journal
https://read.qxmd.com/read/38764181/deficits-in-brain-glucose-transport-among-younger-adults-with-obesity
#1
JOURNAL ARTICLE
Felona Gunawan, Brooke C Matson, Anastasia Coppoli, Lihong Jiang, Yuyan Ding, Rachel Perry, Elizabeth Sanchez-Rangel, Renata Belfort DeAguiar, Kevin L Behar, Douglas L Rothman, Graeme F Mason, Janice J Hwang
OBJECTIVE: Obesity is associated with alterations in eating behavior and neurocognitive function. In this study, we investigate the effect of obesity on brain energy utilization, including brain glucose transport and metabolism. METHODS: A total of 11 lean participants and 7 young healthy participants with obesity (mean age, 27 years) underwent magnetic resonance spectroscopy scanning coupled with a hyperglycemic clamp (target, ~180 mg/dL) using [1-13 C] glucose to measure brain glucose uptake and metabolism, as well as peripheral markers of insulin resistance...
May 19, 2024: Obesity
https://read.qxmd.com/read/38757229/altered-proteome-profiles-related-to-visceral-adiposity-may-mediate-the-favorable-effect-of-green-mediterranean-diet-the-direct-plus-trial
#2
JOURNAL ARTICLE
Hila Zelicha, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Matthias Blüher, Nora Klöting, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Yoash Chassidim, Ilan Shelef, Frank B Hu, Iris Shai
OBJECTIVE: The objective of this study was to explore the effects of a green Mediterranean (green-MED) diet, which is high in dietary polyphenols and green plant-based protein and low in red/processed meat, on cardiovascular disease and inflammation-related circulating proteins and their associations with cardiometabolic risk parameters. METHODS: In the 18-month weight loss trial Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT-PLUS), 294 participants with abdominal obesity were randomized to basic healthy dietary guidelines, Mediterranean (MED), or green-MED diets...
May 16, 2024: Obesity
https://read.qxmd.com/read/38747118/human-epicardial-fat-has-a-beige-profile-and-contains-higher-type-2-innate-lymphoid-cells-than-subcutaneous-fat
#3
JOURNAL ARTICLE
Elisa Doukbi, Patricia Ancel, Anne Dutour, Astrid Soghomonian, Shaista Ahmed, Victoria Castejon, Christelle Piperoglou, Vlad Gariboldi, Marien Lenoir, Eric Lechevallier, Bastien Gondran-Tellier, Romain Boissier, Mikael Ebbo, Frédéric Vély, Bénédicte Gaborit
OBJECTIVE: Epicardial adipose tissue (EAT) is a visceral fat that has been associated with coronary artery disease and atrial fibrillation. Previous work has revealed that EAT exhibits beige features. METHODS: First, a new pan-genomic microarray analysis was performed on previously collected paired human EAT and thoracic subcutaneous AT (thSAT) from the EPICAR study (n = 31) to decipher a specific immune signature and its link with browning genes. Then, adaptive (T and B cells) and innate lymphoid cell (ILC1, ILC2, and ILC3) immunophenotyping assay panels, including CD127, CD117, and prostaglandin D2 receptor 2, were performed on prospectively collected paired human multiorgan donors (n = 18; INTERFACE study)...
May 15, 2024: Obesity
https://read.qxmd.com/read/38741246/long-term-sustained-effects-of-the-look-ahead-lifestyle-intervention-on-body-composition-among-adults-with-type-2-diabetes
#4
JOURNAL ARTICLE
Maxine Ashby-Thompson, Stanley Heshka, Andrea Anderson, Henry Pownall, Blandine Laferrère, Ashok Balasubramanyam, Steven B Heymsfield, Thomas A Wadden, Dympna Gallagher
OBJECTIVE: The objective of the study was to test whether there are sustained effects of the Look AHEAD intensive lifestyle intervention (ILI), versus diabetes support and education (DSE), on weight and body composition 12 to 16 years after randomization. METHODS: Participants were a subset of enrollees in the Look AHEAD dual-energy x-ray absorptiometry substudy who completed the final visit, composed of men (DSE = 99; ILI = 94) and women (DSE = 134; ILI = 135) with type 2 diabetes and mean (SD) age 57...
May 13, 2024: Obesity
https://read.qxmd.com/read/38714525/metabolic-surgery-the-sooner-the-better-for-long-term-success
#5
JOURNAL ARTICLE
Michael Kachmar, Vance L Albaugh
No abstract text is available yet for this article.
May 7, 2024: Obesity
https://read.qxmd.com/read/38710591/smaller-subcortical-volume-relates-to-greater-weight-gain-in-girls-with-initially-healthy-weight
#6
JOURNAL ARTICLE
Shana Adise, Jonatan Ottino-Gonzalez, Panteha Hayati Rezvan, Eric Kan, Kyung E Rhee, Michael I Goran, Elizabeth R Sowell
OBJECTIVE: Among 3614 youth who were 9 to 12 years old and initially did not have overweight or obesity (12% [n = 385] developed overweight or obesity), we examined the natural progression of weight gain and brain structure development during a 2-year period with a high risk for obesity (e.g., pre- and early adolescence) to determine the following: 1) whether variation in maturational trajectories of the brain regions contributes to weight gain; and/or 2) whether weight gain contributes to altered brain development...
May 6, 2024: Obesity
https://read.qxmd.com/read/38708662/the-carbohydrate-insulin-model-is-always-correct-a-point-worth-reiterating-even-when-commenting-on-studies-that-do-not-concern-it
#7
LETTER
John R Speakman, Lin Gao, Sumei Hu
No abstract text is available yet for this article.
May 6, 2024: Obesity
https://read.qxmd.com/read/38706431/the-association-between-weight-loss-medications-and-cardiovascular-complications
#8
JOURNAL ARTICLE
Onur Baser, Gabriela Samayoa, Katarzyna Rodchenko, Lauren Isenman, Erdem Baser, Nehir Yapar
OBJECTIVE: Obesity and its cardiovascular complications are major causes of morbidity and mortality. Little is known in real-world settings about the effect of newly approved antiobesity medications (AOMs) on cardiovascular complications among patients with obesity. METHODS: This retrospective cohort study examined the association between newly approved AOM use and cardiovascular events among Medicare patients with obesity using data from 2020 to 2022. Patient age, gender, comorbidity scores, socioeconomic status, and baseline cardiovascular comorbidities were compared descriptively...
May 6, 2024: Obesity
https://read.qxmd.com/read/38706387/caution-needed-on-causal-inferences-in-obesity
#9
LETTER
David S Ludwig, Cara B Ebbeling, Mark I Friedman
No abstract text is available yet for this article.
May 6, 2024: Obesity
https://read.qxmd.com/read/38699960/the-grade-of-obesity-affects-the-noninvasive-diagnosis-of-advanced-fibrosis-in-individuals-with-masld
#10
JOURNAL ARTICLE
Yasmina Chouik, Adrien Aubin, Marianne Maynard-Muet, Bérénice Segrestin, Laurent Milot, Valérie Hervieu, Fabien Zoulim, Emmanuel Disse, Massimo Levrero, Cyrielle Caussy
OBJECTIVE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with obesity. We aimed to assess the impact of obesity on the performance of different noninvasive tests, including liver stiffness measurement (LSM) and Agile3+ (A3+), to detect advanced fibrosis (AF) in a population of patients with MASLD encompassing a wide range of BMI values. METHODS: A total of 479 patients with MASLD were consecutively included (Lyon Hepatology Institute)...
May 3, 2024: Obesity
https://read.qxmd.com/read/38664956/adaptive-thermogenesis-at-the-level-of-resting-energy-expenditure-after-diet-alone-or-diet-plus-bariatric-surgery
#11
JOURNAL ARTICLE
Silvia Y Lopez Torres, Marthe I Aukan, Barbara A Gower, Catia Martins
OBJECTIVE: The objective of this study was to compare the magnitude of adaptive thermogenesis (AT), at the level of resting energy expenditure (REE), after a very low-energy diet alone or combined with Roux-en-Y gastric bypass or sleeve gastrectomy, as well as to investigate the association between AT and changes in appetite. METHODS: A total of 44 participants with severe obesity underwent 10 weeks of a very low-energy diet alone or combined with Roux-en-Y gastric bypass or sleeve gastrectomy...
April 25, 2024: Obesity
https://read.qxmd.com/read/38664858/correction-to-nadph-oxidase-4-in-mouse-%C3%AE-cells-participates-in-inflammation-on-chronic-nutrient-overload
#12
(no author information available yet)
No abstract text is available yet for this article.
April 25, 2024: Obesity
https://read.qxmd.com/read/38664310/obesity-related-inflammatory-protein-signature-in-cardiovascular-clinical-outcomes-results-from-the-gutenberg-health-study
#13
JOURNAL ARTICLE
Marina Panova-Noeva, Thomas Koeck, Corinna Schoelch, Andreas Schulz, Jürgen H Prochaska, Matthias Michal, Konstantin Strauch, Alexander K Schuster, Karl J Lackner, Thomas Münzel, Anita M Hennige, Philipp S Wild
OBJECTIVE: The objective of this study was to investigate whether an obesity-related inflammatory protein signature (OIPS) is associated with adverse cardiovascular events. METHODS: The Olink Target 96 Inflammation panel was performed in 6662 participants from the population-based Gutenberg Health Study (GHS). The OIPS was selected by a logistic regression model, and its association with cardiovascular outcomes was evaluated by Cox regression analysis. The GHS-derived OIPS was externally validated in the MyoVasc study...
April 25, 2024: Obesity
https://read.qxmd.com/read/38664236/body-weight-variability-and-the-risk-of-liver-related-outcomes-in-type-2-diabetes-and-steatotic-liver-disease-a-cohort-study
#14
JOURNAL ARTICLE
Nathalie C Leite, Claudia R L Cardoso, Cristiane A Villela-Nogueira, Gil F Salles
OBJECTIVE: The objective of this study was to evaluate the effects of body weight variability (BWV) on the occurrence of adverse liver outcomes in individuals with type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD). METHODS: A total of 549 patients with T2D and MASLD had BWV parameters assessed during the first 2 years of follow-up. The associations between increasing BWV and liver outcomes (clinical cirrhosis or a liver stiffness measurement on transient elastography > 15 kPa, performed after a median of 7 years of cohort entry) were examined by multivariable logistic regressions...
April 25, 2024: Obesity
https://read.qxmd.com/read/38664233/presurgery-health-influences-outcomes-following-vertical-sleeve-gastrectomy-in-adolescents
#15
JOURNAL ARTICLE
Debi Swertfeger, Ahlee Kim, Hannah Sexmith, Maria E Moreno-Fernandez, W Sean Davidson, Michael Helmrath, Todd Jenkins, Tsuyoshi Okura, Esmond Geh, Stavra A Xanthakos, Sara Szabo, Takahisa Nakamura, Senad Divanovic, Amy Sanghavi Shah
OBJECTIVE: Weight loss following vertical sleeve gastrectomy (VSG) in youth can range from 10% to 50%. We examined whether there are differences in demographic or metabolic parameters before VSG in youth who achieve above-average weight loss (AAWL) versus below-average weight loss (BAWL) at 1 year post VSG and if youth with BAWL still achieve metabolic health improvements at 1 year post VSG. METHODS: Demographic, anthropometric, and clinical lab data were collected before VSG and at 1, 3, 6, and 12 months after VSG...
April 25, 2024: Obesity
https://read.qxmd.com/read/38659126/response-to-fitch-and-huett-garcia
#16
LETTER
Hamlet Gasoyan, Elizabeth R Pfoh, Rebecca Schulte, Phuc Le, Michael B Rothberg
No abstract text is available yet for this article.
April 24, 2024: Obesity
https://read.qxmd.com/read/38659125/response-to-early-and-later-stage-persistence-with-antiobesity-medications-a-retrospective-cohort-study
#17
LETTER
Angela Fitch, Amber Huett-Garcia
No abstract text is available yet for this article.
April 24, 2024: Obesity
https://read.qxmd.com/read/38653583/hedonic-hunger-eating-behavior-and-food-reward-and-preferences-1-year-after-initial-weight-loss-by-diet-or-bariatric-surgery
#18
JOURNAL ARTICLE
Marthe Isaksen Aukan, Graham Finlayson, Catia Martins
OBJECTIVE: The objective of this study was to investigate changes in hedonic hunger, eating behavior, and food reward and preferences at 1-year (1Y) follow-up after an initial weight loss (WL) induced by a 10-week, very low-energy diet alone (controls) or in combination with bariatric surgery. METHODS: Patients scheduled for sleeve gastrectomy or Roux-en-Y gastric bypass and controls were recruited. Body weight/composition, hedonic hunger (Power of Food Scale), eating behavior traits (Dutch Eating Behavior Questionnaire and Three-Factor Eating Questionnaire), and food reward and preferences (computerized behavioral task) were measured at baseline, 11 weeks, and 1Y follow-up...
April 23, 2024: Obesity
https://read.qxmd.com/read/38644683/physiology-of-the-weight-loss-plateau-in-response-to-diet-restriction-glp-1-receptor-agonism-and-bariatric-surgery
#19
JOURNAL ARTICLE
Kevin D Hall
OBJECTIVE: The objective of this study was to investigate why different weight-loss interventions result in varying durations of weight loss prior to approaching plateaus. METHODS: A validated mathematical model of energy metabolism and body composition dynamics was used to simulate mean weight- and fat-loss trajectories in response to diet restriction, semaglutide 2.4 mg, tirzepatide 10 mg, and Roux-en-Y gastric bypass (RYGB) surgery interventions...
April 22, 2024: Obesity
https://read.qxmd.com/read/38644654/maternal-obesity-sex-specific-in-utero-changes-in-fetal-brain-autophagy-and-mtor
#20
JOURNAL ARTICLE
Nana Merabova, Lierni Ugartemendia, Andrea G Edlow, Claudia Ibarra, Nune Darbinian, Gabriel Tatevosian, Laura Goetzl
OBJECTIVE: Maternal obesity affects 39.7% of reproductive-age women in the United States. Emerging research has suggested that in utero exposure to maternal obesity is associated with adverse neurodevelopmental outcomes, but knowledge of underlying mechanisms in human samples is lacking. METHODS: A matched case-control study was performed in women with singleton fetuses who were undergoing elective pregnancy termination at gestational ages 15 to 21 weeks...
April 21, 2024: Obesity
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