L Kananen, S Marttila, T Nevalainen, L Kummola, I Junttila, N Mononen, M Kähönen, O T Raitakari, A Hervonen, M Jylhä, T Lehtimäki, M Hurme, J Jylhävä
The epigenetic clock, defined as the DNA methylome age (DNAmAge), is a candidate biomarker of ageing. In this study, we aimed to characterize the behaviour of this marker during the human lifespan in more detail using two follow-up cohorts (the Young Finns study, calendar age i.e. cAge range at baseline 15-24 years, 25-year-follow-up, N = 183; The Vitality 90+ study, cAge range at baseline 19-90 years, 4-year-follow-up, N = 48). We also aimed to assess the relationship between DNAmAge estimate and the blood cell distributions, as both of these measures are known to change as a function of age...
June 2016: Age (2005-)