journal
https://read.qxmd.com/read/36988543/intravenous-ascorbic-acid-vitamin-c-causing-pseudohyperglycemia
#1
LETTER
Jeremy Hardin, Lee Cantrell, Andrew Lafree
No abstract text is available yet for this article.
March 29, 2023: Clinical Toxicology
https://read.qxmd.com/read/36988542/unexpected-refractory-hypotension-following-intradermal-minoxidil-injection
#2
LETTER
Momoko Asada, Yuji Okazaki, Toshihisa Ichiba, Hiroshi Naito, Akira Namera
No abstract text is available yet for this article.
March 29, 2023: Clinical Toxicology
https://read.qxmd.com/read/36988456/lactic-acidosis-in-a-patient-who-ingested-rotenone-containing-beans-pachyrhizus-erosus
#3
LETTER
Kai-Wen Cheng, Hsien-Yi Chen, Chun-Fa Huang, Te-Hao Wang, Jiun-Hao Yu
No abstract text is available yet for this article.
March 29, 2023: Clinical Toxicology
https://read.qxmd.com/read/36988452/non-fatal-intoxications-involving-the-novel-benzodiazepine-clonazolam-case-series-from-the-emerging-drugs-network-of-australia-victoria-project
#4
JOURNAL ARTICLE
Rebekka Syrjanen, Shaun L Greene, Jared W Castle, Matthew Di Rago, Sarah E Hodgson, Rachelle Abouchedid, Andis Graudins, Jennifer L Schumann
INTRODUCTION: Clonazolam is an unregistered novel benzodiazepine which emerged in global illicit drug markets in 2014. We describe the clinical features of four cases of non-fatal clonazolam mono-intoxications from patients presenting to emergency departments in Australia. CASES: Four patients aged between 16 and 19 years presented to hospital with a sedative toxidrome (Glasgow Coma Scale range 8-13) and elevated heart rate (median heart rate 100 beats per minute, range 92-105) following reported benzodiazepine exposure...
March 29, 2023: Clinical Toxicology
https://read.qxmd.com/read/36988441/trends-in-concomitant-and-single-opioid-and-benzodiazepine-exposures-reported-to-the-california-poison-control-system-following-the-centers-for-disease-control-and-prevention-release-of-opioid-guidelines-in-2016
#5
JOURNAL ARTICLE
Emily Chu, Gina Cocos, Ho Jun Lee, Jane Go, Justin Lewis, Dorie E Apollonio
INTRODUCTION: In March 2016, the Centers for Disease Control and Prevention released the Guideline for Prescribing Opioids for Chronic Pain, intended for primary care clinicians. One recommendation advised against concurrent prescription of opioids and benzodiazepines. Although existing research suggests a reduction in co-prescribing of these drug classes by clinicians after guideline release, there are limited data assessing its possible effect on patient medical outcomes, such as overdoses...
March 29, 2023: Clinical Toxicology
https://read.qxmd.com/read/36939145/the-minor-cannabinoid-cannabigerol-cbg-is-a-highly-specific-blood-biomarker-of-recent-cannabis-smoking
#6
JOURNAL ARTICLE
John M Rague, Ming Ma, Gregory Dooley, George Sam Wang, Kyle Friedman, Thomas K Henthorn, Ashley Brooks-Russell, Michael J Kosnett
INTRODUCTION: The determination of recent cannabis use is of forensic interest in the investigation of automotive crashes, workplace incidents and other mishaps. Because Δ9-tetrahydrocannabinol may persist in blood after psychoactive effects of intoxication resolve, particularly in regular users, short-lived minor cannabinoids such as cannabigerol have merited examination as adjunct indicators of recent cannabis inhalation. METHODS: As part of an observational cohort study, whole blood cannabinoids including cannabigerol were measured in whole blood by liquid chromatography with tandem mass spectrometry at baseline, and 30 minutes after initiation of a 15-minute supervised interval of ad libitum cannabis smoking in occasional (1-2 days/week over the past 30 days) ( n  = 24) and daily cannabis smokers ( n  = 32)...
March 20, 2023: Clinical Toxicology
https://read.qxmd.com/read/36939139/clinical-features-of-snake-envenomation-in-south-korea
#7
JOURNAL ARTICLE
Jeong Mi Moon, Byeong Jo Chun, Yong Soo Cho
INTRODUCTION: Three venomous snakes of the Gloydius genus belonging to the Viperidae family cause most snake envenomations in South Korea. Envenomation signs often include local swelling, coagulopathy, and rhabdomyolysis. The benefit of additional antivenom after the initial does is unclear. METHODS: This retrospective study divided patients into four groups according to the presence of rhabdomyolysis (creatine kinase ≥1000 IU/L) and coagulopathy, which were defined using the Korean Society on Thrombosis and Hemostasis disseminated intravascular coagulation score (rhabdomyolysis, coagulopathy, combination, and local effects groups)...
March 20, 2023: Clinical Toxicology
https://read.qxmd.com/read/36939119/variable-sensitivity-to-diethylene-glycol-poisoning-is-related-to-differences-in-the-uptake-transporter-for-the-toxic-metabolite-diglycolic-acid
#8
JOURNAL ARTICLE
Julie D Tobin, Courtney N Jamison, Corie N Robinson, Kenneth E McMartin
INTRODUCTION/CONTEXT: Poisonings with diethylene glycol are characterized by acute kidney injury and peripheral neuropathy. In animal studies on the toxicities of diethylene glycol and its metabolite diglycolic acid, remarkable differences in susceptibility to acute kidney injury were observed in identically-dosed rats. In those studies, only about 60% showed acute kidney injury, yet all rats with acute kidney injury showed marked diglycolic acid accumulation in tissues, while no diglycolic acid accumulated in rats without injury...
March 20, 2023: Clinical Toxicology
https://read.qxmd.com/read/36919499/clinical-characteristics-of-hospitalized-patients-with-paracetamol-poisoning-before-and-after-restrictions-of-over-the-counter-sale-of-paracetamol
#9
JOURNAL ARTICLE
Charlotte Uggerhøj Andersen, Steffen Hansen, Kim Peder Dalhoff, Lars Peter Nielsen, Jørn Munkhof Møller, Anne Estrup Olesen
INTRODUCTION: Paracetamol poisoning is a frequent cause of hospitalization in Denmark. On 30 September 2013, the Danish authorities restricted packages available without a prescription in pharmacy outlets to contain a maximum of 10 g of paracetamol. We aimed to investigate the effects of this regulation. METHODS: This was a cross-sectional study of two groups of patients admitted consecutively to a Danish University Hospital due to poisoning with paracetamol in 365 days in 2012-13 before 30 September 2013, and a corresponding 365-day period in 2017-18...
March 15, 2023: Clinical Toxicology
https://read.qxmd.com/read/36919497/an-outbreak-of-amanita-exitialis-poisoning
#10
JOURNAL ARTICLE
Hui Meng, ZhaoYin Chen, LanChun Chen, WeiXin Tang, Fang He, XianRang Yan, XiaoHong Lin, XiaoLong Se, MingFei Xie, ZhanHan Li, LiJuan Lu, Xuetao Yu
BACKGROUND: The mushroom Amanita exitialis is reported to cause acute liver injury. It is found in Southern China, and has been previously associated with a high incidence of mortality. METHODS: We described a series of 10 patients with Amanita exitialis poisoning admitted to The Second Affiliated Hospital of the Chinese University of Hong Kong (Shenzhen) in April 2022. Patient demographics, clinical features, laboratory results, therapeutic interventions, and outcome data were collected...
March 15, 2023: Clinical Toxicology
https://read.qxmd.com/read/36919488/association-of-prescription-drug-monitoring-programs-with-benzodiazepine-prescription-dispensation-and-overdose-in-adolescents-and-young-adults
#11
JOURNAL ARTICLE
Michael S Toce, Kenneth A Michelson, Joel D Hudgins, Karen L Olson, Michael C Monuteaux, Florence T Bourgeois
INTRODUCTION: Prescription drug monitoring programs are state-run databases designed to support safe prescribing of controlled substances and reduce prescription drug misuse. We analyzed healthcare claims data to determine the association between prescription drug monitoring programs with mandated provider review and adolescent and young adult benzodiazepine prescription dispensing and overdose. METHODS: We performed a state-level retrospective cohort study to evaluate the association between implementation of prescription drug monitoring programs with mandated provider review and benzodiazepine prescription dispensing and benzodiazepine-related overdoses among adolescents (13-18 years) and young adults (19-25 years) between 1 January 2008 and 31 December 2019...
March 15, 2023: Clinical Toxicology
https://read.qxmd.com/read/36892558/implementation-of-a-pharmacist-toxicology-service-on-treatment-of-paracetamol-acetaminophen-overdose
#12
JOURNAL ARTICLE
Kathryn Albert, Kayla Wilson, Shannon Hasara
INTRODUCTION: Paracetamol is a leading cause of fatality following a toxic ingestion. Individualized treatment is imperative in improving outcomes. Acetylcysteine is the standard of care for paracetamol overdose. Laboratory values and other clinical criteria can be used to guide treatment duration. Our hospital's protocol allows paracetamol overdose to be managed by the emergency department pharmacists. The purpose of this study was to evaluate the effect of a pharmacist toxicology service on the management of paracetamol overdose...
March 9, 2023: Clinical Toxicology
https://read.qxmd.com/read/36892552/outcomes-of-wasp-and-bee-stings-in-taiwan
#13
JOURNAL ARTICLE
Thi Ngat Nguyen, Mei-Jy Jeng, Nai-Yu Chen, Chen-Chang Yang
BACKGROUND: The families of Hymenoptera causing commonly poisonous animal stings in Taiwan include Apoidea (bee) and Vespidae (wasp). This study aimed to investigate the epidemiologic, clinical characteristics, and outcomes of the severity of envenomation following wasp or bee stings in Taiwan. METHODS: We conducted a retrospective study by identifying all wasp and bee sting-related envenomation reported to the Taiwan National Poison Control Center between January 2001 and November 2021...
March 9, 2023: Clinical Toxicology
https://read.qxmd.com/read/36892538/unintentional-poisoning-from-decanted-toxic-household-chemicals
#14
JOURNAL ARTICLE
Katharina von Fabeck, Audrey Boulamery, Corinne Schmitt, Mathieu Glaizal, Luc de Haro, Nicolas Simon
BACKGROUND: Although poisonings due to a toxic substance being decanted into a secondary container are often reported to poison centers, we were unable to locate prior European data about their circumstances, incidence and consequences. We sought to describe the circumstances and outcomes of this behavior. MATERIALS AND METHOD: We conducted a prospective study of all poison exposures involving transfer to a secondary container reported to our poison center during a six month interval (January 1, 2021 through June 30, 2021)...
March 9, 2023: Clinical Toxicology
https://read.qxmd.com/read/36892525/trends-in-pediatric-nonprescription-analgesic-antipyretic-exposures-during-the-covid-19-pandemic
#15
JOURNAL ARTICLE
Sara Karami, Cooma Asonye, Ellen Pinnow, Valerie Pratt, Lynda McCulley, Nana Dwumfour, Esther H Zhou
OBJECTIVE: To examine pediatric exposure trends involving selected nonprescription analgesics/antipyretics, before and during the COVID-19 pandemic. METHODS: Using descriptive and interrupted time-series analyses, we assessed monthly United States poison center data involving pediatric (<18 years) exposures to nonprescription paracetamol (acetaminophen), ibuprofen, acetylsalicylic acid, and naproxen before (January 2015-February 2020) and during (March 2020-April 2021) the pandemic...
March 9, 2023: Clinical Toxicology
https://read.qxmd.com/read/36892513/hospitalised-poisonings-in-australian-children-a-10-year-retrospective-study
#16
JOURNAL ARTICLE
Abrar Arbaeen, Firouzeh Noghrehchi, Nial J Wheate, Rose Cairns
INTRODUCTION: Paediatric poisoning is a major cause of childhood injury, and most poisonings are preventable. We aimed to describe hospitalisations resulting from poisoning and envenomation in Australian children, including demographics, cause of the exposure, hospital length of stay, rates of intensive care unit admission and in-hospital deaths. We also aimed to describe risk factors for increased length of stay and intensive care unit admission. METHODS: A retrospective analysis was performed of hospitalised poisoning and envenomation cases of children (<15 years) in Australia from 1 July 2009 to 30 June 2019...
March 9, 2023: Clinical Toxicology
https://read.qxmd.com/read/36815683/efficacy-of-unithiol-2-3-dimercaptopropanesulfonate-and-acetylcysteine-in-a-patient-with-arthroplastic-cobalt-toxicity
#17
LETTER
Daniela Pelclova, Karel Lach
No abstract text is available yet for this article.
February 23, 2023: Clinical Toxicology
https://read.qxmd.com/read/36815350/psilocybin-services-in-oregon-a-call-for-awareness-among-clinical-toxicologists
#18
JOURNAL ARTICLE
Daniel L Sudakin
BACKGROUND: In 2023, Oregon enacted laws regulating the manufacture and use of psilocybin products in licensed facilities for supervised sessions with trained facilitators. COMMENTARY: This commentary summarizes the final rules for psilocybin services in Oregon, and provides perspectives from a clinical toxicologist on some of the issues that may arise. These include the scope of practice for non-clinical facilitators, prevention and management of adverse drug reactions, and toxicological uncertainties with regards to dose considerations for people with mental health and other medical conditions...
February 23, 2023: Clinical Toxicology
https://read.qxmd.com/read/36795061/derivation-and-internal-validation-of-a-clinical-prediction-score-to-predict-major-effect-or-death-in-acute-metamfetamine-toxicity
#19
JOURNAL ARTICLE
Rex Pui Kin Lam, Chi Keung Chan, Man Li Tse, Eric Ho Yin Lau, Zonglin Dai, Matthew Sik Hon Tsui, Timothy Hudson Rainer
OBJECTIVE: Metamfetamine use can cause serious complications or death. We aimed to derive and internally validate a clinical prediction score to predict major effect or death in acute metamfetamine toxicity. METHODS: We performed secondary analysis of 1,225 consecutive cases reported from all local public emergency departments to the Hong Kong Poison Information Centre between 1 January 2010 and 31 December 2019. We split the entire dataset chronologically into derivation (first 70% of cases) and validation (the remaining 30% of cases) cohorts...
February 16, 2023: Clinical Toxicology
https://read.qxmd.com/read/36794335/a-comparison-of-the-accuracy-of-mushroom-identification-applications-using-digital-photographs
#20
JOURNAL ARTICLE
Sarah E Hodgson, Christine McKenzie, Tom W May, Shaun L Greene
OBJECTIVE: To compare the accuracy of three popular mushroom identification software applications in identifying mushrooms involved in exposures reported to the Victorian Poisons Information Centre and Royal Botanic Gardens Victoria. BACKGROUND: Over the past 10 years, an increasing number of software applications have been developed for use on smart phones and tablet devices to identify mushrooms. We have observed an increase in poisonings after incorrect identification of poisonous species as edible, using these applications...
February 15, 2023: Clinical Toxicology
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