Hung-Chuan Pan, Cheng-Ning Yang, Wen-Jane Lee, Jason Sheehan, Sheng-Mao Wu, Hong-Shiu Chen, Mao-Hsun Lin, Li-Wei Shen, Shu-Hua Lee, Chin-Chang Shen, Liang-Yi Pan, Shing-Hwa Liu, Meei-Ling Sheu
Neuro-inflammation involves distinct alterations of microglial phenotypes, containing nocuous pro-inflammatory M1-phenotype and neuroprotective anti-inflammatory M-phenotype. Currently, there is no effective treatment for modulating such alterations. M1/M2 marker of primary microglia influenced by Melatonin were detected via qPCR. Functional activities were explored by western blotting, luciferase activity, EMSA, and ChIP assay. Structure interaction was assessed by molecular docking and LIGPLOT analysis. ER-stress detection was examined by ultrastructure TEM, calapin activity, and ERSE assay...
March 26, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology