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Breast Care

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https://read.qxmd.com/read/30498426/does-exercise-have-a-preventive-effect-on-secondary-lymphedema-in-breast-cancer-patients-following-local-treatment-a-systematic-review
#1
REVIEW
Freerk T Baumann, Alexandra Reike, Michael Hallek, Joachim Wiskemann, Vanessa Reimer
Background: Secondary lymphedema (SL) is a possible side effect of breast cancer treatment. Current data describe a positive influence of exercise on upper lymphedema. This systematic review evaluates studies examining a potential preventive effect of exercise on SL incidence. Methods: A systematic literature search of PubMed, LIVIVO, and the Cochrane Library was performed. Results: 8 randomized controlled trials were included in the review...
October 2018: Breast Care
https://read.qxmd.com/read/30498425/nipple-sparing-mastectomy-with-primary-implant-reconstruction-surgical-and-oncological-outcome-of-435-breast-cancer-patients
#2
Zoran Radovanovic, Milan Ranisavljevic, Dragana Radovanovic, Ferenc Vicko, Tatjana Ivkovic-Kapicl, Nenad Solajic
Background: This study aimed to examine the incidence of surgical complications associated with nipple-sparing mastectomy (NSM) with primary implant reconstruction, analyze risk factors for early and late surgical complications of NSM, and determine the incidence of local recurrences and the safety of sparing the nipple-areola complex (NAC). Methods: This retrospective cohort study included 435 patients with 441 NSM procedures over a period of 9 years (2004-2012)...
October 2018: Breast Care
https://read.qxmd.com/read/30498424/the-warwick-experience-of-the-oncotype-dx%C3%A2-breast-recurrence-score%C3%A2-assay-as-a-predictor-of-chemotherapy-administration
#3
Mashuk Alam Khan, Laura Henderson, Dayalan Clarke, Simon Harries, Lucie Jones
Introduction: Oncotype DX® analyses the expression of 21 genes within tumour tissue to determine a Recurrence Score® (RS). RS is a marker of risk for distant recurrence in oestrogen receptor-positive early breast cancer, allowing patient-specific benefit of chemotherapy to be evaluated. Our aim was to determine whether the introduction of Oncotype DX led to a net reduction in chemotherapy use. Methods: Consecutive patients that underwent Oncotype DX at Warwick Hospital were reviewed...
October 2018: Breast Care
https://read.qxmd.com/read/30498423/intraductal-papilloma-without-atypia-on-image-guided-breast-biopsy-upgrade-rates-to-carcinoma-at-surgical-excision
#4
Doris Leithner, Benjamin Kaltenbach, Petra Hödl, Volker Möbus, Volker Brandenbusch, Stephan Falk, Clara Park, Thomas J Vogl, Markus Müller-Schimpfle
Background: The management of intraductal papilloma without atypia (IDP) in breast needle biopsy remains controversial. This study investigates the upgrade rate of IDP to carcinoma and clinical and radiologic features predictive of an upgrade. Methods: Patients with a diagnosis of IDP on image-guided (mammography, ultrasound, magnetic resonance imaging) core needle or vacuum-assisted biopsy and surgical excision of this lesion at a certified breast center between 2007 and 2017 were included in this institutional review board-approved retrospective study...
October 2018: Breast Care
https://read.qxmd.com/read/30498422/granulomatous-lobular-mastitis-antituberculous-treatment-and-outcome-in-22-patients
#5
Lu Liu, Fei Zhou, Xiaoxia Zhang, Shuchen Liu, Liyuan Liu, Yujuan Xiang, Mingming Guo, Lixiang Yu, Fei Wang, Zhongbing Ma, Liang Li, Dezong Gao, Qiang Zhang, Qinye Fu, Zhigang Yu
Background: Granulomatous lobular mastitis (GLM) is a rare chronic inflammatory condition of the breast. The purpose of this study was to describe antituberculous treatment of GLM and the long-term follow-up outcome. Methods: This retrospective study included 22 patients who had been histopathologically diagnosed with GLM at the Second Hospital of Shandong University from January 2011 to March 2015. Clinical characteristics, ultrasonography and mammography findings, laboratory tests, treatment regimens, follow-up information, and recurrences were recorded...
October 2018: Breast Care
https://read.qxmd.com/read/30498421/jumping-breast-phenomenon-following-subcutaneous-mastectomy-first-description-and-grading-of-a-well-known-breast-deformity
#6
Sherko Kümmel, Aylin Kümmel, Friederike Hagemann, Anna Rüland, Christine Dittmer-Grabowski, Suzan Botzenhardt, Jens-Uwe Blohmer, Mattea Reinisch
Introduction: One of the goals of breast cancer surgery is to preserve the breast. However, where this is not possible, various breast reconstructive procedures are available. The most common procedure is the immediate insertion of a subpectoral implant after removing the breast tissue. A significant challenge involving subpectoral implants is the deformation of the breast upon contraction of the pectoral muscle causing elevation of the breast and development of wrinkles or ripples in the caudal and cranial quadrants (jumping breast), especially in slim patients with a thin subcutaneous fat layer...
October 2018: Breast Care
https://read.qxmd.com/read/30498420/new-technologies-for-sentinel-lymph-node-detection
#7
REVIEW
Amit Goyal
The 'standard of care' method for sentinel node mapping is the combination technique using radioisotope and blue dye although some centres use radioisotope or blue dye alone. Radioisotope usage requires licensing, has regulatory issues around handling and disposal of waste, and logistically may be unavailable or difficult to implement in some centres or less developed country. This has led to the development of alternative methods such as superparamagnetic iron oxide (SPIO), fluorescence techniques using indocyanine green (ICG) or fluorescein, computed tomography lymphography, and contrast-enhanced ultrasound scan (CEUS) using microbubbles...
October 2018: Breast Care
https://read.qxmd.com/read/30498419/lymph-nodes-in-breast-cancer-what-can-we-learn-from-translational-research
#8
REVIEW
Florentia Peintinger, Roland Reitsamer, Marjolein L Smidt, Thorsten Kühn, Cornelia Liedtke
Clinical observations about lack of survival benefit after extensive axillary surgery and biological discordance between primary breast tumors and axillary lymph nodes raise the question of the actual metastatic potential of axillary nodal disease. The exploration of intratumoral heterogeneity and detection of genomic differences between the primary and lymph nodes indicate some similarity between the number of mutations in synchronous axillary node metastases and those in the primary lesion, suggesting a favorable prognosis...
October 2018: Breast Care
https://read.qxmd.com/read/30498418/current-status-and-future-perspectives-of-axillary-management-in-the-neoadjuvant-setting
#9
Thorsten Kühn, Jean-Marc Classe, Oreste David Gentilini, Corrado Tinterri, Florentia Peintinger, Jana de Boniface
Axillary surgery has undergone considerable changes in recent years, especially in relation to patients who undergo neoadjuvant chemotherapy (NACT). Due to constantly decreasing rates of recurrence and death from breast cancer, modern surgical strategies aim at de-escalating the extent of local treatment and avoiding unnecessary procedures. This relates especially to lymph node surgery which is associated with considerable morbidity. In patients who initially present with clinically node-negative disease, sentinel lymph node biopsy (SLNB) is increasingly performed after NACT...
October 2018: Breast Care
https://read.qxmd.com/read/30498417/what-is-the-best-management-of-cn0pn1-sn-breast-cancer-patients
#10
REVIEW
Jana de Boniface, Marcus Schmidt, Jutta Engel, Marjolein L Smidt, Birgitte Vrou Offersen, Toralf Reimer
Although the majority of breast cancer patients are clinically node-negative (cN0) at diagnosis, 15-20% will have a metastatic sentinel lymph node (SLN, pN1(sn)). While a less radical approach regarding axillary surgery in cN0 patients with a positive SLN biopsy is advocated, the limitations of 5 published trials on axillary management in pN1(sn) are discussed intensely in the literature and support the performance of ongoing validation and extension trials, especially considering the lack of data in the setting of mastectomy...
October 2018: Breast Care
https://read.qxmd.com/read/30498416/is-axillary-sentinel-lymph-node-biopsy-required-in-patients-who-undergo-primary-breast-surgery
#11
REVIEW
Toralf Reimer, Jutta Engel, Marcus Schmidt, Birgitte Vrou Offersen, Marjolein L Smidt, Oreste David Gentilini
Local treatment of the axilla in clinically node-negative (cN0) early breast cancer patients with routine sentinel lymph node biopsy (SLNB) is debated for various reasons: i) pN staging information may not be necessary for the postoperative treatment decision regarding adjuvant systemic therapy in the great majority of patients; ii) the SLNB-positive rate is declining below 20% in specialized breast centers; iii) albeit being a minimally invasive procedure, SLNB causes a significant reduction in quality of life in 23% of patients; and iv) previous randomized trials from the pre-SLNB era did not show a disadvantage for patients without axillary surgery with regard to overall survival...
October 2018: Breast Care
https://read.qxmd.com/read/30498415/lymph-node-management-in-breast-cancer-a-highly-dynamic-evolution
#12
EDITORIAL
Thorsten Kühn
No abstract text is available yet for this article.
October 2018: Breast Care
https://read.qxmd.com/read/30319333/news-from-asco-2018
#13
Marija Balic, Natalija Dedic, Leticia De Mattos-Arruda, Simon Gampenrieder
No abstract text is available yet for this article.
August 2018: Breast Care
https://read.qxmd.com/read/30319332/primary-rhabdomyosarcoma-of-the-breast-imaging-findings-and-literature-review
#14
Zuhal Bayramoglu, Rejin Kebudi, Ravza Yilmaz, Sema Buyukkapu Bay, Abut Kebudi, Hasan Karanlik, Ayca Iribas, Emin Darendeliler, Semen Onder, Bilge Bilgic, Ibrahim Adaletli
Background: Primary breast rhabdomyosarcoma (RMS) can occur in children. There is a lack of knowledge regarding radiologic findings and added diffusion-weighted magnetic resonance imaging (MRI) features of RMS in the literature. Case Report: A 12-year-old girl was diagnosed with primary alveolar RMS of the breast. Gray scale ultrasound revealed posterior acoustic enhancement behind a well-circumscribed, multilobulated hypoechoic mass. Doppler ultrasound revealed increased peripheral and central vascularity...
August 2018: Breast Care
https://read.qxmd.com/read/30319331/recent-developments-in-radiation-oncology-an-overview-of-individualised-treatment-strategies-in-breast-cancer
#15
REVIEW
Montserrat Pazos, Stephan Schönecker, Daniel Reitz, Paul Rogowski, Maximilian Niyazi, Filippo Alongi, Christiane Matuschek, Michael Braun, Nadia Harbeck, Claus Belka, Stefanie Corradini
Radiation therapy (RT) for breast cancer has dramatically changed over the past years, leading to individualized risk-adapted treatment strategies. Historically, the choice of RT regimen was limited to conventional fractionation protocols using standard tangential fields. Nowadays, technological and technical improvements in modern RT have added a variety of other RT modalities, different fractionation schedules, and individualised treatment volumes to the portfolio of breast RT. This review aims to give a short overview on the main topics which have recently found their way into clinical practice: hypofractionated treatment protocols, accelerated partial breast irradiation (APBI) for low-risk patients, deep inspiration breath hold (DIBH) for maximal heart protection, extent of regional nodal irradiation for high-risk patients, and the implementation of new radiation techniques such as intensity modulated RT (IMRT) and volumetric modulated RT (VMAT)...
August 2018: Breast Care
https://read.qxmd.com/read/30319330/late-administration-of-trastuzumab-emtansine-might-lead-to-loss-of-chance-for-better-outcome-in-patients-with-her2-positive-metastatic-breast-cancer
#16
REVIEW
Luis Manso, Alfonso Sanchez-Muñoz, Isabel Calvo, Yann Izarzugaza, Jessica Plata, Cesar Rodriguez
The optimal sequence of anti-human epidermal growth factor receptor 2 (HER2) therapies in metastatic breast cancer (MBC) is still undetermined. Physicians must therefore make decisions based on clinical trials and their own experience for the best treatment sequence in these patients. The objective of this review is to summarize the efficacy and safety data for trastuzumab emtansine (T-DM1) in patients with MBC. Additionally, the concept of 'loss of chance for a better outcome' is investigated. It applies to patients who are not receiving the best possible treatment for their disease...
August 2018: Breast Care
https://read.qxmd.com/read/30319329/explorative-analysis-of-low-dose-metronomic-chemotherapy-with-cyclophosphamide-and-methotrexate-in-a-cohort-of-metastatic-breast-cancer-patients
#17
Slavomir Krajnak, Marco Battista, Walburgis Brenner, Katrin Almstedt, Tania Elger, Anne-Sophie Heimes, Annette Hasenburg, Marcus Schmidt
Background: Low-dose metronomic chemotherapy (LDMC) is increasingly used in metastatic breast cancer (MBC). In this retrospective analysis, we examined the therapeutic effects and side effects of LDMC in a cohort of MBC patients. Methods: Patients with MBC were included when LDMC with oral cyclophosphamide (CTX) and methotrexate (MTX) was administered between 2009 and 2015. The primary endpoint was disease control rate (DCR) ≥ 24 weeks after the start of LDMC...
August 2018: Breast Care
https://read.qxmd.com/read/30319328/prevalence-of-cardiac-disease-in-breast-cancer-patients-at-time-of-diagnosis-compared-to-the-general-female-population-in-germany
#18
Eva Lorenz, Maria Blettner, Björn Lange, Marcus Schmidt, Astrid Schneider, Lukas Schwentner, Daniel Wollschläger, Hiltrud Merzenich
Background: Advances in oncological therapy have significantly improved breast cancer survival; therefore comorbid conditions are becoming more relevant. We investigated the prevalence of prior cardiovascular diseases and risk factors in patients with breast cancer compared to those in the general female population in Germany. Methods: The PASSOS heart study is a retrospective multicenter cohort study on cardiac late effects in breast cancer patients treated between 1998 and 2008...
August 2018: Breast Care
https://read.qxmd.com/read/30319327/neoadjuvant-model-as-a-platform-for-research-in-breast-cancer-and-novel-targets-under-development-in-this-field
#19
REVIEW
Santiago Escrivá-de-Romaní, Miriam Arumí, Esther Zamora, Meritxell Bellet
For decades, the neoadjuvant setting has provided a useful scenario for research in breast cancer. Historically, neoadjuvant clinical trials, either hormone therapy-based or chemotherapy-based, have tried to recapitulate the results of their counterpart adjuvant studies, but with smaller patient numbers, more rapid outcomes (clinical response and/or pathologic complete response (pCR)), together with additional biologic information. As for neoadjuvant chemotherapy trials, the increase in pCR rates has been recently accepted as an appropriate surrogate marker to accelerate drug approval in high-risk breast cancer patients...
August 2018: Breast Care
https://read.qxmd.com/read/30319326/standard-neoadjuvant-treatment-in-early-locally-advanced-breast-cancer
#20
REVIEW
Cristina Pernaut, Flora Lopez, Eva Ciruelos
Neoadjuvant treatment allows us to improve surgical results and test new drugs. In recent years, there have been significant advances in the field of neoadjuvant treatment, including hormonal neoadjuvant therapy in luminal tumors, double blockade in HER2-positive tumors, and the use of platinum salts in triple-negative tumors.
August 2018: Breast Care
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