journal
Journals Twin Research and Human Geneti...

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies

https://read.qxmd.com/read/37842863/estimating-the-genetic-contribution-to-astigmatism-and-myopia-in-the-mexican-population
#21
JOURNAL ARTICLE
Talía V Román-López, Brisa García-Vilchis, Vanessa Murillo-Lechuga, Enrique Chiu-Han, Xanat López-Camaño, Oscar Aldana-Assad, Santiago Diaz-Torres, Ulises Caballero-Sánchez, Ivett Ortega-Mora, Diego Ramírez-González, Diego Zenteno, Zaida Espinosa-Valdés, Andrea Tapia-Atilano, Sofía Pradel-Jiménez, Miguel E Rentería, Alejandra Medina-Rivera, Alejandra E Ruiz-Contreras, Sarael Alcauter
Astigmatism and myopia are two common ocular refractive errors that can impact daily life, including learning and productivity. Current knowledge suggests that the etiology of these conditions is the result of a complex interplay between genetic and environmental factors. Studies in populations of European ancestry have demonstrated a higher concordance of refractive errors in monozygotic (MZ) twins compared to dizygotic (DZ) twins. However, there is a lack of studies on genetically informative samples of multi-ethnic ancestry...
October 16, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37799059/effects-of-genetic-relatedness-of-kin-pairs-on-univariate-ace-model-performance
#22
JOURNAL ARTICLE
Xuanyu Lyu, S Mason Garrison
The current study explored the impact of genetic relatedness differences (ΔH) and sample size on the performance of nonclassical ACE models, with a focus on same-sex and opposite-sex twin groups. The ACE model is a statistical model that posits that additive genetic factors (A), common environmental factors (C), and specific (or nonshared) environmental factors plus measurement error (E) account for individual differences in a phenotype. By extending Visscher's (2004) least squares paradigm and conducting simulations, we illustrated how genetic relatedness of same-sex twins (HSS ) influences the statistical power of additive genetic estimates (A), AIC-based model performance, and the frequency of negative estimates...
October 6, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37706311/c-c-li-and-quasi-random-mating
#23
JOURNAL ARTICLE
Alan E Stark
A simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies is stated and illustrated. The title 'Quasi-random mating' is proposed. Confusion about the Hardy-Weinberg principle can be avoided only if there is clear separation between the basic deterministic model and factors influencing a population's structure. Eighty years passed before C. C. Li coined the term 'pseudo-random mating'. The lesson taught by Li has not been taken on board.
September 14, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37706309/a-10-year-observational-study-on-twin-pregnancy-role-of-fetal-sex-pairing-on-obstetric-outcome
#24
JOURNAL ARTICLE
Silvia Vannuccini, Sara Bolzonella, Chiara Colucci, Costanza Nicchi, Noemi Strambi, Mariarosaria Di Tommaso
Fetal sex contributes to the determination of obstetric outcome, as pregnancies carrying male babies seem to have an increased risk of maternal-fetal complications. Most studies have been conducted on singleton pregnancies, whereas less evidence is available for twins. A 10-year retrospective observational study was conducted on a cohort of 1180 women with twin pregnancy delivered at a single tertiary hospital. Clinical data on maternal characteristics, and obstetric and neonatal outcomes were collected, and the analysis was performed on monochorionic (MC) and dichorionic (DC) diamniotic twins separately...
September 14, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37655615/early-spontaneous-twinning-recorded-by-time-lapse
#25
JOURNAL ARTICLE
Roberto Matorras, Alberto Vendrell, Marcos Ferrando, Zaloa Larreategui
Monozygotic twins (MZT) are 2.5 times more frequent in ART than in natural conceptions. A number of ART-related mechanisms have been probably linked with MZT. Studies that retrospectively analyze the time-lapse (TL) records resulting in MZT suggest that some morphokinetic traits of the inner cell mass and the trophectoderm could be predictors of MZT, but results are controversial. We present the complete TL record of one case of MZT that split itself at the very moment of the division into two cells, with one of the cells coming out through a hole in the zona pellucida (ZP)...
September 1, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37655526/mitochondrial-dna-copy-number-and-heteroplasmy-in-monozygotic-twins-discordant-for-schizophrenia
#26
JOURNAL ARTICLE
Phyo W Win, Shiva M Singh, Christina A Castellani
Schizophrenia (SZ) is a severe, complex, and common mental disorder with high heritability (80%), an adult age of onset, and high discordance (∼50%) in monozygotic twins (MZ). Extensive studies on familial and non-familial cases have implicated a number of segregating mutations and de novo changes in SZ that may include changes to the mitochondrial genome. Yet, no single universally causal variant has been identified, highlighting its extensive genetic heterogeneity. This report specifically focuses on the assessment of changes in the mitochondrial genome in a unique set of monozygotic twins discordant (MZD) for SZ using blood...
September 1, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37655521/the-co-twin-control-design-implementation-and-methodological-considerations
#27
JOURNAL ARTICLE
Bodine M A Gonggrijp, Steve G A van de Weijer, Catrien C J H Bijleveld, Jenny van Dongen, Dorret I Boomsma
Establishing causal relationships in observational studies is an important step in research and policy decision making. The association between an exposure and an outcome can be confounded by multiple factors, often making it hard to draw causal conclusions. The co-twin control design (CTCD) is a powerful approach that allows for the investigation of causal effects while controlling for genetic and shared environmental confounding factors. This article introduces the CTCD and offers an overview of analysis methods for binary and continuous outcome and exposure variables...
September 1, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37650338/genetic-and-environmental-influences-on-blood-pressure-and-serum-lipids-across-age-groups
#28
JOURNAL ARTICLE
Ke Miao, Yutong Wang, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
Aging plays a crucial role in the mechanisms of the impacts of genetic and environmental factors on blood pressure and serum lipids. However, to our knowledge, how the influence of genetic and environmental factors on the correlation between blood pressure and serum lipids changes with age remains to be determined. In this study, data from the Chinese National Twin Registry (CNTR) were used. Resting blood pressure, including systolic and diastolic blood pressure (SBP and DBP), and fasting serum lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) were measured in 2378 participants (1189 twin pairs)...
August 31, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37650223/maternal-and-neonatal-outcomes-of-twin-pregnant-women-with-anemia
#29
JOURNAL ARTICLE
Nacheng Lin, Ping Shen, Huilian Hu, Wenying Song, Yali Hu, Yimin Dai, Yi-Hua Zhou
The aim of this study was to investigate the prevalence of anemia in twin pregnancies and the influence of anemia on maternal and neonatal outcomes. This retrospective study included twin pregnant women who delivered in a tertiary hospital in China from January 2018 to December 2018. Patients were divided by WHO criteria (hemoglobin <11.0 g/dL): the anemic and nonanemic groups. Patients with anemia were further classified as recovered or unrecovered subgroup after oral iron therapy. Maternal and neonatal outcomes in women carrying twins were compared using Student's t test and the chi-squared test or the Fisher exact test...
August 31, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37641518/the-18th-international-twin-congress-and-a-look-at-twin-research-in-wales-twin-research-reviews-temperamental-similarities-and-twin-relations-maximizing-twin-designs-rare-tubal-ectopic-pregnancy-twins-academic-self-concept-formation-in-the-media-identical-infant
#30
JOURNAL ARTICLE
Nancy L Segal
The 18th International Society for Twin Studies convention took place between June 15-17, 2023, in Budapest, Hungary. A selective sampling of highlights from the meeting are presented. This is followed by a brief overview of ongoing twin research at the University of Aberystwyth in Wales and some twin treasures in the National Library. Next, reviews of timely research that examine temperamental similarities and twin relations, the maximization of twin research designs, a rare ectopic twin pregnancy, and twins' academic self-concept formation are presented...
August 29, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37640686/human-genetics-society-of-australasia-position-statement-genetic-testing-and-personal-insurance-products-in-australia-corrigendum
#31
JOURNAL ARTICLE
Aideen M McInerney-Leo, Samantha Ayres, Jackie Boyle, Chris Jacobs, Ainsley J Newson
No abstract text is available yet for this article.
August 29, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37489533/candidate-genes-for-prediction-of-efficacy-and-safety-of-statin-therapy-in-the-kazakh-population
#32
JOURNAL ARTICLE
Raikhan Y Tuleutayeva, Assem R Makhatova, Saule O Rakhyzhanova, Lashyn K Zhazykbayeva, Dana K Kozhakhmetova
The purpose of this research was to determine the frequency of mutation of the cytochrome CYP3A5 genes and transport proteins SLCO1B1 and MDR1 in patients with coronary heart disease in the Kazakh nation. A prospective cohort clinical and genetic study was conducted. The study was conducted in 2017-2019. Medical records containing information about drug prescription conducted in hospitals and outpatient departments were carefully analyzed. In the examined group of 178 patients treated with statins, a significant frequency of genetic variants that determine the increased risk of complications of statin use was revealed...
July 25, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37476981/the-effect-of-genetic-predisposition-to-alzheimer-s-disease-and-related-traits-on-recruitment-bias-in-a-study-of-cognitive-aging
#33
JOURNAL ARTICLE
Lina M Gomez, Brittany L Mitchell, Kerrie McAloney, Jessica Adsett, Natalie Garden, Madeline Wood, Santiago Diaz-Torres, Luis M Garcia-Marin, Michael Breakspear, Nicholas G Martin, Michelle K Lupton
The recruitment of participants for research studies may be subject to bias. The Prospective Imaging Study of Ageing (PISA) aims to characterize the phenotype and natural history of healthy adult Australians at high future risk of Alzheimer's disease (AD). Participants approached to take part in PISA were selected from existing cohort studies with available genomewide genetic data for both successfully and unsuccessfully recruited participants, allowing us to investigate the genetic contribution to voluntary recruitment, including the genetic predisposition to AD...
July 21, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37458219/causal-relationship-between-inflammation-and-preeclampsia-genetic-evidence-from-a-mendelian-randomization-study
#34
JOURNAL ARTICLE
Qiongxiang Zhong, Chanjiao Yao, Wei Zhong
Preeclampsia (PE) is a hypertensive disorder of pregnancy. PE patients were reported to have higher serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) than those in healthy controls. However, whether the expressions of these inflammation biomarkers have a causal relationship with PE is unspecified. We applied the Mendelian randomization method to infer the causal relationship between inflammation biomarkers (e.g., CRP, IL-6, interleukin 1 receptor antagonist [IL-1ra] and TNF-α) and PE...
July 17, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37400944/twin-research-and-human-genetics-news-views-comments-memoirs-and-autobiographies-by-twins-research-angles-and-human-interest-twin-research-reviews-fetal-reduction-in-twin-pregnancy-twins-personality-and-military-service-growth-restriction-in-twins-advances
#35
JOURNAL ARTICLE
Nancy L Segal
Twins' memoirs and autobiographies both enlighten and entertain. These works, often overlooked by researchers, may suggest new avenues for investigation, such as nonshared environmental events that propel twins in different directions. Of course, MZ twins' generally parallel experiences and DZ twins generally criss-crossing paths are the bases of fascinating life stories. The following sections examined recent research on fetal reduction in twin pregnancy, twins' personality and military service, growth restriction in twins, and advances in conjoined twin separation...
July 4, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37288525/assisted-reproduction-and-discussion-of-rare-cases-in-monozygotic-twinning
#36
JOURNAL ARTICLE
Yuge Tan
Assisted reproductive technology is a crucial factor that increases the incidence of monozygotic twinning in humans. This article discusses the impact of various indicators in assisted reproductive technology studies on pregnancy outcomes, especially studies with a large number of clinical cases. Furthermore, three rare cases in multiples pregnancy are discussed: fetus papyraceous of a pair of male monozygotic twins in a set of triplets, two pairs of sesquizygotic twins with sex-discordance, and rare conjoined triplets...
June 8, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37272376/the-garden-of-forking-paths-an-evaluation-of-joseph-s-a-reevaluation-of-the-1990-minnesota-study-of-twins-reared-apart-iq-study
#37
JOURNAL ARTICLE
Thomas J Bouchard
Joseph has written what purports to be a refutation of studies of Twins Reared-Apart (TRAs) with a singular focus on the Minnesota Study of Twins Reared-Apart (MISTRA). I show, in detail, that (a) his criticisms of previous TRA studies depend on sources that were discredited prior to MISTRA, as they all failed the test of replicability, (b) the list of biases he uses to invalidate MISTRA do not support his arguments, (c) the accusations of questionable research practices are unsubstantiated, (d) his claim that MISTRA should be evaluated in the context of psychology's replication crisis is refuted...
June 5, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37701934/thg-volume-26-issue-3-cover
#38
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
June 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37448258/handedness-and-23-early-life-characteristics-in-37-495-dutch-twins
#39
JOURNAL ARTICLE
Veronika V Odintsova, Jenny van Dongen, Catharina E M van Beijsterveldt, Lannie Ligthart, Gonneke Willemsen, Eco J C de Geus, Conor V Dolan, Dorret I Boomsma
In studies of singletons, a range of early-life characteristics have been reported to be associated with handedness, but some of these associations have failed to replicate. We examined associations between 23 early life characteristics with handedness in a large sample of 37,495 5-year-old twins. We considered three definitions of handedness: left-handedness (LH), mixed-handedness (MH), and non-right-handedness (NRH). Our main aim was to test whether the associations with sex, birth weight, gestational age, and season of birth - as reported in singletons - replicate in twins, and to examine twin-specific variables, including zygosity, chorionicity, birth order, and intertwin delivery time...
June 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/37226803/human-genetics-society-of-australasia-position-statement-genetic-carrier-testing-for-recessive-conditions
#40
JOURNAL ARTICLE
Danya F Vears, Jackie Boyle, Chris Jacobs, Aideen McInerney-Leo, Ainsley J Newson
This Position Statement provides guidelines to assist all health professionals who receive requests for carrier testing and laboratory staff conducting the tests.In this Statement, the term 'carrier testing' refers to genetic testing in an individual to determine whether they have inherited a pathogenic variant associated with an autosomal or X-linked recessive condition previously identified in a blood relative. Carrier testing recommendations: (1) Carrier testing should only be performed with the individual's knowledge and consent; (2) An individual considering (for themselves, or on behalf of another) whether to have a carrier test should be supported to make an informed decision; (3) The mode of inheritance, the individual's personal experience with the condition, and the healthcare setting in which the test is being performed should be considered when determining whether carrier testing should be offered by a genetic health professional...
May 25, 2023: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
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