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Chinese Medicine

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https://read.qxmd.com/read/30733823/baduanjin-exerts-anti-diabetic-and-anti-depression-effects-by-regulating-the-expression-of-mrna-lncrna-and-circrna
#1
Tian An, Zhong-Chen He, Xin-Qing Zhang, Jun Li, Ai-Ling Chen, Fang Tan, Hong-Dong Chen, Bo-Han Lv, Juan Lian, Si-Hua Gao, Guang-Jian Jiang
Background: Baduanjin, a traditional Chinese exercise therapy, has been widely used in China to treat type 2 diabetes (T2DM) with depression (DD). However, the underlying mechanism of Baduanjin in anti-DD is unclear. This study was focused on investigating the effects of Baduanjin on symptoms of depression and blood glucose in patients with DD and the underlying mechanism. Methods: We performed a 12-week Baduanjin intervention on patients with DD and longitudinally compared the differential expressions of lncRNAs, circRNAs, and mRNAs between pre- (BDD) and post- (ADD) Baduanjin intervention in the same group...
2019: Chinese Medicine
https://read.qxmd.com/read/30728853/chinese-herb-pair-paeoniae-radix-alba-and-atractylodis-macrocephalae-rhizoma-suppresses-lps-induced-inflammatory-response-through-inhibiting-mapk-and-nf-%C3%AE%C2%BAb-pathway
#2
Yangyang Zhou, Hongxun Tao, Anqi Wang, Zhangfeng Zhong, Xu Wu, Mei Wang, Zhaoxiang Bian, Shengpeng Wang, Yitao Wang
Background: The combination of Radix Paeoniae Alba (RPA) and Rhizoma Atractylodis Macrocephalae (RAM) has long been used as a classic herb pair for the treatment of gynecologic and gastrointestinal diseases, but the underlying mechanisms of the herb pair remain unknown. This study aims to explore the anti-inflammatory potentials of RPA-RAM herb pair and to elucidate the underlying mechanisms. Methods: The bioactive parts of RPA-RAM were extracted and screened through the inhibitory effects against nitric oxide (NO) production...
2019: Chinese Medicine
https://read.qxmd.com/read/30636970/differential-proteomics-for-studying-action-mechanisms-of-traditional-chinese-medicines
#3
REVIEW
Yi-Yao Yang, Feng-Qing Yang, Jian-Li Gao
Differential proteomics, which has been widely used in studying of traditional Chinese medicines (TCMs) during the past 10 years, is a powerful tool to visualize differentially expressed proteins and analyzes their functions. In this paper, the applications of differential proteomics in exploring the action mechanisms of TCMs on various diseases including cancers, cardiovascular diseases, diabetes, liver diseases, kidney disorders and obesity, etc. were reviewed. Furthermore, differential proteomics in studying of TCMs identification, toxicity, processing and compatibility mechanisms were also included...
2019: Chinese Medicine
https://read.qxmd.com/read/30619503/systems-biology-approaches-in-the-study-of-chinese-herbal-formulae
#4
REVIEW
Fei-Fei Cai, Wen-Jun Zhou, Rong Wu, Shi-Bing Su
Systems biology is an academic field that attempts to integrate different levels of information to understand how biological systems function. It is the study of the composition of all components of a biological system and their interactions under specific conditions. The core of systems biology is holistic and systematic research, which is different from the manner of thinking and research of all other branches of biology to date. Chinese herbal formulae (CHF) are the main form of Chinese medicine and are composed of single Chinese herbal medicines (CHMs) with pharmacological and pharmacodynamic compatibility...
2018: Chinese Medicine
https://read.qxmd.com/read/30598693/an-innovative-anti-cancer-chinese-herbal-formula-exhibited-multi-targeted-efficacies-in-metastatic-breast-cancer-mouse-model
#5
Grace Gar-Lee Yue, Julia Kin-Ming Lee, Ben Chung-Lap Chan, Hin-Fai Kwok, Sandy Wan-Heng Hoi, Daniel Man-Yuen Sze, Kwok-Pui Fung, Ping-Chung Leung, Clara Bik-San Lau
Background: The incidence and mortality of cancer metastasis is high worldwide. Despite of the chemotherapeutic agents, many cancer patients still take traditional Chinese herbal prescriptions as adjuvant treatments. However, most of these herbal formulae/products lack of evidence-based efficacy. Based on our previous investigations on anti-tumor, anti-angiogenic, anti-metastatic, bone protective and immunomodulating activities of various Chinese herbal medicines, four constituent herbs, namely Andrographis paniculata , Acanthopanax senticosus , Camellia sinensis , and Hedyotis diffusa were eventually selected to form an innovative herbal formula...
2018: Chinese Medicine
https://read.qxmd.com/read/30574173/gut-microbiota-was-modulated-by-moxibustion-stimulation-in-rats-with-irritable-bowel-syndrome
#6
Xiaomei Wang, Qin Qi, Yuanyuan Wang, Huangan Wu, Xiaoming Jin, Huan Yao, Duiyin Jin, Yanan Liu, Cun Wang
Background: The pathogenesis of irritable bowel syndrome (IBS) is closely related to intestinal dysbacteriosis and can be controlled by moxibustion treatment. However, the mechanism underlying the therapeutic value of moxibustion in IBS treatment remains unknown. Methods: An IBS rat model was established by colorectal distention (CRD) stimulus and mustard oil clyster. Sixty-five male rats were randomly divided into six groups: normal, IBS model, moxibustion, electroacupuncture (EA), Bifid-triple Viable Capsule (BTVC) and Pinaverium Bromide (PB) groups...
2018: Chinese Medicine
https://read.qxmd.com/read/30568725/cardiac-function-evaluation-for-a-novel-one-step-detoxification-product-of-aconiti-lateralis-radix-praeparata
#7
Ya-Nan He, Ding-Kun Zhang, Jun-Zhi Lin, Xue Han, Ya-Ming Zhang, Hai-Zhu Zhang, Jin Pei, Ming Yang, Jia-Bo Wang
Background: Aconiti Lateralis Radix Praeparata has been used as the first cardiac drug over a 1000 years in Asian countries. Although most detoxification products are confirmed to be safe, the effect is not potent as desired. In previous study, we designed a one-step detoxification product by fresh cutting and continuously dried, which preserved more water-soluble alkaloids while eliminating toxicity. It is thus necessary to find more in vivo evidence to support its industrial development...
2018: Chinese Medicine
https://read.qxmd.com/read/30555525/metabonomic-study-of-the-protective-effect-of-fukeqianjin-formula-on-multi-pathogen-induced-pelvic-inflammatory-disease-in-rats
#8
Yan Zhang, Wei Li, Liang Zou, Yun Gong, Peng Zhang, Shasha Xing, Hang Yang
Background: Fukeqianjin formula has been effectively used in the treatment of pelvic inflammatory disease (PID) and the related complications in clinic. Although there have been some studies about the underlying mechanism that focus on its anti-inflammatory and immunoregulatory activities. But the mechanism is still not fully understood. The aim of this study was to investigate the alteration of plasma metabolic profiles in PID rats and the regulatory effect of Fukeqianjin formula on potential biomarkers...
2018: Chinese Medicine
https://read.qxmd.com/read/30524499/application-of-metabolomics-in-toxicity-evaluation-of-traditional-chinese-medicines
#9
REVIEW
Li Duan, Long Guo, Lei Wang, Qiang Yin, Chen-Meng Zhang, Yu-Guang Zheng, E-Hu Liu
Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable attention in the past two decades. Metabolomics is an "omics" approach that aims to comprehensively analyze all metabolites in biological samples. In agreement with the holistic concept of TCM, metabolomics has shown great potential in efficacy and toxicity evaluation of TCM. Recently, a large amount of metabolomic researches have been devoted to exploring the mechanism of toxicity induced by TCM, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity...
2018: Chinese Medicine
https://read.qxmd.com/read/30505341/pharmacological-effects-of-medicinal-components-of-atractylodes-lancea-thunb-dc
#10
REVIEW
Xie Jun, Peng Fu, Yu Lei, Peng Cheng
Atractylodes lancea Thunb. DC. (AL) has a long history as one of the important herbs used in East Asia. This review is on the purpose of providing a comprehensive summary of the pharmacological effects of AL and its extractions. The publication from PubMed, ScienceDirect, Springer, and Wiley database was collected and summarized. The potential application of AL on the disease could be attributed to its pharmacological properties such as anti-cancer, anti-inflammatory and other essential effects. Hence, this review aims at providing evidence of the pharmacological activities of AL as one of natural products used in clinical trial...
2018: Chinese Medicine
https://read.qxmd.com/read/30479655/predicting-the-potential-global-distribution-of-diosgenin-contained-dioscorea-species
#11
Liang Shen, Jiang Xu, Lu Luo, Haoyu Hu, Xiangxiao Meng, Xiwen Li, Shilin Chen
Background: Diosgenin, mainly extracted from wild diosgenin-contained Dioscorea species, is a well-known starting material of steroidal and contraceptive drugs. However, due to large market demand and increasingly ecological damage, wild Dioscorea species resources available have been gradually declining. Therefore, identification of new potential ecological distribution of diosgenin-contained Dioscorea species is necessary for diosgenin production. Methods: In this study, a large occurrence dataset (1808 data points) of diosgenin-contained Dioscorea species was obtained from Eastern Asia, Southern North America and Southern Africa...
2018: Chinese Medicine
https://read.qxmd.com/read/30479654/a-preliminary-review-of-studies-on-adaptogens-comparison-of-their-bioactivity-in-tcm-with-that-of-ginseng-like-herbs-used-worldwide
#12
REVIEW
Lian-Ying Liao, Yi-Fan He, Li Li, Hong Meng, Yin-Mao Dong, Fan Yi, Pei-Gen Xiao
Modern studies have shown that adaptogens can non-specifically enhance the resistance of human body under a wide range of external stress conditions with a multi-targeted and multi-channel network-like manner, especially by affect the immune-neuro-endocrine system and the hypothalamic-pituitary-adrenal axis. This review article draws the attention to the relationships of adaptogens, tonics from traditional Chinese medicine (TCM) and ginseng-like herbs worldwide, which all have similar plant sources and clinical applications...
2018: Chinese Medicine
https://read.qxmd.com/read/30386417/comparing-the-antidiabetic-effects-and-chemical-profiles-of-raw-and-fermented-chinese-ge-gen-qin-lian-decoction-by-integrating-untargeted-metabolomics-and-targeted-analysis
#13
Yan Yan, Chenhui Du, Zhenyu Li, Min Zhang, Jin Li, Jinping Jia, Aiping Li, Xuemei Qin, Qiang Song
Background: Microbial fermentation has been widely applied in traditional Chinese medicine (TCM) for thousands of years in China. Various beneficial effects of fermentation for applications in TCM or herbals have been reported, such as enhanced anti-ovarian cancer, antioxidative activity, and neuroprotective effects. Ge-Gen-Qin-Lian decoction (GQD), a classic TCM formula, has been used to treat type 2 diabetes mellitus in China. In this study, GQD was fermented with Saccharomyces cerevisiae , and the antidiabetic activities and overall chemical profiles of raw and fermented GQD (FGQD) were systematically compared...
2018: Chinese Medicine
https://read.qxmd.com/read/30386416/blood-and-urinary-metabolomic-evidence-validating-traditional-chinese-medicine-diagnostic-classification-of-major-depressive-disorder
#14
Lan-Ying Liu, Hong-Jian Zhang, Li-Yuan Luo, Jin-Bao Pu, Wei-Qing Liang, Chun-Qin Zhu, Ya-Ping Li, Pei-Rong Wang, Yuan-Yuan Zhang, Chun-Yu Yang, Zhang-Jin Zhang
Background: Major depressive disorder (MDD) is a highly heterogeneous disease. Further classification may characterize its heterogeneity. The purpose of this study was to examine whether metabolomic variables could differentiate traditional Chinese medicine (TCM) diagnostic subtypes of MDD. Methods: Fifty medication-free patients who were experiencing a recurrent depressive episode were classified into Liver Qi Stagnation (LQS, n = 30) and Heart and Spleen Deficiency (HSD, n = 20) subtypes according to TCM diagnosis...
2018: Chinese Medicine
https://read.qxmd.com/read/30364385/the-antityrosinase-and-antioxidant-activities-of-flavonoids-dominated-by-the-number-and-location-of-phenolic-hydroxyl-groups
#15
Ai-Ren Zuo, Huan-Huan Dong, Yan-Ying Yu, Qing-Long Shu, Li-Xiang Zheng, Xiong-Ying Yu, Shu-Wen Cao
Background: Compounds with the ability to scavenge reactive oxygen species (ROS) and inhibit tyrosinase may be useful for the treatment and prevention from ROS-related diseases. The number and location of phenolic hydroxyl of the flavonoids will significantly influence the inhibition of tyrosinase activity. Phenolic hydroxyl is indispensable to the antioxidant activity of flavonoids. Isoeugenol, shikonin, baicalein, rosmarinic acid, and dihydromyricetin have respectively one, two, three, four, or five phenolic hydroxyls...
2018: Chinese Medicine
https://read.qxmd.com/read/30364348/indigenous-medicinal-plants-of-pakistan-used-to-treat-skin-diseases-a-review
#16
REVIEW
Alamgeer, Amber Sharif, Hira Asif, Waqas Younis, Humayun Riaz, Ishfaq Ali Bukhari, Asaad Mohamed Assiri
Ethno-pharmacological relevance: Plants are providing reliable therapy since time immemorial. Pakistan has a great diversity in medicinal flora and people use these ethno-medicines to deal with many skin problems. This review explores the fundamental knowledge on various dermatological properties of medicinal plants of Pakistan and is aimed to provide a baseline for the discovery of new plants having activities against skin issues. Material and method: A total of 244 published articles were studied using different research engines like PubMed, Google, Google-scholar and science direct...
2018: Chinese Medicine
https://read.qxmd.com/read/30337951/internationalization-of-traditional-complementary-medicine-products-market-entry-as-medicine
#17
REVIEW
Jiatong Li, Jianfan Zhu, Hao Hu, Joanna E Harnett, Chi Ieong Lei, Ka Yin Chau, Ging Chan, Carolina Oi Lam Ung
Internationalization of Traditional/Complementary Medicine (T&CM) products is important for initiating and sustaining developments in this field. Particularly for traditional Chinese medicines (TCMs), the global market continues to expand due to an interest in the potential clinical benefits of traditional approaches that are largely considered lower risk and lower cost than many conventional treatments. While the benefits of internationalization hold clear advantages for the business of T&CM products, keeping abreast of regulatory processes in different countries and regions that regularly revise market entry requirements is challenging...
2018: Chinese Medicine
https://read.qxmd.com/read/30258489/rapid-screening-and-identification-of-bioactive-compounds-specifically-binding-to-beta-2-adrenoceptor-from-san-ao-decoction-using-affinity-magnetic-fine-particles-coupled-with-high-performance-liquid-chromatography-mass-spectrometry
#18
Fuhuan Fei, Huanmei Sun, Xixi Cheng, Jiajun Liu, Jing Wang, Qian Li, Yajun Zhang
Background: San-ao decoction (SAD) has been widely used in Chinese medicine against respiratory diseases, such as asthma and rhinallergosis. The bioactive compounds for such pharmacological action remain unknown. Methods: We developed a methodology to isolate the bioactive compounds of SAD. The assay involved the immobilization of beta 2-adrenoceptor ( β 2 -AR) onto magnetic fine particles, the capture of target compounds by the immobilized receptor, the identification of the receptor bound compounds by reversed-phase high-performance liquid chromatography coupled with tandem mass spectrometry...
2018: Chinese Medicine
https://read.qxmd.com/read/30250499/traditional-medicinal-plants-used-for-respiratory-disorders-in-pakistan-a-review-of-the-ethno-medicinal-and-pharmacological-evidence
#19
REVIEW
Alamgeer, Waqas Younis, Hira Asif, Amber Sharif, Humayun Riaz, Ishfaq Ali Bukhari, Asaad Mohamed Assiri
Respiratory disorders are a common cause of malady and demise in Pakistan due to its remoteness, cold and harsh climatic conditions as well as scarce health care facilities. The people rely upon the indigenous plant resources to cure various respiratory disorders. The primary objective of this review was to assemble all available ethno-medicinal data of plants used for respiratory disorders in Pakistan. Pharmacological activity of these plants (based upon published scientific research), distribution, diversity, use, preparation methods, economical value, conservation status and various available herbal products of some plants have also been explored...
2018: Chinese Medicine
https://read.qxmd.com/read/30214471/characterization-and-anti-tumor-activity-of-a-polysaccharide-isolated-from-dendrobium-officinale-grown-in-the-huoshan-county
#20
Yuan Wei, Linwei Wang, Dujun Wang, Dan Wang, Chongwei Wen, Bangxin Han, Zhen Ouyang
Background: Polysaccharides are carbohydrate chains composed of linked monosaccharide units. Accumulating studies report that polysaccharides isolated from Dendrobium officinale have a variety of functions. However, the composition and anti-tumor activity of D. officinale grown in the Huoshan area are largely unknown. Methods: A polysaccharide (DOPA-1) was isolated from D. officinale by hot water extraction and ethanol precipitation, followed by purification via DEAE-cellulose and Sephadex G-100 chromatography...
2018: Chinese Medicine
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