journal
https://read.qxmd.com/read/38967740/multidisciplinary-approach-for-locally-advanced-non-small-cell-lung-cancer-nsclc-2023-expert-consensus-of-the-spanish-lung-cancer-group-gecp-controversies-and-discussion
#21
LETTER
Arturo Navarro Martín, Nuria Rodriguez de Dios, Jose Luis Lopez Guerra, Felipe Couñago Lorenzo
No abstract text is available yet for this article.
July 5, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38967739/comprehensive-analysis-of-psmg3-in-pan-cancer-and-validation-of-its-role-in-hepatocellular-carcinoma
#22
JOURNAL ARTICLE
Mengli Zheng, Xiaochun Chen, Zhe Xu, Zhitao Ye, Lixian Zhong, Zhicao Chen, Guiquan Chen, Boyong Cai
BACKGROUND: Proteasome assembly chaperone 3 (PSMG3), a subunit of proteasome, has been found to be associated with lung cancer. However, the role of PSMG3 in other cancers has not been elucidated. The objective of this study was to explore the immune role of PSMG3 in pan-cancer and confirm the oncogenic significance in liver hepatocellular carcinoma (LIHC). METHODS: We examined the differential expression of PSMG3 across various cancer types using data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) databases...
July 5, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38967738/the-effect-of-combined-head-and-tail-approach-during-laparoscopic-d3-lymph-node-dissection-on-pain-severity-and-complications-in-patients-with-right-colon-cancer
#23
JOURNAL ARTICLE
Liang Wang, Jun Zhao, Lianghui Shi, Bing Wang, Xiaofeng Zhang
OBJECTIVE: To examine the impact of a combined craniocaudal approach on pain and complications during laparoscopic D3 lymph node dissection in clients diagnosed with right colon cancer (RCC). METHODS: 100 RCC patients were divided into Group A and Group B. Both groups underwent laparoscopic D3 lymph node dissection, with Group A undergoing an intermediate approach and Group B undergoing a combined head and tail approach. Two groups of patients' perioperative (surgical time, intraoperative blood loss, number of lymph node dissection) indicators, postoperative recovery (postoperative exhaust time, postoperative hospital stay, drainage tube removal time) indicators, perioperative pain level (VAS scores 1, 3, and 5 days following surgery), and incidence of complications (vascular injury, intestinal obstruction, anastomotic bleeding, incision infection), and the therapeutic efficacy [CEA, CA19-9] indicators were compared...
July 5, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38967737/endoplasmic-reticulum-stress-regulates-apoptosis-and-chemotherapeutic-via-enhancing-tnfrsf10b-recycling-to-the-cell-membrane-in-triple-negative-breast-cancer
#24
JOURNAL ARTICLE
Dapeng Zhao, Jian Song, Chongyao Ji
BACKGROUND: Triple-negative breast cancer (TNBC) is the most common malignant tumor in China. The expression and cell surface levels of TNF receptor superfamily member 10B (TNFRSF10B) are associated with apoptosis and chemotherapy. However, the precise molecular mechanisms that govern the regulation of TNFRSF10B remain unclear. MATERIALS AND METHODS: RNA-Seq data related to TNBC chemotherapy resistance were acquired from the GEO database. The mRNA and protein levels of TNFRSF10B were detected using RT-PCR and Western blotting, respectively...
July 5, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38965192/serum-biomarkers-reg1a-and-reg3a-combined-with-the-traditional-cea-represent-a-novel-nomogram-for-the-screening-and-risk-stratification-of-colorectal-cancer
#25
JOURNAL ARTICLE
Long Yu, Hao Wang, Fulong Wang, Jian Guo, Binyi Xiao, Zhenlin Hou, Zhenhai Lu, Zhizhong Pan, Yaxian Zhou, Sibin Ye, Desen Wan, Bo Lin, Qingjian Ou, Yujing Fang
BACKGROUND: To develop and validate a serum protein nomogram for colorectal cancer (CRC) screening. METHODS: The serum protein characteristics were extracted from an independent sample containing 30 colorectal cancer and 12 polyp tissues along with their paired samples, and different serum protein expression profiles were validated using RNA microarrays. The prediction model was developed in a training cohort that included 1345 patients clinicopathologically confirmed CRC and 518 normal participants, and data were gathered from November 2011 to January 2017...
July 4, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38965191/lasso-cox-interpretable-model-of-afp-negative-hepatocellular-carcinoma
#26
JOURNAL ARTICLE
Han Li, Chengyuan Zhou, Chenjie Wang, Bo Li, Yanqiong Song, Bo Yang, Yan Zhang, Xueting Li, Mingyue Rao, Jianwen Zhang, Ke Su, Kun He, Yunwei Han
BACKGROUND: In AFP-negative hepatocellular carcinoma patients, markers for predicting tumor progression or prognosis are limited. Therefore, our objective is to establish an optimal predicet model for this subset of patients, utilizing interpretable methods to enhance the accuracy of HCC prognosis prediction. METHODS: We recruited a total of 508 AFP-negative HCC patients in this study, modeling with randomly divided training set and validated with validation set...
July 4, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38958901/seom-gg-clinical-guidelines-for-the-management-of-germ-cell-testicular-cancer-2023
#27
JOURNAL ARTICLE
José Angel Arranz Arija, Xavier García Del Muro, Raquel Luque Caro, María José Méndez-Vidal, Begoña Pérez-Valderrama, Jorge Aparicio, Miguel Ángel Climent Durán, Cristina Caballero Díaz, Ignacio Durán, Enrique González-Billalabeitia
Testicular germ cell tumors are the most common tumors in adolescent and young men. They are curable malignancies that should be treated with curative intent, minimizing acute and long-term side effects. Inguinal orchiectomy is the main diagnostic procedure, and is also curative for most localized tumors, while patients with unfavorable risk factors for recurrence, or those who are unable or unwilling to undergo close follow-up, may require adjuvant treatment. Patients with persistent markers after orchiectomy or advanced disease at diagnosis should be staged and classified according to the IGCCCG prognostic classification...
July 3, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38958900/cross-sectional-study-of-hepatitis-b-virus-infection-in-female-breast-cancer-patients-in-china-for-the-first-time-diagnosed
#28
JOURNAL ARTICLE
Zhao-Xing Li, Jie Huang, Lei Hu, Zhi-Yu Jiang, Liang Ran, Xin-Yu Liang, Rui-Ling She, Chen-Yu Ma, Jun-Han Feng, Jing-Yu Song, Xiu-Quan Qu, Bai-Qing Peng, Kai-Nan Wu, Ling-Quan Kong
BACKGROUND: The correlation between breast cancer and hepatitis B virus (HBV) remains inconclusive. This study aims to explore the serological status of HBV infection and past infection in different age groups of female breast cancer patients, patients with benign breast diseases, and individuals undergoing routine physical examinations. METHODS: Serum data on HBV serological markers were collected and analyzed from 6072 female breast cancer patients first diagnosed from September 2012 to July 2020 at the First Affiliated Hospital of Chongqing Medical University, along with 4019 women with benign breast diseases and 54,740 healthy females undergoing routine physical examinations in the same period...
July 3, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38951439/correction-logistic-regression-and-other-statistical-tools-in-diagnostic-biomarker-studies
#29
Dina Mohamed Ahmed Samir Elkahwagy, Caroline Joseph Kiriacos, Manar Mansour
No abstract text is available yet for this article.
July 1, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38951438/access-to-systemic-treatment-of-non-melanoma-skin-cancer-in-spain-a-survey-analysis
#30
JOURNAL ARTICLE
Pablo Cerezuela-Fuentes, Maria Gonzalez-Cao, Teresa Puertolas, Jose Luis Manzano, Cayetana Maldonado, Oriol Yelamos, Miguel A Berciano-Guerrero, Juan Martin-Liberal, Eva Muñoz-Couselo, Enrique Espinosa, Ana Drozdowskyj, Alfonso Berrocal, Ainara Soria, Ivan Marquez-Rodas, Salvador Martin-Algarra, Maria Quindos, Susana Puig
BACKGROUND: Novel and highly effective drugs for non-melanoma skin cancer (NMSC) improve patient outcomes, but their high cost strains healthcare systems. Spain's decentralized public health system, managed by 17 autonomous communities (AaCc), raises concerns about equitable access. METHODS: A cross-sectional survey (July-September 2023) was sent to Spanish Multidisciplinary Melanoma Group (GEM Group) members to assess access to new drugs. FINDINGS: Fifty physicians from 15 Spanish AaCc responded to the survey...
July 1, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38951437/angiosarcoma-a-10-year-retrospective-study-from-a-high-volume-uk-regional-referral-centre
#31
JOURNAL ARTICLE
Ahrin Anna Morrow, James Hodson, Costanza Figura, Salena Bains, Robert M Warner, L Max Almond
PURPOSE: Angiosarcoma (AS) is a rare malignancy with considerable heterogeneity seen in its aetiology, anatomical location, and clinicopathological behaviour. Diagnosis is often delayed and prognosis poor. The purpose of this study was to perform a retrospective review of all cases of AS over 10 years at a high-volume regional UK referral centre. METHODS/PATIENTS: We reviewed all cases of AS discussed at the sarcoma multidisciplinary meetings of University Hospitals Birmingham NHS Foundation Trust from September 2013 to August 2023...
July 1, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38935241/letter-to-the-editor-regarding-sbrt%C3%A2-sg%C3%A2-01-final-results-of-a-prospective-multicenter-study-on-stereotactic-body-radiotherapy-for-liver-metastases
#32
LETTER
Cem Onal, Aysenur Elmali
No abstract text is available yet for this article.
June 27, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38935240/comparison-of-the-efficacy-and-safety-of-domestically-produced-tislelizumab-camrelizumab-and-imported-pembrolizumab-in-the-treatment-of-advanced-nsclc-a-real-world-retrospective-study
#33
JOURNAL ARTICLE
Jia Hu, MengTing Li, ZeYu Xie, JiSheng Chen
BACKGROUND: Since the imported PD-1 inhibitor pembrolizumab was listed in China in 2018, China has opened up the era of immunotherapy for malignant tumors, with several domestically produced PD-1 inhibitors coming onto the market one after another. To find out whether there are differences in the efficacy and safety of domestic and imported PD-1 inhibitors in patients with advanced non-small cell lung cancer, we conducted this retrospective study in two tertiary hospitals in China. METHODS: Patients with advanced NSCLC treated with tislelizumab or camrelizumab or pembrolizumab who met the inclusion criteria were screened through the electronic medical record system...
June 27, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38926258/clinical-pathological-and-gene-expression-profiling-of-estrogen-receptor-discordance-in-breast-cancer
#34
JOURNAL ARTICLE
Xi Wang, Shengnan Bao, Mengping Jiang, Xian Zou, Yongmei Yin
BACKGROUND: Breast cancer (BC) is the world's largest tumor species in which hormone receptor-positive patients have relatively good prognosis. However, majority of patients will develop late resistance, one of the important factors is due to the loss of the original estrogen receptor (ER) expression. METHODS: We conducted this study in 115 patients with BC who experienced second biopsy at Jiangsu Province Hospital (JSPH) and divided patients into two subgroups ER + to - and ER + to + ...
June 26, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38926257/the-role-of-ampk-in-pancreatic-cancer-from-carcinogenesis-to-treatment
#35
REVIEW
Shahrzad Shahrokhi Nejad, Sepideh Razi, Nima Rezaei
Pancreatic cancer has doubled over the previous two decades. Routine therapies are becoming incredibly resistant and failing to compensate for the burden caused by this aggressive neoplasm. As genetic susceptibility has always been a highlighted concern for this disease, identifying the molecular pathways involved in the survival and function of pancreatic cancer cells provides insight into its variant etiologies, one of which is the role of AMPK. This regulating factor of cell metabolism is crucial in the homeostasis and growth of the cell...
June 26, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38922538/safety-and-efficacy-of-restarting-immune-checkpoint-inhibitors-in-non-small-cell-lung-cancer-patients-following-immune-related-adverse-events-a-systematic-review-and-meta-analysis
#36
REVIEW
Kexin Tan, Aolin Wang, Yumin Zheng, Shuo Wang, Chao Wang, Jia Li, Xingyu Lu, Huijing Dong, Jiabin Zheng, Huijuan Cui
OBJECTIVE: This meta-analysis aims to evaluate the safety and efficacy of restarting immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC) after experiencing immune-related adverse events (irAEs). METHODS: A comprehensive search of PubMed, Web of Science, Embase, and the Cochrane Library was conducted to identify studies investigating the safety and efficacy of restarting ICIs in NSCLC patients after irAEs. Outcome measures, including objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) after ICI restarting, were extracted...
June 26, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38922537/shifting-cold-to-hot-tumors-by-nanoparticle-loaded-drugs-and-products
#37
REVIEW
Irfan Ahmad, Kamil K Atiyah Altameemi, Mohaned Mohammed Hani, Afaq Mahdi Ali, Hasanain Khaleel Shareef, Zahraa F Hassan, Mahmood Hasen Shuhata Alubiady, Salah Hassan Zain Al-Abdeen, Hussein Ghafel Shakier, Ahmed Huseen Redhee
Cold tumors lack antitumor immunity and are resistant to therapy, representing a major challenge in cancer medicine. Because of the immunosuppressive spirit of the tumor microenvironment (TME), this form of tumor has a low response to immunotherapy, radiotherapy, and also chemotherapy. Cold tumors have low infiltration of immune cells and a high expression of co-inhibitory molecules, such as immune checkpoints and immunosuppressive molecules. Therefore, targeting TME and remodeling immunity in cold tumors can improve the chance of tumor repression after therapy...
June 26, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38918302/a-prognostic-nomogram-to-predict-the-cancer-specific-survival-of-patients-with-initially-diagnosed-metastatic-gastric-cancer-a-validation-study-in-a-chinese-cohort
#38
JOURNAL ARTICLE
Ziming Zhao, Erxun Dai, Bao Jin, Ping Deng, Zulihaer Salehebieke, Bin Han, Rongfan Wu, Zhaowu Yu, Jun Ren
BACKGROUND: Few studies have been designed to predict the survival of Chinese patients initially diagnosed with metastatic gastric cancer (mGC). Therefore, the objective of this study was to construct and validate a new nomogram model to predict cancer-specific survival (CSS) in Chinese patients. METHODS: We collected 328 patients with mGC from Northern Jiangsu People's Hospital as the training cohort and 60 patients from Xinyuan County People's Hospital as the external validation cohort...
June 25, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38914756/seom-gemcad-ttd-clinical-guidelines-for-the-management-of-hepatocarcinoma-patients-2023
#39
JOURNAL ARTICLE
Carlos López López, Mariona Calvo, Juan Carlos Cámara, Beatriz García-Paredes, Carlos Gómez-Martin, Ana María López, Roberto Pazo-Cid, Javier Sastre, Ricardo Yaya, Jaime Feliu
Hepatocellular carcinoma (HCC) is the most common primary malignancy in the liver and is the third cause of cancer-related death worldwide. Surveillance with abdominal ultrasound should be offered to individuals at high risk for developing HCC. Accurate diagnosis, staging, and liver function are crucial when determining the optimal therapeutic approach. The BCLC staging system is widely endorsed in Western countries. Managing this pathology requires a multidisciplinary, personalized approach, generally with a multimodal strategy...
June 24, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38914755/seom-gemcad-ttd-clinical-guidelines-for-the-adjuvant-treatment-of-colon-cancer-2023
#40
JOURNAL ARTICLE
Carles Pericay, Clara Montagut, Juan José Reina, Marcos Melian, Julia Alcaide, Noelia Tarazona, Ana Ruiz-Casado, Encarnación González-Flores, Begoña Graña, Cristina Grávalos
Colorectal cancer (CRC) has a 5-year overall survival rate of over 60%. The decrease in the rate of metastatic disease is due to screening programs and the population's awareness of healthy lifestyle. Similarly, advancements in surgical methods and the use of adjuvant chemotherapy have contributed to a decrease in the recurrence of resected disease. Before evaluating a patient's treatment, it is recommended to be discussed in a multidisciplinary tumor board. In stage II tumors, the pathologic characteristics of poor prognosis must be known (T4, number of lymph nodes analyzed less than 12, lymphovascular or perineural invasion, obstruction or perforation, poor histologic grade, presence of tumor budding) and it is mandatory to determine the MSI/MMR status for avoiding administering fluoropyridimidines in monotherapy to patients with MSI-H/dMMR tumors...
June 24, 2024: Clinical & Translational Oncology
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