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Clinical Research in Cardiology : Official Journal of the German Cardiac Society

https://read.qxmd.com/read/39017675/reply-to-insights-on-increased-epicardial-adipose-tissue-and-left-atrial-mechanical-dysfunction-in-heart-failure
#1
LETTER
Michelle Lobeek, Thomas M Gorter, Michiel Rienstra
No abstract text is available yet for this article.
July 17, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/39017674/insights-on-increased-epicardial-adipose-tissue-and-left-atrial-mechanical-dysfunction-in-heart-failure
#2
LETTER
Yunus Emre Yavuz
No abstract text is available yet for this article.
July 17, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/39012508/prediction-model-for-leaflet-thrombosis-in-patients-undergoing-transcatheter-aortic-valve-implantation-the-effort-study
#3
JOURNAL ARTICLE
Gloria M Steiner-Gager, Jovan Rogozarski, Christina Kronberger, Al Medina Dizdarevic, Peter Quehenberger, Ruediger Schernthaner, Christian Loewe, Lukas Reider, Andreas Strassl, Katarina Kovacevic Miljevic, Bernd Jilma, Cihan Ay, Oliver Königsbrügge, Marek Postula, Christian Hengstenberg, Jolanta M Siller-Matula
BACKGROUND: Leaflet thrombosis (LT) is a multifaceted and underexplored condition that can manifest following transcatheter aortic valve implantation (TAVI). The objective of this study was to formulate a prediction model based on laboratory assessments and clinical parameters, providing additional guidance and insight into this relatively unexplored aspect of post-TAVI complications. METHODS: The present study was an observational prospective hypothesis-generating study, including 101 patients who underwent TAVI and a screening for LT (the primary endpoint) by multidetector computed tomography (MDCT)...
July 16, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/39012507/a-screening-for-cerebral-deoxygenation-during-vt-ablations-in-patients-with-structural-heart-disease
#4
JOURNAL ARTICLE
Julian Müller, Lena Koch, Philipp Halbfass, Karin Nentwich, Artur Berkovitz, Sebastian Barth, Christian Wächter, Heiko Lehrmann, Thomas Deneke
BACKGROUND: Patients undergoing ventricular tachycardia (VT) ablation often present with structural heart disease (SHD) and reduced ejection fraction. Inducing VT by programmed electrical stimulation (PES) puts these patients at risk for hemodynamic instability and cerebral hypoperfusion. OBJECTIVE: The present study screens for cerebral oxygen desaturation phases (ODPs) in patients undergoing VT ablation. METHODS: Forty-seven patients (age 61 ± 14 years, 72% males) underwent ablation of sustained VT with simultaneous neuromonitoring using near-infrared spectroscopy (NIRS)...
July 16, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/39009912/natural-history-of-initially-asymptomatic-severe-aortic-stenosis-a-one-stage-meta-analysis
#5
JOURNAL ARTICLE
Joshua Teik Ann Tan, George Shiyao He, Jolene Li Ling Chia, Gladys Qiao Xuan Tan, Yao Neng Teo, Yao Hao Teo, Nicholas L Syn, Ping Chai, Raymond C C Wong, Tiong-Cheng Yeo, William K F Kong, Kian-Keong Poh, Ching-Hui Sia
BACKGROUND: Current guidelines on the management strategy for patients with asymptomatic severe aortic stenosis (AS) remain unclear. This uncertainty stems from the lack of data regarding the natural history of these patients. To address this gap, we performed a systematic review and meta-analysis examining the natural history of asymptomatic severe AS patients receiving conservative treatment. METHODS: The PubMed, Cochrane, and Embase databases were searched from inception to 24 January 2024 using the keywords "asymptomatic" AND "aortic" AND "stenosis"...
July 15, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38990250/intentional-coronary-revascularization-versus-conservative-therapy-in-patients-after-peripheral-artery-revascularization-due-to-critical-limb-ischemia-the-incorporate-trial
#6
JOURNAL ARTICLE
Gabor G Toth, Marianne Brodmann, Sadeek S Kanoun Schnur, Stanislaw Bartus, Mislav Vrsalovic, Oleg Krestianinov, Petr Kala, Jacek Bil, Robert Gil, Jan Kanovsky, Luigi Di Serafino, Luca Paolucci, Emanuele Barbato, Fabio Mangiacapra, Zoltan Ruzsa
OBJECTIVES: INCORPORATE trial was designed to evaluate whether default coronary-angiography (CA) and ischemia-targeted revascularization is superior compared to a conservative approach for patients with treated critical limb ischemia (CLI). Registered at clinicaltrials.gov (NCT03712644) on October 19, 2018. BACKGROUND: Severe peripheral artery disease is associated with increased cardiovascular risk and poor outcomes. METHODS: INCORPORATE was an open-label, prospective 1:1 randomized multicentric trial that recruited patients who had undergone successful CLI treatment...
July 11, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38985159/contraceptive-counselling-and-uptake-of-contraception-among-women-with-cardiovascular-diseases-a-systematic-review-and-meta-analysis
#7
REVIEW
Tesfaye Regassa Feyissa, Shahinoor Akter, Melissa L Harris
To address the lack of clarity regarding contraceptive counselling and uptake of contraception among women with cardiovascular disease (CVD), this study aimed to conduct a systematic review and meta-analysis on contraceptive counselling and the subsequent uptake of contraception among women with CVD. A search across six databases identified 1228 articles, with 11 studies (2580 participants) included. The pooled prevalence of contraceptive counselling was 63%, varying from 36 to 94% in individual studies. Inconsistent delivery and documentation of counselling were noted, along with a lack of knowledge about pregnancy complications and misconceptions regarding CVD severity...
July 10, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38980329/quantitative-flow-ratio-or-angiography-for-the-assessment-of-non-culprit-lesions-in-acute-coronary-syndromes-a-randomized-trial
#8
JOURNAL ARTICLE
Helen Ullrich-Daub, Maximilian Olschewski, Boris Schnorbus, Anis Belhady, Till Köhler, Markus Vosseler, Thomas Münzel, Tommaso Gori
BACKGROUND: Patients undergoing percutaneous coronary intervention for acute coronary syndromes often have multivessel disease (MVD). Quantitative flow ratio (QFR) is an angiography-based technology that may help quantify the functional significance of non-culprit lesions, with the advantage that measurements are possible also once the patient is discharged from the catheterization laboratory. AIM: Our two-center, randomized superiority trial aimed to test whether QFR, as compared to angiography, modifies the rate of non-culprit lesion interventions (primary functional endpoint) and improves the outcomes of patients with acute coronary syndromes and MVD (primary clinical endpoint)...
July 9, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38958753/drug-coated-balloon-versus-drug-eluting-stent-for-treating-de-novo-large-vessel-coronary-artery-disease-a-systematic-review-and-meta-analysis-of-13-studies-involving-2888-patients
#9
JOURNAL ARTICLE
Rodolfo Caminiti, Giampiero Vizzari, Alfonso Ielasi, Giampaolo Vetta, Antonio Parlavecchio, Domenico Giovanni Della Rocca, Carolina Montonati, Dario Pellegrini, Mariano Pellicano, Maurizio Tespili, Antonio Micari
INTRODUCTION: Drug-coated balloon (DCB) is an established treatment option for in-stent restenosis and small vessel, de novo, coronary artery disease (CAD). Although the use of this tool is increasing in everyday practice, data regarding performance in the treatment of de novo, large vessel CAD (LV-CAD) is still lacking. A systematic review and meta-analysis were conducted to evaluate the efficacy and safety of DCB versus drug-eluting stent (DES) in this setting. METHODS: A comprehensive literature search was performed including Medline, Embase, and Cochrane electronic databases up to January 24, 2024, for studies which compared the efficacy and safety of DCB versus DES in the treatment of de novo lesions in large vessels (≥ 2...
July 3, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38958752/cardio-ankle-vascular-index-and-left-ventricular-mass-as-markers-of-nocturnal-blood-pressure-fall-in-the-general-population
#10
JOURNAL ARTICLE
Cesare Cuspidi, Rita Facchetti, Elisa Gherbesi, Fosca Quarti-Trevano, Raffaella Dell'Oro, Giuseppe Mancia, Guido Grassi
BACKGROUND: Findings regarding the association between Cardio-Ankle Vascular Index (CAVI) and the extent of nocturnal blood pressure (BP) fall in the general population are scanty. We sought to investigate this issue in the participants enrolled in the Pressioni Monitorate E Loro Associazioni (PAMELA) study. METHODS: The study included 491 participants who attended the second and third surveys of the PAMELA study performed after 10 and 25 years from the initial evaluation...
July 3, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38953945/cardiovascular-complications-during-delivery-hospitalizations-in-inflammatory-bowel-disease-patients
#11
JOURNAL ARTICLE
Chengu Niu, Jing Zhang, Kaiwen Zhu, George Agbakoba, Karin Dunnigan, Patrick I Okolo
BACKGROUND: The relationship between inflammatory bowel disease (IBD) and cardiovascular outcomes among pregnant women has yet to be thoroughly investigated. Our aim is to assess the odds of cardiovascular disease and cardiac arrhythmias during hospital admissions for delivery and identify contributing factors associated with cardiovascular complications in pregnant women with IBD. METHODS: We performed a retrospective analysis of data from the National Inpatient Sample, obtained from delivery admissions of pregnant women with and without IBD, identified via International Classification of Diseases codes, from 2009 to 2019...
July 2, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38953944/patients-with-paradoxical-low-flow-low-gradient-aortic-stenosis-gain-the-least-benefit-from-tavi-among-all-hemodynamic-subtypes
#12
JOURNAL ARTICLE
Miriam Puls, Bo Eric Beuthner, Rodi Topci, Christoph Friedemann Jacob, Kristin Elisabeth Steinhaus, Niels Paul, Tim Beißbarth, Karl Toischer, Claudius Jacobshagen, Gerd Hasenfuß
BACKGROUND: Substantial controversy exists regarding the clinical benefit of patients with severe paradoxical low-flow, low-gradient aortic stenosis (PLF-LG AS) from TAVI. Therefore, we compared post-TAVI benefit by long-term mortality (all-cause, CV and SCD), clinical improvement of heart failure symptoms, and cardiac reverse remodelling in guideline-defined AS subtypes. METHODS: We prospectively included 250 consecutive TAVI patients. TTE, 6mwt, MLHFQ, NYHA status and NT-proBNP were recorded at baseline and 6 months...
July 2, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38922425/characterization-of-patients-with-extensive-left-atrial-myopathy-referred-for-atrial-fibrillation-ablation-incidence-predictors-and-outcomes
#13
JOURNAL ARTICLE
Teba González-Ferrero, Marco Bergonti, Lorenzo Marcon, Carlos Minguito-Carazo, Carlos Tilves Bellas, Juan Carlos Pesquera Lorenzo, José Luis Martínez-Sande, Laila González-Melchor, Francisco Javier García-Seara, Jesús Alberto Fernández-López, José Ramón González-Juanatey, Hein Heidbuchel, Andrea Sarkozy, Moisés Rodríguez-Mañero
BACKGROUND: Although atrial fibrosis has a relevant impact on ablation success rate, experimental studies have reported that extensive fibrosis may be accompanied by a reduced burden secondary to a prominent depression of atrial excitability. OBJECTIVES: We aimed to identify clinical and echocardiographic factors associated with extensive left atrial myopathy (ELAM), to analyze the predictive ability of established scores (AF score, APPLE, and DR-FLASH) and assess outcomes in terms of AF recurrence, left atrial flutter, and post-procedural heart failure admissions...
June 26, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38922424/net-burden-in-left-atrial-blood-is-associated-with-biomarkers-of-thrombosis-and-cardiac-injury-in-patients-with-enlarged-left-atria
#14
JOURNAL ARTICLE
Kimberly Martinod, Annika Claessen, Caroline Martens, Krystin Krauel, Leydi Carolina Velásquez Pereira, Jens Witsch, Thilo Witsch
BACKGROUND: Emerging data suggest an association between left atrial (LA) enlargement, thrombus formation, and ischemic stroke. However, it is unknown what may mediate such clot formation in LA dysfunction. Neutrophils promote large vessel occlusion and microthrombosis via neutrophil extracellular trap (NET) release, thus lying at the interface of inflammation, thrombosis, and fibrosis. APPROACH: We conducted a prospective all-comers cohort study in patients undergoing catheterization procedures with atrial transseptal access (MitraClip, MC; left atrial appendage closure, LAAC; pulmonary vein ablation, PVA; patent foramen ovale closure, PFO)...
June 26, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38918204/the-pathophysiological-approach-the-best-for-phenotyping-patients-with-pulmonary-arterial-hypertension-reply
#15
LETTER
Pietro Ameri, Matteo Toma, Davide Stolfo
No abstract text is available yet for this article.
June 25, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38918203/the-pathophysiological-approach-the-best-for-phenotyping-patients-with-pulmonary-arterial-hypertension
#16
LETTER
Giovanna Manzi, Roberto Badagliacca, Domenico Filomena, Michele D'Alto, Carmine Dario Vizza
No abstract text is available yet for this article.
June 25, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38916609/comment-on-glp-1-ra-and-heart-failure-related-outcomes-in-patients-with-and-without-history-of-heart-failure-an-updated-systematic-review-and-meta-analysis
#17
LETTER
Ting Mao
No abstract text is available yet for this article.
June 25, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38916608/reply-to-comment-on-glp-1-ra-and-heart-failure-related-outcomes-in-patients-with-and-without-history-of-heart-failure-an-updated-systematic-review-and-meta-analysis
#18
LETTER
Alessandro Villaschi, Giulio G Stefanini, Mauro Chiarito
No abstract text is available yet for this article.
June 25, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38913172/new-avenues-for-the-assessment-of-stable-ischemic-heart-disease
#19
REVIEW
Peter Ong, Johanna McChord, Valeria Martínez Pereyra, Udo Sechtem, Raffi Bekeredjian, Andreas Seitz
Myocardial ischemia is a complex condition which may result from epicardial and/or microvascular causes involving functional and structural mechanisms. These mechanisms may overlap in a given patient illustrating the difficulties for appropriate management. Assessment of myocardial ischemia can be performed using noninvasive and invasive tools. However, despite living in the era of individualized precision medicine, these tools are not yet used in a broader fashion. Emerging noninvasive techniques such as quantitative perfusion cardiac magnetic resonance imaging (CMR) and stress perfusion computed tomography (CT) or photon-counting CT techniques may contribute to new standards in the assessment of stable angina patients...
June 24, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38913171/influence-of-donor-age-and-donor-recipient-age-difference-on-intimal-hyperplasia-in-pediatric-patients-with-young-and-adult-donors-vs-adult-patients-after-heart-transplantation
#20
JOURNAL ARTICLE
Sarah Ulrich, Leonie Arnold, Sebastian Michel, Anja Tengler, Laura Rosenthal, Jörg Hausleiter, Christoph S Mueller, Brigitte Schnabel, Konstantin Stark, Konstantinos Rizas, Ulrich Grabmaier, Julinda Mehilli, Andre Jakob, Marcus Fischer, Julia Birnbaum, Christian Hagl, Steffen Massberg, Nikolaus Haas, Robert Dalla Pozza, Madeleine Orban
AIM: Optimal selection and allocation of donor hearts is a relevant aspect in transplantation medicine. Donor age and cardiac allograft vasculopathy (CAV) affect post-transplant mortality. To what extent donor age impacts intimal hyperplasia (CAVIH ) in pediatric and adult patients after heart transplantation (HTx) is understudied. METHODS: In a cohort of 98 HTx patients, 58 pediatric (24.1% with adult donors) and 40 adult patients, we assessed the effect of donor age and donor-recipient age difference (D-R) on the continuous parameter of maximal intima thickness (mIT) in optical coherence tomography...
June 24, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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