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Archives of Medical Science: AMS

Pratishtha Mehra, Vimal Mehta, Rishi Sukhija, Anjan K Sinha, Mohit Gupta, M P Girish, Wilbert S Aronow
No abstract text is available yet for this article.
January 2019: Archives of Medical Science: AMS
Xuecan Zhu, Pei Zhao, Yonggang Lu, Lijing Huo, Mingchen Bai, Fang Yu, Yanqing Tie
Introduction: Exposure to the fine particulate matter PM2.5 is strongly associated with atherosclerotic diseases, creating considerable public concern. Nevertheless, the mechanisms have not been fully elucidated. We exposed atherosclerosis-prone apoE-deficient mice to PM2.5 to begin investigating these mechanisms. Material and methods: Thirty-two 8-week-old male apoE-/- mice were divided to two groups fed with high-fat diet: a control group instilled with 0.9% saline, and an experimental group instilled with PM2...
January 2019: Archives of Medical Science: AMS
Suseela Yelumalai, Nelli Giribabu, Kamarulzaman Karim, Siti Zawiah Omar, Naguib Bin Salleh
Introduction: Diabetes mellitus (DM) has been associated with sperm damage. In view of the fact that quercetin possesses antioxidant and anti-inflammatory activities, this compound may help to protect sperm against damage in DM. In this study, in-vivo effects of quercetin on sperm parameters in DM were investigated. Material and methods: Quercetin (10, 25 and 50 mg/kg/b.w.) was given orally to streptozotocin-nicotinamide induced adult male diabetic rats for 28 days...
January 2019: Archives of Medical Science: AMS
Serdar Turkyilmaz, Arif Burak Cekic, Arif Usta, Etem Alhan, Birgül Vanizor Kural, Cengiz Ercin, Kutay Sağlam
Introduction: Ethyl pyruvate (EP), a natural flavoring and fragrance agent, has been shown to exert anti-inflammatory and antioxidant actions. We tested the potential beneficial effects of EP in a rat model of acute necrotizing pancreatitis (ANP), a serious condition with a significant inflammatory explosion and oxidative stress. Material and methods: Fifty-two adult male Sprague-Dawley rats were divided into four groups: sham + saline, sham + EP, ANP + saline, and ANP + EP...
January 2019: Archives of Medical Science: AMS
Mohd Fahami Nur Azlina, Hj Mohd Saad Qodriyah, Muhamad Nurul Akmal, Ibrahim Abdel Aziz Ibrahim, Yusof Kamisah
Introduction: Piper sarmentosum (Piperaceae) is traditionally used by Asians to treat numerous common ailments including asthma, fever and gastritis. The aim of the research was to determine and compare the effects of Piper sarmentosum (PS) with omeprazole (OMZ) on gastric parameters in rats exposed to restraint stress. Material and methods: The methanolic extract of PS was prepared in the dose of 500 mg/kg. Twenty-eight male Wistar rats were assigned to 4 equal sized groups: two control groups and two treated groups which were supplemented with either PS or OMZ orally at a dose of 500 mg/kg and 20 mg/kg body weight respectively...
January 2019: Archives of Medical Science: AMS
Zheng Zhang, Beili Wang, Aihua Fei
Introduction: Exercise training is a coadjuvant therapy in preventive cardiology, and it delays cardiac dysfunction and exercise intolerance in heart failure (HF). However, the mechanisms underlying muscle function improvement and cardioprotection are poorly understood. In this study, we tested whether exercise training would counteract skeletal muscle atrophy via activation of the BDNF pathway in myocardial infarction (MI)-induced HF mice. Material and methods: A cohort of male Sham-operated and MI mice were assigned into 8-week moderate exercise training, and untrained counterparters were used as control...
January 2019: Archives of Medical Science: AMS
Yunjuan Bai, Yun Chen, Xiaochen Chen, Jiukun Jiang, Xiao Wang, Liping Wang, Jigang Wang, Jianbin Zhang, Liang Gao
Introduction: Histone deacetylase inhibitors (HDACIs) inhibit human osteosarcoma growth and cause apoptosis. Previously, we reported that HDACIs induce autophagy via the FOXO1 pathway. Whether there is involvement of autophagy in anti-osteosarcoma activity of HDACIs is still unknown. Material and methods: Confocal microscopy was performed to determine the formation of GFP-LC3 puncta. Western blotting was conducted to measure FOXO1, and autophagy-related protein levels...
January 2019: Archives of Medical Science: AMS
Jian Cheng, Haohao Wang, Zhida Zhang, Keyong Liang
Introduction: Oxidative stress is currently proposed as a risk factor associated with the development and progression of osteoporosis. Here, the effect of 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glycoside (THSG) on oxidative damage was investigated in an osteoblast-like MC3T3-E1 cell model. Material and methods: In this study, MC3T3-E1 cells were treated with hydrogen peroxide (H2 O2 ) (100 µM) and THSG (20, 50 and 100 μM), and alkaline phosphatase (ALP). ROS and MDA levels were measured using specific kits...
January 2019: Archives of Medical Science: AMS
Ayşegül Uğur Kurtoğllu, Belkıs Koçtekin, Erdal Kurtoğlu, Mustafa Yildiz
Introduction: Hemolysis due to ineffective erythropoiesis is a serious problem β-thalassemia major (β-TM) patients. The role of complement system in the etiopathogenesis of hemolysis observed in β-TM were released. Hemolysis induced by activation of complement system is prevented by complement regulatory proteins. Decay accelerating factor (CD55), membrane inhibitor of reactive lysis (CD59), and complement reception 1 (CR1, CD35) are among these proteins. The absence of these proteins thus accounts for the increased susceptibility of erythrocytes to complement lysis...
January 2019: Archives of Medical Science: AMS
Jiyun Li, Guimei Wu, Yanmin Cao, Zhi Hou
Introduction: This study aimed to explore the bio-function of miR-210 in the pathogenesis of pre-eclampsia and provide new insights into the diagnosis and treatment of pre-eclampsia. Material and methods: A JAR cell line cultured in standard or hypoxic conditions was used in this study. Expression levels of miR-210 and PTPN2 were determined using real-time polymerase chain reaction (RT-PCR). Protein and phosphorylation levels were assessed using western blotting...
January 2019: Archives of Medical Science: AMS
Zhen Zhang, Yun Feng, Zhen-Yu Li, Xiao-Zhong Cao
Introduction: Glycyrrhizinic acid is a natural product of pharmacological relevance and its anticancer activity against breast cancer cell lines has not been evaluated. Therefore the main purpose of the present study was to investigate the anticancer effects of glycyrrhizinic acid in MCF-7 human breast cancer cells. Material and methods: The MTT assay was used to evaluate the anticancer effects while a clonogenic assay was used to study its effects on colony formation tendency...
January 2019: Archives of Medical Science: AMS
Zhou Chen, Yinghui Zhang, Xuezhi Zhao
Introduction: Familial focal and segmental glomerulosclerosis (FFSGS) was found in a large cohort of patients in our previous study. Under the sponsorship of the National Natural Science Foundation of China, we conducted linkage analysis and full exon sequencing on the genomes of 54 patients diagnosed with FFSGS. The results revealed a FAM40A gene signature in those patients. To determine whether FAM40A was associated with podocyte lesions and whether changes in the podocyte cytoskeleton could affect podocyte function, mouse podocytes (MPs) were used in this study...
January 2019: Archives of Medical Science: AMS
Xuekun Shi, Yuhua Guan, Shaoyan Jiang, Tiandong Li, Bing Sun, Huan Cheng
Introduction: The renin-angiotensin system is associated with blood pressure regulation, inflammation, oxidative stress and insulin resistance. It can decrease intracellular oxidative stress. Stimulation with H2 O2 leads to increased oxidative stress and activation of the AKT/mTOR pathway. However, the role of renin-angiotensin system inhibitors in oxidative stress-induced endothelial cell dysfunction and H2 O2 -induced AKT activation remains unclear. Material and methods: Human coronary artery endothelial cells (HCAECs) were used...
January 2019: Archives of Medical Science: AMS
Aleksandra Ciałkowska-Rysz, Tomasz Dzierżanowski
Introduction: Painful mucosal and cutaneous lesions are often less responsive or even refractory to systemic opioid analgesics. There is evidence suggesting that the effectiveness of topical morphine be restricted to inflammatory pain. The studied groups were small and the observation period relatively short. The aim of this study was to assess the effectiveness and safety of topical morphine for pain related to mucosal lesions and skin ulcers. Material and methods: The study was a 14-day randomized placebo-controlled cross-over trial (RCT) with a 28-day follow-up open phase (OP)...
January 2019: Archives of Medical Science: AMS
Mehdi Moghtadaei, Babak Otoukesh, Hamidreza Pazoki-Toroudi, Bahram Boddouhi, Ali Yeganeh
Introduction: It has been shown that long bone fractures are correlated with the inflammatory response. In the initial injury, surgical reduction and fixation of fractures induce the immunoinflammatory response. This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. Material and methods: This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures...
January 2019: Archives of Medical Science: AMS
Bogdan Batko, Marcin Stajszczyk, Jerzy Świerkot, Karol Urbański, Filip Raciborski, Mariusz Jędrzejewski, Piotr Wiland
Introduction: There are no reliable data regarding the prevalence of rheumatoid arthritis (RA) in Poland. Material and methods: The first stage was a face-to-face survey on a nationwide representative sample of 3000 people, which identified respondents with a physician-confirmed diagnosis of RA. The second stage was a survey of RA patients, which characterized the disease course and treatment. It was evaluated by analysis of a representative group of 1957 RA patients in routine clinical practice...
January 2019: Archives of Medical Science: AMS
Yinghui Liang, Rongrong Shao, Zhiying Zhang, Xinmin Li, Longhao Zhou, Suqin Guo
Introduction: Childhood-onset schizophrenia with obsessive-compulsive symptoms (COSO) and without obsessive-compulsive symptoms (COS) share considerable overlap in clinical features and genetic risk factors. However, the extent of brain functional abnormalities in COSO and COS is poorly understood. Material and methods: A total of 51 first-episode childhood schizophrenic patients and 30 healthy age- and sex-matched controls were recruited. We used the Yale-Brown Obsessive Compulsive Scale to divide patients into COSO ( n = 21) and COS ( n = 30) groups...
January 2019: Archives of Medical Science: AMS
Joanna Sordyl, Ilona Kopyta, Beata Sarecka-Hujar, Tomasz Francuz, Paweł Matusik, Ewa Małecka-Tendera
Introduction: Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches. Material and methods: The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children)...
January 2019: Archives of Medical Science: AMS
Ahter Tanay Tayyar, Ahmet Tayyar, Sukran Kozali, Resul Karakus, Nadiye Koroglu, Ilkbal Temel Yuksel, Gonca Yetkin Yildirim, Ismail Dag, Mustafa Eroglu
Introduction: Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism. In this study, our aim was to investigate the circulating FGF-19 and β-klotho levels in intrahepatic cholestasis of pregnancy (ICP) cases. Material and methods: A cross-sectional study including 40 women whose pregnancies were complicated with ICP were recruited for the study group. Forty randomly selected healthy pregnant women comprised the control group...
January 2019: Archives of Medical Science: AMS
Mariusz Piechota, Anna Piechota, Małgorzata Misztal, Szymon Bernas, Iwona Pietraszek-Grzywaczewska
Introduction: The mortality rate in patients with severe liver dysfunction with no option of transplantation is unacceptably high. The main aim of this study was to evaluate the usefulness of applying extracorporeal liver support (ECLS) techniques in this group of patients. Material and methods: Data from hospital admissions of 101 patients with severe liver dysfunction who were admitted to the department of Anaesthesiology and intensive therapy between 2006 and 2015 were retrospectively analysed...
January 2019: Archives of Medical Science: AMS
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