journal
https://read.qxmd.com/read/38749755/single-cell-transcriptomic-analysis-reveals-myocardial-fibrosis-mechanism-of-doxorubicin-induced-cardiotoxicity
#1
JOURNAL ARTICLE
Yige Huyan, Xiao Chen, Yuan Chang, Xiumeng Hua, Xuexin Fan, Dan Shan, Zhenyu Xu, Menghao Tao, Hang Zhang, Sheng Liu, Jiangping Song
Myocardial fibrosis is a pathological feature of doxorubicin-induced chronic cardiotoxicity that severely affects the prognosis of oncology patients. However, the specific cellular and molecular mediators driving doxorubicin-induced cardiac fibrosis, and the relative impact of different cell populations on cardiac fibrosis, remain unclear.This study aimed to explore the mechanism of doxorubicin-induced cardiotoxicity and myocardial fibrosis and to find potential therapeutic targets. Single-cell RNA sequencing was used to analyze the transcriptome of non-cardiomyocytes from normal and doxorubicin-induced chronic cardiotoxicity in mouse model heart tissue...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749754/sirtuin-6-deacetylates-apoptosis-associated-speck-like-protein-asc-to-inhibit-endothelial-cell-pyroptosis-in-atherosclerosis
#2
JOURNAL ARTICLE
Jian Huang, Shuilin Dong, Yanhui Wu, Huiming Yi, Wei Zhang, Xi Ai
Endothelial cell dysfunction is the main pathology of atherosclerosis (AS). Sirtuin 6 (SIRT6), a deacetylase, is involved in AS progression. This study aimed to investigate the impacts of SIRT6 on the pyroptosis of endothelial cells and its underlying mechanisms. ApoE-/- mice were fed a high-fat diet (HFD) to establish the AS mouse model, atherosclerotic lesions were evaluated using oil red O staining, and blood lipids and inflammatory factors were measured using corresponding kits. Human umbilical vein endothelial cells (HUVECs) were treated with oxidized low-density lipoprotein (ox-LDL) to establish the cell model, and pyroptosis was evaluated by flow cytometry, ELISA, and western blot...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749753/triglyceride-glucose-index-predicts-major-adverse-cardiovascular-and-cerebrovascular-events-in-patients-with-atrial-fibrillation
#3
JOURNAL ARTICLE
Chunhui Yin, Qiqi Hou, Qi Qi, Quanle Han, Xiaoyao Wang, Shouling Wu, Kangbo Li
This study aimed to explore the relationship between the trajectory of the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCE) in patients with atrial fibrillation (AF).This prospective study included 1979 patients with AF, who were initially selected from the Kailuan study. Patients of AF were split into four groups according to the value of TyG index. The clinical endpoint was MACCE, including myocardial infarction and ischemic stroke. Cox proportional hazard models were employed to examine the hazard ratio (HR) and 95% confidence interval (CI) for MACCE in various trajectory groups...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749752/a-randomized-controlled-study-of-enhanced-external-counterpulsation-with-cardiac-rehabilitation-in-patients-with-nonobstructive-coronary-artery-disease-and-coronary-microvascular-dysfunction
#4
JOURNAL ARTICLE
Yuanzhuo Zhang, Xiaoyan Yin, Lei Ren
Treatment with enhanced external counterpulsation (EECP) or cardiac rehabilitation (CR) benefits patients with coronary heart disease; this paper intends to explore the feasibility of EECP combined with CR in patients with nonobstructive coronary heart disease (NOCAD) and coronary microcirculation disorders (CMD).In January 2021-2022 month June our income NOCAD patients as the research object, the line of cardiac magnetic resonance (CMR), myocardial perfusion reserve (MPR) < 2.0 coronary microcirculation disorders (CMD, 80 cases)...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749751/descriptions-of-etiology-clinical-course-and-prognosis-of-patients-presenting-with-pericardial-effusion
#5
JOURNAL ARTICLE
Koichiro Hori, Yuko Kato, Shinya Suzuki, Naomi Hirota, Takuto Arita, Naoharu Yagi, Mikio Kishi, Hiroto Kano, Shunsuke Matsuno, Takayuki Otsuka, Takayuki Hori, Minoru Matsuhama, Mitsuru Iida, Junji Yajima, Takeshi Yamashita, Tokuhisa Uejima, Yuji Oikawa
Pericardial effusion (PE) presentation varies from an incidental finding to a life-threatening situation; thus, its etiology and clinical course remain unknown. The aim of the present study was to retrospectively investigate these factors.We analyzed 171 patients (0.4%) who presented with PE among 34,873 patients who underwent echocardiography between 2011 and 2021 at our hospital. Clinical and prognostic information was retrieved from electronic medical records. The primary endpoints were all-cause death, hospitalization due to heart failure (HF), and other cardiovascular events such as cardiovascular death, acute coronary syndrome, elective percutaneous coronary intervention, and stroke...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749750/a-case-of-coronary-artery-perforation-caused-by-manual-cardiopulmonary-resuscitation-in-the-catheterization-laboratory
#6
JOURNAL ARTICLE
Kei Morishita, Takatoshi Unno, Takahiko Murakami, Kensuke Okada, Hiroshi Matsunaga, Kazuo Asada, Yasutoshi Omori, Akiko Ishihara, Yoshiro Kamoi, Takahiro Tanaka
Cardiopulmonary resuscitation (CPR) is essential for the survival of cardiac arrest patients, but it can cause severe traumatic complications. In the catheterization laboratory, various physical constraints complicate the appropriate performance of CPR. However, we are not aware of reports of CPR complications in this setting. Here, we report a case of coronary artery perforation (CAP) caused by manual CPR in the catheterization laboratory. The patient, a 68-year-old woman, initially underwent successful percutaneous coronary intervention (PCI) for unstable angina...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749749/long-term-maintenance-of-normal-serum-vitamin-b-1-levels-is-associated-with-better-outcomes-in-patients-with-heart-failure
#7
JOURNAL ARTICLE
Junko Morimoto, Keisuke Satogami, Takaya Naraoka, Akira Taruya, Atsushi Tanaka
Deficiency of vitamin B1 (VB1), an essential micronutrient, causes heart failure (HF). A recent randomized controlled trial failed to show any improvement in HF prognosis after short-term VB1 supplementation. In the current study, we investigated the efficacy of long-term maintenance of normal blood VB1 levels in preventing adverse outcomes in patients with HF.This study included 88 consecutive patients with HF who received guideline-directed medical therapy at Arida Municipal Hospital. The patients were divided into 3 groups: a control group with normal VB1 levels and no VB1 supplementation (normal group, n = 25), and those presenting with VB1 deficiency, who either required short-term VB1 supplementation (short-term supplementation group, n = 25), or long-term maintenance of normal blood VB1 levels (long-term maintenance group, n = 38)...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749748/comparative-analysis-of-the-anti-inflammatory-effects-of-liraglutide-and-dulaglutide
#8
JOURNAL ARTICLE
Yi Hou, Yini Fan, Yuan Cheng, Xiaoyue Peng, Chunyan Shan, Yanhui Yang
Inflammation plays a pathophysiological role in atherosclerosis and its clinical consequences. In addition to glycemic control, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are of wide concern for cardioprotective effects. The structure, half-life, homology, and clinical efficacy of GLP-1RAs exhibit remarkable disparity. Several studies have compared the disparities in anti-inflammatory effects between daily and weekly GLP-1RAs. This study aimed to compare the similarities and differences between liraglutide and dulaglutide in terms of inhibiting atherosclerotic inflammation and improving co-cultured endothelial cell function...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749747/a-surviving-case-of-myocardial-infarction-with-ventricular-septal-rupture-and-ventricular-aneurysm-following-gastrointestinal-bleeding
#9
JOURNAL ARTICLE
Misa Kusumoto, Jumpei Yamamoto, Sakura Kaneda, Takuya Matsushiro, Masaya Yamamoto, Hisao Hara, Nobuyuki Inoue, Yukio Hiroi
A 55-year-old man presented to the emergency department with worsening shortness of breath 1 month after a gastrointestinal bleed. He had congestive heart failure, and an electrocardiogram suggested ischemic heart disease involvement. Echocardiography revealed a ventricular septal defect complicated by a left ventricular aneurysm in the inferior-posterior wall. Conservative treatment was started, but hemodynamic collapse occurred on the third day of admission and coronary angiography revealed a revascularizing lesion in the right fourth posterior descending coronary artery...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749746/potential-effects-of-ischemic-postconditioning-and-changes-in-heat-shock-protein-72-in-patients-with-acute-myocardial-infarction-without-prodromal-angina
#10
JOURNAL ARTICLE
Toshiharu Takeuchi, Yuya Kitani, Akiho Minoshima, Hisanobu Ota, Naoki Nakagawa, Kazuhiro Sumitomo, Yoshinao Ishii, Naoyuki Hasebe
The effectiveness of ischemic postconditioning (iPoC) in patients with ST-elevation myocardial infarction (STEMI) without ischemic preconditioning has not been determined. Therefore, we investigated the impact of iPoC and its potential mechanism related to heat shock protein 72 (HSP72) induction on myocardial salvage in patients with STEMI without prodromal angina (PA).We retrospectively analyzed data from 102 patients with STEMI with successful reperfusion among 323 consecutive patients with acute coronary syndrome...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749745/role-of-sleep-disordered-breathing-and-epicardial-connections-in-the-recurrence-of-atrial-fibrillation
#11
JOURNAL ARTICLE
Eiji Nyuta, Masao Takemoto, Yoshibumi Antoku, Takahiro Mito, Togo Sakai, Tomohiro Takiguchi, Shota Ikeda, Tokushi Koga, Takuya Tsuchihashi
The presence of epicardial connections (ECs) between the pulmonary veins (PVs) and atrium may contribute to atrial fibrillation (AF) recurrence. This study aimed to determine the impact of sleep-disordered breathing (SDB) on the presence of ECs and the interplay between SDB and ECs on AF recurrence.We retrospectively reviewed 400 consecutive non-valvular AF patients. Among them, 235 patients exhibiting a 3% oxygen desaturation index (ODI) of ≥ 10 events/hour underwent polysomnography to evaluate the SDB severity, measured by the apnea-hypopnea index (AHI)...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749744/plin5-suppresses-lipotoxicity-and-ferroptosis-in-cardiomyocyte-via-modulating-pir-nf-%C3%AE%C2%BAb-axis
#12
JOURNAL ARTICLE
Xiaoyu Shen, Jiamei Zhang, Zhou Zhou, Ruiqun Yu
Cardiomyocyte lipotoxicity and ferroptosis are the key to the development of diabetic cardiomyopathy (DCM). Perilipin 5 (PLIN5) is perceived as a significant target of DCM. This study aimed to focus on the role and mechanism of PLIN5 on lipotoxicity and ferroptosis in DCM.Following transfection, mouse cardiomyocytes HL-1 were induced by 0.1 mM palmitic acid (PA) to set up lipotoxic cardiomyocyte models. The cell viability and lipid accumulation were evaluated by cell counting kit-8 assay and Oil red O staining, respectively...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38749743/impact-of-cancer-history-on-temporal-changes-in-the-cardiopulmonary-exercise-test-of-patients-with-cardiovascular-disease
#13
JOURNAL ARTICLE
Keisuke Satogami, Junko Morimoto, Takaya Naraoka, Motoki Taniguchi, Takahiro Nishi, Yoshinori Asae, Akira Taruya, Atsushi Tanaka
The elevated risk of cardiovascular disease (CVD) in cancer patients and survivors is likely the result of normal age-related pathologies coupled with the direct and indirect effects of cancer therapy that extend across multiple systems. The purpose of this study was to investigate the impact of cardiac rehabilitation (CR) on CVD patients with a history of cancer.In this study, patients who had participated in the outpatient CR program were enrolled and were divided into 2 groups (cancer survivor group and no-cancer group) based on their history of cancer...
May 15, 2024: International Heart Journal
https://read.qxmd.com/read/38479851/comparison-of-the-pre-established-and-finally-selected-treatment-strategies-for-endovascular-treatment-in-femoropopliteal-artery-lesions
#14
JOURNAL ARTICLE
Michiaki Higashitani, Daisuke Ueshima, Kenji Suzuki, Yasutaka Yamauchi, Mitsugu Hirokami, Yoshinori Tsubakimoto, Akihiko Takahashi, Taku Kato, Hiroshi Ando, Masato Nakamura
This study aimed to compare lower limb events associated with preplanned and finally selected treatment strategies-the validity and usefulness of the physician-chosen strategy were verified.We examined the data of 1003 patients in the registry of multicenter endovascular treatment for superficial femoral and popliteal artery disease study and prospectively enrolled patients who underwent endovascular treatment (EVT) of the femoropopliteal (FP) artery between February 2017 and June 2018 from 67 Japanese institutes...
March 12, 2024: International Heart Journal
https://read.qxmd.com/read/38479850/circ_0020887-silencing-combats-hypoxic-induced-cardiomyocyte-injury-in-an-mir-370-3p-cyp1b1-dependent-manner
#15
JOURNAL ARTICLE
Huiqin Chen, Zhendong Cheng, Meiai Wang, Qian Huang, Dandan Zheng, Qiuhong Huang, Kefeng Cai
Targeting circular RNA has been a novel approach to preventing and limiting acute myocardial infarction (AMI). Here, we planned to investigate the role and mechanism of circ_0020887 in AMI progression.Hypoxic injury in human cardiomyocytes (AC16) was measured using cell counting kit-8 assay, 5-ethynyl-2'-deoxyuridine assay, flow cytometry, and colorimetric assay kits. RNA and protein expressions were determined using real-time quantitative PCR and western blotting. Direct interplay between RNAs was determined using dual-luciferase reporter, RNA pull-down, and RIP assays...
March 12, 2024: International Heart Journal
https://read.qxmd.com/read/38479849/spontaneous-remission-without-steroid-therapy-in-isolated-cardiac-sarcoidosis-with-severe-left-ventricular-systolic-dysfunction
#16
JOURNAL ARTICLE
Takaya Ozawa, Kenji Goto, Katsuya Miura, Kazunari Kobayashi, Yuetsu Kikuta, Katsumasa Sato, Masahito Taniguchi, Shigeki Hiramatsu, Hideo Takebayashi, Seiichi Haruta
Spontaneous remission is often observed in extracardiac cases of sarcoidosis, such as skin sarcoidosis. However, for cardiac sarcoidosis (CS), the prognosis is unfavorable. Although corticosteroids are the first-line treatment for CS, data regarding the natural history of isolated CS are limited. We describe a rare case of isolated CS with severe left ventricular systolic dysfunction that improved without steroid therapy.
March 12, 2024: International Heart Journal
https://read.qxmd.com/read/38479848/clinical-features-and-outcomes-of-shoshin-beriberi
#17
JOURNAL ARTICLE
Yoshiki Mizuguchi, Hideyuki Mouri, Taisuke Jo, Yohei Hashimoto, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Takumi Taniguchi
Shoshin beriberi is a fulminant form of wet beriberi, but there are no large-scale studies detailing the clinical features of this disease. We investigated the clinical features and outcomes of Shoshin beriberi using data from a nationwide database in Japan.Using the Diagnosis Procedure Combination database, we identified patients with Shoshin beriberi between July 2010 and March 2021. We retrospectively investigated the characteristics, comorbidities, treatment, and in-hospital mortality of patients with Shoshin beriberi...
March 12, 2024: International Heart Journal
https://read.qxmd.com/read/38479847/nutrition-assessment-and-education-of-patients-with-heart-failure-by-cardiologists
#18
JOURNAL ARTICLE
Taishi Dotare, Daichi Maeda, Yuya Matsue, Yutaka Nakamura, Tsutomu Sunayama, Takashi Iso, Taisuke Nakade, Tohru Minamino
Although nutritional assessment and education are important for hospitalized patients with heart failure, the extent of their implementation in real-world clinical practice is unknown. Therefore, this study aimed to investigate the evaluation and management of nutrition during hospitalization for heart failure using a questionnaire survey for cardiologists.In this cross-sectional multicenter survey, 147 cardiologists from 32 institutions completed a web-based questionnaire (response rate, 95%).The survey showed that 78...
March 12, 2024: International Heart Journal
https://read.qxmd.com/read/38479846/h-type-hypertension-status-and-influencing-factors-of-the-elderly-people-over-80-years-old-based-on-random-forest-model
#19
JOURNAL ARTICLE
Xiaobo Zhang, Botang Guo, Hong Zhu, Dahe Li, Yuanyuan Zhao, Qi Liu, Jingbo Hou
Hypertension is a common chronic disease in elderly people over 80 years old. Clinically, H-type hypertension occurs when hypertension coexists with hyperhomocysteinemia level of ≥ 10 umol/L. Effective identification of risk factors for H-type hypertension in the elderly can greatly improve patient prognosis.Consecutively, 494 patients with hypertension admitted to the Fourth Affiliated Hospital of Harbin Medical University from January 2019 to December 2021 were selected as the study population. They were divided into H-type hypertension (n = 197) and non-H-type hypertension groups (n = 297)...
March 12, 2024: International Heart Journal
https://read.qxmd.com/read/38479845/coexistence-case-of-papillary-fibroelastoma-and-lambl-s-excrescence-of-the-left-heart-which-is-occasionally-associated-with-significant-stroke
#20
JOURNAL ARTICLE
Takatoshi Unno, Ryuichi Kato, Masao Kuwada, Mitsunori Ishino, Takahiko Nagase, Takahisa Tanaka, Chiyo Yoshino, Takafumi Nishida, Yoshinori Yoshida, Ryo Oyama, Takafumi Kikuchi, Takayuki Tatebayashi, Sadahito Kuwao
Papillary fibroelastoma (PFE) is a benign tumor that arises mostly from left-sided valves. PFE can cause stroke, and surgical resection may be needed. Lambl's excrescence (LE) is a filiform valvular lesion and is considered a possible cause of stroke. A 79-year-old man with light-headedness and left-sided hemiparesis was diagnosed with stroke. Transesophageal echocardiography (TEE) revealed a round-shaped mobile mass in the left ventricular outflow tract (LVOT), which was considered the cause of the stroke...
March 12, 2024: International Heart Journal
journal
journal
41021
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.