journal
Journals Journal of Neuroimmune Pharmac...

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology

https://read.qxmd.com/read/33834418/hiv-1-gp120-induced-endolysosome-de-acidification-leads-to-efflux-of-endolysosome-iron-and-increases-in-mitochondrial-iron-and-reactive-oxygen-species
#1
Peter W Halcrow, Koffi L Lakpa, Nabab Khan, Zahra Afghah, Nicole Miller, Gaurav Datta, Xuesong Chen, Jonathan D Geiger
The HIV-1 coat protein gp120 continues to be implicated in the pathogenesis of HIV-1 associated neurocognitive disorder (HAND); a condition known to affect ~50% of people living with HIV-1 (PLWH). Autopsy brain tissues of HAND individuals display morphological changes to mitochondria and endolysosomes, and HIV-1 gp120 causes mitochondrial dysfunction including increased levels of reactive oxygen species (ROS) and de-acidification of endolysosomes. Ferrous iron is linked directly to ROS production, ferrous iron is contained in and released from endolysosomes, and PLWH have elevated iron and ROS levels...
April 8, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33791922/synergistic-effect-and-mechanism-of-apoptosis-induction-by-morphine-and-the-hiv-1gp120v3-loop-in-hippocampal-neurons
#2
Xueqin Yan, Zheng Gong, Rui Pan, Huili Wang, Haijie Tang, Hanyang He, Saixian Wen, Yongmei Fu, Jun Dong
HIV-associated neurocognitive disorders (HAND) are a collective name for neurological disorders associated with HIV-1 infection. The incidence and severity of HAND are increased by concomitant opioid use disorder, such as heroin and morphine abuse. Our previous study showed that the HIV-1 envelope protein gp120 and morphine synergistically induce apoptosis in rat hippocampal neurons. However, the underlying mechanism remains unclear. We hypothesized that morphine and gp120 activated the neuronal apoptosis signaling pathway via their typical membrane receptors...
March 31, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33788119/chronic-opioid-administration-is-associated-with-prevotella-dominated-dysbiosis-in-sivmac251-infected-cart-treated-macaques
#3
Samuel D Johnson, Howard S Fox, Shilpa Buch, Siddappa N Byrareddy
People living with the human immunodeficiency virus (HIV) have an elevated risk of opioid misuse due to both prescriptions for HIV-associated chronic pain and because injection drug use remains a primary mode of HIV transmission. HIV pathogenesis is characterized by chronic immune activation and microbial dysbiosis, and translocation across the gut barrier exacerbating inflammation. Despite the high rate of co-occurrence, little is known about the microbiome during chronic opioid use in the context of HIV and combination antiretroviral therapy (cART)...
March 31, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33751445/lysosomal-stress-response-lsr-physiological-importance-and-pathological-relevance
#4
REVIEW
Koffi L Lakpa, Nabab Khan, Zahra Afghah, Xuesong Chen, Jonathan D Geiger
Extensive work has characterized endoplasmic reticulum (ER) and mitochondrial stress responses. In contrast, very little has been published about stress responses in lysosomes; subcellular acidic organelles that are physiologically important and are of pathological relevance. The greater lysosomal system is dynamic and is comprised of endosomes, lysosomes, multivesicular bodies, autophagosomes, and autophagolysosomes. They are important regulators of cellular physiology, they represent about 5% of the total cellular volume, they are heterogeneous in their sizes and distribution patterns, they are electron dense, and their subcellular positioning within cells varies in response to stimuli, insults and pH...
March 22, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33649998/effects-of-antiretroviral-therapy-in-the-central-nervous-system-beyond-viral-suppression
#5
Kelly L Jordan-Sciutto
Persistence of cognitive, behavioral and, to a lesser extent, motor dysfunction in People living with HIV (PLWH) despite viral suppression has raised the question about the potential contribution of antiretroviral (ARV) compounds themselves. Converging clinical and experimental evidence support a contribution of ARV compounds. In this issue we explore the existing clinical evidence on the impact of antiretroviral therapy (ART) on the CNS across the age continuum and in women. We further examine cell type specific effects of ARV drugs as well as the class specific effects...
March 2, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33619645/expression-of-human-immunodeficiency-virus-transactivator-of-transcription-hiv-tat-1-86-protein-alters-nociceptive-processing-that-is-sensitive-to-anti-oxidant-and-anti-inflammatory-interventions
#6
Thomas J Cirino, Amy R Alleyne, Vinicius Duarte, Ariana Figueroa, Chloe A Simons, Emet M Anceaume, Justin Kendrick, Olivia Wallman, Shainnel O Eans, Heather M Stacy, Jessica M Medina, Jay P McLaughlin
Despite the success of combined antiretroviral therapy (cART) in reducing viral load, a substantial portion of Human Immunodeficiency Virus (HIV)+ patients report chronic pain. The exact mechanism underlying this co-morbidity even with undetectable viral load remains unknown, but the transactivator of transcription (HIV-Tat) protein is of particular interest. Functional HIV-Tat protein is observed even in cerebrospinal fluid of patients who have an undetectable viral load. It is hypothesized that Tat protein exposure is sufficient to induce neuropathic pain-like manifestations via both activation of microglia and generation of oxidative stress...
February 22, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33586062/prolonged-peripheral-immunosuppressive-responses-as-consequences-of-random-amphetamine-treatment-amphetamine-withdrawal-and-subsequent-amphetamine-challenges-in-rats
#7
Wojciech Glac, Joanna Dunacka, Beata Grembecka, Grzegorz Świątek, Irena Majkutewicz, Danuta Wrona
Drug-induced immunosuppression may underline increased hypothalamic-pituitary-adrenal axis response to stress observed following chronic psychostimulant treatment. However, the consequences of random amphetamine (AMPH) treatment, withdrawal and AMPH challenge after withdrawal on the peripheral immunity and systemic corticosterone response are unknown. In this study, the total blood and spleen leukocyte, lymphocyte, T, B, NK, TCD4+ /TCD8+ cell numbers and ratio, pro-inflammatory interferon gamma (IFN-γ), and anti-inflammatory interleukin-4 (IL-4) production, and plasma corticosterone concentration in Wistar rats were investigated after: chronic, random AMPH/SAL treatment alone (20 injections in 60 days, 1 mg/kg b...
February 13, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33544324/a-role-for-extracellular-vesicles-in-sars-cov-2-therapeutics-and-prevention
#8
REVIEW
Jatin Machhi, Farah Shahjin, Srijanee Das, Milankumar Patel, Mai Mohamed Abdelmoaty, Jacob D Cohen, Preet Amol Singh, Ashish Baldi, Neha Bajwa, Raj Kumar, Lalit K Vora, Tapan A Patel, Maxim D Oleynikov, Dhruvkumar Soni, Pravin Yeapuri, Insiya Mukadam, Rajashree Chakraborty, Caroline G Saksena, Jonathan Herskovitz, Mahmudul Hasan, David Oupicky, Suvarthi Das, Ryan F Donnelly, Kenneth S Hettie, Linda Chang, Howard E Gendelman, Bhavesh D Kevadiya
Extracellular vesicles (EVs) are the common designation for ectosomes, microparticles and microvesicles serving dominant roles in intercellular communication. Both viable and dying cells release EVs to the extracellular environment for transfer of cell, immune and infectious materials. Defined morphologically as lipid bi-layered structures EVs show molecular, biochemical, distribution, and entry mechanisms similar to viruses within cells and tissues. In recent years their functional capacities have been harnessed to deliver biomolecules and drugs and immunological agents to specific cells and organs of interest or disease...
February 5, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33537927/mutations-of-human-dopaminetransporter-at-tyrosine88-aspartic-acid206-and-histidine547-influence-basal-and-hiv-1-tat-inhibited-dopamine-transport
#9
Pamela M Quizon, Yaxia Yuan, Yike Zhu, Yi Zhou, Matthew J Strauss, Wei-Lun Sun, Chang-Guo Zhan, Jun Zhu
HIV-1 transactivator of transcription (Tat) has a great impact on the development of HIV-1 associated neurocognitive disorders through disrupting dopamine transmission. This study determined the mutational effects of human dopamine transporter (hDAT) on basal and Tat-induced inhibition of dopamine transport. Compared to wild-type hDAT, the maximal velocity (Vmax ) of [3 H]dopamine uptake was decreased in D381L and Y88F/D206L/H547A, increased in D206L/H547A, and unaltered in D206L. Recombinant TatR1 - 86 inhibited dopamine uptake in wild-type hDAT, which was attenuated in either DAT mutants (D206L, D206L/H547A, and Y88F/D206L/H547A) or mutated TatR1 - 86 (K19A and C22G), demonstrating perturbed Tat-DAT interaction...
February 3, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33534108/repurposing-of-tetracyclines-for-covid-19-neurological-and-neuropsychiatric-manifestations-a-valid-option-to-control-sars-cov-2-associated-neuroinflammation
#10
LETTER
Adriano José Maia Chaves Filho, Franciane Gonçalves, Melina Mottin, Carolina Horta Andrade, Silvia Nunes Szente Fonseca, Danielle S Macedo
The recent outbreak of coronavirus disease 2019 (COVID-19) has gained considerable attention worldwide due to its increased potential to spread and infect the general population. COVID-19 primarily targets the human respiratory epithelium but also has neuro-invasive potential. Indeed, neuropsychiatric manifestations, such as fatigue, febrile seizures, psychiatric symptoms, and delirium, are consistently observed in COVID-19. The neurobiological basis of neuropsychiatric COVID-19 symptoms is not fully understood...
February 3, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33512659/pretreatment-of-indobufen-and-aspirin-and-their-combinations-with-clopidogrel-or-ticagrelor-alleviates-inflammasome-mediated-pyroptosis-via-inhibiting-nf-%C3%AE%C2%BAb-nlrp3-pathway-in-ischemic-stroke
#11
Fengyang Li, Dan Xu, Kai Hou, Xue Gou, Ning Lv, Weirong Fang, Yunman Li
Increasing studies showed that several anti-platelet drugs turned out to be a promising strategy for inflammatory response. In this study, we investigated the protective efficiency of pretreatment of indobufen or aspirin combined with clopidogrel or ticagrelor (IACT) on cerebral ischemic injury via NF-κB/NLRP3 pathway. Ischemia/reperfusion (I/R) injury was simulated in vivo by middle cerebral artery occlusion/reperfusion (MCAO/R) model, and rats were pretreated with indobufen and aspirin and their combinations with clopidogrel or ticagrelor respectively...
January 29, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33502706/intrathecal-administration-of-an-anti-nociceptive-non-cpg-oligodeoxynucleotide-reduces-glial-activation-and-central-sensitization
#12
C Leiguarda, A Villarreal, C Potilinski, T Pelissier, M F Coronel, J Bayo, A J Ramos, A Montaner, M J Villar, L Constandil, Pablo R Brumovsky
Inflammatory pain associates with spinal glial activation and central sensitization. Systemic administration of IMT504, a non-CpG oligodeoxynucleotide originally designed as an immunomodulator, exerts remarkable anti-allodynic effects in rats with complete Freund´s adjuvant (CFA)-induced hindpaw inflammation. However, the anti-nociceptive mechanisms of IMT504 remain unknown. Here we evaluated whether IMT504 blocks inflammatory pain-like behavior by modulation of spinal glia and central sensitization. The study was performed in Sprague Dawley rats with intraplantar CFA, and a single lumbosacral intrathecal (i...
January 27, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33492630/immunomodulatory-potential-of-cannabidiol-in-multiple-sclerosis-a-systematic-review
#13
REVIEW
Alessia Furgiuele, Marco Cosentino, Marco Ferrari, Franca Marino
Multiple sclerosis (MS) is the most common chronic autoimmune disease of the central nervous system. Efficacy of treatments for MS is associated with risk of adverse effects, and effective and well-tolerated drugs remain a major unmet need. Cannabis (Cannabis sativa L., fam. Cannabaceae) and cannabinoids are popular among MS patients to treat spasticity and pain. Cannabinoids are endowed with remarkable immunomodulating properties, and in particular the non-psychotropic cannabinoid cannabidiol (CBD) is increasingly recognized as anti-inflammatory and immunosuppressive, nevertheless with excellent tolerability even at high doses...
January 25, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33462776/purinergic-signaling-of-atp-in-covid-19-associated-guillain-barr%C3%A3-syndrome
#14
REVIEW
Júlia Leão Batista Simões, Margarete Dulce Bagatini
Declared as a global public health emergency, coronavirus disease 2019 (COVID-19) is presented as a disease of the respiratory tract, although severe cases can affect the entire organism. Several studies have shown neurological symptoms, ranging from dizziness and loss of consciousness to cerebrovascular and neurodegenerative diseases. In this context, Guillain-Barré syndrome, an immune-mediated inflammatory neuropathy, has been closely associated with critical cases of infection with "severe acute respiratory syndrome of coronavirus 2" (SARS-CoV-2), the etiological agent of COVID-19...
January 18, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33405097/sars-cov2-alters-blood-brain-barrier-integrity-contributing-to-neuro-inflammation
#15
LETTER
Jessica L Reynolds, Supriya D Mahajan
No abstract text is available yet for this article.
March 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33426604/ace-2-interacting-domain-of-sars-cov-2-aids-peptide-suppresses-inflammation-to-reduce-fever-and-protect-lungs-and-heart-in-mice-implications-for-covid-19-therapy
#16
Ramesh K Paidi, Malabendu Jana, Rama K Mishra, Debashis Dutta, Sumita Raha, Kalipada Pahan
COVID-19 is an infectious respiratory illness caused by the virus strain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and until now, there is no effective therapy against COVID-19. Since SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) for entering into host cells, to target COVID-19 from therapeutic angle, we engineered a hexapeptide corresponding to the ACE2-interacting domain of SARS-CoV-2 (AIDS) that inhibits the association between receptor-binding domain-containing spike S1 and ACE-2...
January 11, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33405099/immunoproteasome-inhibitor-onx-0914-affects-long-term-potentiation-in-murine-hippocampus
#17
LETTER
Alexander Maltsev, Sergei Funikov, Alexander Burov, Daria Spasskaya, Vasilina Ignatyuk, Tatjana Astakhova, Yulia Lyupina, Alexey Deikin, Vera Tutyaeva, Natalia Bal, Vadim Karpov, Alexey Morozov
No abstract text is available yet for this article.
January 6, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33405098/is-covid-19-gender-sensitive
#18
REVIEW
Shreya Mukherjee, Kalipada Pahan
While clinical characteristics exhibit that susceptibility to COVID-19 infection is equally likely between males and females, clinical outcomes show that males experience both a higher severity and fatality for COVID-19 infection than females. This review examines the evidence for these sex and gender differences and aims to illustrate possible mechanisms behind such sensitivity. Successful entry of SARS-CoV-2 into the body is dependent on the angiotensin-converting enzyme 2 (ACE2) receptor and the transmembrane protease serine 2 (TMPRSS2)...
January 6, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33403500/pharmacotherapeutics-of-sars-cov-2-infections
#19
REVIEW
Bhavesh D Kevadiya, Jatin Machhi, Jonathan Herskovitz, Maxim D Oleynikov, Wilson R Blomberg, Neha Bajwa, Dhruvkumar Soni, Srijanee Das, Mahmudul Hasan, Milankumar Patel, Ahmed M Senan, Santhi Gorantla, JoEllyn McMillan, Benson Edagwa, Robert Eisenberg, Channabasavaiah B Gurumurthy, St Patrick M Reid, Chamindie Punyadeera, Linda Chang, Howard E Gendelman
The COVID-19 pandemic has affected more than 38 million people world-wide by person to person transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therapeutic and preventative strategies for SARS-CoV-2 remains a significant challenge. Within the past several months, effective treatment options have emerged and now include repurposed antivirals, corticosteroids and virus-specific antibodies. The latter has included convalescence plasma and monoclonal antibodies. Complete viral eradication will be achieved through an effective, safe and preventative vaccine...
January 6, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/33392865/correction-to-can-cytokine-blocking-prevent-depression-in-covid-19-survivors
#20
Francesco Benedetti, Mario Gennaro Mazza, Giulio Cavalli, Fabio Ciceri, Lorenzo Dagna, Patrizia Rovere-Querini
No abstract text is available yet for this article.
January 4, 2021: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
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