journal
Journals Neuropsychiatric Disease and T...

Neuropsychiatric Disease and Treatment

https://read.qxmd.com/read/38410689/identification-and-analysis-of-zic-related-genes-in-cerebellum-of-autism-spectrum-disorders
#1
JOURNAL ARTICLE
Heli Li, Jinru Cui, Cong Hu, Hao Li, Xiaoping Luo, Yan Hao
OBJECTIVE: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with significant genetic heterogeneity. The ZIC gene family can regulate neurodevelopment, especially in the cerebellum, and has been implicated in ASD-like behaviors in mice. We performed bioinformatic analysis to identify the ZIC gene family in the ASD cerebellum. METHODS: We explored the roles of ZIC family genes in ASD by investigating (i) the association of ZIC genes with ASD risk genes from the Simons Foundation Autism Research Initiative (SFARI) database and ZIC genes in the brain regions of the Human Protein Atlas (HPA) database; (ii) co-expressed gene networks of genes positively and negatively correlated with ZIC1, ZIC2, and ZIC3, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and receiver operating characteristic (ROC) curve analysis of genes in these networks; and (iii) the relationship between ZIC1, ZIC2, ZIC3, and their related genes with cerebellar immune cells and stromal cells in ASD patients...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38410688/what-do-farmers-need-for-suicide-prevention-considerations-for-a-hard-to-reach-population
#2
JOURNAL ARTICLE
Anna Scheyett, Ian Lee Marburger, Andrea Scarrow, Stephanie M Hollifield, Jennifer Ward Dunn
PURPOSE: Farmers have suicide rates much higher than the general population, with elevated mental health symptoms and high stress levels. Farmers are a hard-to-reach population due to occupational demands and a culture where conversations about mental health are often stigmatizing. This study explored ways to tailor suicide prevention strategies to unique characteristics of farmers by speaking with groups close to farmers who were open to discussing stress and suicide prevention: women married to farmers and agricultural Extension agents...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38405425/research-advancements-on-the-correlation-between-spontaneous-intracerebral-hemorrhage-of-different-etiologies-and-imaging-markers-of-cerebral-small-vessel-disease
#3
REVIEW
Yu-Tong Liu, Chun-Yan Lei, Lian-Mei Zhong
OBJECTIVE: The purpose of this review is to identify the correlation between ICH and CSVD imaging markers under SMASH-U classification by searching and analyzing a large number of literatures in recent years, laying a theoretical foundation for future clinical research. At the same time, by collecting clinical data to evaluate patient prognosis, analyzing whether there are differences or supplements between clinical trial conclusions and previous theories, and ultimately guiding clinical diagnosis and treatment through the analysis of imaging biomarkers...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38405424/association-of-age-and-response-to-methylphenidate-hcl-treatment-in-adult-adhd-a-proton-magnetic-resonance-spectroscopy-study
#4
JOURNAL ARTICLE
Gonca Ayse Unal, Ayse Nur Inci Kenar
PURPOSE: This study investigated the age-dependent effects of methylphenidate (MPH) on brain metabolites including choline (Cho), N-acetyl aspartate (NAA) and creatine (Cr) levels in the dorsolateral prefrontal cortex (DLPFC), striatum, cerebellum, and anterior cingulate cortex (ACC) regions of the brain in adult patients with attention deficit hyperactivity disorder (ADHD). PATIENTS AND METHODS: The study was included 60 patients with ADHD between the ages of 18 and 60 years...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38405423/the-association-between-acupuncture-therapy-and-the-risk-of-disability-development-in-dementia-patients-a-nationwide-cohort-study
#5
JOURNAL ARTICLE
Chia-Yu Huang, Mei-Yao Wu, Ming-Cheng Huang, Teng-Shun Yu, Peter Karl Mayer, Hung-Rong Yen
PURPOSE: Disability is the comorbidity of dementia for which there is no available preventive measure. The aim of this study was to investigate the association between acupuncture treatment and the risk of disability development in dementia patients. PATIENTS AND METHODS: A cohort study was performed using a nationwide health database in Taiwan. The included dementia patients were divided into acupuncture and non-acupuncture cohorts based on whether they received acupuncture treatment during the follow-up period...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38375417/genetic-markers-associated-with-postpartum-depression-a-review
#6
REVIEW
Joshua Harry Chandra, Candy Kurniawan, Irma Melyani Puspitasari
Postpartum depression (PPD) is a common illness in mothers after childbirth. PPD negatively affect the mother's quality of life and the bond with the infant, which can interfere with the infant's emotional, social, and cognitive development. PPD is caused by various biological and psychosocial factors. The aim of this review is to summarize the latest evidence of the associations between genetic polymorphisms and PPD. PubMed and Scopus were used as the literature search databases for this review. The keywords used were postpartum depression, postnatal depression, genetic, and polymorphism...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38371917/lifestyle-influence-on-mild-cognitive-impairment-progression-a-decision-tree-prediction-model-study
#7
JOURNAL ARTICLE
Jiwen Hou, Hua Jiang, Yan Han, Rong Huang, Xiang Gao, Wei Feng, Zongjun Guo
PURPOSE: This study assessed the influences of different lifestyle on mild cognitive impairment (MCI) progression and established a decision tree prediction model to analyse their predictive significance on MCI progression incidence. PATIENTS AND METHODS: From October 2015 to February 2020,330 patients with MCI were recruited, and demographic and lifestyle information collected. They were followed up for 19.04 ± 10.227 months. Cognitive function was assessed using the Mini-Mental State Examination Scale every 6 months, and they were divided into MCI stable group and MCI progression group...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38351925/perspectives-from-adults-with-tourette-syndrome-on-research-priorities-and-registry-development-a-focus-group-study
#8
JOURNAL ARTICLE
David A Isaacs, Kemberlee Bonnet, Michelle R Eckland, Kimberly Markowitz, Maria Pena, David G Schlundt
PURPOSE: Adults with Tourette syndrome (TS) have worse mental health, physical health, and quality of life than the general population. The factors contributing to negative outcomes across multiple health domains in adults with TS remain uncertain, in part due to a lack of longitudinal studies in this population. In attempt to address these knowledge gaps, our center has initiated development of a regional registry for adults with TS. During the goal-setting and design phase of registry development, we conducted focus groups with adults with TS to identify research issues of greatest importance to this population and to obtain feedback on design and implementation of an adult TS registry...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38348059/excess-mortality-in-individuals-with-autism-spectrum-disorder-a-population-based-cohort-study
#9
JOURNAL ARTICLE
Yu-Hsin Huang, Shu-I Wu, Min-Jing Lee, Yi-Lung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Tai-Hsin Hung, Michael E Dewey, Robert Stewart, Vincent Chin-Hung Chen
PURPOSE: Autism spectrum disorder (ASD) may be associated with increased mortality, but relevant findings have been inconsistent. The modifying effects of gender and intellectual disability on excess mortality in individuals with ASD are underexplored. PATIENTS AND METHODS: Using Taiwan's National Health Insurance Research Database and the National Death Registry, this population-based cohort study selected the data of 75,946 patients with ASD (ASD cohort) and 75,946 age group-, gender-, and income-matched (1:1) patients without ASD (non-ASD cohort)...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38348058/a-thematic-analysis-investigating-the-inaugural-psychosis-reach-family-ambassador-peer-training-program
#10
JOURNAL ARTICLE
Akansha Vaswani-Bye, Chris McCain, Jennifer M Blank, Mackenzie E Tennison, Sarah L Kopelovich
PURPOSE: Caregivers of loved ones with psychosis are tasked with navigating a barren care landscape for their loved ones and for themselves. The dearth of resources they face has a negative impact on outcomes for caregivers and their loved ones. The Psychosis REACH program, based on principles from Cognitive Behavioral Therapy for psychosis was developed as a community-based resource for families to address this care gap. A role for family peers called the Psychosis REACH Family Ambassadors (pRFAs) was developed to reinforce skill learning for caregivers by utilizing a task-sharing approach...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38344423/characteristics-of-oral-gut-microbiota-in-model-rats-with-cums-induced-depression
#11
JOURNAL ARTICLE
Yan Li, Penghong Liu
PURPOSE: The diversity and composition of the oral and gut microbiota of depressed rats were analyzed to explore the microbiological etiology of major depressive disorder (MDD). METHODS: The depressed rat model was established by inducing chronic unpredictable mild stress (CUMS). After the establishment of the model, body weight measurements and behavioral tests were conducted. The diversity and composition of oral and gut microbiota were analyzed using 16SrRNA sequencing...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38333613/the-inter-relationships-between-depressive-symptoms-and-suicidality-among-macau-residents-after-the-relatively-static-management-covid-19-strategy-a-perspective-of-network-analysis
#12
JOURNAL ARTICLE
Mei Ieng Lam, Hong Cai, Pan Chen, Ka-In Lok, Ines Hang Iao Chow, Tong Leong Si, Zhaohui Su, Chee H Ng, Feng-Rong An, Yu-Tao Xiang
BACKGROUND: Suicidality is a global public health problem which has increased considerably during the coronavirus disease 2019 (COVID-19) pandemic. This study examined the inter-relationships between depressive symptoms and suicidality using network analysis among Macau residents after the "relatively static management" COVID-19 strategy. METHODS: An assessment of suicidal ideation (SI), suicide plan (SP), suicide attempt (SA) and depressive symptoms was conducted with the use of individual binary response items (yes/no) and Patient Health Questionnaire (PHQ-9)...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38333612/-18-f-fdg-pet-ct-for-localizing-the-epileptogenic-focus-in-patients-with-different-types-of-focal-cortical-dysplasia
#13
JOURNAL ARTICLE
Feng Wang, Shu-Ting Hong, Ying Zhang, Zhen Xing, Yuan-Xiang Lin
PURPOSE: To determine the diagnostic and localization value of 18 F-fluorodeoxyglucose-positron emission tomography (PET)/computed tomography (CT) in patients with focal cortical dysplasia (FCD) who underwent epilepsy surgery. METHODS: One hundred and eight patients with pathologically proven FCD who underwent surgery for refractory epilepsy were retrospectively analyzed. All patients underwent magnetic resonance imaging (MRI), 18 F-FDG-PET/CT, and video electroencephalography...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38312123/association-of-htr1a-gene-polymorphisms-with-efficacy-and-plasma-concentrations-of-atypical-antipsychotics-in-the-treatment-of-male-patients-with-schizophrenia
#14
JOURNAL ARTICLE
Ying Qin, Jingwen Zhao, Yong Yang, Yanjing Liu, Hui Xiang, Jingfeng Tong, Chengchen Huang
PURPOSE: We investigate the association of HTR1A rs10042486 and rs6295 with efficacy and plasma concentrations of atypical antipsychotics in the treatment of male patients with schizophrenia. PATIENTS AND METHODS: A total of 140 male patients diagnosed with schizophrenia who were treated with any single atypical antipsychotic between May 2020 and May 2022 were retrospectively included. Clinical symptoms were assessed using Positive and Negative Syndrome Scale (PANSS)...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38288269/link-between-obsessive-compulsive-disorder-and-apoe-gene-polymorphisms
#15
JOURNAL ARTICLE
Ayse Dondu, Metin Caliskan, Seda Orenay-Boyacioglu
OBJECTIVE: Many researchers have considered obsessive compulsive disorder (OCD) to be a neurodegenerative disease just like Alzheimer's disease (AD). The most studied gene in neurodegenerative diseases is apolipoprotein E (ApoE) gene, and ApoE ɛ4 allele in particular. Although a small number of studies have explored the relationship between ApoE gene polymorphisms and OCD, the link between age at onset of OCD, its subtypes and ApoE gene polymorphisms has not been revealed so far...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38288268/decline-in-working-memory-in-stable-schizophrenia-may-be-related-to-attentional-impairment-mediating-effects-of-negative-symptoms-a-cross-sectional-study
#16
Nan Du, Xiaojing Meng, Jingwei Li, Li Shi, Xulai Zhang
BACKGROUND: Schizophrenia (SCZ) is a severe mental illness, Cognitive deficits and negative symptoms (NS) are prevalent in individuals with SCZ and are crucial indicators of functional recovery. It is well known that cognitive symptoms and negative symptoms are interrelated and that negative symptoms can affect the ability to take cognitive tests. However, the specific relationship between attention, working memory (WM), and NS in stable SCZ remains unclear. This study aims to explore these associations and provide valuable insights for the subsequent treatment of SCZ...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38282834/mind-matters-exploring-the-intersection-of-psychological-factors-and-cognitive-abilities-of-university-students-by-using-ann-model
#17
JOURNAL ARTICLE
Mohsin Khan, Syed Khalid Perwez, Rahul Paul Gaddam, Rabuni Aiswarya, Mohammed Abrar Basha, Abhradeep Malas, Shafiul Haque, Faraz Ahmad
PURPOSE: While previous studies have suggested close association of psychological variables of students withtheir higher-order cognitive abilities, such studies have largely been lacking for third world countries like India, with their unique socio-economic-cultural set of challenges. We aimed to investigate the relationship between psychological variables (depression, anxiety and stress) and cognitive functions among Indian students, and to predict cognitive performance as a function of these variables...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38282833/effect-of-object-on-kinesthetic-motor-imagery-in-autism-spectrum-disorder-a-pilot-study-based-on-eye-tracking-methodology
#18
JOURNAL ARTICLE
Ying Liu, Jinsheng Hu
INTRODUCTION: Social disturbance is a significant autism spectrum disorder (ASD) symptom. Action representation, which is a fundamental component of social interaction, can be investigated through kinesthetic motor imagery (KMI). KMI has been commonly studied with the well-developed laterality judgment paradigm, wherein participants are required to discriminate the laterality of a hand rotated by different angles along one or more axes. Here, we investigated the KMI processing in individuals with ASD by hand laterality judgment paradigm with eye-tracking methodology...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38268571/trauma-informed-care-in-psychedelic-therapy-research-a-qualitative-literature-review-of-evidence-based-psychotherapy-interventions-in-ptsd-and-psychedelic-therapy-across-conditions
#19
REVIEW
Nadav Liam Modlin, Michael Creed, Maria Sarang, Carolina Maggio, James J Rucker, Victoria Williamson
INTRODUCTION: Post-traumatic stress disorder (PTSD) is associated with significant patient burden. While pharmacotherapies and evidence-based psychotherapy interventions (EBPI) are effective, studies consistently highlight inadequate outcomes and high treatment dropout. Psychedelic therapy (PT) has shown preliminary promise across difficult-to-treat conditions, including MDMA-assisted therapy for PTSD, however trials of classical psychedelics in PTSD are lacking. Understanding patients' experiences of EBPI could help promote safety in PT...
2024: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/38260047/relationship-between-liver-fibrosis-and-increased-risk-of-symptomatic-intracranial-hemorrhage-in-ischemic-stroke-patients-undergoing-mechanical-thrombectomy
#20
JOURNAL ARTICLE
Jing Xu, Xiaohao Zhang, Yan E, Wei Wang, Junshan Zhou, Yanyan Shi, Shuaiyu Chen
BACKGROUND: Liver fibrosis has been reported to be associated with hematoma expansion and mortality in patients with intracerebral hemorrhage. This study aimed to detect the association between liver fibrosis and symptomatic intracranial hemorrhage (sICH) in ischemic stroke after mechanical thrombectomy (MT). METHODS: We retrospectively included patients with large artery occlusion in the anterior circulation and treated with MT at a single stroke center. The fibrosis-4 index (FIB-4) was used to assess the severity of liver fibrosis...
2024: Neuropsychiatric Disease and Treatment
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