Seyyed M H Haddad, Christopher J M Scott, Miracle Ozzoude, Courtney Berezuk, Melissa Holmes, Sabrina Adamo, Joel Ramirez, Stephen R Arnott, Nuwan D Nanayakkara, Malcolm Binns, Derek Beaton, Wendy Lou, Kelly Sunderland, Sujeevini Sujanthan, Jane Lawrence, Donna Kwan, Brian Tan, Leanne Casaubon, Jennifer Mandzia, Demetrios Sahlas, Gustavo Saposnik, Ayman Hassan, Brian Levine, Paula McLaughlin, J B Orange, Angela Roberts, Angela Troyer, Sandra E Black, Dar Dowlatshahi, Stephen C Strother, Richard H Swartz, Sean Symons, Manuel Montero-Odasso, Ondri Investigators, Robert Bartha
Alterations in tissue microstructure in normal-appearing white matter (NAWM), specifically measured by diffusion tensor imaging (DTI) fractional anisotropy (FA), have been associated with cognitive outcomes following stroke. The purpose of this study was to comprehensively compare conventional DTI measures of tissue microstructure in NAWM to diverse vascular brain lesions in people with cerebrovascular disease (CVD) and to examine associations between FA in NAWM and cerebrovascular risk factors. DTI metrics including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured in cerebral tissues and cerebrovascular anomalies from 152 people with CVD participating in the Ontario Neurodegenerative Disease Research Initiative (ONDRI)...
2022: International Journal of Biomedical Imaging