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Journals Therapeutics and Clinical Risk...

Therapeutics and Clinical Risk Management

https://read.qxmd.com/read/38250050/erratum-hard-candy-consumption-does-not-have-an-effect-on-volume-and-ph-of-gastric-content-in-patients-undergoing-elective-gastrointestinal-endoscopic-procedures-a-randomized-controlled-trial-corrigendum
#21
(no author information available yet)
[This corrects the article DOI: 10.2147/TCRM.S377421.].
2024: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38230373/profile-of-sofosbuvir-and-velpatasvir-combination-in-the-treatment-of-chronic-hepatitis-c-in-children-and-adolescents-current-evidence
#22
REVIEW
Dania Brigham, Michael R Narkewicz
Chronic hepatitis C (HCV) affects up to 3.25 million children and adolescents. Early treatment of HCV in children and adolescents reduces progression to advanced liver disease and cancer. Treatment for HCV has evolved to highly effective direct acting antiviral therapy in adults and now in children ≥3 years of age. This review focuses on the role of sofosbuvir and velpatasvir (SOF/VEL), a newer treatment of children and adolescents with chronic HCV. SOF/VEL is a pangenotypic DAA with primary clearance via the liver and biliary excretion...
2024: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38230372/the-efficacy-and-safety-of-diazepam-for-intraoperative-blood-pressure-stabilization-in-hypertensive-patients-undergoing-vitrectomy-under-nerve-block-anesthesia-a-prospective-single-center-double-blind-randomized-controlled-trial
#23
Tianwei Qian, Qiaoyun Gong, Yiyang Shu, Hangqi Shen, Xia Wu, Weijun Wang, Zhihua Zhang, Hui Cao, Xun Xu
PURPOSE: To evaluate the effectiveness and safety of diazepam in maintaining stable intraoperative blood pressure (BP) in hypertensive patients undergoing vitrectomy under nerve block anesthesia. METHODS: A total of 180 hypertensive patients undergoing vitrectomy with nerve block anesthesia were randomized into two groups. The intervention group was given oral diazepam 60 min before operation, while the control group was given oral placebo 60 min before operation...
2024: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38170095/mini-percutaneous-nephrolithotomy-vs-standard-percutaneous-nephrolithotomy-a-perioperative-decision-support-system-for-surgical-success-comparison
#24
JOURNAL ARTICLE
Kerem Gencer
PURPOSE: This study aimed to rank the features that are important in terms of safety and effectiveness in choosing the surgical method and providing appropriate care to the patient by using the variables examined before and after the surgery to evaluate the success of mini percutaneous nephrolithotomy and standard percutaneous nephrolithotomy surgeries. PATIENTS AND METHODS: The features evaluated before and after surgery were ranked according to their importance in the features considered, using Multivariate Adaptive Regression Splines (MARS), LASSO, Ridge, Elastic_net, and Random Forest algorithms as variable selection techniques...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38164204/safety-and-efficacy-of-subcutaneous-daratumumab-in-systemic-al-amyloidosis
#25
REVIEW
Michael Sang Hughes, Suzanne Lentzsch
INTRODUCTION: Systemic AL amyloidosis, a plasma cell dyscrasia, is characterized by the production of misfolded immunoglobulin light chain. These misfolded proteins aggregate into amyloid fibrils and deposit throughout the body, resulting in widespread organ dysfunction and ultimately death. Achieving rapid and maximal elimination of the plasma cell clone is crucial to long-term survival. Daratumumab, an anti-CD38 monoclonal antibody delivered intravenously, has been swiftly incorporated into standard first-line treatment regimens...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38107500/efficacy-and-safety-of-hydrogen-therapy-in-patients-with-early-stage-interstitial-lung-disease-a-single-center-randomized-parallel-group-controlled-trial
#26
JOURNAL ARTICLE
Chang Tang, Lanting Wang, Zihua Chen, Jin Yang, Haiqing Gao, Chenggong Guan, Qiaozhi Gu, Shan He, Fanping Yang, Shengan Chen, Li Ma, Zhen Zhang, Ying Zhao, Lin Tang, Yu Xu, Yue Hu, Xiaoqun Luo
PURPOSE: Several in vivo experiments have shown that molecular hydrogen is a promising therapeutic agent for interstitial lung diseases (ILD). In this study, hydrogen therapy was investigated to determine whether it is superior to N-Acetylcysteine (NAC) for the treatment of patients with early-stage ILD. PATIENTS AND METHODS: A prospective, single-center, randomized, controlled clinical trial was conducted in 87 patients with early-stage ILD. Hydrogen or NAC therapy was randomly assigned (1:1 ratio) to the eligible patients...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38089965/erythrocyte-sedimentation-rate-for-assisted-diagnosis-of-pediatric-osteomyelitis-a-meta-analysis
#27
REVIEW
Han Qi, Zhitao Zhu, Dongsheng Zhu
OBJECTIVE: For the diagnosis of pediatric osteomyelitis, the sensitivity, specificity, and predictive value of erythrocyte sedimentation rate (ESR) were evaluated in this study. METHODS: A systematic computer-based search was performed for relevant articles focusing on the ESR diagnosis of pediatric osteomyelitis in PubMed, Embase, and the Cochrane Library with an inclusion criteria: 1) the diagnostic utility of ESR for diagnosing osteomyelitis patients under the age of 18;2) two-by-two contingency tables can be obtained...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38074485/clinical-utility-of-deutetrabenazine-as-a-treatment-option-for-chorea-associated-with-huntington-s-disease-and-tardive-dyskinesia
#28
REVIEW
Samuel Frank, Aljoharah Alakkas
Deutetrabenazine (DTBZ) is used for the treatment of tardive dyskinesia (TD) and chorea in Huntington's Disease (HD). Four pivotal clinical trials showed the efficacy of DTBZ in these conditions. Long term follow-up studies confirmed evidence of overall safety and continued efficacy of this drug. Indirect comparisons revealed relative superiority of DTBZ over TBZ in terms of safety, but direct comparisons of safety and efficacy between the VMAT2 and dopamine blocking agents is lacking. Deutetrabenazine is safe and effective in the treatment of TD and chorea in HD in doses up to 72 mg daily and for up to three years in duration...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38074484/effect-of-the-ramathibodi-rapid-response-system-triggered-by-the-ramathibodi-early-warning-score-and-clinical-warning-signs-on-in-hospital-mortality-and-the-incidence-of-cardiopulmonary-resuscitation-in-adult-hospitalized-patients
#29
JOURNAL ARTICLE
Chutipong Kwantong, Yuda Sutherasan, Detajin Junhasavasdikul, Tananchai Petnak, Pongdhep Theerawit
PURPOSE: The Ramathibodi Rapid Response System (RRRS), implemented in March 2017, aims to identify and respond to patients with deteriorating conditions outside the ICU. It employs the Ramathibodi early warning score and clinical signs to monitor all admitted patients, providing expert physician monitoring and early treatment for stabilization and appropriate care triage. This study assesses the RRRS's effectiveness in reducing in-hospital mortality and CPR events outside the ICU. PATIENTS AND METHODS: We conducted a retrospective observational study from March 2014 to February 2020 in a tertiary care hospital's general wards...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38050618/a-novel-nomogram-to-predict-symptomatic-intracranial-hemorrhage-in-ischemic-stroke-patients-after-intravenous-thrombolysis
#30
JOURNAL ARTICLE
Zhuangzhuang Jiang, Dongjuan Xu, Hongfei Li, Xiaolan Wu
OBJECTIVE: This study aimed to create and validate a novel nomogram to predict the risk of symptomatic intracranial hemorrhage (sICH) in patients with acute ischemic stroke (AIS) who underwent intravenous thrombolysis (IVT). METHODS: In this retrospective study, 784 patients with AIS who received IVT were enrolled. The patients were randomly divided into two groups: a training set (n=550, 70%) and a testing set (n=234, 30%). Utilizing multivariable logistic regression analysis, relevant factors for the predictive nomogram were selected...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38050617/population-specific-distribution-of-tpmt-deficiency-variants-and-ancestry-proportions-in-ecuadorian-ethnic-groups-towards-personalized-medicine
#31
JOURNAL ARTICLE
Jennifer Gallardo-Cóndor, Pablo Naranjo, Sebastián Atarihuana, Dayana Coello, Patricia Guevara-Ramírez, Rodrigo Flores-Espinoza, Germán Burgos, Andrés López-Cortés, Alejandro Cabrera-Andrade
PURPOSE: Thiopurine S-methyltransferase (TPMT) is an enzyme that metabolizes purine analogs, agents used in the treatment of acute lymphoblastic leukemia. Improper drug metabolism leads to toxicity in chemotherapy patients and reduces treatment effectiveness. TPMT variants associated with reduced enzymatic activity vary across populations. Therefore, studying these variants in heterogeneous populations, such as Ecuadorians, can help identify molecular causes of deficiency for this enzyme...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38047039/effectiveness-of-heart-failure-checklist-management-in-patients-with-chronic-heart-failure-an-open-label-single-center-controlled-study-during-18-months-of-follow-up
#32
JOURNAL ARTICLE
Xiaorong Xu, Jing Cheng, Yeping Zhang, Xin Wang, Mulei Chen, Lin Xu, Wenshu Zhao
BACKGROUND: The efficacy of chronic heart failure (CHF) checklist management in reducing adverse outcomes of heart failure patients is still uncertain. This study explores whether CHF checklist management is more useful than usual care in reducing adverse health outcomes in the medium- and long-term among CHF patients. METHODS: In our prospective study, 132 patients with CHF were randomly assigned to CHF management group and usual care group by random number method...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38047038/practical-guidance-for-the-use-of-patisiran-in-the-management-of-polyneuropathy-in-hereditary-transthyretin-mediated-amyloidosis
#33
REVIEW
Stacy Dixon, Xuan Kang, Dianna Quan
Variant transthyretin amyloidosis (ATTRv) is an autosomal dominant inherited genetic disorder that affects 5000-10,000 people worldwide. It is caused by mutations in the transthyretin (TTR) gene and results in amyloid deposition in a variety of organs due to abnormal accumulation of TTR protein fibrils. Although this is a multisystem disorder, the heart and peripheral nerves are the preferentially affected organs. Over 150 TTR gene mutations have been associated with this disease and the clinical phenotype can vary significantly...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38023629/magnitude-and-impacts-of-adverse-events-of-injectable-containing-shorter-regimen-in-programmatic-management-of-multi-drug-resistant-tuberculosis-in-ethiopia-a-retrospective-cohort-study
#34
JOURNAL ARTICLE
Daniel Legese Achalu, Foziya Getachew Mohammed, Mekonnen Teferi
BACKGROUND: Since its launch as a standardized treatment for multidrug-resistant tuberculosis (MDR-TB) in Ethiopia in April 2018, the safety profile of the shorter injectable regimen under a programmatic setting has not been well studied. Thus, this study aimed to assess the status of adverse events in patients treated with a shorter injectable regimen in Ethiopia. METHODS: This is a retrospective cohort study. Data were collected using a structured data abstraction form and analyzed using SPSS, version 25, both descriptively and analytically...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38023628/efficacy-and-safety-of-remdesivir-in-hospitalized-pediatric-covid-19-a-retrospective-case-controlled-study
#35
JOURNAL ARTICLE
Ahmed Khalil, Asmaa Mohamed, Manasik Hassan, Samar Magboul, Hossamaldein Ali, Ahmed Salah Elmasoudi, Khaled Ellithy, Mohammad Qusad, Abdulla Alhothi, Eman Al Maslamani, Mohammed Al Amri, Ashraf Soliman
INTRODUCTION: While most children experience mild coronavirus disease 2019 (COVID-19) infections, a minority of cases progress to severe or critical illness. This study aimed to assess the efficacy and safety of Remdesivir (RDV) therapy in children with moderate to severe COVID-19, enhancing clinical decision-making and expanding our understanding of antiviral treatments for pediatric patients. METHODS: The study included 60 patients, 38 receiving RDV treatment and 22 serving as the control group...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38023627/bridging-the-gap-in-traditional-pivc-placement-an-evaluation-of-operation-stick-vascular-access-outcomes
#36
JOURNAL ARTICLE
Nicholas Mielke, Yuying Xing, Steven Matthew Gibson, Emily DiLoreto, Amit Bahl
OBJECTIVE: Education and training is core to improving peripheral intravenous access outcomes. This study aimed to show that a vascular access training program (Operation STICK) in the emergency department (ED) improves the outcomes of traditionally placed peripheral intravenous catheters (PIVC). METHODS: This was a pre-post quasi-experimental study of traditionally placed PIVCs at a large ED in southeastern Michigan, United States. A control group (non-OSTICK) was compared to an experimental group (OSTICK) using a 3:1 propensity score matched analysis...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38023626/assessment-of-drug-related-problems-and-health-related-quality-of-life-domains-in-elderly-patients-with-type-2-diabetes-mellitus
#37
JOURNAL ARTICLE
Ahmad Al-Azayzih, Roaa J Kanaan, Shoroq M Altawalbeh
AIMS OF THE STUDY: This study aimed to investigate the prevalence and predictors of Drug-related problems (DRPs), as well as to evaluate the impact of DRPs on the health-related quality of life in geriatric patients with type 2 diabetes mellitus. METHODOLOGY: A cross-sectional study was conducted over a three-month period. Patients aged 60 years and older visited diabetes clinics from October 1, 2022, to December 31, 2022, were included in the study. Data were collected through structured questionnaires, whereas lab results, medication records, comorbidities, and the consequences of DRPs were collected from electronic medical records...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38023625/eptinezumab-for-the-prevention-of-migraine-clinical-utility-patient-preferences-and-selection-a-narrative-review
#38
REVIEW
Claudia Altamura, Nicoletta Brunelli, Marilena Marcosano, Alessandro Alesina, Luisa Fofi, Fabrizio Vernieri
The new Calcitonin Gene-Related Peptide (CGRP)-targeted therapies have proven high efficacy and tolerability in episodic and chronic migraine. Eptinezumab is a humanized monoclonal antibody that selectively binds CGRP with high affinity. Eptinezumab was approved by the Food and Drug Administration on February 21st, 2020, for the preventive treatment of migraine in adults. It is administered intravenously over 30 minutes with a standard dose of 100 mg and has a T-max of 30 minutes-1 hour and a half-life of 27 days...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38023624/effect-of-oral-care-solution-on-sore-throat-after-i-gel-laryngeal-mask-general-anesthesia-a-randomized-controlled-trial
#39
JOURNAL ARTICLE
Yan Zhang, Wenjun Meng, Chengwen Hu, Meirong Dong, Youqun Chu, Fang Kang, Juan Li, Xia Chen
BACKGROUND: Sore throat is a common complication after general anesthesia. Oral care solutions have been used to reduce the incidence of oral complications or ventilator-associated pneumonia, but their effect on postoperative sore throat (POST) is unclear. This study aims to investigate whether oral care solution can alleviate POST in patients undergoing i-gel laryngeal mask general anesthesia. METHODS: A total of 120 patients who were scheduled for elective surgery under laryngeal mask general anesthesia were enrolled...
2023: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38023623/real-world-evaluation-of-a-pharmacoinvasive-strategy-for-stemi-in-latin-america-a-cost-effective-approach-with-short-term-benefits
#40
JOURNAL ARTICLE
Alexandra Arias-Mendoza, Jorge A Ortega-Hernández, Diego Araiza-Garaygordobil, Héctor González-Pacheco, Mireya Martínez-García, Enrique Hernández-Lemus, Rodrigo Gopar-Nieto, Tomás Tadeo Sandoval-Aguilar, Daniel Sierra-Lara Martinez, Salvador Mendoza-García, Alfredo Altamirano-Castillo, José Luis Briseño-de-la-Cruz, Midori Alondra Ortega-Hernández, Luis Alejandro Soliz-Uriona, Jorge Gaspar-Hernández
PURPOSE: While pharmacoinvasive strategy (PI) is a safe and effective approach whenever access to primary percutaneous intervention (pPCI) is limited, data on each strategy's economic cost and impact on in-hospital stay are scarce. The objective is to compare the cost-effectiveness of a PI with that of pPCI for the treatment of ST-elevation myocardial infarction (STEMI) in a Latin-American country. PATIENTS AND METHODS: A total of 1747 patients were included, of whom 470 (26...
2023: Therapeutics and Clinical Risk Management
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