Huihui Cao, Jinying Ou, Xi Chen, Lijun Yan, Jiabin Yang, Wei Zhao, Junshan Liu, Linzhong Yu
BACKGROUND: Encephalitis caused by dengue virus (DENV) is considered a manifestation of severe dengue. Tanreqing injection (TRQ) is a well-known Chinese patented medicine, which has been used to treat brain-related disorders by inhibiting inflammation. Nevertheless, the effects of TRQ on DENV encephalitis have not been studied. The aim of this study was to evaluate the effects of TRQ on DENV encephalitis and to explore its potential mechanisms. METHODS: The cytotoxicity of TRQ was examined by MTT assay, and the anti-DENV activities of TRQ in BHK-21 baby hamster kidney fibroblast were evaluated through CCK-8 and plaque assays...
February 14, 2024: Chinese Medicine
https://read.qxmd.com/read/38317158/comparative-transcriptome-analysis-and-identification-of-candidate-r2r3-myb-genes-involved-in-anthraquinone-biosynthesis-in-rheum-palmatum-l
#34
JOURNAL ARTICLE
Xia Zhao, Feng Yan, Yi-Min Li, Jing Tang, Xiao-Chen Hu, Zhao Feng, Jing Gao, Liang Peng, Gang Zhang
BACKGROUND: Rheum palmatum L. has important medicinal value because it contains biologically active anthraquinones. However, the key genes and TFs involved in anthraquinone biosynthesis and regulation in R. palmatum remain unclear. METHODS: Based on full length transcriptome data, in this study, we screened the differentially expressed genes in the anthraquinone biosynthesis pathway. The R2R3-MYB family genes of R. palmatum were systematically identified based on full-length transcriptome sequencing followed by bioinformatics analyses...
February 6, 2024: Chinese Medicine
https://read.qxmd.com/read/38311790/identification-and-expression-analysis-of-expansin-gene-family-in-salvia-miltiorrhiza
#35
JOURNAL ARTICLE
Yunyun Li, Bin Li, Qiyue Pang, Yaoyu Lou, Donghao Wang, Zhezhi Wang
BACKGROUND: Expansins (EXP) are important enzymes that are involved in the extension of plant cells and regulation of root configurations, which play important roles in resisting various stresses. As a model medicinal plant, Salvia miltiorrhiza is well recognized for treating coronary heart disease, myocardial infection, and other cardiovascular and cerebrovascular diseases; however, the SmEXP gene family has not yet been analyzed. METHODS: The SmEXP family was systematically analyzed using bioinformatics...
February 4, 2024: Chinese Medicine
https://read.qxmd.com/read/38310315/integrated-traditional-chinese-and-western-medicine-in-the-prevention-and-treatment-of-non-alcoholic-fatty-liver-disease-future-directions-and-strategies
#36
REVIEW
Xin Ding, Xu He, Bulang Tang, Tian Lan
Traditional Chinese medicine (TCM) has been widely used for several centuries for metabolic diseases, including non-alcoholic fatty liver disease (NAFLD). At present, NAFLD has become the most prevalent form of chronic liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and even hepatocellular carcinoma. However, there is still a lack of effective treatment strategies in Western medicine. The development of NAFLD is driven by multiple mechanisms, including genetic factors, insulin resistance, lipotoxicity, mitochondrial dysfunction, endoplasmic reticulum stress, inflammation, gut microbiota dysbiosis, and adipose tissue dysfunction...
February 3, 2024: Chinese Medicine
https://read.qxmd.com/read/38287373/gromwell-ameliorates-glucocorticoid-induced-muscle-atrophy-through-the-regulation-of-akt-mtor-pathway
#37
JOURNAL ARTICLE
Ahyoung Yoo, Jung-In Kim, Hyunjung Lee, Farida S Nirmala, Jeong-Hoon Hahm, Hyo Deok Seo, Chang Hwa Jung, Tae Youl Ha, Jiyun Ahn
BACKGROUND: Muscle atrophy is characterized by decreased muscle mass, function, and strength. Synthetic glucocorticoids, including dexamethasone (Dexa), are commonly used to treat autoimmune diseases. However, prolonged exposure of Dexa with high dose exerts severe side effects, including muscle atrophy. The purpose of this study was to investigate whether Gromwell root extract (GW) can prevent Dexa-induced muscle atrophy in C2C12 cells and mice and to characterize the composition of GW to identify bioactive compounds...
January 29, 2024: Chinese Medicine
https://read.qxmd.com/read/38279104/decoction-regulating-phytochemicals-micromorphology-changes-and-anti-inflammation-activity-enhancements-originated-from-herb-medicine-supermolecules
#38
JOURNAL ARTICLE
Luping Yang, Xiang Zhang, Zhijia Wang, Xiaoyu Lin, Yaozhi Zhang, Jihui Lu, Linying Wu, Shuchang Yao, Wenguang Jing, Xuemei Huang, Penglong Wang
BACKGROUND: Mahuang Fuzi decoction (MGF) is composed of three herb medicines that has been clinically used to treat inflammatory diseases for a long history. At present, more and more active phytochemicals' aggregations have been found during the thermodynamic process of herb medicine decoction, and revealing the clinical efficacy of herb medicine through supramolecular strategies is the focus of current research. However, it is not clear whether decoction induced supermolecules' morphological changes to modify activity...
January 26, 2024: Chinese Medicine
https://read.qxmd.com/read/38273399/zhuifeng-tougu-capsules-in-the-treatment-of-knee-osteoarthritis-cold-dampness-obstruction-syndrome-a-randomized-double-blind-multicenter-clinical-study
#39
JOURNAL ARTICLE
Longmei Zhao, Shasha Zhou, SiWei Wang, Rui Wu, Qingliang Meng, Zhenbin Li, Jiangyun Peng, Ying Liu, Min Lu, Ming Li, Caifeng Zhu, Yue Sun, Yanlin He, Yue Jin, Jingyue Gao, Shumin Zhang, Peihao Li, Rongjun Liao, Wei Liu, Guoming Zhang
BACKGROUND: In Traditional Chinese Medicine (TCM) theory, cold dampness obstruction is one of the common syndromes of osteoarthritis. Therefore, in clinical practice, the main treatment methods are to dispel wind, remove dampness, and dissipate cold, used to treat knee osteoarthritis (KOA). This report describes a mulitercenter clinical study to assess Zhuifeng Tougu Capsule's efficacy and safety in the treatment of patients who are cold dampness obstruction syndrome in KOA, and to provide evidence-based medical for the rational use of Zhuifeng Tougu Capsules in clinical practice...
January 25, 2024: Chinese Medicine
https://read.qxmd.com/read/38268006/ganoderma-lucidum-polysaccharide-ameliorates-cholesterol-gallstone-formation-by-modulating-cholesterol-and-bile-acid-metabolism-in-an-fxr-dependent-manner
#40
JOURNAL ARTICLE
Dan Huang, Shuang Shen, Qian Zhuang, Xin Ye, Yueqin Qian, Zhixia Dong, Xinjian Wan
BACKGROUND: Cholesterol gallstone (CG) disease is a worldwide common disease characterized by cholesterol supersaturation in gallbladder bile. Ganoderma lucidum polysaccharide (GLP) has been shown to possess various beneficial effects against metabolic disorders. However, the role and underlying mechanism of GLP in CG formation are still unknown. This study aimed to determine the role of GLP in ameliorating lithogenic diet (LD)-induced CG formation. METHODS: Mice were fed either a normal chow diet, a LD, or LD supplemented with GLP...
January 24, 2024: Chinese Medicine
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