journal
https://read.qxmd.com/read/38659126/response-to-fitch-and-huett-garcia
#41
LETTER
Hamlet Gasoyan, Elizabeth R Pfoh, Rebecca Schulte, Phuc Le, Michael B Rothberg
No abstract text is available yet for this article.
April 24, 2024: Obesity
https://read.qxmd.com/read/38659125/response-to-early-and-later-stage-persistence-with-antiobesity-medications-a-retrospective-cohort-study
#42
LETTER
Angela Fitch, Amber Huett-Garcia
No abstract text is available yet for this article.
April 24, 2024: Obesity
https://read.qxmd.com/read/38653583/hedonic-hunger-eating-behavior-and-food-reward-and-preferences-1-year-after-initial-weight-loss-by-diet-or-bariatric-surgery
#43
JOURNAL ARTICLE
Marthe Isaksen Aukan, Graham Finlayson, Catia Martins
OBJECTIVE: The objective of this study was to investigate changes in hedonic hunger, eating behavior, and food reward and preferences at 1-year (1Y) follow-up after an initial weight loss (WL) induced by a 10-week, very low-energy diet alone (controls) or in combination with bariatric surgery. METHODS: Patients scheduled for sleeve gastrectomy or Roux-en-Y gastric bypass and controls were recruited. Body weight/composition, hedonic hunger (Power of Food Scale), eating behavior traits (Dutch Eating Behavior Questionnaire and Three-Factor Eating Questionnaire), and food reward and preferences (computerized behavioral task) were measured at baseline, 11 weeks, and 1Y follow-up...
April 23, 2024: Obesity
https://read.qxmd.com/read/38644683/physiology-of-the-weight-loss-plateau-in-response-to-diet-restriction-glp-1-receptor-agonism-and-bariatric-surgery
#44
JOURNAL ARTICLE
Kevin D Hall
OBJECTIVE: The objective of this study was to investigate why different weight-loss interventions result in varying durations of weight loss prior to approaching plateaus. METHODS: A validated mathematical model of energy metabolism and body composition dynamics was used to simulate mean weight- and fat-loss trajectories in response to diet restriction, semaglutide 2.4 mg, tirzepatide 10 mg, and Roux-en-Y gastric bypass (RYGB) surgery interventions...
April 22, 2024: Obesity
https://read.qxmd.com/read/38644654/maternal-obesity-sex-specific-in-utero-changes-in-fetal-brain-autophagy-and-mtor
#45
JOURNAL ARTICLE
Nana Merabova, Lierni Ugartemendia, Andrea G Edlow, Claudia Ibarra, Nune Darbinian, Gabriel Tatevosian, Laura Goetzl
OBJECTIVE: Maternal obesity affects 39.7% of reproductive-age women in the United States. Emerging research has suggested that in utero exposure to maternal obesity is associated with adverse neurodevelopmental outcomes, but knowledge of underlying mechanisms in human samples is lacking. METHODS: A matched case-control study was performed in women with singleton fetuses who were undergoing elective pregnancy termination at gestational ages 15 to 21 weeks...
April 21, 2024: Obesity
https://read.qxmd.com/read/38932728/efficacy-and-safety-of-semaglutide-2-4%C3%A2-mg-by-race-and-ethnicity-a-post-hoc-analysis-of-three-randomized-controlled-trials
#46
RANDOMIZED CONTROLLED TRIAL
Domenica Rubino, Hanna Angelene, Anthony Fabricatore, Jamy Ard
OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of semaglutide 2.4 mg, a glucagon-like peptide-1 receptor agonist, by race and ethnicity, across three phase 3 trials. METHODS: The Semaglutide Treatment Effect in People with Obesity (STEP) clinical trials evaluated the efficacy and safety of once-weekly subcutaneous semaglutide 2.4 mg. Here, STEP 1 and 3 data were pooled for analysis; STEP 2 data were examined separately...
July 2024: Obesity
https://read.qxmd.com/read/38932724/isocaloric-replacement-of-ultraprocessed-foods-was-associated-with-greater-weight-loss-in-the-pounds-lost-trial
#47
RANDOMIZED CONTROLLED TRIAL
Qisi Yao, Carolina D de Araujo, Filippa Juul, Catherine M Champagne, George A Bray, Frank M Sacks, Maya K Vadiveloo
OBJECTIVE: Higher intake of ultraprocessed foods (UPFs) is associated with obesity. We examined whether replacing UPFs (NOVA 4) with minimally processed foods and culinary ingredients (NOVA 1 + 2) was associated with differential weight change in this secondary prospective analysis of the Preventing Overweight Using Novel Dietary Strategies (POUNDS) Lost trial. METHODS: We estimated percent energy intake (%kcal) from the four NOVA groups using 24-h dietary recalls in a subset of 356 participants...
July 2024: Obesity
https://read.qxmd.com/read/38932722/time-dependent-changes-in-feeding-behavior-and-energy-balance-associated-with-weight-gain-in-mice-fed-obesogenic-diets
#48
JOURNAL ARTICLE
Payam A Fathi, Michelle B Bales, Julio E Ayala
OBJECTIVE: Obesity is characterized by dysregulated homeostatic mechanisms resulting in positive energy balance; however, when this dysregulation occurs is unknown. We assessed the time course of alterations to behaviors promoting weight gain in male and female mice switched to an obesogenic high-fat diet (HFD). METHODS: Male and female C57BL/6J mice were housed in metabolic chambers and were switched from chow to a 60% or 45% HFD for 4 and 3 weeks, respectively...
July 2024: Obesity
https://read.qxmd.com/read/38932715/brain-structure-differences-in-pediatric-obesity-cause-or-consequence
#49
JOURNAL ARTICLE
Susan Carnell
No abstract text is available yet for this article.
July 2024: Obesity
https://read.qxmd.com/read/38932711/effects-of-discounting-fruits-vegetables-and-noncaloric-beverages-in-new-york-city-supermarkets-on-purchasing-intake-and-weight
#50
RANDOMIZED CONTROLLED TRIAL
Atene S Poskute, Ian Yi Han Ang, Nabilah Rahman, Allan Geliebter
OBJECTIVE: The objective of this study was to assess purchasing, intake, and weight after discounting fruits and vegetables (F&V) and noncaloric beverages in New York City supermarkets. METHODS: A 16-week randomized controlled trial was conducted with a 4-week baseline, an 8-week intervention with 50% discounts on F&V and noncaloric beverages, and a 4-week follow-up. Purchasing was tracked via loyalty cards, and intake was tracked via 24-h dietary recalls...
July 2024: Obesity
https://read.qxmd.com/read/38803313/unraveling-the-roles-of-ectopic-adipose-depots-and-physical-activity-in-age-related-mitochondrial-decline
#51
JOURNAL ARTICLE
Brian A Irving, Hawley E Kunz
No abstract text is available yet for this article.
June 2024: Obesity
https://read.qxmd.com/read/38803308/associations-between-regional-adipose-tissue-distribution-and-skeletal-muscle-bioenergetics-in-older-men-and-women
#52
JOURNAL ARTICLE
Andrea M Brennan, Paul M Coen, Theresa Mau, Megan Hetherington-Rauth, Frederico G S Toledo, Erin E Kershaw, Peggy M Cawthon, Philip A Kramer, Sofhia V Ramos, Anne B Newman, Steven R Cummings, Daniel E Forman, Reichelle X Yeo, Giovanna Distefano, Iva Miljkovic, Jamie N Justice, Anthony J A Molina, Michael J Jurczak, Lauren M Sparks, Stephen B Kritchevsky, Bret H Goodpaster
OBJECTIVE: The aim of this study was to examine associations of ectopic adipose tissue (AT) with skeletal muscle (SM) mitochondrial bioenergetics in older adults. METHODS: Cross-sectional data from 829 adults ≥70 years of age were used. Abdominal, subcutaneous, and visceral AT and thigh muscle fat infiltration (MFI) were quantified by magnetic resonance imaging. SM mitochondrial energetics were characterized in vivo (31 P-magnetic resonance spectroscopy; ATPmax ) and ex vivo (high-resolution respirometry maximal oxidative phosphorylation [OXPHOS])...
June 2024: Obesity
https://read.qxmd.com/read/38803306/association-between-insulin-sensitivity-and-lean-mass-loss-during-weight-loss
#53
RANDOMIZED CONTROLLED TRIAL
Ciera L Bartholomew, Catia Martins, Barbara Gower
OBJECTIVE: The study objective was to assess the relationship between insulin sensitivity and changes in total lean mass (LM) and appendicular LM (ALM) during weight loss. METHODS: Individuals were randomly assigned to either a standard or a moderately reduced carbohydrate diet for 16 weeks. Body composition was assessed using dual-energy x-ray absorptiometry and insulin sensitivity index (SI ) using an intravenous glucose tolerance test. Multiple linear regression was used to determine whether baseline SI was predictive of changes in total LM and ALM...
June 2024: Obesity
https://read.qxmd.com/read/38803303/characterization-of-tirzepatide-treated-patients-achieving-different-glycemic-control-levels-in-surpass-ap-combo
#54
RANDOMIZED CONTROLLED TRIAL
Yuqian Bao, Lin Han, Liying Du, Linong Ji
OBJECTIVE: The study objective was to characterize subgroups of Asia-Pacific patients with type 2 diabetes who achieved different glycated hemoglobin (HbA1c) targets on tirzepatide treatment. METHODS: This was a post hoc analysis of the SURPASS AP-Combo study. Baseline characteristics, changes in metabolic markers, and safety were compared between tirzepatide-treated patients achieving HbA1c <7.0% (<53 mmol/mol) and those achieving ≥7...
June 2024: Obesity
https://read.qxmd.com/read/38741246/long-term-sustained-effects-of-the-look-ahead-lifestyle-intervention-on-body-composition-among-adults-with-type-2-diabetes
#55
RANDOMIZED CONTROLLED TRIAL
Maxine Ashby-Thompson, Stanley Heshka, Andrea Anderson, Henry Pownall, Blandine Laferrère, Ashok Balasubramanyam, Steven B Heymsfield, Thomas A Wadden, Dympna Gallagher
OBJECTIVE: The objective of the study was to test whether there are sustained effects of the Look AHEAD intensive lifestyle intervention (ILI), versus diabetes support and education (DSE), on weight and body composition 12 to 16 years after randomization. METHODS: Participants were a subset of enrollees in the Look AHEAD dual-energy x-ray absorptiometry substudy who completed the final visit, composed of men (DSE = 99; ILI = 94) and women (DSE = 134; ILI = 135) with type 2 diabetes and mean (SD) age 57...
June 2024: Obesity
https://read.qxmd.com/read/38644161/early-outcomes-of-referrals-to-the-english-national-health-service-digital-weight-management-programme
#56
JOURNAL ARTICLE
Katharine Taylor, Tejal Indulkar, Bethany Thompson, Christine Pinkard, Emma Barron, Tom Frost, Priyantha Jayawardane, Neil Davies, Chirag Bakhai, Nita Gandhi Forouhi, Paul Aveyard, Susan Jebb, Jonathan Valabhji
OBJECTIVE: The study objective was to assess participant weight change for the English National Health Service (NHS) Digital Weight Management Programme, the first such digital intervention to achieve population coverage. METHODS: A service evaluation was used to assess intervention effectiveness for adults with obesity and a diagnosis of hypertension and/or diabetes, between April 2021 and March 2022, using prospectively collected, national service-level data in England...
June 2024: Obesity
https://read.qxmd.com/read/38577709/mutations-in-the-leptin-melanocortin-pathway-and-weight-loss-after-bariatric-surgery-a-systematic-review-and-meta-analysis
#57
REVIEW
Nianrong Zhang, Hao Wang, Shuman Ran, Zhe Wang, Biao Zhou, Siqi Wang, Zhengqi Li, Baoyin Liu, Yuntao Nie, Yishan Huang, Hua Meng
OBJECTIVE: The objective of this meta-analysis was to quantify the overall effects of gene mutations in the leptin-melanocortin pathway on short- and long-term weight loss after bariatric surgery. METHODS: MEDLINE, PubMed, and Embase were searched, and data were analyzed using ReviewManager (RevMan) version 5.4. The datasets were divided into two subgroups based on postoperative time, and the outcome measure was the percentage of total weight loss. Meta-regression analysis was performed, and the outcome was presented as the weighed mean difference of percentage of total weight loss...
June 2024: Obesity
https://read.qxmd.com/read/38650523/overweight-obesity-gestational-weight-gain-postpartum-weight-retention-and-maternal-neonatal-complications-in-the-military
#58
JOURNAL ARTICLE
Rebecca A Krukowski, Erin Solomon, Juan Lang, Emily Stone, Wen You, Rosemary Estevez Burns, Carol Copeland, Zoran Bursac, Marion E Hare, Teresa M Waters
OBJECTIVE: The objective of this study was to examine the prevalence of overweight/obesity and excessive gestational weight gain (GWG) among military beneficiaries and to assess associations of these risk factors with maternal/neonatal complications and substantial postpartum weight retention (PPWR). METHODS: We obtained data for 48,391 TRICARE beneficiaries who gave birth in 2018 or 2019 in the United States. We used logistic regression and ANOVA to examine relationships among overweight/obesity, GWG, maternal/neonatal complications, and substantial PPWR...
May 2024: Obesity
https://read.qxmd.com/read/38650517/impaired-metabolic-flexibility-to-fasting-is-associated-with-increased-ad-libitum-energy-intake-in-healthy-adults
#59
JOURNAL ARTICLE
Yigit Unlu, Paolo Piaggi, Emma J Stinson, Tomás Cabeza De Baca, Theresa L Rodzevik, Mary Walter, Jonathan Krakoff, Douglas C Chang
OBJECTIVE: We investigated how changes in 24-h respiratory exchange ratio (RER) and substrate oxidation during fasting versus an energy balance condition influence subsequent ad libitum food intake. METHODS: Forty-four healthy, weight-stable volunteers (30 male and 14 female; mean [SD], age 39.3 [11.0] years; BMI 31.7 [8.3] kg/m2 ) underwent 24-h energy expenditure measurements in a respiratory chamber during energy balance (50% carbohydrate, 30% fat, and 20% protein) and 24-h fasting...
May 2024: Obesity
https://read.qxmd.com/read/38600046/pre-pregnancy-maternal-obesity-and-infant-neurodevelopmental-outcomes-in-latino-infants
#60
JOURNAL ARTICLE
Mahsa Babaei, Christopher J Machle, Pari Mokhtari, Jonatan Ottino González, Kelsey A Schmidt, Tanya L Alderete, Shana Adise, Bradley S Peterson, Michael I Goran
OBJECTIVE: This study explores the impact of maternal pre-pregnancy BMI on infant neurodevelopment at 24 months in low-income Latino families. It also investigates whether infant diet mediates this relationship. METHODS: Latino mother-infant pairs (n = 163) were enrolled at 1 month post partum and were followed for 2 years, with assessments at 6-month intervals. Maternal pre-pregnancy anthropometrics were self-reported at baseline, and child neurodevelopment was assessed at 24 months using the Bayley Scales of Infant Development...
May 2024: Obesity
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