journal
https://read.qxmd.com/read/37766596/modifiable-kidney-disease-risk-factors-among-nondiabetic-adults-with-obesity-from-the-multi-ethnic-study-of-atherosclerosis
#1
JOURNAL ARTICLE
Meera N Harhay, Yuna Kim, Kari Moore, Michael O Harhay, Ronit Katz, Michael G Shlipak, Holly J Mattix-Kramer
OBJECTIVE: It is unknown whether weight change or physical fitness is associated with chronic kidney disease (CKD) risk among nondiabetic adults with obesity. METHODS: This was a prospective, longitudinal cohort study of adults with obesity without baseline CKD or diabetes enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). Linear mixed-effects and multistate models were adjusted for demographics, time-varying covariates including blood pressure, and comorbidities these were used to examine associations of weight change and slow walking pace (<2 miles/h) with (i) rate of annual estimated glomerular filtration rate (eGFR) decline and (ii) incident CKD, defined as eGFRCr-Cys  < 60 mL/min/1...
September 28, 2023: Obesity
https://read.qxmd.com/read/37752728/genetic-dissection-of-serum-vaspin-highlights-its-causal-role-in-lipid-metabolism
#2
JOURNAL ARTICLE
Jana Breitfeld, Katrin Horn, Diana Le Duc, Akhil Velluva, Carola Marzi, Harald Grallert, Nele Friedrich, Maik Pietzner, Uwe Völker, Henry Völzke, Emma Ahlqvist, Dina Mansour Aly, Tiinamaija Tuomi, Ronny Baber, Jürgen Kratzsch, Joachim Thiery, Berend Isermann, Markus Loeffler, Nora Klöting, Matthias Blüher, Michael Stumvoll, John T Heiker, Anke Tönjes, Markus Scholz, Peter Kovacs
OBJECTIVE: Vaspin (visceral adipose tissue derived serine protease inhibitor, SERPINA12) is associated with obesity-related metabolic traits, but its causative role is still elusive. The role of genetics in serum vaspin variability to establish its causal relationship with metabolically relevant traits was investigated. METHODS: A meta-analysis of genome-wide association studies for serum vaspin from six independent cohorts (N = 7446) was conducted...
September 26, 2023: Obesity
https://read.qxmd.com/read/37752619/mir-484-promotes-nonalcoholic-fatty-liver-disease-progression-in-mice-via-downregulation-of-sorbs2
#3
JOURNAL ARTICLE
Yinzhao Jia, Hao Pan, Jing Liu, Tiezeng Huang, Ke Han, Qiaojuan Mei, Ling Zeng, Jinzhao Zhou, Yong Zhang
OBJECTIVE: MicroRNA 484 (miR-484) plays a pivotal role in the development and progression of different diseases and is typically described as a mitochondrial regulator. Whether miR-484 is involved in lipid metabolism or exerts a role in nonalcoholic fatty liver disease remains unclear. METHODS: miR-484 levels were examined in the livers of male mice fed a high-fat diet and in hepatocytes treated with free fatty acids. Sorbin and SH3 structural domain-containing protein 2 (Sorbs2) were identified as a novel target of miR-484 by sequencing mRNA in the livers of miR-484 knockout mice...
September 26, 2023: Obesity
https://read.qxmd.com/read/37751990/naltrexone-bupropion-for-binge-eating-disorder-a-randomized-double-blind-placebo-controlled-trial
#4
JOURNAL ARTICLE
Carlos M Grilo, Janet A Lydecker, Ania M Jastreboff, Brian Pittman, Sherry A McKee
OBJECTIVE: Binge-eating disorder (BED) is a prevalent psychiatric disorder associated with obesity. Few evidence-based treatments exist for BED, particularly pharmacological options. This study tested the efficacy of naltrexone/bupropion for BED. METHODS: A randomized, double-blind, placebo-controlled, 12-week trial tested naltrexone/bupropion for BED with and without obesity. Eighty-nine patients (70.8% women, 69.7% White, mean age 45.7 y, mean body mass index [BMI] 35...
September 26, 2023: Obesity
https://read.qxmd.com/read/37749823/a-test-score-does-not-a-construct-make
#5
JOURNAL ARTICLE
Yana Suchy
No abstract text is available yet for this article.
September 25, 2023: Obesity
https://read.qxmd.com/read/37749805/replacing-the-body-mass-index-with-the-sagittal-abdominal-diameter-abdominal-height
#6
JOURNAL ARTICLE
Henry S Kahn
The body mass index (BMI; weight/height2 ), providing no information about the relative size of any adipose tissue depots, may accordingly misclassify degrees of cardiometabolic risk. However, in supine persons the abdominal height above the exam table (the sagittal abdominal diameter, SAD) is associated preferentially with the accumulation of visceral fat. Since visceral fat is a marker of insulin resistance, type 2 diabetes, coronary heart disease, and hypertension, SAD could contribute to the estimation of generalized cardiometabolic risk...
September 25, 2023: Obesity
https://read.qxmd.com/read/37746932/visceral-adipocyte-size-links-obesity-with-dysmetabolism-more-than-fibrosis-and-both-can-be-estimated-by-circulating-mirnas
#7
JOURNAL ARTICLE
Yair Pincu, Nataly Makarenkov, Alexandra A Tsitrina, Marina Rosengarten-Levine, Yulia Haim, Uri Yoel, Idit F Liberty, Oleg Dukhno, Ivan Kukeev, Matthias Blüher, Isana Veksler-Lublinsky, Assaf Rudich
OBJECTIVE: In obesity, adipocyte hypertrophy is detrimental to health, but its' interrelation with fibrosis in the visceral adipose tissue (VAT) depot remains unclear. Because VAT is less accessible via biopsy, biomarkers for VAT quality are needed. The authors hypothesized that VAT adipocyte size and fibrosis are interrelated and can be estimated by circulating microRNAs (circ-miRNAs), contributing to subphenotyping obesity. METHODS: Adipocyte size and AT fibrosis were estimated in n = 43 participants (BMI ≥ 30 kg/m2 )...
September 25, 2023: Obesity
https://read.qxmd.com/read/37735781/rapid-increases-in-bmi-waist-to-height-ratio-during-adolescence-and-subsequent-neurobehavioral-deficits
#8
JOURNAL ARTICLE
Ting Yu, Yining Jiang, Jue Fan, Xiangrong Guo, Hui Hua, Dongqing Xu, Yuefen Wang, Chonghuai Yan, Jian Xu
OBJECTIVE: The aim of this study was to explore prospective relationships between changing patterns of BMI/waist to height ratio (WHtR) during adolescence and subsequent neurobehavioral development. METHODS: In this prospective cohort study, randomized stratified sampling was used to recruit six middle schools and 609 students in Shanghai, China. In Grades 6, 7, and 9, the Youth Self Report scale was used to assess student neurobehavioral status and anthropometric measurements were conducted to calculate BMI z scores and WHtRs...
September 21, 2023: Obesity
https://read.qxmd.com/read/37731285/relationships-of-pregnancy-and-postpartum-diet-quality-with-offspring-birth-weight-and-weight-status-through-12%C3%A2-months
#9
JOURNAL ARTICLE
Leah Lipsky, Jenna Cummings, Anna Maria Siega-Riz, Tonja Nansel
OBJECTIVE: This study examined relationships of maternal pregnancy and postpartum diet quality with infant birth size and weight status indicators through 12 months and tested whether breastfeeding duration modifies these associations. METHODS: In the Pregnancy Eating Attributes Study (PEAS), dietary intake was assessed six times in 458 mothers who were followed from early pregnancy through 12 months postpartum (2014-2018). Logistic and linear mixed models estimated relationships of pregnancy and postpartum diet quality (Healthy Eating Index [HEI]) with offspring who were large-for-gestational-age (LGA) at birth, as well as body mass index (BMI) z score (BMIz) and weight-for-length z score (WFLz) at birth, 6 weeks, 6 months, and 12 months...
September 20, 2023: Obesity
https://read.qxmd.com/read/37731271/effects-of-short-term-supervised-exercise-training-on-liver-fat-in-adolescents-with-obesity-a-randomized-controlled-trial
#10
JOURNAL ARTICLE
Emir Tas, Reid D Landes, Eva C Diaz, Shasha Bai, Xiawei Ou, Robert Buchmann, Xiaoxu Na, Radhika Muzumdar, Elisabet Børsheim, Jonathan A Dranoff
OBJECTIVE: The objective of this study was to quantify the effects of a 4-week, supervised, high-intensity interval training (HIIT) on intrahepatic triglyceride content (IHTG, percentage), cardiorespiratory fitness (CRF), and cardiometabolic markers in adolescents with obesity. METHODS: A total of 40 adolescents (age 13-18 y, BMI 36.7 ± 5.8 kg/m2 ) at risk for metabolic dysfunction-associated steatotic liver disease (MASLD) based on obesity and elevated Fibroscan measured controlled attenuation parameter (CAP) scores were randomized to HIIT three times a week for 4 weeks (n = 34) or observation (control; n = 6)...
September 20, 2023: Obesity
https://read.qxmd.com/read/37731225/association-of-fat-mass-and-fat-free-mass-with-all-cause-and-cause-specific-mortality-in-asian-individuals-a-prospective-cohort-study
#11
JOURNAL ARTICLE
Zhijun Ying, Chi Pang Wen, Huakang Tu, Wanlu Li, Sai Pan, Yizhan Li, Yihong Luo, Zecheng Zhu, Min Yang, Zhenya Song, David Ta-Wei Chu, Xifeng Wu
OBJECTIVE: The study's objective was to investigate the association of fat mass index (FMI) and fat-free mass index (FFMI) with all-cause mortality and cause-specific mortality in the Chinese population. METHODS: A total of 422,430 participants (48.1% men and 51.9% women) from the Taiwan MJ Cohort with an average follow-up of 9 years were included. RESULTS: The lowest (Q1) and highest (Q5) quintiles of FMI and FFMI were associated with increased all-cause mortality...
September 20, 2023: Obesity
https://read.qxmd.com/read/37731222/weight-independent-effects-of-roux-en-y-gastric-bypass-surgery-on-remission-of-nonalcoholic-fatty-liver-disease-in-mice
#12
JOURNAL ARTICLE
Christopher L Axelrod, Ingeborg Langohr, Wagner S Dantas, Elizabeth C Heintz, Bolormaa Vandanmagsar, Shengping Yang, Elizabeth R M Zunica, R Leigh Townsend, Vance L Albaugh, Hans-Rudolf Berthoud, John P Kirwan
OBJECTIVE: Obesity is a driver of non-alcoholic fatty liver disease (NAFLD), and interventions that decrease body weight, such as bariatric surgery and/or calorie restriction (CR), may serve as effective therapies. This study compared the effects of Roux-en-Y gastric bypass surgery (RYGB) and CR on hepatic function in mice with obesity and NAFLD. METHODS: C57BL/6J mice were fed a high-fat diet to promote obesity. At 16 weeks of age, mice were randomized to sham surgery (sham), RYGB, or CR weight matched to RYGB (WM)...
September 20, 2023: Obesity
https://read.qxmd.com/read/37731207/variation-in-executive-function-relates-to-bmi-increases-in-youth-who-were-initially-of-a-healthy-weight-in-the-abcd-study
#13
JOURNAL ARTICLE
Shana Adise, Jonatan Ottino-Gonzalez, Lauren Goedde, Andrew T Marshall, Eric Kan, Kyung E Rhee, Michael I Goran, Elizabeth R Sowell
OBJECTIVE: The study aim was to determine whether (A) differences in executive function (EF) and cognition precede weight gain or (B) weight gain causes changes to EF and cognition. METHODS: Data were gathered from the Adolescent Brain Cognitive Development (ABCD) Study (release 4.0; ages 9-12 years old [N = 2794]; 100% had healthy weight at baseline [i.e., 9/10 years old], 12.4% had unhealthy weight by ages 11/12 years). EF and cognition were assessed across several domains (e...
September 20, 2023: Obesity
https://read.qxmd.com/read/37726964/are-24-hour-movement-recommendations-associated-with-obesity-related-indicators-in-the-young-population-a-meta-analysis
#14
REVIEW
José Francisco López-Gil, Miguel Angel Tapia-Serrano, Javier Sevil-Serrano, Pedro Antonio Sánchez-Miguel, Antonio García-Hermoso
OBJECTIVE: This study aimed to determine the relationship between meeting all three 24-hour movement recommendations (i.e., physical activity, sleep duration, and screen time) and obesity-related indicators among young people. METHODS: Four databases were systematically searched (PubMed, Scopus, Web of Science, and Cochrane Library). RESULTS: Meeting the 24-hour movement recommendations was cross-sectionally associated with lower overall obesity-related indicators (r = -0...
September 19, 2023: Obesity
https://read.qxmd.com/read/37723848/risk-factors-for-metabolic-syndrome-in-self-identified-and-questioning-sexual-minority-women
#15
JOURNAL ARTICLE
Young Mee Choi, Courtney S Pilkerton, Jun Xiang, Amie M Ashcraft, Keri A Seymour, Nova Szoka
OBJECTIVE: Studies have shown sexual minority women (SMW) have a higher incidence of obesity, but the risk of metabolic syndrome (MetS) in SMW is unclear. We examined the association between sexual orientation and MetS and its components. METHODS: Data were extracted from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2016 examining women aged 20 to 59 years. Participants were divided into three categories: heterosexual, self-identified SMW, and questioning SMW...
September 18, 2023: Obesity
https://read.qxmd.com/read/37712194/energy-expenditure-deficits-drive-obesity-in-a-mouse-model-of-alstr%C3%A3-m-syndrome
#16
JOURNAL ARTICLE
Erin J Stephenson, Clint E Kinney, Amanda S Stayton, Joan C Han
OBJECTIVE: Alström syndrome (AS) is a rare multisystem disorder of which early onset childhood obesity is a cardinal feature. Like humans with AS, animal models with Alms1 loss-of-function mutations develop obesity, supporting the notion that ALMS1 is required for the regulatory control of energy balance across species. This study aimed to determine which component(s) of energy balance are reliant on ALMS1. METHODS: Comprehensive energy balance phenotyping was performed on Alms1tvrm102 mice at both 8 and 18 weeks of age...
September 15, 2023: Obesity
https://read.qxmd.com/read/37712179/cumulative-bmi-and-incident-prediabetes-over-30%C3%A2-years-of-follow-up-the-cardia-study
#17
JOURNAL ARTICLE
Pamela J Schreiner, Sejong Bae, Norrina Allen, Kiang Liu, Jared P Reis, Colin Wu, Katherine H Ingram, Donald Lloyd-Jones, Cora E Lewis, Jamal S Rana
OBJECTIVE: This study examined how cumulative BMI (cBMI) is associated with incident prediabetes in a biracial observational cohort study followed from young adulthood to middle age. METHODS: Black and White men and women (n = 4190) from the Coronary Artery Risk Development in Young Adults (CARDIA) study, ages 18 to 30 years in 1985 to 1986 and free of prediabetes or diabetes at baseline, were followed for 30 years. Cox regression was used to determine how cBMI was associated with incident prediabetes after controlling for traditional cardiovascular risk factors...
September 15, 2023: Obesity
https://read.qxmd.com/read/37691173/overweight-and-obesity-are-associated-with-better-survival-in-stemi-patients-with-diabetes
#18
JOURNAL ARTICLE
Hamza Chaudhry, Ramez Bodair, Ziyad Mahfoud, Soha Dargham, Jassim Al Suwaidi, Hani Jneid, Charbel Abi Khalil
OBJECTIVE: The relationship between obesity and in-hospital outcomes in individuals with type 2 diabetes mellitus (T2DM) who develop an ST-elevation myocardial infarction (STEMI) was assessed. METHODS: Data from the National Inpatient Sample (NIS) from 2008 to 2017 were analyzed. Patients with STEMI and T2DM were classified as being underweight or having normal weight, overweight, obesity, and severe obesity. The temporal trend of those BMI ranges and in-hospital outcomes among different obesity groups were assessed...
September 10, 2023: Obesity
https://read.qxmd.com/read/37670579/the-tissue-specific-metabolic-effects-of-the-ppar%C3%AE-agonist-ciprofibrate-in-insulin-resistant-male-individuals-a-double-blind-randomized-placebo-controlled-crossover-study
#19
JOURNAL ARTICLE
Vera H W de Wit-Verheggen, Froukje Vanweert, Juho Raiko, Viktor Liénard, Gert Schaart, Anne Gemmink, Emmani B M Nascimento, Matthijs K C Hesselink, Joachim E Wildberger, Roel Wierts, Peter J Joris, Joel Haas, David Montaigne, Bart Staels, Esther Phielix, Patrick Schrauwen, Vera B Schrauwen-Hinderling, Tineke van de Weijer
OBJECTIVE: Insulin resistance is characterized by ectopic fat accumulation leading to cardiac diastolic dysfunction and nonalcoholic fatty liver disease. The objective of this study was to determine whether treatment with the peroxisome proliferator-activated receptor-α (PPARα) agonist ciprofibrate has direct effects on cardiac and hepatic metabolism and can improve insulin sensitivity and cardiac function in insulin-resistant volunteers. METHODS: Ten insulin-resistant male volunteers received 100 mg/d of ciprofibrate and placebo for 5 weeks in a randomized double-blind crossover study...
September 5, 2023: Obesity
https://read.qxmd.com/read/37667838/ectopic-lipid-deposition-in-muscle-and-liver-quantified-by-proton-magnetic-resonance-spectroscopy
#20
REVIEW
Mijke Buitinga, Pandichelvam Veeraiah, Florian Haans, Vera B Schrauwen-Hinderling
Advances in the development of noninvasive imaging techniques have spurred investigations into ectopic lipid deposition in the liver and muscle and its implications in the development of metabolic diseases such as type 2 diabetes. Computed tomography and ultrasound have been applied in the past, though magnetic resonance-based methods are currently considered the gold standard as they allow more accurate quantitative detection of ectopic lipid stores. This review focuses on methodological considerations of magnetic resonance-based methods to image hepatic and muscle fat fractions, and it emphasizes anatomical and morphological aspects and how these may influence data acquisition, analysis, and interpretation...
September 5, 2023: Obesity
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