journal
https://read.qxmd.com/read/38531804/investigating-the-spatial-distribution-of-proliferating-cells-in-primary-ovarian-cancers
#1
JOURNAL ARTICLE
Mohamed A A A Hegazi, Fabio Pasqualini, Gianluigi Taverna, Robert S Bresalier, Maurizio Chiriva-Internati, Fabio Grizzi
BACKGROUND: Ovarian cancer (OC) accounts for about 4% of female cancers globally. While Ki67-immunopositive (Ki67+ ) cell density is commonly used to assess proliferation in OC, the two-dimensional (2D) distribution pattern of these cells is poorly understood. This study explores the 2D distribution pattern of Ki67+ cells in primary OC tissues and models the proliferation process to improve our understanding of this hallmark of cancer. METHODS: A total of 100 tissue cores, included in a tissue microarray (TMA) representing 5 clear cell carcinomas, 62 serous carcinomas, 10 mucinous adenocarcinomas, 3 endometrioid adenocarcinomas, 10 lymph node metastases from OC, and 10 samples of adjacent normal ovary tissue, were stained using a standardized immunohistochemical protocol...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531803/analysis-and-investigation-of-bioinformatics-and-epigenetics-reveal-the-underlying-mechanisms-by-which-flot2-modulates-the-progression-of-diffuse-large-b-cell-lymphoma
#2
JOURNAL ARTICLE
Yujing Zhang, Yao Chen, Qiang Guo, Ying Zhang, Aichun Liu
BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) poses a significant threat to the quality of life for people worldwide. Regrettably, effective treatment strategies for this disease remain elusive in clinical practice due to the unclear understanding of its molecular mechanisms. Therefore, this study was devised to address these issues and identify novel diagnostic, therapeutic, and prognostic biomarkers for DLBCL. METHODS: Gene expression and clinical data for DLBCL patients were retrieved from The Cancer Genome Atlas (TCGA) database, and relevant clinical data, tumor mutational burden (TMB), and gene expression levels were extracted...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531802/formononetin-restrains-tumorigenesis-of-breast-tumor-by-restraining-sting-nf-%C3%AE%C2%BAb-and-interfering-with-the-activation-of-pd-l1
#3
JOURNAL ARTICLE
Hongmei Liu, Zhipeng Wang, Zhigang Liu
BACKGROUND: Breast cancer (BC), a common tumor in women, has high morbidity and mortality. Formononetin, an active ingredient in red clover and Astragalus membranaceus , has a wide range of pharmacological applications, including as an anticancer agent. Since immunotherapy is a hot topic in the treatment strategy of BC, it was dedicated to appraising the specific mechanism of formononetin in BC immunotherapy in this research. METHODS: Different formononetin concentrations (0, 20, 40, 60, 80, 100 μM) were used to treat BC cells transfected with pcDNA3...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531801/lncrna-meg3-aggravates-renal-fibrosis-caused-by-unilateral-ureteral-obstruction-in-rats-by-activating-the-hedgehog-pathway
#4
JOURNAL ARTICLE
Pei Dong, Sheng Zhang, Da-Jun Hu, Rui Hou, Li Lei
BACKGROUND: The hedgehog signaling pathway exerts vital functions in regulating epithelial-to-mesenchymal transition (EMT) in renal interstitial fibrosis (RIF). It was reported that lncRNA-maternally expressed gene 3 (lncRNA Meg3) can regulate hepatic fibrosis by regulating the expression of smoothened (Smo) in the hedgehog signaling pathway. However, the specific role of lncRNA Meg3 in renal fibrosis resulting from unilateral ureteral obstruction (UUO) by regulating the hedgehog signaling pathway has not been reported...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531800/the-value-of-combined-detection-of-serum-bnp-cardiac-troponin-i-and-dynamic-electrocardiogram-in-early-clinical-diagnosis-and-prognosis-of-patients-with-acute-myocardial-infarction
#5
JOURNAL ARTICLE
Qinxia Yu, Shuyan Yu
BACKGROUND: Acute myocardial infarction (AMI) is a prevalent cardiovascular disease resulting from myocardial ischemia and necrosis due to coronary artery occlusion. AMI is characterized by a sudden onset and high mortality, underscoring the significance of early diagnosis and treatment for improving patient prognosis. This study endeavors to assess the utility of a combined assessment involving serum brain natriuretic peptide (BNP), cardiac troponin-I (cTnI), and dynamic electrocardiogram (ECG) in the early clinical diagnosis and prognosis prediction of AMI...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531799/application-of-acoustic-radiation-force-pulse-imaging-technology-in-the-evaluation-of-the-efficacy-of-calf-intermuscular-vein-thrombosis
#6
JOURNAL ARTICLE
Chengfang Wang, Yijia Zhou, Ruhui Ruan
BACKGROUND: The continuous advancement in ultrasound technology has given rise to Acoustic Radiation Force Impulse (ARFI) elastography, which boasts non-invasiveness, ease of operation, rapid inspection, and high accuracy. It has been successfully employed in detecting tissue hardness across various diseases. This study aims to investigate the application of acoustic radiation force pulse imaging technology in evaluating the efficacy of calf intermuscular vein thrombosis. METHODS: This study is retrospective in nature, involving a total of 120 patients diagnosed with calf intermuscular venous thrombosis (MCVT) who were admitted to our hospital...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531798/phentolamine-protects-against-apoptosis-and-inflammation-in-a-neonatal-pneumonia-cell-model-induced-by-lps-by-regulating-the-trka-akt-signaling-pathways
#7
JOURNAL ARTICLE
Qian Liu, Shengwei Wu, Zhenlin Chen, Jin Cai
BACKGROUND: Phentolamine is an α-adrenergic receptor blocker that can be used to treat neonatal pneumonia, but its underlying mechanism is unclear. The purpose of this study is to probe the function of phentolamine on lipopolysaccharide (LPS)-induced inflammation and cell death in an in vitro model of neonatal pneumonia. METHODS: Human MRC-5 cells were incubated with varying doses of phentolamine in vitro to evaluate cell viability. Subsequently, LPS was introduced to further investigate the combined effects of phentolamine and LPS on cell viability and apoptosis in MRC-5 cells...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531797/knockdown-of-linc01128-downregulates-fut8-to-inhibit-oxldl-induced-vascular-smooth-muscle-cell-apoptosis-in-atherosclerosis
#8
JOURNAL ARTICLE
Guozhen Ni, Jian Xu
BACKGROUND: The apoptosis of vascular smooth muscle cells (VSMCs) contributes to the progression of atherosclerosis (AS). Long intergenic non-protein coding RNA 1128 (LINC01128) has been implicated in AS, and this study aims to uncover the role and mechanism of LINC01128 in regulating oxidized low-density lipoprotein (oxLDL)-induced VSMCs. METHODS: The position of LINC01128 in cells and its target genes were predicted using bioinformatics. The localization of LINC01128 in human VSMCs was determined through fluorescence in situ hybridization...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531796/dna-methylation-regulated-hoxc8-s-role-in-her2-positive-breast-cancer-function-and-its-contribution-to-herceptin-resistance
#9
JOURNAL ARTICLE
Xiaofeng Xie, Sijia Tang, Zhengyang Yu
BACKGROUND: The epidermal growth factor receptor 2 ( HER2 ) is overexpressed in 30% of breast cancers, and this overexpression is strongly correlated with a poor prognosis. Herceptin is a common treatment for HER2-positive breast cancer; however, cancer cells tend to adapt gradually to the drug, rendering it ineffective. The study revealed an association between the methylation status of the Homeobox C8 ( HOXC8 ) gene and tumor development. Therefore, it is of paramount importance to delve into the interaction between HOXC8 and HER2-positive breast cancer, along with its molecular mechanisms...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531795/unlocking-the-therapeutic-potential-of-lncrna-blacat1-in-hypopharynx-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
Fan-Li Liu, Zhan-Cheng Zhang, Sheng-Li Zhou, Xu-Liang Liu, Wei Xu
BACKGROUND: Identifying the key molecular targets in hypopharynx squamous cell carcinoma (HSCC) is crucial for understanding this prevalent and highly fatal type of head and neck tumor. The study aims to enhance comprehension of the HSCC process by accurately identifying these key molecular targets. MATERIALS AND METHODS: In this study, we examined 47 clinical tissue samples from individuals diagnosed with HSCC using RNA-seq high-throughput assay. Quantitative real-time PCR (RT-PCR) was used to compare long non-coding RNA (lncRNA) bladder cancer-associated transcript 1 ( BLACAT1 ) expression in HSCC tissues versus adjacent non-tumor tissues...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531794/creation-of-an-atherosclerosis-model-using-palmitic-acid-and-oleic-acid-in-the-vascular-smooth-muscle-cells-of-rats
#11
JOURNAL ARTICLE
Fan Zhang, Guangping Li, Xueyin Li, Yi Zheng, Wanting Du, Bo Zhao, Da Sun
BACKGROUND: Atherosclerosis (AS) is a chronic vascular inflammatory disease resulting from vascular endothelial injury and lipid deposition, closely linked to abnormal lipid metabolism within the body. The critical processes involved in atherosclerosis encompass lipid deposition, oxidation, metabolic disruptions, and inflammatory stimulation within the inner vessel wall. Lipid deposition emerges as a pivotal factor triggering these pathological changes, with vascular smooth muscle cells (VSMCs) playing a significant role in the development of AS...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531793/characterizing-the-efficacy-and-safety-of-chemotherapy-plus-everolimus-in-her2-negative-metastatic-breast-cancer-harboring-altered-pi3k-akt-mtor
#12
JOURNAL ARTICLE
Rong Wang, Qiao-Yan Zhu, Wei-Wu Ye, Yuan Huang, Zhan-Hong Chen, Ya-Bing Zheng, Xiao Zou, Jian Wang, Dan-Lu Jiang, Xiao-Jia Wang, Zheng-Yang Xu, Wen-Ming Cao
BACKGROUND: The clinical outcomes of chemotherapy (CT) for the treatment of metastatic triple-negative (TN) and hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (mBC) have proven to be disappointing. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway, a tumor-promoting signaling cascade frequently mutated in breast cancer (BC), has been implicated in chemoresistance...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531792/upregulated-atf1-promotes-lipopolysaccharide-induced-inflammatory-response-and-inhibits-osteogenic-differentiation-of-human-periodontal-ligament-cells-by-regulating-nf-%C3%AE%C2%BAb-pathway
#13
JOURNAL ARTICLE
Wei Guo, Shuyun Yan, Ge Zhao
BACKGROUND: Periodontitis is a chronic inflammatory disease resulting from bacterial plaque infection. While the involvement of activating transcription factor 1 (ATF1) has been extensively explored in various human diseases, its specific role in periodontitis remains unclear. This study aims to elucidate the expression and biological function of ATF1 in the context of periodontitis. METHODS: Primary human periodontal ligament cells (hPDLCs) were procured from clinical samples and subsequently characterized...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531791/melatonin-s-protective-effects-on-neurons-in-an-in-vitro-cell-injury-model
#14
JOURNAL ARTICLE
Wei Gu, Mimi Wu, Shihe Cui, Jinhua Bo, Hao Wu
BACKGROUND: Currently, the role of melatonin (MT) in neuronal damage remains unclear and this study aimed to explore the protective effects of MT on neurons in an in vitro cell injury model. METHODS: The Sprague Dawley (SD) rat traumatic brain injury (TBI) model was prepared, and brain tissue extract (BTE) from the injured area were generated. To establish a cell injury model in vitro , the BTE was added to the culture medium during the neuron culture process. MT was introduced into the culture medium of the cell injury model to observe its protective effects on neurons...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531790/mechanical-stretch-induced-atp-release-from-osteocytes-promotes-osteogenesis-of-bone-marrow-mesenchymal-stem-cells
#15
JOURNAL ARTICLE
Yiwen Ru, Hong Gu, Lian Sun, WeiBing Zhang, Lin Wang
BACKGROUND: Mandibular distraction osteogenesis (MDO) is a highly effective method for bone regeneration, commonly employed in treating craniofacial defects and deformities. Osteocytes sense mechanical forces in the pericellular space, relay external stimuli to biochemical changes, and send signals to other effector cells, including bone marrow mesenchymal stem cells (BM-MSCs), to regulate bone resorption and formation. Piezo1 potentially affects the secretion signal molecules of bone cells under mechanical stretch...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531789/dental-artificial-intelligence-systems-a-review-of-various-data-types
#16
JOURNAL ARTICLE
Ruoyan Zhang, Haiwen Chen, Yanning Ma, Zuolin Jin
With the rapid development of dental artificial intelligence systems (DAIS), a new field known as "Data Dentistry", proposed by Schwendicke in 2021, has successfully bridged the gap between medicine and engineering. This literature review introduces advanced techniques in data collection, outlines the current state of DAIS in data processing, and anticipates the future of DAIS by emphasizing the importance of more extensive and enhanced datasets. The key findings include: Versatility of imaging data: Various types of imaging data, such as X-ray, cone beam computed tomography (CBCT), facial photos, and face and oral scans, can be transformed into datasets used by artificial intelligence systems...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531788/rare-but-still-there-a-scoping-review-on-endometriosis-associated-ovarian-cancer
#17
JOURNAL ARTICLE
Karl Livori, Jean Calleja-Agius
Endometriosis is a medical condition affecting at least up to 10% of women of reproductive age. This condition occurs when ectopic endometrial glands and stroma implant outside the uterus and there are several theories regarding the underlying origins of the disease. Endometriosis is one of the major causes of severe dysmenorrhoea, chronic pelvic pain and infertility. While endometriosis is generally a non-malignant condition, it rarely may transform into an invasive cancer, and increase the risk for epithelial ovarian cancer, notably endometrioid or clear cell ovarian cancer...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531787/recent-progress-of-chitosan-nanoparticles-for-the-development-of-superior-delivery-of-vaccines
#18
JOURNAL ARTICLE
Moeka Nakashima, Naoko Suga, Yuka Ikeda, Sayuri Yoshikawa, Satoru Matsuda
Chitosan seems to be an innovative biological material potentially utilized as a nanoparticle carrier for drug delivery, which could be low toxic, biocompatible, and easy to prepare. Chitosan nanoparticles have been employed in gene delivery. As a type of multifunctional adjuvant, chitosan nanoparticles could activate the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway to induce cell protection and/or proliferation via the modulation of autophagy within dendritic cells. In general, adjuvants may improve the innate and/or adaptive immune responses to a vaccine antigen by facilitating the antigen presentation of antigen presenting cells such as dendritic cells...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531786/ph-dependent-non-covalent-release-of-chemotherapy-from-carriers
#19
JOURNAL ARTICLE
Qixin Leng, Aishwarya Anand, Archibald James Mixson
Although Warburg discovered pH discrepancies between tumor and normal tissues nearly 100 years ago, developing therapies to take advantage of this concept was relatively slow for the first 70 years. During the last 30 years, there has been an exponential increase in the use of pH-dependent strategies for both low molecular weight drugs and nanoparticles. Two frequently discussed approaches are the chemotherapy's release from pH-sensitive covalent linkages of macromolecules or from pH-dependent disruption of charged polymeric nanoparticles...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531785/mycobacterial-endocarditis-a-rare-form-of-infective-endocarditis
#20
JOURNAL ARTICLE
John Dawi, Scarlet Affa, Abraham Chorbajian, Yura Misakyan, Aishvaryaa Shree Mohan, Brandon Norris, Jacob Ochsner, Sonyeol Yoon, Vishwanath Venketaraman
This research project delves into the multifaceted dynamics of Mycobacterium tuberculosis (M.tb) endocarditis, a significant yet uncommon manifestation of tuberculosis (TB). Beginning with an overview of M.tb and the global challenges posed by TB, we navigate through the bacterium's evolution, transmission modes, and the intricate host immune response. The pathology and pathophysiology of M.tb endocarditis are explored, emphasizing its complexities and the host's efforts to contain the pathogen. The study extends to atypical mycobacterial endocarditis, highlighting the emergence of species like M...
March 2024: Discovery Medicine
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