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Asia-Pacific Journal of Clinical Oncology

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https://read.qxmd.com/read/30761763/the-diameter-of-metastasis-in-positive-sentinel-lymph-node-biopsy-affects-axillary-tumor-load-in-early-breast-cancer
#1
Michał Falco, Bartłomiej Masojć, Tomasz Byrski, Andrzej Kram
INTRODUCTION: Omission of axillary lymph node dissection (ALND) after positive sentinel lymph biopsy (SLNB) has become a standard procedure for breast cancer patients with one or two metastatic lymph nodes. Here the aim was model development for selection for ALND. MATERIAL AND METHODS: We analyzed 323 positive SLNB breast cancer patients, who afterwards underwent ALND. In 126 (39%), there were positive additional axillary lymph nodes. Specimens of resected lymph nodes were scanned and the volumes of tumors (expressed as diameter in mm) were calculated...
February 13, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30761750/right-versus-left-sided-metastatic-colorectal-cancer-teasing-out-clinicopathologic-drivers-of-disparity-in-survival
#2
Shehara Mendis, Sophie Beck, Belinda Lee, Margaret Lee, Rachel Wong, Suzanne Kosmider, Jeremy Shapiro, Desmond Yip, Simone Steel, Louise Nott, Ross Jennens, Lara Lipton, Matthew Burge, Kathryn Field, Sumitra Ananda, Hui-Li Wong, Peter Gibbs
BACKGROUND: Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute. METHODS: The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectively captured data on consecutive mCRC patients. RC were defined as tumors proximal to the splenic flexure; LC were those at and distal to the splenic flexure and included rectal cancers...
February 13, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30761749/translation-and-psychometric-testing-of-cancer-survivors-unmet-needs-chinese-version
#3
Weijie Xing, Winnie Kwok Wei So, Kai Chow Choi, Cho Lee Wong, Man Tong, Yin Ping Choy, Alex Molassiotis, Patsy Yates, Raymond Javan Chan
AIM: The aim of the study was to translate the Cancer Survivors' Unmet Needs (CaSUN) scale into Chinese, and then test its psychometric properties, for cancer survivors in Hong Kong. METHODS: The original questionnaire was translated from English into traditional Chinese (CaSUN-Chi), following standardized procedures. An expert panel was invited to assess the items' content validity, and pilot test on 15 patients to evaluate its readability. The sample for psychometric evaluation was drawn from a large multinational study assessing unmet needs of cancer survivors, with a convenience sample of 300 was recruited...
February 13, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30761745/association-of-hormone-replacement-therapy-with-increased-risk-of-meningioma-in-women-a-hospital-based-multicenter-study-with-propensity-score-matching
#4
Xiaochen Shu, Yun Jiang, Tao Wen, Shun Lu, Lu Yao, Fang Meng
AIM: There is no consensus regarding the association between hormone replacement therapy (HRT) and risk of meningioma so far. We conducted the first study among Chinese female patients to investigate the influence of HRT use on the risk of meningioma. METHODS: We retrospectively collected records of diagnosis of meningioma for women aged 50 years and above during 2011-2016 and dispense of HRT prior to meningioma diagnosis in three tertiary hospitals in China. Meningioma cases were matched with controls at a ratio of 1:2 by using nearest neighbor propensity scores matching in order to balance the baseline characteristics between groups, which generated a total of 629 cases with 1258 controls...
February 13, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30761737/patterns-of-follow-up-care-after-curative-radiotherapy-%C3%A2-chemotherapy-for-stage-i-iii-non-small-cell-lung-cancer
#5
Sharanya Mohan, Nadine Beydoun, Elias Nasser, Andrew Nguyen, Jesmin Shafiq, Shalini Vinod
OBJECTIVES: To describe patterns of follow-up care for non-small cell lung cancer patients treated with curative radiotherapy and to evaluate the role of routine imaging. MATERIALS AND METHODS: We retrospectively analyzed follow-up care of patients with stage I-III non-small cell lung cancer treated with curative radiotherapy (minimum dose of 50 Gy) between 2007 and 2011 at three Sydney institutions. Patient demographics, tumor characteristics and treatment factors were collected from oncology and hospital records...
February 13, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30747499/registry-based-randomized-clinical-trials-as-a-method-to-improve-cancer-care-in-australia
#6
LETTER
Siavash Foroughi, Hui-Li Wong, Lucy Gately, Margaret Lee, Koen Simons, Jeanne Tie, Antony Wilks Burgess, Peter Gibbs
No abstract text is available yet for this article.
February 12, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30747483/embracing-the-full-spectrum-of-real-world-data-for-cancer-medicines-research-in-australia
#7
LETTER
Monica Tang, Andrea Schaffer, Sallie-Anne Pearson
No abstract text is available yet for this article.
February 12, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30746847/what-contributes-to-resilience-in-cancer-patients-a-principal-component-analysis-of-the-connor-davidson-resilience-scale
#8
Wei Son Tan, Lisa Beatty, Emma Kemp, Bogda Koczwara
PURPOSE: Research suggests resilience is a complex multifactorial construct, which may improve health outcomes in cancer, but significant controversy exists regarding its definition and measurement. This study aimed to determine the components of resilience and their relative weight, as measured by the Connor-Davidson Resilience Scale in cancer patients. METHODS: As part of a larger study, a questionnaire including the Connor-Davidson Resilience Scale was distributed to 228 cancer patients...
February 11, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30740893/association-between-human-papillomavirus-infection-and-prostate-cancer-a-global-systematic-review-and-meta-analysis
#9
REVIEW
Mohsen Moghoofei, Mohsen Keshavarz, Saeed Ghorbani, Farhad Babaei, Javid Sadri Nahand, Ahmad Tavakoli, Helya Sadat Mortazavi, Arezoo Marjani, Shayan Mostafaei, Seyed Hamidreza Monavari
Although an increasing number of studies have been conducted to evaluate the association between human papillomavirus (HPV) infections and distribution of HPV types worldwide with the risk of prostate cancer (PC), the results remain inadequate. Hence, we investigated the association between HPV infection and PC risk using a meta-analysis. Relevant studies from January 1990 to December 2016 were searched in PubMed, Web of sciences, and Scopus databases. Pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were calculated to find the association between the prevalence of HPV and prostate cancer risk...
February 10, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30740890/significance-of-methylation-status-of-maspin-gene-and-its-protein-expression-in-prognosis-of-gallbladder-cancer
#10
Kavita Baghel, Hasan Raza Kazmi, Abhijit Chandra, Saloni Raj, Rajeshwar Nath Srivastava
AIM: We investigated prognostic significance of methylation status of MASPIN gene and its protein expression in normal subjects, cholelithiasis and gallbladder cancer (GBC) patients. METHODS: MASPIN protein expression and its promoter methylation in gallbladder tissue of cholelithiasis (n = 36), GBC (n = 46) and controls (n = 25) were investigated. Clinicopathological parameters and prognosis of patients with GBC were correlated with protein expression of MASPIN...
February 10, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30729683/androgen-deprivation-therapy-in-nonmetastatic-prostate-cancer-patients-indications-treatment-effects-and-new-predictive-biomarkers
#11
REVIEW
Dong Fang, Liqun Zhou
Men with prostate cancer with positive margins, extraprostatic extension, positive lymph nodes, high prostate-specific antigen, or high Gleason Score are at high risk of recurrence following primary therapy. Androgen deprivation therapy (ADT), which includes medical/surgical castration, antiandrogen therapy, and combined androgen blockade, can be combined with primary therapy to shrink the tumor, reduce margin positivity, and reduce the risk of recurrence. However, many problems still remain, such as optimizing the application of ADT in the treatment of prostate cancer, for example, ideal patient population and optimal timing and duration of therapy...
February 6, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30714343/reply-to-m-alexander-et-al
#12
LETTER
Kyaw Zin Thein, Sai-Ching J Yeung, Thein Hlaing Oo
No abstract text is available yet for this article.
February 3, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30701671/timing-of-brain-metastases-development-in-metastatic-renal-cell-cancer-patients-treated-with-targeted-therapies-and-survival-outcomes-an-australian-multicenter-study
#13
Francis J Ha, Lavinia Spain, Anthony Dowling, Edmond M Kwan, Carmel Pezaro, Daphne Day, Puey Ling Chia, Ben Tran, David Pook, Andrew J Weickhardt
AIM: Targeted therapy (TT) has improved survival for metastatic renal cell carcinoma (mRCC). However, survival is usually limited if brain metastases (BMs) develop. We aimed to evaluate survival outcomes in mRCC patients based on timing of BM diagnosis. METHODS: We conducted a multicenter, retrospective study of mRCC patients with BM who received TT at any point between 2005 and 2014. We determined overall survival (OS) from stage IV diagnosis, TT initiation and BM diagnosis, and prognostic factors...
January 30, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30698349/hurdles-in-radiation-planning-for-glioblastoma-can-delayed-contrast-enhanced-computed-tomography-be-a-potential-solution
#14
Narendra Kumar, Nikesh Hanumanthappa, Raviteja Miriyala, Sameer Vyas, Pravin Salunke, Arun S Oinam, Budhi S Yadav, Renu Madan, Chinnababu Dracham, Rakesh Kapoor
OBJECTIVE: Conformal radiation is the standard of care in treatment of glioblastoma. Although co-registration of magnetic resonance imaging (MRI) with early contrast enhanced computed tomography (CECT) is recommended for target delineation by consensus guidelines, ground realities in developing countries often result in availability of less-than-ideal MR sequences for treatment planning. Purpose of this study is to analyze the impact of incorporation of delayed-CECT sequences for radiation planning in glioblastomas, as an adjunct or alternative to MRI...
January 30, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30693655/clinical-efficacy-of-concurrent-bevacizumab-for-malignant-ascites-in-nonsquamous-cell-carcinoma-of-the-lung
#15
Jui-Feng Hsu, Yen-Lung Lee, Hsu-Liang Chang, Po-Ju Wei, Yu-Ting Shen, Chi-Min Lin, Ching-Yi Li, Inn-Wen Chong, Chih-Jen Yang
PURPOSE: Lung cancer with malignant peritoneal carcinomatosis and malignant ascites is rare, often indicates the terminal stage, and is refractory to treatment. The median survival time of lung cancer patients with malignant ascites has been reported to be as short as 15 days to 2 months in retrospective studies. METHODS: We reviewed all lung cancer patients who had cytologically or pathologically proven malignant ascites and received aggressive therapy including chemotherapy, anti-angiogenesis agents and target therapy at a Taiwan hospital from January 2015 to December 2017...
January 29, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30693649/outcome-of-chemotherapy-with-or-without-targeted-agents-in-metastatic-colorectal-cancer-patients-with-deficient-dna-mismatch-repair-a-single-center-cohort-study
#16
Yue Yu, Jianming Ying, Wen Zhang, Weihua Li, Yongkun Sun, Lin Yang, Chengxu Cui, Yixin Zeng, Aiping Zhou
AIMS: Metastatic colorectal cancer (mCRC) with deficient DNA mismatch repair (dMMR) is a rare disease accounting only for 4-5% of the whole mCRC and its optimal treatment still remains unclear. We conducted a retrospective study to evaluate the outcome of chemotherapy with or without bevacizumab or cetuximab in this setting. METHODS: A total of 729 colorectal cancer patients with dMMR status were screened for eligibility. The Kaplan-Meier method, the log-rank test and Cox analysis were utilized for survival analyses...
January 29, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30693645/association-of-apobec3-deletion-with-cancer-risk-a-meta-analysis-of-26-225-cases-and-37-201-controls
#17
REVIEW
Mohammad Hashemi, Abdolkarim Moazeni-Roodi, Mohsen Taheri
Previous studies have found inconsistent results regarding gene deletion in APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) and risk of cancer. We conducted a meta-analysis of all eligible case-control studies to find out the associations between APOBEC3 deletion and cancer risk by pooling the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Overall, the findings from 20 studies (13 articles) involving of a total of 26 225 cases and 37 201 controls revealed that DD genotype was associated significantly with increased cancer risk compared to II genotype (OR = 1...
January 29, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30632282/preoperative-c-reactive-protein-to-albumin-ratio-is-a-predictor-of-survival-after-pancreatic-resection-for-pancreatic-ductal-adenocarcinoma
#18
Shinichi Ikuta, Tsukasa Aihara, Naoki Yamanaka
AIM: Systemic inflammation and nutritional status are associated with clinical outcomes of cancer patients. We investigated the prognostic value of preoperative C-reactive protein to albumin ratio (CAR) in patients with pancreatic ductal adenocarcinoma (PDA) after pancreatic resection. METHODS: One-hundred and thirty-six PDA patients who underwent pancreatic resection between January 2005 and June 2017 were retrospectively enrolled. Preoperative inflammation-based scores including CAR, modified Glasgow prognostic score (mGPS), neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, lymphocyte to monocyte ratio (LMR) and prognostic nutritional index (PNI) were evaluated as potential predictor of overall survival (OS) using Cox regression models...
January 10, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30609237/the-value-of-magnetic-resonance-imaging-in-esophageal-carcinoma-tool-or-toy
#19
REVIEW
Ying Zhu, Lei Fu, Wang Jing, Dong Guo, Yan Chen, Li Kong, Jinming Yu
Currently, the use of magnetic resonance imaging (MRI) in patients with esophageal carcinoma is limited. However, the quality of MRI for esophageal carcinoma continues to improve and the importance of MRI in patients with esophageal carcinoma has been gradually recognized. Compared with endoscopic ultrasound and computed tomography applied in T and N staging, MRI has now achieved excellent results after the imaging technique has been optimized. We review the literature on MRI and discuss the future of MRI in esophageal carcinoma...
January 4, 2019: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/30549220/impact-of-modified-folfox-6-for-patients-with-gastric-cancer-and-a-gastrointestinal-obstruction
#20
Hiroki Yukami, Tetsuji Terazawa, Masahiro Goto, Masahiko Aoki, Ken Asaishi, Toshifumi Yamaguchi, Shin Kuwakado, Takayuki Kii, Kazuhide Higuchi
AIM: Gastric cancer patients are normally treated with oral fluoropyrimidine and cisplatin or oxaliplatin; however, treating patients who also have a gastrointestinal obstruction is often difficult because of their poor oral intake. Instead, a modified (m)FOLFOX-6 regimen is administered, even to patients with gastrointestinal obstructions. The aim of this study was to assess the efficacy of mFOLFOX-6 for gastric cancer patients with a gastrointestinal obstruction. METHODS: Patients with a poor oral intake because of a gastrointestinal obstruction who received mFOLFOX-6 as systemic chemotherapy were retrospectively analyzed...
December 13, 2018: Asia-Pacific Journal of Clinical Oncology
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