journal
https://read.qxmd.com/read/38307954/prospective-association-of-daily-ambulatory-activity-with-metabolic-syndrome-in-middle-aged-and-older-japanese-adults-the-toon-health-study
#21
JOURNAL ARTICLE
Naofumi Yamamoto, Koutatsu Maruyama, Isao Saito, Kiyohide Tomooka, Takeshi Tanigawa, Ryoichi Kawamura, Yasunori Takata, Haruhiko Osawa
BACKGROUND: This cohort study aimed to examine the relationship between objectively measured daily ambulatory activity (AA) variables and the onset of metabolic syndrome (MetS) in middle-aged and older Japanese individuals. METHODS: A total of 1,034 participants (women, 76.8%; mean age, 56.9 years) who were initially free from MetS, underwent objective assessment of daily AA using a uniaxial accelerometer at baseline. The number of steps, time accumulated in light-intensity AA (LIAA), moderate-to-vigorous intensity AA (MVAA), and total AA (LIAA + MVAA) were calculated...
February 2, 2024: International Journal of Obesity
https://read.qxmd.com/read/38302593/what-is-the-pipeline-for-future-medications-for-obesity
#22
REVIEW
Eka Melson, Uzma Ashraf, Dimitris Papamargaritis, Melanie J Davies
Obesity is a chronic disease associated with increased risk of obesity-related complications and mortality. Our better understanding of the weight regulation mechanisms and the role of gut-brain axis on appetite has led to the development of safe and effective entero-pancreatic hormone-based treatments for obesity such as glucagon-like peptide-1 (GLP-1) receptor agonists (RA). Semaglutide 2.4 mg once weekly, a subcutaneously administered GLP-1 RA approved for obesity treatment in 2021, results in 15-17% mean weight loss (WL) with evidence of cardioprotection...
February 1, 2024: International Journal of Obesity
https://read.qxmd.com/read/38302592/pre-labor-and-post-labor-cesarean-delivery-and-early-childhood-adiposity-in-the-canadian-healthy-infant-longitudinal-development-child-cohort-study
#23
JOURNAL ARTICLE
Sarah L Bridgman, Suzanne Penfold, Catherine J Field, Andrea M Haqq, Piushkumar J Mandhane, Theo J Moraes, Stuart E Turvey, Elinor Simons, Padmaja Subbarao, Anita L Kozyrskyj
BACKGROUND/OBJECTIVES: Delivery by cesarean section (CS) compared to vaginal delivery has been associated with increased risk of overweight in childhood. Our study examined if the presence or absence of labor events in CS delivery altered risk of overweight in early childhood (1-5 years) compared to vaginal delivery and if this association differed according to infant sex. SUBJECTS/METHODS: The study included 3073 mother-infant pairs from the CHILD Cohort Study in Canada...
February 1, 2024: International Journal of Obesity
https://read.qxmd.com/read/38302591/weight-loss-and-cardiovascular-disease-risk-outcomes-of-semaglutide-a-one-year-multicentered-study
#24
JOURNAL ARTICLE
Wissam Ghusn, Sima Fansa, Diego Anazco, Elif Tama, Bryan Nicolalde, Khushboo Gala, Alan De la Rosa, Daniel Sacoto, Lizeth Cifuentes, Alejandro Campos, Fauzi Feres, Maria Daniela Hurtado, Andres Acosta
BACKGROUND/OBJECTIVE: There are limited real-world studies assessing semaglutide weight loss and associated comorbidity and metabolic outcomes over periods ≥ 6 months. We aim to assess weight loss, metabolic, and cardiovascular outcomes of 12 months of semaglutide. SUBJECT/METHODS: We conducted a multicentered retrospective cohort study on semaglutide use. We included patients with a body-mass index (BMI) ≥ 27 kg/m2 who were prescribed weekly semaglutide subcutaneous injections...
February 1, 2024: International Journal of Obesity
https://read.qxmd.com/read/38297032/change-in-neighborhood-socioeconomic-status-and-childhood-weight-status-and-body-composition-from-birth-to-adolescence
#25
JOURNAL ARTICLE
Shuang Zhou, Hein Raat, Yueyue You, Susana Santos, Amy van Grieken, Haijun Wang, Junwen Yang-Huang
BACKGROUND: We aim to assess the associations between the change in neighborhood socioeconomic score (SES) between birth and 6 years and childhood weight status and body composition from 6 to 13 years. METHODS: Data for 3909 children from the Generation R Study, a prospective population-based cohort in the Netherlands were analyzed. The change in neighborhood SES between birth and 6 years was defined as static-high, static-middle, static-low, upward, and downward mobility...
January 31, 2024: International Journal of Obesity
https://read.qxmd.com/read/38297031/oligogenic-inheritance-in-severe-adult-obesity
#26
JOURNAL ARTICLE
Sumaya Almansoori, Suzanne I Alsters, Andrianos M Yiorkas, Nikman Adli Nor Hashim, Robin G Walters, Harvinder S Chahal, Sanjay Purkayastha, Nader Lessan, Alexandra I F Blakemore
BACKGROUND/OBJECTIVE: The genetic architecture of extreme non-syndromic obesity in adults remains to be elucidated. A range of genes are known to cause monogenic obesity, but even when pathogenic mutations are present, there may be variable penetrance. METHODS: Whole-exome sequencing (WES) was carried out on a 15-year-old male proband of Pakistani ancestry who had severe obesity. This was followed by family segregation analysis, using Sanger sequencing. We also undertook re-analysis of WES data from 91 unrelated adults with severe obesity (86% white European ancestry) from the Personalised Medicine for Morbid Obesity (PMMO) cohort, recruited from the UK National Health Service...
January 31, 2024: International Journal of Obesity
https://read.qxmd.com/read/38297030/allometric-versus-traditional-body-shape-indices-and-risk-of-colorectal-cancer-a-mendelian-randomization-analysis
#27
JOURNAL ARTICLE
Marina O Rontogianni, Emmanouil Bouras, Elom Kouassivi Aglago, Heinz Freisling, Neil Murphy, Michelle Cotterchio, Jochen Hampe, Annika Lindblom, Rish K Pai, Paul D P Pharoah, Amanda I Phipps, Franzel J B van Duijnhoven, Kala Visvanathan, Bethany van Guelpen, Christopher I Li, Hermann Brenner, Andrew J Pellatt, Shuji Ogino, Marc J Gunter, Ulrike Peters, Sofia Christakoudi, Konstantinos K Tsilidis
BACKGROUND: Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus, new allometric indices have been developed, namely A Body Shape Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI), which are uncorrelated with weight and height; these have also been associated with CRC risk in observational studies, but information from Mendelian randomization (MR) studies is missing...
January 31, 2024: International Journal of Obesity
https://read.qxmd.com/read/38297029/the-effect-of-bariatric-surgery-type-on-cardiac-reverse-remodelling
#28
JOURNAL ARTICLE
J A Henry, I Abdesselam, O Deal, A J Lewis, J Rayner, M Bernard, A Dutour, B Gaborit, F Kober, A Soghomonian, B Sgromo, J Byrne, T Bege, B A Borlaug, S Neubauer, O J Rider
INTRODUCTION: Bariatric surgery is effective in reversing adverse cardiac remodelling in obesity. However, it is unclear whether the three commonly performed operations; Roux-en-Y Gastric Bypass (RYGB), Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic Adjustable Gastric Band (LAGB) are equal in their ability to reverse remodelling. METHODS: Fifty-eight patients underwent CMR to assess left ventricular mass (LVM), LV mass:volume ratio (LVMVR) and LV eccentricity index (LVei) before and after bariatric surgery (26 RYGB, 22 LSG and 10 LAGB), including 46 with short-term (median 251-273 days) and 43 with longer-term (median 983-1027 days) follow-up...
January 31, 2024: International Journal of Obesity
https://read.qxmd.com/read/38291203/cost-effectiveness-of-weight-management-pharmacotherapies-in-canada-a-societal-perspective
#29
JOURNAL ARTICLE
Anamaria-Vera Olivieri, Sergey Muratov, Sara Larsen, Maria Luckevich, Katalina Chan, Mark Lamotte, David C W Lau
OBJECTIVES: This study aimed to assess the cost-effectiveness of weight-management pharmacotherapies approved by Canada Health, i.e., orlistat, naltrexone 32 mg/bupropion 360 mg (NB-32), liraglutide 3.0 mg and semaglutide 2.4 mg as compared to the current standard of care (SoC). METHODS: Analyses were conducted using a cohort with a mean starting age 50 years, body mass index (BMI) 37.5 kg/m2 , and 27.6% having type 2 diabetes...
January 31, 2024: International Journal of Obesity
https://read.qxmd.com/read/38287094/does-sex-modify-the-effect-of-pre-pandemic-body-mass-index-on-the-risk-of-long-covid-evidence-from-the-longitudinal-analysis-of-the-survey-of-health-ageing-and-retirement-in-europe
#30
JOURNAL ARTICLE
Piotr Wilk, Saverio Stranges, Sarah Cuschieri
BACKGROUND: Research on Long COVID risk factors is ongoing. High body mass index (BMI) may increase Long COVID risk, yet no evidence has been established regarding sex differences in the relationship between BMI and the risk of Long COVID. Investigating the nature of this relationship was the main objective of this study. METHODS: A population-based prospective study involving a sample of respondents aged 50 years and older (n = 4004) from 27 European countries that participated in the 2020 and 2021 Survey of Health, Ageing and Retirement in Europe's (SHARE) Corona Surveys and in Waves 7 and 8 of the main SHARE survey...
January 29, 2024: International Journal of Obesity
https://read.qxmd.com/read/38273035/in-utero-exposure-to-maternal-diabetes-or-hypertension-and-childhood-hypothalamic-gliosis
#31
JOURNAL ARTICLE
Kelsey L W Olerich, Leticia E Sewaybricker, Sarah Kee, Susan J Melhorn, Suchitra Chandrasekaran, Ellen A Schur
Exposure to maternal diabetes (DM) or hypertension (HTN) during pregnancy impacts offspring metabolic health in childhood and beyond. Animal models suggest that induction of hypothalamic inflammation and gliosis in the offspring's hypothalamus is a possible mechanism mediating this effect. We tested, in children, whether in utero exposures to maternal DM or HTN were associated with mediobasal hypothalamic (MBH) gliosis as assessed by brain magnetic resonance imaging (MRI). The study included a subsample of 306 children aged 9-11 years enrolled in the ABCD Study®; 49 were DM-exposed, 53 were HTN-exposed, and 204 (2:1 ratio) were age- and sex-matched children unexposed to DM and/or HTN in utero...
January 25, 2024: International Journal of Obesity
https://read.qxmd.com/read/38273034/metabolic-syndrome-and-epigenetic-aging-a-twin-study
#32
JOURNAL ARTICLE
Tiina Föhr, Arne Hendrix, Anna Kankaanpää, Eija K Laakkonen, Urho Kujala, Kirsi H Pietiläinen, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, Xiaoling Wang, Jaakko Kaprio, Miina Ollikainen, Elina Sillanpää
BACKGROUND: Metabolic syndrome (MetS) is associated with premature aging, but whether this association is driven by genetic or lifestyle factors remains unclear. METHODS: Two independent discovery cohorts, consisting of twins and unrelated individuals, were examined (N = 268, aged 23-69 years). The findings were replicated in two cohorts from the same base population. One consisted of unrelated individuals (N = 1 564), and the other of twins (N = 293)...
January 25, 2024: International Journal of Obesity
https://read.qxmd.com/read/38273033/obesity-and-overweight-as-risk-factors-for-low-back-pain-in-children-and-adolescents-a-meta-analysis
#33
REVIEW
José Manuel García-Moreno, Inmaculada Calvo-Muñoz, Antonia Gómez-Conesa, José Antonio López-López
BACKGROUND: Childhood obesity and overweight are associated with musculoskeletal pain, but the association between low back pain (LBP) and overweight/obesity in this population needs clarification. The objective of this meta-analysis is to ascertain the relationship between LBP and obesity/overweight in children and adolescents. METHODS: Various databases and specialized journals were queried from inception to October 2022. Encompassed were all studies examining the association between overweight or obesity and LBP among participants aged 6 to 18 years...
January 25, 2024: International Journal of Obesity
https://read.qxmd.com/read/38267484/impact-of-polygenic-score-for-bmi-on-weight-loss-effectiveness-and-genome-wide-association-analysis
#34
JOURNAL ARTICLE
Hassan S Dashti, Frank A J L Scheer, Richa Saxena, Marta Garaulet
BACKGROUND: While environmental factors play an important role in weight loss effectiveness, genetics may also influence its success. We examined whether a genome-wide polygenic score for BMI was associated with weight loss effectiveness and aimed to identify common genetic variants associated with weight loss. METHODS: Participants in the ONTIME study (n = 1210) followed a uniform, multimodal behavioral weight-loss intervention. We first tested associations between a genome-wide polygenic score for higher BMI and weight loss effectiveness (total weight loss, rate of weight loss, and attrition)...
January 24, 2024: International Journal of Obesity
https://read.qxmd.com/read/38253643/relationship-between-metabolic-status-physical-activity-and-cardiovascular-disease-in-participants-with-obesity
#35
JOURNAL ARTICLE
Yingxin Liu, Ai Zhao, Guiju Sun, Ruoting Wang, Jingyi Zhang, Gregory Y H Lip, Guowei Li
OBJECTIVE: We aimed to investigate the independent and joint associations between metabolic status, PA (physical activity) and risk of CVD (cardiovascular disease) in participants with obesity. METHODS: We included 109,301 adults with obesity free of baseline CVD enrolled from 2006 to 2010 in the UK Biobank cohort (aged 56 ± 7.9 years). Based on metabolic status, obesity was grouped into metabolically healthy obesity (MHO; free of hypertension, hypercholesterolemia and diabetes; n = 26,989; BMI 33 ± 3...
January 22, 2024: International Journal of Obesity
https://read.qxmd.com/read/38245659/adipose-tissue-derived-metabolite-risk-scores-and-risk-for-type-2-diabetes-in-south-asians
#36
JOURNAL ARTICLE
Meghana D Gadgil, Jing Cheng, David M Herrington, Namratha R Kandula, Alka M Kanaya
BACKGROUND: South Asians are at higher risk for type 2 diabetes (T2D) than many other race/ethnic groups. Ectopic adiposity, specifically hepatic steatosis and visceral fat may partially explain this. Our objective was to derive metabolite risk scores for ectopic adiposity and assess associations with incident T2D in South Asians. METHODS: We examined 550 participants in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort study aged 40-84 years without known cardiovascular disease or T2D and with metabolomic data...
January 20, 2024: International Journal of Obesity
https://read.qxmd.com/read/38245658/offspring-sex-modifies-the-association-between-early-pregnancy-adiposity-and-2-year-old-physical-activity-the-glowing-study
#37
JOURNAL ARTICLE
Eva C Diaz, David K Williams, Erin K Howie, Elisabet Børsheim, Aline Andres
BACKGROUND: Rodent models suggest that in utero exposure to under and overnutrition programs offspring physical activity (PA) behaviors. Such nexus has not been established in humans. This study evaluated the association of early pregnancy maternal adiposity with offspring PA at age 2 years (2-yo-PA) taking into consideration prenatal and postnatal factors. METHODS: Women (n = 153) were enrolled early in pregnancy (<10 weeks). At enrollment, maternal adiposity [air displacement plethysmography, fat mass index (FMI, kg/m2 )] and PA (accelerometers, activity counts) were measured, and age, race, and education self-reported...
January 20, 2024: International Journal of Obesity
https://read.qxmd.com/read/38233538/association-of-excess-visceral-fat-and-severe-illness-in-hospitalized-covid-19-patients-in-japan-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Yuki Goto, Yuiko Nagamine, Mariko Hanafusa, Tomoki Kawahara, Nobutoshi Nawa, Ukihide Tateishi, Yutaka Ueki, Shigeru Miyamae, Kenji Wakabayashi, Nobuyuki Nosaka, Yasunari Miyazaki, Shuji Tohda, Takeo Fujiwara
BACKGROUND/OBJECTIVES: Obesity, defined by body mass index (BMI), is a well-known risk factor for the severity of coronavirus disease 2019 (COVID-19). Adipose tissue distribution has also been implicated as an important factor in the body's response to infection, and excess visceral fat (VF), which is prevalent in Japanese, may contribute significantly to the severity. Therefore, this study aimed to evaluate the association of obesity and VF with COVID-19 severe illness in Japan. SUBJECTS/METHODS: This retrospective cohort study involved 550 COVID-19 patients admitted to a tertiary care hospital with BMI and body composition data, including VF...
January 17, 2024: International Journal of Obesity
https://read.qxmd.com/read/38228876/endothelial-and-exercise-vasodilation-are-reduced-in-postmenopausal-females-with-obesity-versus-lean-and-overweight
#39
JOURNAL ARTICLE
Stephen M Fischer, Arun Maharaj, Yejin Kang, Katherine N Dillon, Mauricio A Martinez, Arturo Figueroa
BACKGROUND: Obesity (OB) is highly prevalent in females after menopause, especially visceral adipose tissue (VAT) accumulation which contributes to endothelial dysfunction. The endothelium assists in regulating blood flow (BF) during exercise and is attenuated in females with OB. The purpose of this study was to examine upper and lower limb flow-mediated dilation (FMD) and BF regulation during graded low-intensity submaximal exercises in postmenopausal females with BMI in the lean (LN), overweight (OW) and OB categories...
January 17, 2024: International Journal of Obesity
https://read.qxmd.com/read/38225284/post-metabolic-bariatric-surgery-weight-regain-the-importance-of-glp-1-levels
#40
REVIEW
Nursel Çalık Başaran, Idit Dotan, Dror Dicker
Weight regain and insufficient weight loss are essential problems after metabolic bariatric surgery (MBS) in people living with obesity. Changes in the level of glucagon-like peptide-1 (GLP-1) secreted from the gut after bariatric surgery are one of the underlying mechanisms for successful initial weight loss. Studies and meta-analyses have revealed that postprandial GLP-1 levels increase after the Roux-en-Y gastric bypass and sleeve gastrectomy, but fasting GLP-1 levels do not increase significantly. Some observational studies have shown the relationship between higher postprandial GLP-1 levels and successful weight loss after bariatric surgery...
January 15, 2024: International Journal of Obesity
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