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Journals Twin Research and Human Geneti...

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies

https://read.qxmd.com/read/38828552/association-between-rheumatoid-arthritis-and-clonal-hematopoiesis-a-mendelian-randomization-study
#1
JOURNAL ARTICLE
Jie Zhang, Chun Zhou, Shaoxing Guan
Immunity activation and inflammation are the main characteristics of rheumatoid arthritis and clonal hematopoiesis. However, it remains unclear whether rheumatoid arthritis increase the risk of clonal hematopoiesis. Here, a Mendelian randomization (MR) analysis was conduct to explore the causal effects of rheumatoid arthritis on clonal hematopoiesis. Summary statistics data of rheumatoid arthritis (13,838 cases and 33,742 controls) and clonal hematopoiesis (10,203 cases and 173,918 controls) derived from a genomewide association study were selected to analyze...
June 3, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38745426/the-population-based-hungarian-twin-registry-an-update
#2
JOURNAL ARTICLE
David Laszlo Tarnoki, Marton Piroska, Bianka Forgo, Helga Szabo, Luca Zoldi, Dora Melicher, Julia Metneki, Levente Littvay, Adam Domonkos Tarnoki
Between 2006 and 2021, the Hungarian Twin Registry (HTR) operated a volunteer twin registry of all age groups (50% monozygotic [MZ], 50% dizygotic [DZ], 70% female, average age 34 ± 22 years), including 1044 twin pairs, 24 triplets and one quadruplet set. In 2021, the HTR transformed from a volunteer registry into a population-based one, and it was established in the Medical Imaging Centre of Semmelweis University in Budapest. Semmelweis University's innovation fund supported the development of information technology, a phone bank and voicemail infrastructure, administrative materials, and a new website was established where twins and their relatives (parent, foster parent or caregiver) can register...
May 15, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38738462/twins-standing-in-for-co-twins-explanation-and-speculation-twin-research-reviews-single-v-multiple-embryo-transfer-neurimaging-of-twins-with-periventricular-nodular-heterotopia-twin-dietary-study-new-hungarian-text-on-twins-human-interest-valedictorian-and
#3
JOURNAL ARTICLE
Nancy L Segal
An overview of circumstances in which twins take the place of their co-twin is presented. Various explanations and speculations are proposed for understanding twins' willingness to do so in certain situations. This section is followed by reviews of timely twin research, namely single versus multiple embryo transfer; neurimaging of twins with periventricular nodular heterotopia; a twin dietary comparison; and a new book of twin-related readings from Hungary. The final portion of this article concerns human interest stories that both inform and entertain...
May 13, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38699821/twinsmx-exploring-the-genetic-and-environmental-influences-on-health-traits-in-the-mexican-population
#4
JOURNAL ARTICLE
Brisa García-Vilchis, Talia V Román-López, Diego Ramírez-González, Xanat J López-Camaño, Vanessa Murillo-Lechuga, Xóchitl Díaz-Téllez, C Itzamná Sánchez-Moncada, Ian M Espinosa-Méndez, Diego Zenteno-Morales, Zaida X Espinosa-Valdes, Sofia Pradel-Jiménez, Andrea Tapia-Atilano, Ana V Zanabria-Pérez, Federica Livas-Gangas, Oscar Aldana-Assad, Ulises Caballero-Sánchez, César A Dominguez-Frausto, Miguel E Rentería, Alejandra Medina-Rivera, Sarael Alcauter, Alejandra E Ruiz-Contreras
TwinsMX registry is a national research initiative in Mexico that aims to understand the complex interplay between genetics and environment in shaping physical and mental health traits among the country's population. With a multidisciplinary approach, TwinsMX aims to advance our knowledge of the genetic and environmental mechanisms underlying ethnic variations in complex traits and diseases, including behavioral, psychometric, anthropometric, metabolic, cardiovascular and mental disorders. With information gathered from over 2800 twins, this article updates the prevalence of several complex traits; and describes the advances and novel ideas we have implemented such as magnetic resonance imaging...
May 3, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38699817/genetic-and-environmental-influences-on-perceived-stress-in-south-korean-twins
#5
JOURNAL ARTICLE
Gwanwoo Jo, Yoon-Mi Hur
Researchers have proposed that culture significantly influences perceived stress (PS). To date, however, twin studies on PS have been conducted mostly in western, individualistic cultures, which demonstrate that PS due to controllable (personal) life events is more heritable than PS due to uncontrollable (network) life events. This study aimed to investigate genetic and environmental influences on PS in South Korean twins. South Korea practices a dominant collectivist culture. In total, 1372 twin individuals (mean age = 22...
May 3, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38644690/phenomewide-association-study-of-health-outcomes-associated-with-the-genetic-correlates-of-25-hydroxyvitamin-d-concentration-and-vitamin-d-binding-protein-concentration
#6
JOURNAL ARTICLE
Hailey A Kresge, Freida Blostein, Slavina Goleva, Clara Albiñana, Joana A Revez, Naomi R Wray, Bjarni J Vilhjálmsson, Zhihong Zhu, John J McGrath, Lea K Davis
While it is known that vitamin D deficiency is associated with adverse bone outcomes, it remains unclear whether low vitamin D status may increase the risk of a wider range of health outcomes. We had the opportunity to explore the association between common genetic variants associated with both 25 hydroxyvitamin D (25OHD) and the vitamin D binding protein (DBP, encoded by the GC gene) with a comprehensive range of health disorders and laboratory tests in a large academic medical center. We used summary statistics for 25OHD and DBP to generate polygenic scores (PGS) for 66,482 participants with primarily European ancestry and 13,285 participants with primarily African ancestry from the Vanderbilt University Medical Center Biobank (BioVU)...
April 22, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38639037/in-memoriam-dr-auke-tellegen-july-16-1930-march-11-2024
#7
JOURNAL ARTICLE
Nancy L Segal
No abstract text is available yet for this article.
April 19, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38634508/genetic-causal-relationship-between-alanine-aminotransferase-levels-and-risk-of-gestational-diabetes-mellitus-mendelian-randomization-analysis-based-on-two-samples
#8
JOURNAL ARTICLE
Lihua Yin, Yifang Hu, Xiaoxia Hu, Xiaolei Huang, Yingyuan Chen, Yisheng Zhang
Gestational diabetes mellitus (GDM) is a frequent complication of pregnancy. The specific mechanisms underlying GDM have not yet been fully elucidated. Contemporary research indicates a potential association between liver enzyme irregularities and an increased risk of metabolic disorders, including diabetes. The alanine aminotransferase (ALT) level is recognized as a sensitive marker of liver injury. An increase in ALT levels is hypothesized to be linked to the pathogenesis of insulin resistance and diabetes...
April 18, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38619001/brazilian-twin-studies-a-scoping-review
#9
JOURNAL ARTICLE
Eloisa de Souza Fernandes, Isabella França Ferreira, Renata Pereira de Felipe, Nancy Segal, Emma Otta
The current study was motivated by an interest in deepening understanding of Brazilian twin research, which is underrepresented internationally, in an effort to rectify this situation. Our aim was threefold: (1) to carry out a comprehensive investigation of Brazilian research on twins according to the area of knowledge; (2) to evaluate the representation of research in the field of psychology in comparison with other areas; (3) to evaluate characteristics of the research that may have contributed to its exclusion from the comprehensive meta-analysis of 50 years of twin research...
April 15, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38515292/acute-fetal-metabolomic-changes-in-twins-undergoing-fetoscopic-surgery-for-twin-twin-transfusion-syndrome
#10
JOURNAL ARTICLE
Braxton Forde, Samuel Martin, Miki Watanabe-Chailland, Foong-Yen Lim
Fetuses undergo major surgical stress as well as fluid shifts secondary to both twin-twin transfusion (TTTS) as well as the fetoscopic surgery for treatment of TTTS. While the pathophysiology of TTTS is understood, the acute metabolic changes that fetuses experience from fetoscopic surgery are not. We sought to evaluate the changes in recipient metabolomic profile secondary to TTTS surgery. Amniotic fluid was collected at the beginning and end of four TTTS surgical cases performed from 12/2022-2/2023. Samples were immediately processed and evaluated via NMR-based Metabolomics Facility protocol...
March 22, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38509872/human-genetics-society-of-australasia-position-statement-predictive-and-presymptomatic-genetic-testing-in-adults-and-children
#11
JOURNAL ARTICLE
Danya F Vears, Alison McLean, Chloe La Spina, Aideen McInerney-Leo
This Position Statement provides guidelines for health professionals who work with individuals and families seeking predictive genetic testing and laboratory staff conducting the tests. It presents the major practical, psychosocial and ethical considerations associated with presymptomatic and predictive genetic testing in adults who have the capacity to make a decision, children and young people who lack capacity, and adults living with reduced or fluctuating cognitive capacity.Predictive Testing Recommendations: (1) Predictive testing in adults, young people and children should only be offered with pretest genetic counseling, and the option of post-test genetic counseling...
March 21, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38505981/assessment-of-sleep-quality-in-spanish-twin-pregnancy-an-observational-single-center-study
#12
JOURNAL ARTICLE
María de la Calle, Jose L Bartha, Abigail Martin Mens, Silvia M Arribas, David Ramiro-Cortijo
Women with twin pregnancies experience greater sleep disturbance compared to women with singleton pregnancies. The aims of this study were to explore the sleep quality in women with twin pregnancies and to compare their sleep dimensions with coetaneous single pregnancies. This was an observational study in which women were enrolled at the end of pregnancy in the Obstetric Service of Hospital La Paz (Spain). The women were classified as single ( n = 143) or twin pregnancy ( n = 62). Pregnant women responded to the Pittsburgh Sleep Quality Index to evaluate sleep quality, latency, duration, efficiency, perturbance, use of medication, and daytime dysfunction...
March 20, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38505964/most-unusual-twin-pairs-a-look-at-uterus-didelphys-twin-research-reviews-prenatal-aneuploidy-screening-for-twin-pregnancies-twin-conceptions-by-same-sex-male-couples-legal-personality-of-conjoined-twins-twin-study-of-cannabis-use-human-interest-and-importance
#13
JOURNAL ARTICLE
Nancy L Segal
A review of an unusual twin type-twins born to women with two uteri (uterus didelphys)-is presented. This review is followed by summaries of recent research and perspectives concerning prenatal aneuploidy screening for twin pregnancies, twin conceptions by same-sex male couples, legal personality of conjoined twins, and a twin study of cannabis use. Interesting information about twins that has appeared in the media is also presented, namely how being taken for twins saved a pair of sisters; twin children of a jailed Nobel Prize winner, British 'biracial' twins, triplets born at the start of Russia's attack on Ukraine, and twins born in different years...
March 20, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38808696/thg-volume-27-issue-2-cover
#14
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38497097/genomics-research-of-lifetime-depression-in-the-netherlands-the-biobanks-netherlands-internet-collaboration-bionic-project
#15
JOURNAL ARTICLE
Floris Huider, Yuri Milaneschi, Jouke-Jan Hottenga, Mariska Bot, M Liset Rietman, Almar A L Kok, Tessel E Galesloot, Leen M 't Hart, Femke Rutters, Marieke T Blom, Didi Rhebergen, Marjolein Visser, Ingeborg Brouwer, Edith Feskens, Catharina A Hartman, Albertine J Oldehinkel, Eco J C de Geus, Lambertus A Kiemeney, Martijn Huisman, H Susan J Picavet, W M Monique Verschuren, Hanna M van Loo, Brenda W J H Penninx, Dorret I Boomsma
In this cohort profile article we describe the lifetime major depressive disorder (MDD) database that has been established as part of the BIObanks Netherlands Internet Collaboration (BIONIC). Across the Netherlands we collected data on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition ( DSM-5 ) lifetime MDD diagnosis in 132,850 Dutch individuals. Currently, N = 66,684 of these also have genomewide single nucleotide polymorphism (SNP) data. We initiated this project because the complex genetic basis of MDD requires large population-wide studies with uniform in-depth phenotyping...
March 18, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38444332/exploring-hematological-and-biochemical-disparities-in-same-sex-and-opposite-sex-females-a-cross-sectional-twin-study-in-a-ghanaian-population
#16
JOURNAL ARTICLE
Moses Banyeh, Benjamin N Mayeem, Moses Kofi Woli, Augusta S Kolekang, Clement Binwatin Dagungong, David Bure, Romarick Kofi Wemegah, Mikail Ihsan Azindow, Suleman Yakubu, Musah Seidu, Mohammed Madde Baba, Elisha Essoun, Nancy Owireduwaa
There are sex-dependent differences in hematological and biochemical variables in adulthood attributed to the predominant effects of testosterone in males and estrogen in females. The Twin Testosterone Transfer (TTT) hypothesis proposes that opposite-sex females may develop male-typical traits due to exposure to relatively higher levels of prenatal testosterone than same-sex females. Additionally, prenatal testosterone exposure has been suggested as a correlate of current circulating testosterone levels. Consequently, opposite-sex females might exhibit male-typical patterns in their hematological and biochemical variables...
March 6, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38444325/evolutionary-trends-of-polygenic-scores-in-european-populations-from-the-paleolithic-to-modern-times
#17
JOURNAL ARTICLE
Davide Piffer, Emil O W Kirkegaard
This study examines the temporal and geographical evolution of polygenic scores (PGSs) across cognitive measures (Educational Attainment [EA], Intelligence Quotient [IQ]), Socioeconomic Status (SES), and psychiatric conditions (Autism Spectrum Disorder [ASD], schizophrenia [SCZ]) in various populations. Our findings indicate positive directional selection for EA, IQ, and SES traits over the past 12,000 years. Schizophrenia and autism, while similar, showed different temporal patterns, aligning with theories suggesting they are psychological opposites...
March 6, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38410078/the-impossible-dream-panmixia
#18
JOURNAL ARTICLE
Alan E Stark
This study starts with a simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies. The question of differentiating between random and non-random mating is explored by simulation. Sample mating proportions are generated using the model as base. The difficulty of differentiating between random and non-random mating is illustrated.
February 27, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38380982/partnership-with-the-university-of-s%C3%A3-o-paulo-panel-of-twins-a-four-city-tour-and-more-twin-research-reviews-twin-research-on-binge-eating-twins-physical-outcomes-linked-to-different-diets-working-conditions-and-sickness-absence-in-swedish-twins-facial-morphology
#19
JOURNAL ARTICLE
Nancy L Segal
This article begins with an overview of twin research in Brazil, initiated by the University of São Paulo Panel of Twins. I met with many new research collaborators and students while on a fall 2023 four-city lecture tour in that country. A meeting with a world-famous surgeon who recently separated craniopagus conjoined twin pairs is also described. This overview is followed by summaries of twin research on binge eating, twins' physical outcomes linked to different diets, working conditions and sickness absence in Swedish Twins and facial morphology differences in monozygotic twins...
February 21, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/38343356/trends-in-twin-births-and-survival-in-bangladesh-an-analysis-of-half-a-century-of-evidence
#20
JOURNAL ARTICLE
Kazi Zubair Hossain, Iftekhar Hasan
This study assessed the trends in twin births and their survival in Bangladesh by analyzing over a quarter million live births during 1970-2018, pooled from all eight rounds of the Bangladesh Demographic and Health Survey. In these five decades, the twinning rate increased by 1.5 times, from 5.8 to 8.6 twins per 1000 maternities. The decadal twinning rates varied across maternal age, parity, body mass index, household wealth index, and geographic region. The gap in decadal neonatal, infant, and under-five cumulative survival probability between singleton and multiple births was found to be closing, using Kaplan-Meier curves...
February 12, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
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