journal
https://read.qxmd.com/read/38098059/determinants-of-survival-of-adolescents-receiving-antiretroviral-therapy-in-the-centre-region-of-cameroon-a-multi-centered-cohort-analysis
#21
JOURNAL ARTICLE
Nicholas Tendongfor, Joseph Fokam, Collins Ambe Chenwi, Fabrice Léo Tamhouo Nwabo, Armanda Nangmo, Njume Debimeh, Suzie Tetang Ndiang Moyo, Marie Patrice Halle, Anne-Esther Njom-Nlend, Paul Koki Ndombo, Alexis Ndjolo
BACKGROUND: In spite of the global decreasing mortality associated with HIV, adolescents living with HIV (ADLHIV) in sub-Saharan Africa still experience about 50% mortality rate. We sought to evaluate survival rates and determinants of mortality amongst ADLHIV receiving antiretroviral therapy (ART) in urban and rural settings. METHODS: A multi-centered, 10-year retrospective, cohort-study including ADLHIV on ART ≥ 6 months in the urban and rural settings of the Centre Region of Cameroon...
December 15, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/38082352/addressing-hiv-stigma-in-healthcare-community-and-legislative-settings-in-central-and-eastern-europe
#22
REVIEW
Ana-Maria Schweitzer, Arian Dišković, Veronica Krongauz, Julie Newman, Janez Tomažič, Nina Yancheva
INTRODUCTION: Surging HIV prevalence across countries of Central and Eastern Europe (CEE) is largely a result of poor HIV care engagement and a lack of comprehensive support for key populations. This is fostered by widespread stigma across healthcare, community, and legislative settings. DISCUSSION: Throughout CEE, HIV stigma and intersectional stigma are serious obstacles to providing adequate medical care to people living with HIV. Anticipated and enacted (experienced) stigma from healthcare professionals, and fears of breaches in confidentiality, deter individuals from having an HIV test and engaging in HIV care...
December 11, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/38071351/research-priorities-in-hiv-aging-and-rehabilitation-building-on-a-framework-with-the-canada-international-hiv-and-rehabilitation-research-collaborative
#23
JOURNAL ARTICLE
Kelly K O'Brien, Francisco Ibáñez-Carrasco, Kelly Birtwell, Graeme Donald, Darren A Brown, Andrew D Eaton, Bakita Kasadha, Emma Stanmore, Natalie St Clair-Sullivan, Liam Townsend, Jaime H Vera, Patricia Solomon
BACKGROUND: In 2016, the Canada-International HIV and Rehabilitation Research Collaborative established a framework of research priorities in HIV, aging and rehabilitation. Our aim was to review and identify any new emerging priorities from the perspectives of people living with HIV, clinicians, researchers, and representatives from community organizations. METHODS: We conducted a multi-stakeholder international consultation with people living with HIV, researchers, clinicians and representatives of community-based organizations...
December 9, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/38012668/predictors-of-hiv-status-disclosure-among-people-living-with-hiv-plhiv-in-ghana-the-disclosure-conundrum-and-its-policy-implications%C3%A2-in-resource-limited-settings
#24
JOURNAL ARTICLE
Robert Kaba Alhassan, Jerry John Nutor, Akua Gyamerah, Emily Boakye-Yiadom, Emmanuel Kasu, Evelyn Acquah, Emmanuel Doe
BACKGROUND: Globally, over 40 million lives have been claimed by HIV/AIDS. In Ghana, more than 350,000 people are living with HIV. Non-disclosure of HIV status is a major barrier to HIV/AIDS eradication; yet, little is known of the determinants of HIV status disclosure in resource limited settings in Africa like Ghana. OBJECTIVE: Determine the predictors of HIV status disclosure among people living with HIV (PLHIV) and stimulate policy discourse on support systems for self-disclosure in Africa...
November 27, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/38012656/clinical-molecular-and-histological-characteristics-of-severely-necrotic-and-fatal-mpox-in-hiv-infected-patients
#25
JOURNAL ARTICLE
Sandra Rajme-López, Ever A Corral-Herrera, Andrea C Tello-Mercado, Karen M Tepo-Ponce, Raúl E Pérez-Meléndez, Ángela Rosales-Sotomayor, Grecia Figueroa-Ramos, Karla López-López, Judith G Domínguez-Cherit, Oswaldo San-Martín-Morante, Marcela Saeb-Lima, Armando Gamboa-Domínguez, Alfredo Ponce-de-León, Brenda Crabtree-Ramírez, Pilar Ramos-Cervantes, Guillermo M Ruíz-Palacios
BACKGROUND: This case series of 5 patients with severely necrotic mpox highlights the predominantly necrotic nature of lesions seen in cases of severe mpox as shown by skin and lung biopsy, as well as the extensive dissemination of the infection, as shown by polymerase chain reaction (PCR) assessment in different body sites. CASE PRESENTATIONS: Patients were male, the median age was 37, all lived with HIV (2 previously undiagnosed), the median CD4+ cell count was 106 cells/mm3 , and 2/5 were not receiving antiretroviral treatment...
November 27, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37996881/standard-of-care-in-advanced-hiv-disease-review-of-hiv-treatment-guidelines-in-six-sub-saharan-african-countries
#26
REVIEW
Thomas C Scheier, Nabila Youssouf, Mosepele Mosepele, Cecilia Kanyama, Olukemi Adekanmbi, Sulaiman Lakoh, Conrad K Muzoora, Graeme Meintjes, Dominik Mertz, John W Eikelboom, Sean Wasserman
BACKGROUND: The World Health Organization (WHO) recommends an evidence-based package of care to reduce mortality and morbidity among people with advanced HIV disease (AHD). Adoption of these recommendations by national guidelines in sub-Saharan Africa is poorly documented. We aimed to review national guidelines for AHD management across six selected countries in sub-Saharan Africa for benchmarking against the 2021 WHO recommendations. METHODS: We reviewed national guidelines from six countries participating in an ongoing randomized controlled trial recruiting people with AHD...
November 23, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37981694/hiv-gp120-tat-protein-induced-epithelial-mesenchymal-transition-promotes-the-progression-of-cervical-lesions
#27
JOURNAL ARTICLE
Peizhi Wang, Baojun Yang, Huang Huang, Peiyi Liang, Bin Long, Lin Chen, Lijie Yang, Lianhua Tang, Liping Huang, Huichao Liang
BACKGROUND: Human immunodeficiency virus (HIV) infection is associated with an elevated incidence of cervical cancer, and accelerated disease progression, but the underlying mechanisms are not well understood. This study aimed to investigate the relationship between HIV infection and epithelial-mesenchymal transition (EMT) in cervical cancer. METHODS: Tissue samples from HIV-positive and negative patients with cervical intraepithelial neoplasia (CIN) and cervical cancer were analyzed for EMT-related proteins...
November 19, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37964322/-sex-without-fear-exploring-the-psychosocial-impact-of-oral-hiv-pre-exposure-prophylaxis-on-gay-men-in-england
#28
JOURNAL ARTICLE
Rosalie Hayes, Will Nutland, Michael Rayment, Sonali Wayal, Vanesa Apea, Amanda Clarke, Alan McOwan, Ann Sullivan, Monica Desai, Andrew Jajja, Brian Rice, Rob Horne, Sheena McCormack, Mitzy Gafos
Gay, bisexual, and other men who have sex with men (GBMSM) experience a high prevalence of psychosocial health problems, such as harmful substance use and depression, as well as being disproportionately affected by HIV. HIV Pre-Exposure Prophylaxis (PrEP) may provide psychosocial benefits beyond its intended purpose of reducing HIV infection. We explore the psychosocial impact of oral PrEP use on gay men in England using qualitative data from the PROUD study. From February 2014 to January 2016, semi-structured in-depth interviews were conducted with 40 gay men and one trans woman...
November 14, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37957687/qualitative-study-of-barriers-and-facilitators-to-hiv-detection-and-treatment-among-women-who-inject-drugs-during-the-war-against-ukraine
#29
JOURNAL ARTICLE
Olena Karagodina, Oksana Kovtun, Myroslava Filippovych, Oleksandr Neduzhko
BACKGROUND: The Russian Federation's invasion in Ukraine has resulted social hardship, millions of internally displaced persons, the destruction of medical infrastructure, and limited access to HIV services. There is no available information regarding the impact of the war on the HIV treatment cascade among women who inject drugs (WWID) in Ukraine. In this study, we examine the barriers and facilitators of HIV detection, initiation of treatment, and adherence to antiretroviral therapy (ART) among WWID...
November 13, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37951932/association-between-psychological-discomforts-and-sleep-quality-among-people-living-with-hiv-aids
#30
JOURNAL ARTICLE
Mohammad Ebrahimzadeh Mousavi, Safieh Mohammad Nejad, Maryam Shafaati, Rosa Mykyta-Chomsky, Samaneh Akbarpour, Fatemeh Hadavandsiri
BACKGROUND: Psychological discomfort and sleep problems are considered separate disorders. Due to the high prevalence of both disorders among people living with HIV (PLWH), this study was designed to evaluate how those challenges are present among PLWH. METHOD: A cross-sectional study was conducted using data from a national survey of 1185 confirmed PLWH from 15 provinces in Iran from April to August 2019. Psychological discomfort and sleep quality were assessed using standardized versions of related Persian questionnaires...
November 11, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37951907/readmission-rates-in-hiv-associated-burkitt-lymphoma-patients-in-the-usa-a-nationwide-readmission-database-nrd-analysis
#31
JOURNAL ARTICLE
Ashley M Tuin, Clare M Wieland, Elizabeth J Dort, Danielle B Dilsaver, Manasa Velagapudi
BACKGROUND: People with human immunodeficiency virus have an increased risk of developing AIDS-defining malignancies including Burkitt lymphoma. Survival outcomes in HIV-associated Burkitt lymphoma remain worse than non-HIV-associated Burkitt lymphoma, despite widespread implementation of antiretroviral therapy. We aimed to determine the association between HIV status and risk for 30-day and 90-day readmission in the US after index hospitalization for Burkitt lymphoma. METHODS: Data were abstracted from the 2010-2020 Nationwide Readmissions Database; hospitalizations included patients with a primary BL diagnosis and were stratified by comorbid HIV...
November 11, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37926821/uptake-of-retroviral-pre-exposure-prophylaxis-and-its-associated-factors-among-female-sex-workers-northwest-ethiopia
#32
JOURNAL ARTICLE
Belayneh Fentahun Shibesh, Aragaw Bitew Admas, Amarech Wondie Lake, Samuel Befekadu Getu, Daniel Tarekegn Worede
BACKGROUND: Pre-exposure prophylaxis is the use of antiretroviral medications by HIV-negative individuals to prevent infection before exposure. Ethiopia has made progress in reducing new HIV infections, but the burden remains high with ongoing challenges in prevention uptake. This study examined the utilization and factors associated with pre-exposure prophylaxis among female sex workers. METHODS: A community-based cross-sectional study design was conducted in Bahir Dar city administration among female sexual workers in 2022...
November 5, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37925468/strategies-to-improve-the-care-of-older-adults-50%C3%A2-years-and-above-living-with-hiv-in-uganda
#33
JOURNAL ARTICLE
Scovia Nalugo Mbalinda, Derrick Amooti Lusota, Martin Muddu, David Musoke, Mathew Nyashanu
INTRODUCTION: With effective antiretroviral therapy (ART), many persons living with HIV (PLHIV) live to old age. Caring for aged PLHIV necessitates the engagement of caregivers and patients to establish agreed-upon goals of treatment. However, there is limited literature on friendly and centered models of care for elderly PLHIV. We explored strategies to improve care in HIV clinics among PLHIV aged 50 years and above in Uganda. METHODS: We conducted 40 in-depth interviews in two hospitals with elderly PLHIV aged 50 years and above who had lived with HIV for more than ten years...
November 4, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37904200/mixed-methods-implementation-research-to-understand-success-of-intensive-combination-approach-to-roll-back-the-epidemic-in-nigerian-adolescents-icare-nigeria-hiv-testing-uptake-and-linkage-to-care-among-young-men-focusing-on-young-men-who-have-sex-with-men
#34
JOURNAL ARTICLE
Lisa R Hirschhorn, Adedotun Adetunji, Aima A Ahonkhai, Bibilola Oladeji, Olutosin A Awolude, Lisa M Kuhns, Jude Onumabor, Kehinde M Kuti, Olayinka Omigbodun, Amy K Johnson, Ogochukwu Okonkwor, Babafemi Taiwo, Robert Garofalo
BACKGROUND: HIV seroprevalence in Nigeria is increasing among men who have sex with men (MSM) from 14% to 2007 to 23% in 2014, threatening progress towards ending the epidemic in the country. Expanding access to HIV testing and linkage to care for key populations, like young MSM (YMSM), is critical to end the HIV epidemic in Nigeria. The Intensive Combination Approach to Roll Back the Epidemic in Nigerian Adolescents (iCARE Nigeria) pilot intervention successfully implemented a combination of evidence-based interventions utilizing peer navigators and popular social media apps and platforms to reach young men at risk for HIV exposure, including YMSM...
October 30, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37884997/current-art-determinants-for-virologic-failure-and-implications-for-hiv-drug-resistance-an-umbrella-review
#35
REVIEW
SeyedAhmad SeyedAlinaghi, Amir Masoud Afsahi, Ali Moradi, Zohal Parmoon, Pedram Habibi, Pegah Mirzapour, Mohsen Dashti, Afsaneh Ghasemzadeh, Elaheh Karimi, Foziye Sanaati, Zahra Hamedi, Ayoob Molla, Esmaeil Mehraeen, Omid Dadras
OBJECTIVE: The purpose of this study is to investigate the incidence of determinants for virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling this global public health issue is the key to reducing the rate of virological failure and increasing the success of treatment for those living with HIV. METHODS: This umbrella review delves into various aspects of current anti-retroviral therapy (ART) which is the primary treatment for human immunodeficiency virus (HIV) infection...
October 27, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37858245/preventative-behaviours-and-covid-19-infection-in-a-canadian-cohort-of-people-living-with-hiv
#36
JOURNAL ARTICLE
Keely Hammond, Terry Lee, Branka Vulesevic, Joel Singer, Judy Needham, Ann N Burchell, Hasina Samji, Sharon Walmsley, Mark Hull, Mohammad-Ali Jenabian, Jean-Pierre Routy, Shari Margolese, Enrico Mandarino, Aslam H Anis, Curtis L Cooper, Cecilia T Costiniuk
Few studies have examined preventative behaviour practices with respect to COVID-19 among people living with HIV (human immunodeficiency virus). Using a cross-sectional survey from a Canadian Institutes of Health Research Canadian HIV Trials Network study (CTN 328) of people living with HIV on vaccine immunogenicity, we examined the relationships between participant characteristics and behavioural practices intended to prevent COVID-19 infection. Participants living in four Canadian urban centers were enrolled between April 2021-January 2022, at which time they responded to a questionnaire on preventative behaviour practices...
October 20, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37848954/the-hidden-effects-of-covid-19-on-hiv-services-in-zanzibar-country-report
#37
JOURNAL ARTICLE
Mansour Maulid Mshenga, Farhat Jowhar Khalid, Shaaban Hassan Haji, Tatu Bilali Ali, Khadija Abbas Mohamed, Damian Jeremia Damian
The COVID-19 pandemic has had a major effect on HIV-related healthcare services. Zanzibar has experienced several interruptions of HIV services in the areas of testing and counselling, prevention of mother-to-child transmission of HIV, key population, care and treatment services as well due to the hospital operating at a reduced capacity and the strict visit restrictions with health care allocations to COVID 19 pandemic. The community HIV initiatives, such as index testing and ARVs medicine refills, were used to mitigate the consequences of the epidemic and can be applied in future emergencies...
October 17, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37798794/understanding-health-outcome-drivers-among-adherence-club-patients-in-clinics-of-gauteng-south-africa-a-structural-equation-modelling-sem-approach
#38
JOURNAL ARTICLE
Ndumiso Tshuma, Elakpa Daniel Ngbede, Tawanda Nyengerai, Oliver Mtapuri, Sangiwe Moyo, David D Mphuthi, Peter Nyasulu
BACKGROUND: There has been growing interest in understanding the drivers of health outcomes, both in developed and developing countries. The drivers of health outcomes, on the other hand, are the factors that influence the likelihood of experiencing positive or negative health outcomes. Human Immunodeficiency Virus (HIV) continues to be a significant global public health challenge, with an estimated 38 million people living with the aim of this study was therefore to develop and empirically test a conceptual research model using SEM, aimed at explaining the magnitude of various factors influencing HIV and other health outcomes among patients attending Adherence Clubs...
October 5, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37759241/estimating-prevalence-and-modelling-correlates-of-hiv-test-positivity-among-female-sex-workers-men-who-have-sex-with-men-people-who-inject-drugs-transgender-people-and-prison-inmates-in-sierra-leone-2021
#39
JOURNAL ARTICLE
Duah Dwomoh, Issata Wurie, Yvonne Harding, Kojo Mensah Sedzro, Joseph Kandeh, Henry Tagoe, Christabel Addo, Daniel Kojo Arhinful, Abdul Rahman Cherinoh Sessay, James Lahai Kamara, Kemoh Mansaray, William Kwabena Ampofo
Key populations (KPs) are particularly vulnerable to HIV infection and efforts to prevent HIV infections among KPs have been less successful, largely due to existing laws and legislation that classify the groups as illegal. Understanding the HIV infection pathway and the burden of HIV infection among Female Sex Workers (FSWs), Transgender people (TG), Men who have sex with Men (MSM), People who Inject Drugs (PWID), and Prison Inmates (PIs) is critical to combatting the HIV epidemic globally. This study aims to estimate HIV prevalence and model the risk factors of HIV positivity rate among the aforementioned KPs in Sierra Leone...
September 27, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/37730616/understanding-the-social-and-structural-context-of-oral-prep-delivery-an-ethnography-exploring-barriers-and-facilitators-impacting-transgender-women-who-engage-in-street-based-sex-work-in-baltimore-maryland
#40
JOURNAL ARTICLE
Erin E Cooney, Katherine H A Footer, Jennifer L Glick, Anna Passaniti, Meridian Howes, Susan G Sherman
Transgender women who sell sex (TWSS) experience high rates of HIV acquisition. Antiretrovirals for pre-exposure prophylaxis (PrEP) represent an efficacious HIV prevention strategy. The social and structural factors affecting PrEP delivery amongst TWSS are underexplored in the literature. We conducted ethnographic research to examine how multilevel social and structural factors manifest in TWSS's lived experiences and affect PrEP delivery and use. Twenty-four transgender women were recruited from the SAPPHIRE cohort and completed interviews focused on barriers and facilitators to PrEP engagement in the context of street-based sex work...
September 20, 2023: AIDS Research and Therapy
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