journal
https://read.qxmd.com/read/38515183/efficacy-and-safety-of-switching-to-dolutegravir-lamivudine-in-virologically-suppressed-people-with-hiv-1-aged%C3%A2-%C3%A2-%C3%A2-50-years-week-48-pooled-results-from-the-tango-and-salsa-studies
#1
JOURNAL ARTICLE
Sharon Walmsley, Don E Smith, Miguel Górgolas, Pedro E Cahn, Thomas Lutz, Karine Lacombe, Princy N Kumar, Brian Wynne, Richard Grove, Gilda Bontempo, Riya Moodley, Chinyere Okoli, Michelle Kisare, Bryn Jones, Andrew Clark, Mounir Ait-Khaled
BACKGROUND: As the population of people with HIV ages, concerns over managing age-related comorbidities, polypharmacy, immune recovery, and drug-drug interactions while maintaining viral suppression have arisen. We present pooled TANGO and SALSA efficacy and safety results dichotomized by age (< 50 and ≥ 50 years). METHODS: Week 48 data from the open-label phase 3 TANGO and SALSA trials evaluating switch to once-daily dolutegravir/lamivudine (DTG/3TC) fixed-dose combination vs continuing current antiretroviral regimen (CAR) were pooled...
March 21, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38504236/assessing-high-risk-sexual-practices-associated-with-human-immunodeficiency-virus-infection-among-young-female-sex-workers-in-lubumbashi-democratic-republic-of-the-congo-a-cross-sectional-study
#2
JOURNAL ARTICLE
Olivier Mukuku, Yannick Nkiambi Kiakuvue, Georges Yumba Numbi, Bienvenu Mukuku Ruhindiza, Christian Kakisingi, Claude Mulumba Mwamba, Joe Kabongo Katabwa
INTRODUCTION: Young female sex workers (YFSWs) face a higher risk of HIV infection compared to older workers, but there is a lack of comprehensive data on their sexual practices and HIV infection risks, which may present unique challenges and vulnerabilities. The study aimed to identify high-risk sexual practices associated with HIV infection among YFSWs in Lubumbashi. METHODS: We conducted an analytical cross-sectional study and used a comprehensive sample of all YFSWs who presented to the HIV/Sexually Transmitted Infections Screening and Treatment Center in Lubumbashi between April 2016 and December 2017...
March 19, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38494484/factors-influencing-rapid-antiretroviral-therapy-initiation-in-jiulongpo-chongqing-china-a-retrospective-cohort-from-2018-to-2022
#3
JOURNAL ARTICLE
Cheng Chen, Hao Chen, Lingli Wu, Qin Gong, Jingchun He
BACKGROUND: Antiretroviral Therapy (ART) is pivotal in extending the lives of people living with HIV (PLWH) and minimizing transmission. Rapid ART initiation, defined as commencing ART within seven days of HIV diagnosis, is recommended for all PLWH. METHOD: A retrospective cohort study was conducted using data from the China Information System for Disease Control and Prevention. This study included PLWH diagnosed between January 2018 and December 2021 and treated by December 2022...
March 17, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38481233/support-not-blame-safe-partner-disclosure-among-women-diagnosed-with-hiv-late-in-pregnancy-in-south-africa-and-uganda
#4
JOURNAL ARTICLE
Adelline Twimukye, Yussif Alhassan, Beate Ringwald, Thokozile Malaba, Landon Myer, Catriona Waitt, Mohammed Lamorde, Helen Reynolds, Saye Khoo, Miriam Taegtmeyer
BACKGROUND: HIV partner disclosure rates remain low among pregnant women living with HIV in many African countries despite potential benefits for women and their families. Partner disclosure can trigger negative responses like blame, violence, and separation. Women diagnosed with HIV late in pregnancy have limited time to prepare for partner disclosure. We sought to understand challenges around partner disclosure and non-disclosure faced by women diagnosed with HIV late in pregnancy in South Africa and Uganda and to explore pathways to safe partner disclosure...
March 13, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38439093/diffuse-myocardial-fibrosis-is-uncommon-in-people-with-perinatally-acquired-human-immunodeficiency-virus-infection
#5
JOURNAL ARTICLE
Jason L Williams, Frances Hung, Elizabeth Jenista, Piers Barker, Hrishikesh Chakraborty, Raymond Kim, Andrew W McCrary, Svati H Shah, Nathan Thielman, Gerald S Bloomfield
BACKGROUND: Cardiovascular disease (CVD) remains a leading cause of death in people living with HIV. Myocardial fibrosis is well-described in HIV infection acquired in adulthood. We evaluate the burden of fibrosis by cardiac magnetic resonance in people with perinatal HIV infection. METHODS: Individuals with perinatally acquired HIV (pnHIV) diagnosed before 10 years-old and on antiretroviral treatment for ≥ 6 months were matched with uninfected controls...
March 4, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38429716/brief-communication-body-composition-and-hidden-obesity-in-people-living-with-hiv-on-antiretroviral-therapy
#6
JOURNAL ARTICLE
K Konishi, H Nakagawa, T Asaoka, Y Kasamatsu, T Goto, M Shirano
BACKGROUND: Increased incidence of lifestyle diseases as side-effects of antiretroviral therapy (ART) have been reported in people living with HIV (PLWH). Few studies have evaluated obesity and hidden obesity in Japanese PLWH and their association with ART. In order to provide more appropriate drug selection and lifestyle guidance, we investigated the relationship between the effects of HIV infection and ART on the body composition of Japanese PLWH. METHODS: PLWH who visited the outpatient clinic and had body composition measured using the body composition analyzer InBody 570 were included in this study...
March 1, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38378639/factors-associated-with-knowledge-of-mother-to-child-transmission-of-hiv-among-reproductive-age-women-in-indonesia-a-multilevel-analysis
#7
JOURNAL ARTICLE
Agani Afaya, Aloysia Ispriantari
BACKGROUND: Maternal transmission of human immunodeficiency virus (HIV) commonly occurs from mother to child during pregnancy, delivery, and breastfeeding which accounts for almost all the new HIV infections among children aged 0-14 years. Despite major efforts and progress in controlling and preventing HIV, it continues to pose a great public health threat, especially in Indonesia. This study assessed the factors associated with the knowledge of mother-to-child transmission (MTCT) of HIV among reproductive-age women in Indonesia...
February 20, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38350942/characterization-of-intestinal-fungal-community-diversity-in-people-living-with-hiv-aids-plwha
#8
JOURNAL ARTICLE
Pengfei Meng, Guichun Zhang, Xiuxia Ma, Xue Ding, Xiyuan Song, Shuyuan Dang, Ruihan Yang, Liran Xu
Acquired Immune Deficiency Syndrome (AIDS) is a highly dangerous infectious disease caused by the Human Immunodeficiency Virus (HIV), a virus that attacks the human immune system. To explore the correlation between intestinal fungal community and immune function (Immune cells and inflammatory factors) in people living with HIV/AIDS (PLWHA). The feces and blood samples were collected from two groups of subjects: PLWHA and healthy controls. High-throughput sequencing of the internal transcribed spacer 1, flow cytometry, and ELISA were performed to analyze the differences and correlations between fungal microbiota, cellular immune status and serum inflammatory factors in the two groups...
February 13, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38336684/a-call-for-change-addressing-the-implementation-strategy-using-pre-exposure-prophylaxis-for-combating-the-escalating-hiv-crisis-in-zanzibar-s-key-populations
#9
JOURNAL ARTICLE
Mansour Maulid Mshenga, Weiming Tang
The Integrated Bio-Behavioural Surveillance Survey of 2022-2023 among key populations report from Zanzibar has been released. The prevalence of HIV is estimated to be 21.1%, 11.4%, and 9.3% among Female Sex Workers, Men who have Sex with Men, and People Who Injected Drugs, respectively. This has prompted a closer examination of the factors contributing to this trend, with a particular focus on the low coverage of Pre-Exposure Prophylaxis in these key populations. The current prevalence reported in December 2023 signals a critical turning point that necessitates a reevaluation of the barriers and facilitators of Pre Exposure Prophylaxis intervention to combat the epidemic...
February 9, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38297382/outcomes-of-antiretroviral-treatment-for-0-14-year-old-children-living-with-hiv-in-ganzhou-china-2006-2023
#10
JOURNAL ARTICLE
Ting Zeng, Xin Chen, Xiao-Yi Zhang, Chao-Xian Lian, Rong-Rong Yang, Li-Ling Yu, Xiao-Kang Liao, Dan-Dan Huang, Yu-Ning Zhang, Hong-Min Cao
BACKGROUND: Studies on antiretroviral therapy (ART) in children living with HIV (CLHIV) are limited due to the small population and low accession rate of ART. METHODS: All 0-14-year-old CLHIV admitted to the Ganzhou Center for Disease Control and Prevention from January 2006 to June 2023 were included retrospectively. The information of treatment regimens, disease progression, and laboratory tests of the patients under ART were used to explore the outcomes and impacts of long-term ART...
January 31, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38297363/experiences-of-people-living-with-hiv-in-low-and-middle-income-countries-and-their-perspectives-in-self-management-a-meta-synthesis
#11
REVIEW
Tegene Legese Dadi, Anja M C Wiemers, Yadessa Tegene, Girmay Medhin, Mark Spigt
INTRODUCTION: Availability of anti-retroviral treatment has changed HIV in to a manageable chronic disease, making effective self-management essential. However, only a few studies in low- and middle-income countries (LMICs) reported experiences of people living with HIV (PLWH) on self-management. METHODS: This meta-synthesis of qualitative studies investigated perspectives of PLWH in LMICs on self-management. Various databases, including PubMed, EMBASE, EBSCO, and CINHAL, were searched through June 2022...
January 31, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38254208/satisfaction-of-antiretroviral-therapy-services-and-its%C3%A2-associated-factors-among-adult-clients-attending-antiretroviral-therapy-in-woliso-town-ethiopia
#12
JOURNAL ARTICLE
Bayisa Abdissa, Rahel Abdissa, Jiregna Derega, Senahara Korsa Wake
BACKGROUND: Antiretroviral therapy client satisfaction is a significant tool that enables to strengthen the quality of life of the clients. The study aimed to assess the satisfaction of clients with antiretroviral therapy services and its associated factors among adult clients attending antiretroviral therapy. METHODS: A cross-sectional study was undertaken from 28 August to 27 October 2022. Data were analyzed by using Logistic regression. RESULT: Clients who did not attend formal education and attended health education information were significantly associated with satisfaction on antiretroviral therapy services...
January 22, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38212762/hypertension-among-persons-living-with-hiv-aids-and-its-association-with-hiv-related-health-factors
#13
JOURNAL ARTICLE
Mawulorm K I Denu, Ritika Revoori, Maame Araba E Buadu, Oluwakemi Oladele, Kofi Poku Berko
BACKGROUND: Human Immunodeficiency Virus (HIV) infection remains a public health concern in many countries. The increased life expectancy in the post-Antiretroviral Therapy (ART) era has led to an increased risk of cardiovascular disease and death among Persons Living with HIV (PLHIV). Hypertension remains a significant risk factor for cardiovascular disease among PLHIV. Some studies have suggested associations between hypertension among PLHIV and HIV-related health factors. OBJECTIVE: To determine the prevalence of hypertension among PLHIV on antiretroviral medications and examine its association with HIV-related health factors...
January 11, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38185696/effect-of-dolutegravir-based-versus-efavirenz-based-antiretroviral-therapy-on-excessive-weight-gain-in-adult-treatment-na%C3%A3-ve-hiv-patients-at-matsanjeni-health-center-eswatini-a-retrospective-cohort-study
#14
JOURNAL ARTICLE
Didier M Mukuna, Tom Decroo, Clara M Nyapokoto
BACKGROUND: There is limited data on dolutegravir (DTG)-associated weight gain from settings with a dual burden of HIV and overnutrition. METHODS: In Eswatini (at Matsanjeni), among 156 and 160 adult patients on DTG-based and EFV-based antiretroviral therapy (ART), respectively, we studied excessive weight gain (BMI at 24 months ART greater than baseline and ≥25 kg/m2 ). RESULTS: The median BMI increase in DTG-based patients was 1...
January 7, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38185638/bifocal-malakoplakia-in-a-patient-living-with-hiv-case-report
#15
JOURNAL ARTICLE
Mohammed Alsaeed, Mohamed Mursi, Nazik Eltayeb, Hadi Kuriry, Salafa Albaghli, Yasir Alrusayni
BACKGROUND: Malakoplakia is a rare chronic granulomatous disease characterized by the presence of Michaelis-Gutmann bodies (MGBs) within histiocytic aggregates. It predominantly affects immunocompromised individuals, including those living with Human Immunodeficiency Virus (HIV). CASE PRESENTATION: We present a unique case of bifocal malakoplakia in a 49-year-old man, previously with Coronavirus disease 2019 (COVID-19) and HIV positive, presented with respiratory symptoms, weight loss, and lymphadenopathy...
January 7, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38173032/empyema-caused-by-streptococcus-constellatus-in-a-patient-infected-with-hiv-a-case-report-and-literature-review
#16
REVIEW
Hong-Hong Yang, Mei Li, Qing Yu, Qian Liu, Min Liu
BACKGROUND: Empyema caused by Streptococcus constellatus (S. constellatus) is rare in patients with HIV. To analyze the clinical data of a patient living with HIV (PLHIV), who got empyema caused by S. constellatus, investigating the diagnosis and treatment of this disease through literature review to improve the clinical understanding of this disease. CASE PRESENTATION: We have reported here a 58-year-old male PLHIV with cough, wheezing, and fever for 20 days. He has a history type 2 diabetes, alcohol abuse, and a teeth extracted...
January 3, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38173008/brief-communications-changes-in-inflammatory-biomarkers-and-lipid-profiles-after-switching-to-long-acting-cabotegravir-plus-rilpivirine
#17
JOURNAL ARTICLE
Eisuke Adachi, Makoto Saito, Amato Otani, Michiko Koga, Hiroshi Yotsuyanagi
We assessed whether the impact of cabotegravir plus rilpivirine on inflammation reduction differs from that of oral antiretrovirals, using real-world data. Inflammatory biomarkers and lipid profiles were followed from baseline to 8 months after switching. Seventy-eight participants were analyzed. The CD4/CD8 ratio and C-reactive protein did not change. There were transient decreases in CD8 and CD4 counts in the group that switched from the dolutegravir-based regimen, but not in the tenofovir alafenamide-based regimen group...
January 3, 2024: AIDS Research and Therapy
https://read.qxmd.com/read/38115098/adolescent-s-and-youth-s-adherence-to-antiretroviral-therapy-for-better-treatment-outcome-and-its-determinants-multi-center-study-in-public-health-facilities
#18
JOURNAL ARTICLE
Yihenew Zurbachew, Desta Hiko, Girma Bacha, Hailu Merga
BACKGROUND: Low-adherence to Anti-retroviral therapy (ART) negatively affects the clinical, immunological, and virologic outcomes of patients. Adherence is the most important factor in determining Antiretroviral Therapy (ART) treatment success and long-term viral suppression which ultimately reduces morbidity and mortality. Thus, this study aimed to identify factors affecting adherence to antiretroviral therapy among adolescents and youth living with HIV. METHODS: Facility-based cross-sectional study was conducted from March 21 to April 30, 2020 among 316 respondents in selected five high-loaded hospitals with adolescent and youth clients using systematic random sampling technique...
December 19, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/38110982/risk-factors-for-unsuppressed-viral-load-after-intensive-adherence-counseling-among-hiv-infected-persons-in-kampala-uganda-a-nested-case-control-study
#19
JOURNAL ARTICLE
Jonathan Izudi, Barbara Castelnuovo, Rachel King, Adithya Cattamanchi
BACKGROUND: Intensive adherence counseling (IAC) is the global standard of care for people living with human immunodeficiency virus (PLHIV) who have unsuppressed VL after ≥ 6 months of first-line anti-retroviral therapy (ART). We investigated whether the number of IAC sessions is associated with suppressed VL among PLHIV in Kampala, Uganda. METHODS: We conducted a nested case-control study among PLHIV with unsuppressed VL after ≥ 3 IAC sessions (cases) and a 2:1 random sample of PLHIV with suppressed VL after ≥ 3 IAC sessions (controls)...
December 19, 2023: AIDS Research and Therapy
https://read.qxmd.com/read/38104102/prevalence-of-depression-among-people-living-with-hiv-in-rural-hospitals-in-south-western-nigeria-association-with-clinico-demographic-factors
#20
JOURNAL ARTICLE
Waheed Adeola Adedeji, Qing Ma, Abiodun Muhammed Raji, Raymond Cha, Olaniran Mudasiru Rasaki, Alan Hutson, Babafemi O Taiwo, Man E Charurat, Oyindamola B Yusuf, Fatai Adewale Fehintola, Oye Gureje, Gene D Morse
Major depression is the most common neuropsychiatric disorder among people living with HIV (PLWH) and is predictive of high morbidity and mortality among them. This study estimated the prevalence and explored factors associated with depression among PLWH in two rural secondary health facilities providing anti-retroviral therapy (ART) services in Southwestern Nigeria between September and December 2020. The Patient Health Questionnaire-9 (PHQ-9) was used to screen and identify PLWH aged 18 years or older with depression...
December 16, 2023: AIDS Research and Therapy
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