XiaoMeng Xu, XiaoHong Xu, JinLiang Cao, LuoYang Ruan
AIM: The study was to clarify the mechanism of miR-1258 targeting Prep1 (pKnox1) to control Transforming Growth Factor β1 (TGF-β1)/SMAD3 pathway in septic Acute Lung Injury (ALI)-induced oxidative stress and inflammation. METHODS: BEAS-2B cells and C57BL/6 mice were used to make in vitro and in vivo septic ALI models, respectively. miR-1258 expression was checked by RT-qPCR. After transfection in the in vitro experimental model, inflammation, oxidative stress, viability, and apoptosis were observed through ELISA, MTT, and flow cytometry...
April 18, 2024: Clinics
Facai Guo, Yan Bi, Jiangyan Yin, Yi Guo
OBJECTIVES: The pathogenic mechanisms of Thromboangiitis Obliterans (TAO) are not entirely known and autoimmune inflammation plays a vital role in the initiation and continuance of TAO activity. The authors investigated in this study the role of the TLR signaling pathway in the pathogenesis of TAO. METHODS: First, the authors detected the expressions of MyD88, TRIF and NF-κB in vascular walls of 46 patients with TAO and 32 patients with trauma and osteosarcoma by western blot assay...
April 18, 2024: Clinics
Thais Gomes de Almeida, Anamaria Ritti Ricci, Laura Gonzalez Dos Anjos, Jose Maria Soares Junior, Gustavo Arantes Rosa Maciel, Edmund Chada Baracat, Katia Candido Carvalho
OBJECTIVE: The present study aimed to investigate FOXO3a deregulation in Uterine Smooth Muscle Tumors (USMT) and its potential association with cancer development and prognosis. METHODS: The authors analyzed gene and protein expression profiles of FOXO3a in 56 uterine Leiomyosarcomas (LMS), 119 leiomyomas (comprising conventional and unusual leiomyomas), and 20 Myometrium (MM) samples. The authors used techniques such as Immunohistochemistry (IHC), FISH/CISH, and qRT-PCR for the present analyses...
April 17, 2024: Clinics
Ze-Ming Zhang, Na Zhang, Xiao-Fei Wang
BACKGROUND: This study aimed to identify prognostic factors for pregnancy outcomes and construct a prognostic model for pregnancy outcomes in women with Recurrent Spontaneous Abortions (RSA) treated with cyclosporin A. METHODS: A total of 154 RSA patients treated with cyclosporin A between October 2016 and October 2018 were retrospectively recruited. Multivariate logistic regression was applied to identify the prognostic factors for pregnancy success in RSA women treated with cyclosporin A...
2024: Clinics
Danilo Caribé Carneiro, Paula Duarte D'Ambrosio, Alessandro Wasum Mariani, Jaqueline Schaparini Fonini, Gabriela Ketherine Zurita Aguirre, João Pedro Carneiro Leão, Aurelino Fernandes Schmidt Júnior, Eihab O Bedawi, Najib M Rahman, Paulo Manuel Pêgo-Fernandes
OBJECTIVE: This study aims to correlate the RAPID score with the 3-month survival and surgical results of patients undergoing lung decortication with stage III pleural empyema. METHODS: This was a retrospective study with the population of patients with pleural empyema who underwent pulmonary decortication between January 2019 and June 2022. Data were collected from the institution's database, and patients were classified as low, medium, and high risk according to the RAPID score...
April 11, 2024: Clinics
Maria Carolina Machado da Silva, Luiz Philipe de Souza Ferreira, Amanda Della Giustina
No abstract text is available yet for this article.
April 6, 2024: Clinics
Luciana Harumi Miranda Omori, Deoclecio Avigo, Itamar de Souza Santos, Gustavo Diniz Ferreira Gusso, Maria Teresa Bechere Fernandes
INTRODUCTION: Child health actions in Brazil have their primary focus on early childhood. A new epidemiological profile is emerging for children after the first one thousand days: an increase in non-communicable chronic diseases. This research aimed to analyze the attributes of Primary Health Care comparatively among different age groups, using three years of age as the cutoff point. METHODS: The study design was cross-sectional and conducted in three Primary Health Care Units and three Ambulatory Medical Assistance facilities in the Western Region of São Paulo...
April 4, 2024: Clinics
Bruno Henrique Alvarenga, Izabel Cristina Rios, Francisco de Salles Collet E Silva, Edivaldo Massazo Utiyama
OBJECTIVE: To evaluate whether the rate of surgical complications is higher during the first semester of the General Surgery residency in the largest hospital complex in Latin America. During this period, students are expected to have less experience in carrying out procedures. METHODS: During a period of two years, all General Surgery resident doctors at the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, made a notification of all the procedures they performed (n = 14...
April 3, 2024: Clinics
Fang Yu, JiWei Liu, Xiao Wei
OBJECTIVE: Atherosclerosis (AS) is a chronic inflammatory disease of the arterial wall, in which Human Vascular Smooth Muscle Cells (HVSMCs) are involved. Nevertheless, the functions and mechanisms of circRNAs in oxidized Low-Density Lipoprotein (ox-LDL)-induced vascular smooth muscle cells remain unclear. METHODS: Circ-ABCA1 expression was measured in the models of AS. Then, in the vitro model, oligonucleotide transfection was performed, followed by an analysis of VSMC proliferation, migration, inflammation, and phenotypic switch...
March 28, 2024: Clinics
Min Xuan, Na Li, Chunyan Wu
OBJECTIVE: This study aimed to systematically evaluate the efficacy and safety of Endoscopic Ultrasonography (EUS) for the treatment of pancreatic cancer. METHODS: The PubMed, Embase, Web of Science, and Google Scholar databases were searched from the inception of the databases to June 2022. RevMan 5.3.0 software was utilized for data analysis. In total, 13 self-descriptive studies, which enrolled 382 patients, were finally included. RESULTS: It was revealed that EUS for the treatment of pancreatic cancer exhibited a lower incidence of adverse reactions (Relative Risk Ration [RR = 0...
2024: Clinics
Jamila Al-Zadjali, Amal Al-Lawati, Nafila Al Riyami, Koukab Al Farsi, Najwa Al Jarradi, Ammar Boudaka, Ali Al Barhoumi, Mohsen Al Lawati, Amani Al Khaifi, Asma Musleh, Prisca Gebrayel, Sophie Vaulont, Carole Peyssonnaux, Marvin Edeas, Jumana Saleh
This controlled study investigated metabolic changes in non-vaccinated individuals with Long-COVID-19, along with their connection to the severity of the disease. The study involved 88 patients who experienced varying levels of initial disease severity (mild, moderate, and severe), and a control group of 29 healthy individuals. Metabolic risk markers from fasting blood samples were analyzed, and data regarding disease severity indicators were collected. Findings indicated significant metabolic shifts in severe Long-COVID-19 cases, mainly a marked drop in HDL-C levels and a doubled increase in ferritin levels and insulin resistance compared to the mild cases and controls...
March 28, 2024: Clinics
Fabio Minamoto, Pedro Araújo, Paula D'Ambrosio, Alberto Dela Vega, Leticia Lauricella, Paulo Pêgo-Fernandes, Ricardo Terra
BACKGROUND: Lung lymphatic drainage occurs mainly through a peribronchial path, but it is hypothesized that visceral pleural invasion could alter this path. This study aims to investigate the association between visceral pleural invasion, node upstaging, and N2 skip metastasis and the impact on survival in a population of patients with non-small cell lung cancer of 3 cm or smaller. METHODS: We retrospectively queried our institutional database of lung cancer resection for all patients with clinical stage IA NSCLC between June 2009 and June 2022...
March 13, 2024: Clinics
Caio Melo Mesquita, Millena Barroso Oliveira, Marcelo Dias Moreira de Assis Costa, Walbert Andrade Vieira, Rafael Rodrigues Lima, Sigmar de Mello Rode, Luiz Renato Paranhos
BACKGROUND: Local anesthetic puncture is often related to the experience of pain. This study aimed to systematically analyze the literature on changes in pain perception during the anesthetic puncture of dental local anesthesia after Photobiomodulation Therapy (PBMT). MATERIAL AND METHODS: An electronic search was performed in eight primary databases (Embase, LILACS, BBO, LIVIVO, MedLine via PubMed, SciELO, Scopus, and Web of Science) and three additional ones (EASY, Google Scholar, and OATD) to partially capture the "gray literature"...
March 13, 2024: Clinics
Clara Lucato Dos Santos, Indyanara Inacio Barreto, Idevaldo Floriano, Luca Schiliró Tristão, Antonio Silvinato, Wanderley Marques Bernardo
INTRODUCTION: Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder, with main manifestations related to communication, social interaction, and behavioral patterns. The slight dynamics of change in the child over time require that the onset of clinical manifestations presented by the child be more valued, with the aim of stabilizing the condition. Faced with a variety of methods for diagnosing ASD, the question arises as to which method should be used. This systematic review aims to recommend the best tools to perform screening and diagnosis...
March 13, 2024: Clinics
Larissa M Bombardi, Antonio-Carlos Guimaraes de Almeida, Josef Finsterer, Fulvio Alexandre Scorza
No abstract text is available yet for this article.
March 12, 2024: Clinics
Ze Dong Jiang, Cui Wang, James K Jiang, Jin Wang
AIMS: Very Low Birthweight (VLBW) infants with neonatal Chronic Lung Disease (CLD) have been found to have functional impairment of the brainstem auditory pathway at term. This study investigated the functional status of the brainstem auditory pathway in VLBW infants with CLD after term for any abnormality. METHODS: Fifty-two VLBW infants were recruited at 50 weeks of Postconceptional Age: 25 with neonatal CLD and 27 without CLD. None had any other major complications to minimize confounding effects...
March 6, 2024: Clinics
Lindson Mühlmann, Franklin Fernandes Pimentel, Daniel Guimarães Tiezzi, Hélio Humberto Angotti Carrara, Jurandyr Moreira de Andrade, Francisco José Candido Dos Reis
OBJECTIVES: The COVID-19 pandemic has had a significant global impact since its declaration in March 2020. The COVID-19 pandemic has disproportionately impacted cancer patients, particularly those with breast cancer. This study aims to analyze the effects of the pandemic on women diagnosed with breast cancer recurrence. METHODS: A cohort study was conducted at a tertiary public hospital in São Paulo State, Brazil. Data were collected from electronic records...
March 2, 2024: Clinics
Pablo Eduardo Pereira Dutra, Laiana Azevedo Quagliato, Filipe Terra Curupaná, Letícia Zangirolami Peres, Victoria Luiza Pacini, Claudia Regina Menezes da Silva, Juliana Seixas Garcia, Beatriz Campillo Zaragoza, Antonio Egidio Nardi
OBJECTIVE: To adapt the Scale of Perception of Respect for and Maintenance of the Dignity of the Inpatient (CuPDPH) to the Brazilian language and culture and to assess its psychometric properties. RESULTS: The scale was evaluated by 15 experts, and 239 patients from three tertiary hospitals in Rio de Janeiro. All participants signed a consent form. Data have shown adequacy of the model (KMO=0.839, Bartlett's test of sphericity: χ2 (171) = 2241.3, p = 0.000010), good adjusted content validity (CVCa ≥ 0...
February 26, 2024: Clinics
Hailong Chen, Dechang Xu, Ying Yu, Jing Huang, Qian Zhou, Qi Wang
OBJECTIVES: To investigate the impact of Three-Dimensional (3D) laparoscopy compared to traditional laparotomy on serum tumor markers and coagulation function in patients diagnosed with early-stage Endometrial Cancer (EC). METHOD: The authors retrospectively analyzed the clinical data of 75 patients diagnosed with early-stage EC and categorized them into two groups based on the surgical techniques employed. The 3D group consisted of 36 patients who underwent 3D laparoscopic surgery, while the Laparotomy group comprised 39 patients who underwent traditional laparotomy...
February 17, 2024: Clinics
Marcos Roberto Tovani-Palone, Filippo Bistagnino, Pritik A Shah
Neurocutaneous syndromes comprise a heterogeneous group of congenital or hereditary conditions that are known to be associated with the risk of different disorders and complications. Two of the most common neurocutaneous syndromes are Neurofibromatosis type 1 (NF1) and Tuberous Sclerosis Complex (TSC). Although there appears to be a general consensus on the importance of a multidisciplinary approach in managing these cases, there is still very little emphasis in discussions addressed in the literature on the role of dentistry in accordance with the perspective of comprehensive care...
February 15, 2024: Clinics
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