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International Journal of Nanomedicine

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https://read.qxmd.com/read/30992665/multiple-cargo-deliveries-of-growth-factors-and-antimicrobial-peptide-using-biodegradable-nanopolymer-as-a-potential-wound-healing-system
#1
Amritha Vijayan, Pinky Prabha James, C K Nanditha, G S Vinod Kumar
Background: Treatment of wounds with the help of nanoparticles (NPs) is more effective and superior in comparison to traditional wound healing methods as it protects and sustains active drug release at the wound site thus enhancing the safety of the drug and reducing the possibility of side effects. The advantages of this method are the possibility of allowing a reduction in administered dose, limiting toxicity levels to the minimum, and increasing safety of topical delivery of the drug...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30992664/biomimetic-hydroxyapatite-nanocrystals-are-an-active-carrier-for-salmonella-bacteriophages
#2
Andrea Fulgione, Flora Ianniello, Marina Papaianni, Felice Contaldi, Tiziana Sgamma, Cinzia Giannini, Stella Pastore, Raffaele Velotta, Bartolomeo Della Ventura, Norberto Roveri, Marco Lelli, Federico Capuano, Rosanna Capparelli
Purpose: The use of bacteriophages represents a valid alternative to conventional antimicrobial treatments, overcoming the widespread bacterial antibiotic resistance phenomenon. In this work, we evaluated whether biomimetic hydroxyapatite (HA) nanocrystals are able to enhance some properties of bacteriophages. The final goal of this study was to demonstrate that biomimetic HA nanocrystals can be used for bacteriophage delivery in the context of bacterial infections, and contribute - at the same time - to enhance some of the biological properties of the same bacteriophages such as stability, preservation, antimicrobial activity, and so on...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30992663/superparamagnetic-iron-oxide-nanoparticles-combined-with-ngf-and-quercetin-promote-neuronal-branching-morphogenesis-of-pc12-cells
#3
Samira Katebi, Abolghasem Esmaeili, Kamran Ghaedi, Ali Zarrabi
Background: The investigation of agents promoting recovery of nerve regeneration following neurodegenerative diseases has been the most important issue in neuroscience. Nerve growth factor (NGF) and quercetin as potential flavonoids could possibly have therapeutic applications in the field of degenerative diseases such as Parkinson and Alzheimer. Materials and methods: The MTT assay was done at 24, 48, and 72 hours to examine the cytotoxicity of superparamagnetic iron oxide nanoparticles (SPIONs) and quercetin...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988617/psoralen-loaded-lipid-polymer-hybrid-nanoparticles-enhance-doxorubicin-efficacy-in-multidrug-resistant-hepg2-cells
#4
Yueling Yuan, Tiange Cai, Richard Callaghan, Qianwen Li, Yinghong Huang, Bingyue Wang, Qingqing Huang, Manling Du, Qianqian Ma, Peter Chiba, Yu Cai
Background: Psoralen (PSO), a major active component of Psoralea corylifolia, has been shown to overcome multidrug resistance in cancer. A drug carrier comprising a lipid-monolayer shell and a biodegradable polymer core for sustained delivery and improved efficacy of drug have exhibited great potential in efficient treatment of cancers. Methods: The PSO-loaded lipid polymer hybrid nanoparticles were prepared and characterized. In vitro cytotoxicity assay, cellular uptake, cell cycle analysis, detection of ROS level and mitochondrial membrane potential (ΔΨm) and western blot were performed...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988616/in-vitro-comparison-of-liposomal-drug-delivery-systems-targeting-the-oxytocin-receptor-a-potential-novel-treatment-for-obstetric-complications
#5
Susan Hua, Benjamin Vaughan
Introduction: Targeted intervention to the uterus has great potential for the treatment of obstetric complications (eg, preterm birth, dysfunctional labor, and postpartum hemorrhage) by improving the effectiveness and safety of therapeutic compounds. In particular, targeting the oxytocin receptor (OTR) is a novel approach for drug delivery to the uterus. The aim of this study was to report the complete data set for the pharmaceutical synthesis and in vitro characterization of PEGylated liposomes conjugated with anti-OTR monoclonal antibodies (OTR-Lipo) or atosiban (ATO-Lipo, OTR antagonist)...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988615/starch-mediated-synthesis-of-mono-and-bimetallic-silver-gold-nanoparticles-as-antimicrobial-and-anticancer-agents
#6
Diana Lomelí-Marroquín, David Medina Cruz, Alfonso Nieto-Argüello, Ada Vernet Crua, Junjiang Chen, Alejandro Torres-Castro, Thomas J Webster, Jorge L Cholula-Díaz
Background and aim: Bimetallic silver/gold nanosystems are expected to significantly improve therapeutic efficacy compared to their monometallic counterparts by maintaining the general biocompatibility of gold nanoparticles (AuNPs) while, at the same time, decreasing the relatively high toxicity of silver nanoparticles (AgNPs) toward healthy human cells. Thus, the aim of this research was to establish a highly reproducible one-pot green synthesis of colloidal AuNPs and bimetallic Ag/Au alloy nanoparticles (NPs; Ag/AuNPs) using starch as reducing and capping agent...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988614/dibc-a-nanochelating-based-nano-metal-organic-framework-shows-anti-diabetic-effects-in-high-fat-diet-and-streptozotocin-induced-diabetic-rats
#7
Saideh Fakharzadeh, Somayeh Kalanaky, Maryam Hafizi, Mohammad Hassan Nazaran, Homeira Zardooz
Aims: Despite daily increase in diabetic patients in the world, currently approved medications for this disease, at best, only reduce its progression speed. Using novel technologies is a solution for synthetizing more efficient medicines. In the present study, we evaluated anti-diabetic effects of DIBc, a nano metal-organic framework, which is synthetized based on nanochelating technology. Methods: High-fat diet and streptozotocin-induced diabetic rats were treated by DIBc or metformin for 6 weeks...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988613/electrospun-polycaprolactone-collagen-nanofibers-cross-linked-with-1-ethyl-3-3-dimethylaminopropyl-carbodiimide-n-hydroxysuccinimide-and-genipin-facilitate-endothelial-cell-regeneration-and-may-be-a-promising-candidate-for-vascular-scaffolds
#8
Dian Chen, Tonghe Zhu, Wei Fu, Haibo Zhang
Purpose: A promising vascular scaffold must possess satisfying mechanical properties, great hemocompatibility, and favorable tissue regeneration. Combining natural with synthetic materials is a popular method of creating/enhancing such scaffolds. However, the effect of additional modification on the materials requires further exploration. Materials and methods: We selected polycaprolactone (PCL), which has excellent mechanical properties and biocompatibility and can be combined with collagen...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988612/one-step-mechanochemical-preparation-and-prominent-antitumor-activity-of-sn-38-self-micelle-solid-dispersion
#9
Xuanrong Sun, Dabu Zhu, Yue Cai, Guobang Shi, Mengshi Gao, Minzi Zheng
Purpose: The purpose of this study was to overcome the clinical defects of 7-ethyl-10-hydroxycamptothecin (SN-38) and explore its characteristics and antitumor effects. Materials and methods: An amorphous solid dispersion of SN-38 with disodium glycyrrhizin (Na2 GA) was prepared by mechanical ball milling (Na2 GA/SN-38-BM). Moreover, an untreated mixture of Na2 GA and SN-38 (Na2 GA/SN-38-UM), a pure drug SN-38, was prepared for comparison with Na2 GA/SN-38-BM. The samples were characterized by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), dynamic light scattering, and transmission electron microscopy...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988611/structural-switching-electrochemical-dna-aptasensor-for-the-rapid-diagnosis-of-tuberculous-meningitis
#10
Ritu Das, Abhijeet Dhiman, Subodh Kumar Mishra, Sagarika Haldar, Neera Sharma, Anjali Bansal, Yusra Ahmad, Amit Kumar, Jaya Sivaswami Tyagi, Tarun Kumar Sharma
Background: Tuberculous meningitis (TBM) is the most devastating manifestation of extra-pulmonary tuberculosis. About 33% of TBM patients die due to very late diagnosis of the disease. Conventional diagnostic methods based on signs and symptoms, cerebrospinal fluid (CSF) smear microscopy or liquid culture suffer from either poor sensitivity or long turnaround time (up to 8 weeks). Therefore, in order to manage the disease efficiently, there is an urgent and unmet need for a rapid and reliable diagnostic test...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988610/di-o-lauroyl-decitabine-lipid-nanocapsules-toward-extending-decitabine-activity
#11
Thomas Briot, Emilie Roger, Naila Bou Haidar, Jerome Bejaud, Nolwenn Lautram, Catherine Guillet, Sylvain Thépot, Samuel Legeay, Frederic Lagarce
Background: Acute myeloid leukemia mainly affects adult patients. Complete remission for patients younger than 60 years, who are candidates for standard induction therapy, is achieved in 60%-80% of cases. However, the prognosis is still poor for older patients, who are unfit for intensive chemotherapy, and only a few therapies are available. Hypomethylating agents, such as decitabine, are approved for such patients. The current dosing regimen consists of one administration per day, for 5 days, each 4 weeks...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988609/liposomes-targeted-to-mhc-restricted-antigen-improve-drug-delivery-and-antimelanoma-response
#12
Mesha Saeed, Sara Zalba, Ann L B Seynhaeve, Reno Debets, Timo L M Ten Hagen
Purpose: Melanoma is the most aggressive form of skin cancer. Chemotherapy at a late stage fails due to low accumulation in tumors, indicating the need for targeted therapy. Materials and methods: To increase drug uptake by tumor cells, we have targeted doxorubicin-containing liposomes using a T-cell receptor (TCR)-like antibody (scFv G8 and Hyb3) directed against melanoma antigen A1 (MAGE-A1) presented by human leukocyte antigen A1 (M1/A1). With the use of flow cytometry and confocal microscopy, we have tested our formulation in vitro...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30988608/plasma-protein-adsorption-on-fe-3-o-4-peg-nanoparticles-activates-the-complement-system-and-induces-an-inflammatory-response
#13
V Escamilla-Rivera, A Solorio-Rodríguez, M Uribe-Ramírez, O Lozano, S Lucas, A Chagolla-López, R Winkler, A De Vizcaya-Ruiz
Background: Understanding of iron oxide nanoparticles (IONP) interaction with the body milieu is crucial to guarantee their efficiency and biocompatibility in nanomedicine. Polymer coating to IONP, with polyethyleneglycol (PEG) and polyvinylpyrrolidone (PVP), is an accepted strategy to prevent toxicity and excessive protein binding. Aim: The aim of this study was to investigate the feature of IONP adsorption of complement proteins, their activation and consequent inflammatory response as a strategy to further elucidate their biocompatibility...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30962686/traditional-chinese-medicine-combination-therapies-utilizing-nanotechnology-based-targeted-delivery-systems-a-new-strategy-for-antitumor-treatment
#14
REVIEW
Zhe Ma, Yuqi Fan, Yumei Wu, Dereje Kebebe, Bing Zhang, Peng Lu, Jiaxin Pi, Zhidong Liu
Cancer is a major public health problem, and is now the world's leading cause of death. Traditional Chinese medicine (TCM)-combination therapy is a new treatment approach and a vital therapeutic strategy for cancer, as it exhibits promising antitumor potential. Nano-targeted drug-delivery systems have remarkable advantages and allow the development of TCM-combination therapies by systematically controlling drug release and delivering drugs to solid tumors. In this review, the anticancer activity of TCM compounds is introduced...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30962685/osteochondral-repair-using-scaffolds-with-gradient-pore-sizes-constructed-with-silk-fibroin-chitosan-and-nano-hydroxyapatite
#15
Hongli Xiao, Wenliang Huang, Kun Xiong, Shiqiang Ruan, Cheng Yuan, Gang Mo, Renyuan Tian, Sirui Zhou, Rongfeng She, Peng Ye, Bin Liu, Jiang Deng
Background: One of the main problems associated with the development of osteochondral reparative materials is that the accurate imitation of the structure of the natural osteochondral tissue and fabrication of a suitable scaffold material for osteochondral repair are difficult. The long-term outcomes of single- or bilayered scaffolds are often unsatisfactory because of the absence of a progressive osteochondral structure. Therefore, only scaffolds with gradient pore sizes are suitable for osteochondral repair to achieve better proliferation and differentiation of the stem cells into osteochondral tissues to complete the repair of defects...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30962684/ph-sensitive-doxorubicin-loaded-polymeric-nanocomplex-based-on-%C3%AE-cyclodextrin-for-liver-cancer-targeted-therapy
#16
Tianfeng Yang, Guowen Du, Yuxin Cui, Runze Yu, Chen Hua, Wei Tian, Yanmin Zhang
Background: Doxorubicin (DOX) is one of the most effective treatments for hepatocellular carcinoma (HCC), but is restricted by its poor pharmacokinetics. Herein, we exploited efficient targeted drug delivery systems and they have been found to be a worthy strategy for liver cancer therapy. Materials and methods: We investigated polymeric nanoparticles which were synthesized based on host-guest interaction between β-cyclodextrin and benzimidazole. The properties of nanoparticles with regard to size/shape, encapsulation efficiency, and drug release were investigated using conventional experiments...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30936698/intraperitoneal-delivery-of-acetate-encapsulated-liposomal-nanoparticles-for-neuroprotection-of-the-penumbra-in-a-rat-model-of-ischemic-stroke
#17
Po-Wah So, Antigoni Ekonomou, Kim Galley, Leigh Brody, Meliz Sahuri-Arisoylu, Ivan Rattray, Diana Cash, Jimmy D Bell
Background: Ischemic stroke is a devastating condition, with metabolic derangement and persistent inflammation enhancing the initial insult of ischaemia. Recombinant tissue plasminogen remains the only effective treatment but limited as therapy must commence soon after the onset of symptoms. Purpose: We investigated whether acetate, which modulates many pathways including inflammation, may attenuate brain injury in stroke. As acetate has a short blood half-life and high amounts irritate the gastrointestinal tract, acetate was administered encapsulated in a liposomal nanoparticle (liposomal-encapsulated acetate, LITA)...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30936697/biosynthesis-characterization-and-anticancer-effect-of-plant-mediated-silver-nanoparticles-using-coptis-chinensis
#18
Junwen Pei, Binfan Fu, Lifeng Jiang, Taizhen Sun
Background: Tremendous growth in nanotechnology has opened up new frontiers in fundamental and applied aspects, including the synthesis of nanoscale matter and understanding/utilizing its exotic physicochemical and optoelectronic properties. Green-synthesis methods employing either biological microorganisms or plant extracts have emerged as a simple and alternative to chemical synthesis. Methods: In our present study, we aimed to synthesize silver nanoparticles (AgNPs) in combination with an aqueous extract of Coptis chinensis (CC) using a suitable ecofriendly green-synthesis way...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30936696/use-of-transethosomes-for-enhancing-the-transdermal-delivery-of-olmesartan-medoxomil-in-vitro-ex-vivo-and-in-vivo-evaluation
#19
Rofida Albash, Aly A Abdelbary, Hanan Refai, Mohamed A El-Nabarawi
Introduction and aim: Olmesartan medoxomil (OLM) is an antihypertensive drug with low oral bioavailability due to extensive first-pass metabolism. This study aimed to prepare transetho somes (TEs) for enhancing the transdermal delivery of OLM to avoid its oral problems. Methods: TE formulae were prepared utilizing 51.31 full factorial design using various surfactants (SAAs) and different phospholipid-to-SAA ratios. The formulae were characterized regarding their entrapment efficiency percentage (EE%), particle size (PS), polydispersity index (PDI), zeta potential (ZP), and the amount of drug released after 6 hours (Q6h)...
2019: International Journal of Nanomedicine
https://read.qxmd.com/read/30936695/lipid-polymer-hybrid-nanoparticles-as-a-next-generation-drug-delivery-platform-state-of-the-art-emerging-technologies-and-perspectives
#20
REVIEW
Anubhab Mukherjee, Ariana K Waters, Pranav Kalyan, Achal Singh Achrol, Santosh Kesari, Venkata Mahidhar Yenugonda
Lipid-polymer hybrid nanoparticles (LPHNPs) are next-generation core-shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids...
2019: International Journal of Nanomedicine
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