Ahmed H Al-Jedai, Hajer Y Almudaiheem, Ibrahim A Al-Homood, Ibrahim Almaghlouth, Sami M Bahlas, Abdulaziz Mohammed Alolaiw, Mohammad Fatani, Maysa Tariq Eshmawi, Bedor A AlOmari, Khalidah Ahmed Alenzi, Rayan G Albarakat, Nayef Al Ghanim
OBJECTIVE: To provide evidence-based clinical practice recommendations for managing Systemic Lupus Erythematosus (SLE) in Saudi Arabia. METHODS: This EULAR-adapted national guideline in which a multidisciplinary task force utilized the modified Delphi method to develop 31 clinical key questions. A systematic literature review was conducted to update the evidence since the EULAR publication. After reaching a consensus agreement, two rounds of voting and group discussion were conducted to generate consolidated recommendations/statements...
April 30, 2024: Current Rheumatology Reviews
Niloofar Shashaani, Mehrnoush Hasas Yeganeh, Reza Sinaei, Shima Salehi, Reza Shiari
BACKGROUND: Mixed Connective Tissue Disease (MCTD) is a rare condition in children, characterized by a high titer of anti-ribonucleoprotein-U1 (anti-U1 RNP) antibodies, often presenting with overlapping features of two or more rheumatologic disorders, including juvenile idiopathic arthritis (JIA), systemic lupus erythematous (SLE), systemic sclerosis (SSc), and juvenile dermatomyositis/polymyositis (JDM/PM). CASE PRESENTATION: We report the case of an 8-year-old girl with a history of fever, hair loss, lower extremities edema, weakness, oral aphthous ulcers, and a high titer of anti-U1 RNP antibodies, which is consistent with the diagnosis of MCTD...
April 25, 2024: Current Rheumatology Reviews
Vishnu Mittal, Ashima Barak, Anjali Sharma, Abhinav Singhal
Rheumatoid Arthritis (RA) is an inflammatory disease that causes severe joint destruction and persistent inflammation. This review aims to evaluate the efficacy, safety, and mechanisms of action of various herbal interventions in managing RA, providing valuable insights for patients and healthcare practitioners. To investigate the anti-inflammatory and antioxidant properties of selected herbal interventions, including turmeric, ginger, Boswellia serrata (frankincense), green tea, and Ashwagandha, to assess their potential as complementary treatments for RA, a comprehensive analysis is performed on the anti-inflammatory mechanisms and antioxidant effects of selected herbs...
April 25, 2024: Current Rheumatology Reviews
Laxmi Rani, Pooja Mathur, Ravinder Verma, Vivek Kumar, Ashwini Kumar Mishra, Pravat Kumar Sahoo
Rheumatoid arthritis is a systemic autoimmune disorder related to joint inflammation, bone erosion, and deformity. Numerous studies indicate that the causes and consequences of RA are still being debated, and therapeutic strategies are in the translation stage. Non-steroidal anti-inflammatory drugs continue to be often used to relieve pain. Still, due to their poor efficacy, failure to halt the spread of the disease, and undesirable adverse effects, they are no longer regarded as first-line treatments. The development of biologic DMRDs designed to reduce the inflammatory response led to substantial changes to the strategy for managing this disease...
April 15, 2024: Current Rheumatology Reviews
Sukanya Vijayan, Thirumal Margesan
Obesity is a growing global health crisis intricately connected to various chronic conditions, including arthritis. This paper explores the intricate web of hormonal changes in the context of obesity and their profound influence on the development and progression of arthritis. Hormones, such as leptin, insulin, cortisol, and estrogen, all altered in obesity, play pivotal roles in inflammation, cartilage degradation, mechanical stress, and pain associated with obesity-related arthritis. Additionally, the mechanical stress placed on weight-bearing joints by excess body weight accelerates joint wear and tear, contributing to arthritis...
April 15, 2024: Current Rheumatology Reviews
Shikha Chaudhary, Shaweta Sharma, Shivkanya Fuloria
Arthritis is a chronic inflammatory condition that affects millions of individuals worldwide. The conventional treatment options for arthritis often come with limitations and potential side effects, leading to increased interest in herbal plants as alternative therapies. This article provides a comprehensive overview of the use of herbal plants in arthritis treatment, focusing on their traditional remedies, active components, mechanisms of action, and pharmaceutical approaches for enhancing their delivery. Various herbal plants, including turmeric, ginger, Boswellia, and willow bark, have shown anti-inflammatory and analgesic properties, making them valuable options for managing arthritis symptoms...
April 5, 2024: Current Rheumatology Reviews
Komal Rao, Shalini Kumari, Neha Minocha
BACKGROUND: Osteoarthritis (OA) is becoming a major medical burden worldwide due to changing lifestyles and aging populations. Osteoarthritis is a disease characterized by a variety of anatomic and physiological changes to joints, including cartilage degradation, bone remodeling, and the formation of osteophytes. These changes cause pain, stiffness, swelling, and limitations in joint function. Glucosamine serves as a fundamental constituent for cartilage, the resilient connective tissue responsible for cushioning joints...
April 3, 2024: Current Rheumatology Reviews
Mehwish Nawaz Qaisrani, Kulsoom Farhat, Mudassir Noor
Rheumatoid arthritis is a crippling autoimmune disease affecting more than 18 million people worldwide and thus becoming one of the important contributors to the global health burden. The majority of the affected are females, especially those above the age of 50, but males and younger adults are equally vulnerable. It is a constellation of genetic and environmental factors that interplay to manifest the joint deformities and disabilities that are the hallmarks of this disease. Painkillers are used alongside disease-modifying anti-rheumatic drugs to minimize the patient's agony and also to halt the progression of the disease...
April 2, 2024: Current Rheumatology Reviews
Georges El Hasbani, Zi Ying Li, Joanne Szczygiel Cunha
No abstract text is available yet for this article.
March 28, 2024: Current Rheumatology Reviews
Georges El Hasbani, Joseph E Nassar, Imad Uthman, Ali Sm Jawad
No abstract text is available yet for this article.
March 21, 2024: Current Rheumatology Reviews
Nisha Choudhary, Neeraj Sharma
Rheumatoid arthritis (RA) is an autoimmune disorder where inflammation and destruc-tion of bone are the hallmarks of the disease. This review focuses on the etiology, pathophysiolo-gy, and treatment strategies for RA, along with the different approaches used for the synthesis of pyrazoles, the characterization of various properties, and their biological significance for curing RA. The activated immune system of the body causes inflammation of the synovial joint due to the interaction of immune cells, such as T and B lymphocytes, macrophages, plasma cells, den-dritic cells and mast cells...
March 5, 2024: Current Rheumatology Reviews
Vani, Priyanka Kriplani, Ashwani Dhingra, Bhawna Chopra, Ajmer Singh Grewal, Geeta Deswal, Rameshwar Dass, Kumar Guarve
BACKGROUND: A Liposomal delivery system is a novel and distinguishing way of organized medicine administration. The advancements in liposomal technology allow for controlled drug distribution to treat rheumatoid arthritis effectively. Liposomes are microscopic lipid-based vesicles that have shown promise in transporting substances, such as superoxide dismutase, hemoglobin, erythrocyte interleukin-2, gamma interferon, and smaller compounds. OBJECTIVE: Liposomes are biocompatible, nontoxic, biodegradable, non-immunogenic, and flexible, with sizes ranging from 0...
March 4, 2024: Current Rheumatology Reviews
Sofia Audrey Gonzales, Kiana Mortezaei, Daniel Arkfeld
INTRODUCTION/BACKGROUND: Devic's syndrome is a rare autoimmune disorder that occurs when the body's immune system damages and mistakenly attacks the optic nerves and the spinal cord, leading to numerous neurological. Symptoms, such as inflammation, weakness, numbness, and vision problems. Rituximab has mainly been utilized as an immunosuppressive therapy for patients with Devic's syndrome. Although evidence has shown that rituximab is efficient and well tolerated in treating patients with Devic's syndrome, there is the possibility of rituximab exacerbating severe psoriasis and psoriatic arthritis flare...
February 29, 2024: Current Rheumatology Reviews
Anna M Sukhanova, Mariam A Gilavian, Elizaveta V Melnik, Evgenia V Shikh, Alexey E Petukhov, Vladimir I Gegechkori, Sergey P Dementev, Alexander M Vlasov, Galina V Ramenskaya
BACKGROUND: Ankylosing spondylitis (AS) is a chronic inflammatory disease known for causing pain, stiffness, and reduced mobility in the axial skeleton. Adalimumab, a tumor necrosis factor (TNF) inhibitor, has emerged as a promising therapeutic option for AS. METHODS: This systematic review involved a comprehensive search of randomized controlled trials related to AS treatment, conducted in major databases such as MEDLINE, Google Scholar, and PubMed. The search terms encompassed ankylosing spondylitis, adalimumab, methotrexate, other non-biologic DMARDs, glucocorticoids, NSAIDs, and analgesics...
February 26, 2024: Current Rheumatology Reviews
Ashaq Parrey, Manzoor Koka, Mohd Ismail
BACKGROUND: Inflammatory markers are crucial in diagnosing and monitoring rheumatoid arthritis. Patients with rheumatoid arthritis (RA) live with constant pain that limits their daily activities. Our study highlights the effects of disease activity on the quality of life in patients with rheumatoid arthritis. METHODS: Swollen joint count (SJC), tender joint count (TJC), and visual activity scale (VAS) were utilized to acquire patients' subjective feelings of wellness and their performance of routine daily activities to determine the disease activity...
February 19, 2024: Current Rheumatology Reviews
Wilder Carvajal-Gutiérrez, María A Cisneros-Cisneros, Omar-Javier Calixto, Maria-Alejandra Meneses-Toro, Andrés Jesús Prada Rueda, Merardo A Vega-Báez, Duván A Álvarez-Vargas, Adriana C Uscátegui-Ruiz, Consuelo Romero-Sanchez, Juan-Manuel Bello-Gualtero
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease. It has been identified that non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids can be essential risk factors for developing complications such as upper gastrointestinal bleeding (UGIB). OBJECTIVE: This study aimed to describe the safety profile of drugs used to treat RA focused in UGIB. METHODS: A cross-sectional study of patients with RA between 2015 and 2021, a description of the population, and an evaluation of the relationship with UGIB through bivariate analysis and logistic regression...
February 15, 2024: Current Rheumatology Reviews
Xie Hong-Yuan, Tang Yi-Ping, Yi Ting, Liao Xia, Dai Fei, Zhang Quan-Bo, Qing Yu-Feng
BACKGROUND: Ankylosing spondylitis (AS) is an autoimmune disease that has the characteristics of difficult early diagnosis and a high disability rate. OBJECTIVE: The objective of this study was to further explore the possible mechanism and potential function of lncRNA in AS. METHODS: We used lncRNA microarray technology to detect the expression of lncRNA and mRNA in patients with active AS, stable patients, and healthy controls (HC). Afterward, bioinformatics analysis was conducted on differentially expressed genes...
February 7, 2024: Current Rheumatology Reviews
Cesarius Singgih Wahono, Hani Susianti, Arif Luqman Hakim, Firdha Rosita, Mirza Zaka Pratama, Perdana Aditya Rahman, Muhammad Anshory
BACKGROUND: Curcumin-piperine might synergise with vitamin D to induce clinical remission in patients with systemic lupus erythematosus (SLE). OBJECTIVE: To observe the improvement of patients with SLE clinically and the levels of inflammatory cytokines after receiving supplements of curcumin-piperine and cholecalciferol (Vitamin D3). METHODS: Forty-five female SLE patients were included in a three-month double-blind, randomized controlled trial...
January 31, 2024: Current Rheumatology Reviews
Mervat Behiry, Mary Wadie, Nagwa Abdelghaffar Mohamed, Rania Farid, Hala Ramadan
INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic idiopathic systemic autoimmune disorder with dysregulation of adaptive and innate immune systems. Interleukin (IL)-17 is the prototypical pro-inflammatory cytokine of T helper 17 (Th17) cells. Therefore, it contributes to the pathogenesis of human SLE. AIM: The aim of the research paper was the evaluation of IL-17 level as a biomarker in the SLE cohort and its relation to disease activity and analysis of IL-17 concentration in patients with lupus nephritis and non-lupus nephritis...
January 30, 2024: Current Rheumatology Reviews
Amit Sahu, Sunny Rathee, Sanjay Kumar Jain, Umesh Kumar Patil
BACKGROUND: Guggulipid, an oleo-gum resin extracted from the bark of Commiphora wightii of the Burseraceae family, holds a significant place in Ayurvedic medicine due to its historical use in treating various disorders, including inflammation, gout, rheumatism, obesity, and lipid metabolism imbalances. OBJECTIVE: This comprehensive review aims to elucidate the molecular targets of guggulipids and explore their cellular responses. Furthermore, it summarizes the findings from in-vitro, in-vivo, and clinical investigations related to arthritis and various inflammatory conditions...
January 25, 2024: Current Rheumatology Reviews
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