journal
https://read.qxmd.com/read/38877363/pan-immune-inflammation-value-a-new-prognostic-index-in-operative-laryngeal-and-pharyngeal-carcinomas
#1
JOURNAL ARTICLE
Jiaqi Shi, Chang Liu, Ning Yang, Chen Qiu
PURPOSE: This study aimed to further evaluate the potential value of Pan-Immune-Inflammation Value (PIV) as a prognostic marker in patients with laryngeal and pharyngeal tumors. METHODS: A total of 545 patients with laryngeal and pharyngeal tumors who underwent surgery at Qilu Hospital of Shandong University were included. We determined the optimal cutoff of PIV and divided the patients into two groups. The relationship between PIV and clinicopathological features was explored by the chi-square test and the Mann-Whitney U test...
June 14, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38874803/letter-to-editor-response-multidisciplinary-approach-for-locally-advanced-non-small-cell-lung-cancer-nsclc-2023-expert-consensus-of-the-spanish-lung-cancer-group-gecp-controversies-and-discussion
#2
LETTER
Aylen Vanessa Ospina, Sergio Bolufer Nadal, Bartomeu Massuti Sureda, Mariano Provencio
No abstract text is available yet for this article.
June 14, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38872053/the-clinical-features-and-prognostic-implications-of-the-co-mutated-tp53-gene-in-advanced-non-small-cell-lung-cancer
#3
JOURNAL ARTICLE
Bing Bai, Xia An, Qinghui Qu, Xin Liu, Yuanyuan Liu, Li Wei
BACKGROUND: TP53 is a frequently mutated oncogene within non-small cell lung cancer (NSCLC). However, the clinical and prognostic significance of co-mutations in TP53 in patients with advanced NSCLC has not been fully elucidated. METHODS: A total of 174 patients with advanced NSCLC were enrolled in this study. All patients were subjected to sequencing analysis of tumor-related genes and information such as PD-L1 expression, TMB, and co-mutation changes were collected...
June 13, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38869741/biomarkers-in-breast-cancer-2024-an-updated-consensus-statement-by-the-spanish-society-of-medical-oncology-and-the-spanish-society-of-pathology
#4
REVIEW
Ramon Colomer, Blanca González-Farré, Ana Isabel Ballesteros, Vicente Peg, Begoña Bermejo, Belén Pérez-Mies, Susana de la Cruz, Federico Rojo, Sonia Pernas, José Palacios
This revised consensus statement of the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathological Anatomy (SEAP) updates the recommendations for biomarkers use in the diagnosis and treatment of breast cancer that we first published in 2018. The expert group recommends determining in early breast cancer the estrogen receptor (ER), progesterone receptor (PR), Ki-67, and Human Epidermal growth factor Receptor 2 (HER2), as well as BReast CAncer (BRCA) genes in high-risk HER2-negative breast cancer, to assist prognosis and help in indicating the therapeutic options, including hormone therapy, chemotherapy, anti-HER2 therapy, and other targeted therapies...
June 13, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38869740/stereotactic-ablative-radiotherapy-sabr-for-patients-with-lung-tumor-and-severe-pulmonary-function-impairment
#5
JOURNAL ARTICLE
Abraham André Arturo Geng-Cahuayme, Blanca Peregrín-Pastor, Mónica Ramos-Albiac, Enar Recalde-Vizcay, Juan Sebastián Parada-Zuluaga, Jordi Giralt-López de Sagredo, Xavier Maldonado-Pijoan, Alexandra Giraldo-Marín
PURPOSE: To evaluate clinical outcomes after SABR in a cohort of early-stage non-small cell lung cancer (NSCLC) or pulmonary metastases in chronic obstructive pulmonary disease (COPD) patients with forced expiratory volume in the first second predicted (FEV1) ≤ 50%. METHODS: Retrospective single-center study was performed to analyze clinical outcomes and toxicities in COPD patients with severe lung dysfunction treated with SABR from 1st June 2015 to 31st October 2022...
June 13, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38869739/value-of-circulating-tumor-cell-assisting-low-dose-computed-tomography-in-screening-pulmonary-nodules-based-on-existing-liquid-biopsy-techniques-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#6
REVIEW
Yixian Wang, Yuqing Duan, Dingjie Guo, Hongbo Lv, Qiong Li, Xuan Liu, Na Qiao, Hengyu Meng, Xin Zhang, Linwei Lan, Xiumin Liu, Xin Liu
OBJECTIVE: This study aims to assess the diagnostic utility of circulating tumor cells (CTCs) in conjunction with low-dose computed tomography (LDCT) for differentiating between benign and malignant pulmonary nodules and to substantiate the foundation for their integration into clinical practice. METHODS: A systematic literature review was performed independently by two researchers utilizing databases including PubMed, Web of Science, The Cochrane Library, Embase, and Medline, to collate studies up to September 15, 2023, that investigated the application of CTCs in diagnosing pulmonary nodules...
June 13, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38867027/saving-lives-saving-earth-hypofractionation-and-carbon-footprint
#7
JOURNAL ARTICLE
Elías Gomis Sellés, Fernando Picón García, Óscar Muñoz Muñoz, Blas David Delgado León, Patricia Cabrera Roldán, Manuel Borrego Reina, José Luis López Guerra
PURPOSE: The healthcare system contributes approximately 5% of global greenhouse gas emissions, yet the environmental impact of radiotherapy treatments remains inadequately assessed. MATERIAL AND METHODS: We selected all breast cancer patients (1959 patients) treated with adjuvant radiotherapy between 2015 and 2023 in one institution. We analyzed the CO2 emissions associated with travel. We also selected 60 patients randomly to analyze treatment-associated carbon emissions...
June 13, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38867026/prognostic-risk-stratification-value-of-macc1-expression-in-patients-with-gastric-cancer
#8
JOURNAL ARTICLE
Xia Zhang, Xing-Jun Feng, Qiu-Yue Han, Jian-Gang Zhang, Wei-Hua Yan, Aifen Lin
BACKGROUND: The prognostic significance of metastasis-associated in colon cancer-1 (MACC1) has been explored in a variety of malignancies. However, its clinical relevance in patients with gastric cancer (GC) is limited, also remains controversial. METHOD: In this study, we retrospectively evaluated the prognostic value of lesion MACC1 expression in 347 GC patients. Lesion MACC1 expression was analyzed with immunohistochemistry and grouped as MACC1low (n = 172) and MACC1high (n = 175) cases...
June 13, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38865036/the-role-of%C3%A2-igf-igf-1r-signaling-in%C3%A2-the-regulation-of%C3%A2-cancer-stem-cells
#9
REVIEW
Fengchao Liu, Susu Ye, Liu Zhao, Qinghui Niu
Cancer stem cells (CSCs) are a group of tumor cells with high tumorigenic ability and self-renewal potential similar to those of normal stem cells. CSCs are the key "seeds" for tumor development, metastasis, and recurrence. A better insight into the key mechanisms underlying CSC survival improves the efficiency of cancer therapy via specific targeting of CSCs. Insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling plays an important role in the maintenance of cancer stemness. However, the effect of IGF/IGF-1R signaling on stemness and CSCs and the underlying mechanisms are still controversial...
June 12, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38865035/thrombosis-and-infections-associated-with-picc-in-onco-hematological-patients-what-is-their-relevance
#10
JOURNAL ARTICLE
Manuel Sánchez Cánovas, Esmeralda García Torralba, Noel Blaya Boluda, Ana Sánchez Saura, Gabriel Puche Palao, Ana Sánchez Fuentes, Lorena Martínez Montesinos, Carmen Poveda Ganga, Lucía García Tomas, Josefa Bayona Jiménez, Ángeles Cos Zapata, Carmen María Muñoz Jurado, Inmaculada Pina Mingorance, María Amor Caravaca Hernández, Vicente Vicente García, Francisco Ayala de la Peña
PURPOSE: Peripherally inserted central venous catheters (PICC) in the onco-hematological patients may be associated with thrombosis or infections that may have short- to medium-term repercussions. MATERIAL AND METHODS: Single-centre retrospective analysis of a prospectively collected cohort. Primary objective was to establish the PICC-thrombosis and infections incidence. Secondary objectives were to analyze profile of patients suffering from these complications and variables associated with an increased likelihood of developing these events...
June 12, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38862862/advanced-non-squamous-nsclc-with-no-actionable-oncogenic-driver-in-spain-a-cross-sectional-descriptive-analysis-of-data-from-the-thoracic-tumor-registry
#11
JOURNAL ARTICLE
Enric Carcereny, Delvys Rodriguez-Abreu, Rafael Lopez, Fabio Franco, Maria Guirado, Bartomeu Massutí, Manuel Cobo, Ana Blasco, Guillermo Suay, Edel Del Barco, Ana Laura Ortega, Maria Angeles Sala, Patricia Cordeiro, Reyes Bernabé, José Luís González Larriba, Joaquim Bosch-Barrera, Julia Calzas, Joaquín Casal, Airam Padilla, Alfredo Sánchez-Hernandez, Mariano Provencio
BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for the vast majority of all diagnosed lung cancers. According to their histology, most NSCLCs are considered non-squamous cell carcinoma (NSCC), and up to 85% of the latter may lack either one of the two main actionable oncogenic drivers (i.e., EGFR mutations and ALK rearrangements). OBJECTIVE: Our analysis aimed to describe the clinical and epidemiological characteristics of Spanish patients suffering from NSCC with no actionable oncogenic driver in daily clinical practice...
June 11, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38856872/prognostic-value-of-systemic-inflammation-response-indexes-obtained-from-the-complete-blood-count-in-patients-treated-for-advanced-ovarian-carcinoma-in-front-line
#12
JOURNAL ARTICLE
Jaime Espinós, José Manuel Aramendía, Antonio González-Martín, Marta Santisteban, Luisa Sánchez, Ángel Vizcay, José Ángel Mínguez, Juan Luis Alcázar
OBJECTIVE: Various systemic inflammation response indexes (SIRI) have repeatedly been described as prognostic factors in ovarian cancer. They have not been validated in prospective trials and published results are sometimes contradictory. We aimed to explore their role in a cohort of patients diagnosed with stage III and IV ovarian cancer treated at our institution. METHODS: We retrospectively examined the prognostic influence of the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the monocyte-to-lymphocyte ratio (MLR), the red cell distribution width (RDW), and the mean platelet volume (MPV)...
June 10, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38851648/efficacy-and-safety-of-metronomic-oral-vinorelbine-and-its-combination-therapy-as-second-and-later-line-regimens-for-advanced-non-small-cell-lung-cancer-a-retrospective-analysis
#13
JOURNAL ARTICLE
ShiJie Chen, ZhiYong He, MeiFang Li, LiHong Weng, JingHui Lin
OBJECTIVE: This retrospective analysis aimed to evaluate the efficacy and adverse reactions of metronomic oral vinorelbine and its combination therapy as second- and later-line regimens for advanced non-small-cell lung cancer (NSCLC). METHODS: NSCLC patients undergoing metronomic oral vinorelbine as second- and later-line regimens in Fujian Cancer Hospital from October 2018 to October 2022 were enrolled, and patients' demographic and clinical characteristics were collected...
June 9, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38844739/dynamic-change-of-gut-microbiota-in-head-and-neck-concurrent-chemoradiotherapy-patients-and-its-potential-value-in-the-prediction-of-acute-oral-mucositis-grade-as-well-as-quality-of-life
#14
JOURNAL ARTICLE
Ying Chen, Xianghua Ye, Xinke Li, Fang Wang, Jinsong Yang, Xiaoli Sun, Senxiang Yan
PURPOSE: Radiotherapy is the major therapy for head and neck squamous cell carcinoma (HNSCC). However, whether gut microbiota changes in HNSCC patients who received concurrent chemoradiotherapy remains unclear. This study aimed to investigate the dynamic change of gut microbiota composition, construct the first radiotherapy-related gut microbiota database in these patients and identify the potential value of the gut microbiota changing in the prediction of acute oral mucositis grade as well as patients' life quality...
June 6, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38834909/constructing-a-prognostic-model-for-colorectal-cancer-with-synchronous-liver-metastases-after-preoperative-chemotherapy-a-study-based-on-seer-and-an-external-validation-cohort
#15
JOURNAL ARTICLE
Yixin Ding, Xiaoxi Han, Shufen Zhao, Shasha Wang, Jing Guo, Chuanyu Leng, Xiangxue Li, Kongjia Wang, Wensheng Qiu, Weiwei Qi
BACKGROUND: The combination of preoperative chemotherapy and surgical treatment has been shown to significantly enhance the prognosis of colorectal cancer with liver metastases (CRLM) patients. Nevertheless, as a result of variations in clinicopathological parameters, the prognosis of this particular group of patients differs considerably. This study aimed to develop and evaluate Cox proportional risk regression model and competing risk regression model using two patient cohorts. The goal was to provide a more precise and personalized prognostic evaluation system...
June 4, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38831193/lc-ms-metabolomics-analysis-of-serum-metabolites-during-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#16
JOURNAL ARTICLE
Qiliang Peng, Lili Jiang, Yi Shen, Yao Xu, Xinan Shen, Li Zou, Yaqun Zhu, Yuntian Shen
BACKGROUND: This study aimed to investigate the serum metabolite profiles during neoadjuvant chemoradiotherapy (NCRT) in locally advanced rectal cancer (LARC) using liquid chromatography-mass spectrometry (LC-MS) metabolomics analysis. METHODS: 60 serum samples were collected from 20 patients with LARC before, during, and after radiotherapy. LC-MS metabolomics analysis was performed to identify the metabolite variations. Functional annotation was applied to discover altered metabolic pathways...
June 3, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38831192/clinical-effects-of-re-evaluating-a-lung-sbrt-failure-mode-and-effects-analysis-in-a-radiotherapy-department
#17
JOURNAL ARTICLE
Sergi Benavente, Alexandra Giraldo, Alejandro Seoane, Mónica Ramos, Ramona Vergés
PURPOSE: The increasing complexity of radiation treatments can hinder its clinical success. This study aimed to better understand evolving risks by re-evaluating a Failure Mode and Effects Analysis (FMEA) in lung SBRT. METHODS: An experienced multidisciplinary team conducted an FMEA and made a reassessment 3 years later. A process map was developed with potential failure modes (FMs) identified. High-risk FMs and their possible causes and corrective actions were determined...
June 3, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38831191/retrospective-registry-of-patients-with-locally-advanced-metastatic-hr-her2-breast-cancer-treated-in-clinical-practice-in-andalusia
#18
JOURNAL ARTICLE
Natalia Chavarría Piudo, Isabel Blancas, Encarna González Flores, Fernando Henao Carrasco, Pilar López Álvarez, David Morales Pancorbo, Salvador Gámez Casado, María de la Cabeza Lomas Garrido, José Manuel Rodríguez García, Antonia Martínez Guisado, Adrián Sánchez Vega, Manuel Ruíz Borrego
BACKGROUND: Limited data are available regarding the real-world effectiveness and safety of Cyclin Dependent Kinase 4/6 inhibitor (CDK4/6i) (palbociclib/ribociclib) just as a first-line treatment for patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR + /HER2‒) metastatic breast cancer (MBC). OBJECTIVE: To assess whether clinical or demographic characteristics limit access to first-line CDK4/6i treatment in clinical practice in the Autonomous Community of Andalusia (Spain) between November 2017 and April 2020...
June 3, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38822977/multi-index-comprehensive-evaluation-of-the-efficacy-and-response-mechanism-of-immunotherapy-in-non-small-cell-lung-cancer
#19
JOURNAL ARTICLE
Jieqiong Fan, Tao Zhang
OBJECTIVE: This research conducted multi-index comprehensive evaluations of the immunotherapeutic efficacy and response in non-small cell lung cancer (NSCLC). METHODS: Forty-five patients with epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) wild-type advanced NSCLC who received immunotherapy were included. Immunohistochemistry was adopted to detect the expression levels of programmed death ligand 1 (PD-L1) with X-ray cross-complementing protein 1 (XRCC1) and excision repair cross-complementing group 1 (ERCC1) proteins in tumor tissues...
June 1, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38822976/seom-clinical-guidelines-for-cancer-anorexia-cachexia-syndrome-2023
#20
JOURNAL ARTICLE
Ainara Soria Rivas, Yolanda Escobar Álvarez, Ana Blasco Cordellat, Margarita Majem Tarruella, Kevin Molina Mata, Marta Motilla de la Cámara, Mª Del Mar Muñoz Sánchez, Marta Zafra Poves, Carmen Beato Zambrano, Luis Cabezón Gutierrez
Cancer-related anorexia-cachexia syndrome (CACS) is a debilitating condition afflicting up to 80% of advanced-stage cancer patients. Characterized by progressive weight loss, muscle wasting, and metabolic abnormalities, CACS significantly compromises patients' quality of life and treatment outcomes. This comprehensive review navigates through its intricate physiopathology, elucidating its stages and diagnostic methodologies. CACS manifests in three distinct stages: pre-cachexia, established cachexia, and refractory cachexia...
June 1, 2024: Clinical & Translational Oncology
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