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Clinical Research in Cardiology: Official Journal of the German Cardiac Society

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https://read.qxmd.com/read/30778669/doxorubicin-treatments-induce-significant-changes-on-the-cardiac-autonomic-nervous-system-in-childhood-acute-lymphoblastic-leukemia-long-term-survivors
#1
Maxime Caru, Denis Corbin, Delphine Périé, Valérie Lemay, Jacques Delfrate, Simon Drouin, Laurence Bertout, Maja Krajinovic, Caroline Laverdière, Gregor Andelfinger, Daniel Sinnett, Daniel Curnier
AIMS: Acute lymphoblastic leukemia (ALL) is one of the leading malignancies in children worldwide. The cardiotoxicity of anti-cancer treatments leads to a dysfunction of the cardiac autonomic nervous system. Protection strategies, with dexrazoxane treatments, were used to counter these adverse effects. The aim of this study was to investigate the effects of the treatments on the cardiac autonomic nervous system. METHODS AND RESULTS: A total of 203 cALL survivors were included in our analyses and were classified into 3 categories based on the prognostic risk group: standard risk, high risk with and without dexrazoxane...
February 18, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30778668/relation-of-lowering-door-to-balloon-time-and-mortality-in-st-segment-elevation-myocardial-infarction-patients-undergoing-percutaneous-coronary-intervention
#2
David Zahler, Keren Lee-Rozenfeld, Dor Ravid, Zach Rozenbaum, Shmuel Banai, Gad Keren, Yacov Shacham
BACKGROUND: Current guidelines for the treatment of ST-segment elevation myocardial infarction (STEMI) recommend a door-to-balloon time (DBT) of ≤ 90 min for patients undergoing primary percutaneous coronary intervention (PCI). We aimed to investigate the possible impact of further reduction in DBT intervals beyond the 90 min cutoff on short and long-term outcomes among STEMI patients undergoing primary PCI. METHODS: We retrospectively studied 889 STEMI patients (median age 61 years, 83% men) who underwent successful primary PCI and had a DBT of ≤ 90 min...
February 18, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30771067/risk-of-cardiac-arrhythmias-after-electrical-accident-a-single-center-study-of-480-patients
#3
David Pilecky, Mate Vamos, Peter Bogyi, Balazs Muk, Dora Stauder, Hajnalka Racz, Noemi Nyolczas, Gabor Z Duray, Gabor Zacher, Endre Zima
OBJECTIVE: Patients with electrical injury are considered to be at high risk of cardiac arrhythmias. Due to the small number of studies, there is no widely accepted guideline regarding the risk assessment and management of arrhythmic complications after electrical accident (EA). Our retrospective observational study was designed to determine the prevalence of ECG abnormalities and cardiac arrhythmias after EA, to evaluate the predictive value of cardiac biomarkers for this condition and to assess in-hospital and 30-day mortality...
February 15, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30771066/uptake-in-antithrombotic-treatment-and-its-association-with-stroke-incidence-in-atrial-fibrillation-insights-from-a-large-german-claims-database
#4
Stefan H Hohnloser, Edin Basic, Michael Nabauer
BACKGROUND: Underuse of oral anticoagulation (OAC) for stroke prevention in atrial fibrillation (AF) results in thousands of preventable strokes in Germany each year. This study aimed to assess changes in antithrombotic therapy in AF patients after increased use of direct oral anticoagulants (DOACs) in Germany and to evaluate whether the adoption of DOAC therapy was associated with changes in AF-related stroke and bleeding over time. METHODS: Analyses were carried out on a large claims-based dataset of 4 million health-insured Germans...
February 15, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30767060/non-invasive-evaluation-of-the-relationship-between-electrical-and-structural-cardiac-abnormalities-in-patients-with-myotonic-dystrophy-type-1
#5
Lukas Chmielewski, Michael Bietenbeck, Alexandru Patrascu, Sabine Rösch, Udo Sechtem, Ali Yilmaz, Anca-Rezeda Florian
BACKGROUND: Cardiac involvement in myotonic dystrophy type 1 (MD1) includes conduction disease, arrhythmias, and left-ventricular (LV) systolic dysfunction leading to an increased sudden cardiac death risk. An understanding of the interplay between electrical and structural myocardial changes could improve the prediction of adverse cardiac events. We aimed to explore the relationship between signs of cardiomyopathy by conventional and advanced cardiovascular magnetic resonance (CMR), and electrical abnormalities in MD1...
February 14, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30767059/proenkephalin-and-prognosis-in-heart-failure-with-preserved-ejection-fraction-a-great-network-study
#6
Prathap Kanagala, Iain B Squire, Donald J L Jones, Thong Huy Cao, Daniel C S Chan, Gerry McCann, Jatinderpal K Sandhu, Paulene A Quinn, John McAdam, Anna-Marie Marsh, Joan E Davies, Joachim Struck, Andreas Bergmann, Zaid Sabti, Raphael Twerenbold, Thomas Herrmann, Nikola Kozhuharov, Christian Mueller, Leong L Ng
BACKGROUND: Proenkephalin (PENK), a stable endogenous opioid biomarker related to renal function, has prognostic utility in acute and chronic heart failure. We investigated the prognostic utility of PENK in heart failure with preserved ejection fraction (HFpEF), and its relationship to renal function, Body Mass Index (BMI), and imaging measures of diastolic dysfunction. METHODS: In this multicentre study, PENK was measured in 522 HFpEF patients (ejection fraction > 50%, 253 male, mean age 76...
February 14, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30767058/graded-murine-wire-induced-aortic-valve-stenosis-model-mimics-human-functional-and-morphological-disease-phenotype
#7
Sven Thomas Niepmann, Eva Steffen, Andreas Zietzer, Matti Adam, Julia Nordsiek, Isabella Gyamfi-Poku, Kerstin Piayda, Jan-Malte Sinning, Stephan Baldus, Malte Kelm, Georg Nickenig, Sebastian Zimmer, Christine Quast
Aortic valve stenosis (AS) is the most common valve disease requiring therapeutic intervention. Even though the incidence of AS has been continuously rising and AS is associated with significant morbidity and mortality, to date, no medical treatments have been identified that can modify disease progression. This unmet medical need is likely attributed to an incomplete understanding of the molecular mechanism driving disease development. To investigate the pathophysiology leading to AS, reliable and reproducible animal models that mimic human pathophysiology are needed...
February 14, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30759274/atrial-high-rate-episodes-in-patients-with-cardiac-implantable-electronic-devices-implications-for-clinical-outcomes
#8
Kazuo Miyazawa, Daniele Pastori, Yan-Guang Li, Orsolya Székely, Farhan Shahid, Giuseppe Boriani, Gregory Y H Lip
BACKGROUND: Atrial high rate episodes (AHREs) detected by cardiac implantable electronic devices (CIEDs) are associated with an increased risk of stroke. However, the impact of AHRE on improving stroke risk stratification scheme remains uncertain. OBJECTIVE: The purpose of this study was to assess the impact of AHRE on prognosis in relation with cardiovascular events and risk stratification. METHODS: A total of 856 consecutive patients who had dual-chamber CIEDs implanted were retrospectively analyzed...
February 13, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30756153/severe-eosinophilic-myocarditis-associated-with-modafinil-in-a-patient-with-normal-peripheral-eosinophil-count
#9
LETTER
Marina Bäuml, Josefina Udi, Karin Klingel, Christoph Bode, Klaus Warnatz, Andreas Zirlik, Daniel Duerschmied, Paul Biever
No abstract text is available yet for this article.
February 12, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30756152/prognostic-impact-of-recurrences-of-ventricular-tachyarrhythmias-and-appropriate-icd-therapies-in-a-high-risk-icd-population
#10
Tobias Schupp, Ibrahim Akin, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Uzair Ansari, Kambis Mashayekhi, Christel Weiß, Christoph Nienaber, Muharrem Akin, Martin Borggrefe, Michael Behnes
PURPOSE: The study sought to evaluate the prognostic impact of recurrences of ventricular tachyarrhythmias in consecutive ICD recipients with ventricular tachyarrhythmias on admission. METHODS: All consecutive patients surviving at least one episode of ventricular tachyarrhythmias from 2002 to 2016 and discharged with an ICD (pre-existing ICD or ICD implantation at index hospitalization) were included. The primary endpoint was all-cause mortality according to the presence or absence of recurrences of ventricular tachyarrhythmias at 5 years...
February 12, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30737532/transcatheter-aortic-valve-replacement-for-pure-aortic-valve-regurgitation-on-label-versus-off-label-use-of-tavr-devices
#11
Bernhard Wernly, Sarah Eder, Eliano P Navarese, Daniel Kretzschmar, Marcus Franz, Brunilda Alushi, Frederik Beckhoff, Christian Jung, Michael Lichtenauer, Christian Datz, Paul Christian Schulze, Ulf Landmesser, Uta C Hoppe, Volkmar Falk, Alexander Lauten
INTRODUCTION: Transcatheter aortic valve replacement (TAVR) has become the mainstay of treatment for aortic stenosis in patients with high surgical risk. Pure aortic regurgitation (PAR) is considered a relative contraindication for TAVR; however, TAVR is increasingly performed in PAR patients with unfavorable risk profile. Herein, we aim to summarize available data on TAVR for PAR with special emphasis on "on-label" versus "off-label" TAVR devices. METHODS AND RESULTS: Pubmed was searched for studies of patients undergoing TAVR for PAR...
February 8, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30737531/association-between-atrial-fibrillation-and-helicobacter-pylori
#12
REVIEW
Cecilia Tetta, Amalia Ioanna Moula, Francesco Matteucci, Orlando Parise, Bart Maesen, Daniel Johnson, Mark La Meir, Sandro Gelsomino
The connection between atrial fibrillation (AF) and H. pylori (HP) infection is still matter of debate. We performed a systematic review and metanalysis of studies reporting the association between AF and HF. A systematic review of all available reports in literature of the incidence of HP infection in AF and comparing this incidence with subjects without AF were analysed. Risk ratio and 95% confidence interval (CI) and risk difference with standard error (SE) were the main statistics indexes. Six retrospective studies including a total of 2921 were included at the end of the selection process...
February 8, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30737530/hemodynamics-of-paradoxical-severe-aortic-stenosis-insight-from-a-pressure-volume-loop-analysis
#13
Michael Gotzmann, Sabine Hauptmann, Maximilian Hogeweg, Dinah S Choudhury, Fabian Schiedat, Johannes W Dietrich, Timm H Westhoff, Martin Bergbauer, Andreas Mügge
BACKGROUND: Controversy exists about the pathophysiology of different hemodynamic subgroups of AS. In particular, the mechanism of the paradoxical low-flow, low-gradient (PLFLG) AS with preserved ejection fraction (EF) is unclear. METHODS: A total of 41 patients with severe, symptomatic AS were divided into the following 4 subgroups based on the echocardiographically determined hemodynamics: (1) normal-flow, high-gradient (NFHG) AS; (2) low-flow, high-gradient AS; (3) paradoxical low-flow, low-gradient (PLFLG) AS with preserved EF and (4) low-flow, low-gradient (LFLG) AS with reduced EF...
February 8, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30737529/percutaneous-closure-of-a-large-atrial-septal-defect-presenting-with-acute-severe-hemolysis
#14
LETTER
Manli Yu, Xinghua Shan, Yuan Bai, Yongwen Qin, Xianxian Zhao
No abstract text is available yet for this article.
February 8, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30737528/retrieval-of-an-embolised-occluder-with-an-alligator-forceps-during-staged-paravalvular-leakage-closure
#15
LETTER
Karsten Lenk, Andreas Hagendorff, Ulrich Laufs, Ingo Dähnert
No abstract text is available yet for this article.
February 8, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30737527/impacts-of-non-recovery-of-trastuzumab-induced-cardiomyopathy-on-clinical-outcomes-in-patients-with-breast-cancer
#16
Hyun Ju Yoon, Kye Hun Kim, Hyung Yoon Kim, Hyukjin Park, Jae Yeong Cho, Young Joon Hong, Hyung Wook Park, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
OBJECTIVES: The impacts of non-recovery of trastuzumab-induced left ventricular dysfunction (LVD) on clinical outcomes in breast cancer have been poorly studied. We investigated the predictors of LV-functional non-recovery and its impacts on clinical outcomes in breast cancer patients with trastuzumab-induced LVD. METHODS AND RESULTS: A total of 243 patients with trastuzumab-induced LVD were divided into the recovered LVD group (n = 195) and non-recovered LVD group (n = 48)...
February 8, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30725172/impact-of-single-visit-american-versus-european-office-blood-pressure-measurement-procedure-on-individual-blood-pressure-classification-a-cross-sectional-study
#17
Annina S Vischer, Thenral Socrates, Clemens Winterhalder, Jens Eckstein, Michael Mayr, Thilo Burkard
OBJECTIVES: Recently, ACC/AHA and ESC/ESH guidelines defined different office blood pressure measurement (OBPM) procedures and ranges. We aimed to describe the effect of the different methods to calculate OBPM on BP classification. METHODS AND RESULTS: Four standardised OBPM were performed in 802 patients within a single visit. BP values were calculated (EUR-/US-BPM) and categorised (EUR-/US-Ranges) according to ACC/AHA and ESC/ESH guidelines. Comparing the BPM procedures, the mean absolute difference of systolic and diastolic BP was 4 (SD ± 5) and 3 (SD ± 3) and a difference ≥ 5 mmHg was found in 35% and 16%, respectively...
February 6, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30725171/haemodynamic-prosthetic-valve-performance-in-patients-with-early-leaflet-thrombosis-after-transcatheter-aortic-valve-implantation
#18
Manuel Hein, Jan Minners, Nikolaus Jander, Philipp Breitbart, Christian Stratz, Gregor Pache, Franz-Josef Neumann, Philipp Ruile
AIMS: We sought to evaluate haemodynamic prosthetic valve performance in patients with early leaflet thrombosis (LT) after transcatheter aortic valve implantation (TAVI). METHOD AND RESULTS: In this retrospective observational study, 59 patients with LT underwent clinical and echocardiographic follow-up. During a median follow-up of 383 days 41 patients received antiplatelet therapy (APT-group) and 18 patients oral anticoagulation due to atrial fibrillation (AC-group)...
February 6, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30712147/left-atrial-anterior-line-ablation-using-ablation-index-and-inter-lesion-distance-measurement
#19
Francesco Santoro, Andreas Metzner, Natale Daniele Brunetti, Christian-H Heeger, Shibu Mathew, Bruno Reissmann, Christine Lemeš, Tilman Maurer, Thomas Fink, Laura Rottner, Osamu Inaba, Karl-Heinz Kuck, Feifan Ouyang, Andreas Rillig
BACKGROUND: Ablation index (AI) is a novel ablation quality marker that incorporates contact force (CF), time and power in a weighted formula to provide accurate information about lesion formation during catheter ablation. This index has been evaluated for pulmonary vein isolation (PVI) but has not been systematically used for other left atrial (LA) procedures so far. The aim of this study is to evaluate the feasibility and efficacy of this index for LA anterior line (AL) ablation (LAALA)...
February 2, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30710262/polyhedral-erythrocytes-in-intracoronary-thrombus-and-their-association-with-reperfusion-in-myocardial-infarction
#20
Jaroslaw Zalewski, Lukasz Lewicki, Krzysztof Krawczyk, Michal Zabczyk, Radoslaw Targonski, Patrycja Molek, Jadwiga Nessler, Anetta Undas
OBJECTIVE: The tightly packed arrays of polyhedral erythrocytes, polyhedrocytes, formed during thrombus contraction, have been detected in some intracoronary thrombi (ICT) obtained from patients with ST-segment elevation myocardial infarction (STEMI). We sought to investigate determinants of polyhedrocyte content in ICT and its association with reperfusion in STEMI. METHODS: We assessed the composition of ICT obtained during thrombectomy within 12 h since the symptom onset in 110 STEMI patients, following 300 mg of aspirin (n = 110) and 600 mg of clopidogrel (n = 75)...
February 1, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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