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Blood Transfusion, Trasfusione del Sangue

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https://read.qxmd.com/read/30747707/a-phase-iii-study-comparing-secondary-long-term-prophylaxis-versus-on-demand-treatment-with-vwf-fviii-concentrates-in-severe-inherited-von-willebrand-disease
#1
Flora Peyvandi, Giancarlo Castaman, Paolo Gresele, Raimondo De Cristofaro, Piercarla Schinco, Antonella Bertomoro, Massino Morfini, Gabriella Gamba, Giovanni Barillari, Víctor Jiménez-Yuste, Cristoph Königs, Alfonso Iorio, Augusto B Federici
BACKGROUND: There is a lack of prospective clinical trials specifically designed to evaluate the benefits of prophylaxis with vWF/FVIII concentrates in patients with inherited von Willebrand disease (vWD). The aim of the study was to compare efficacy of secondary long-term prophylaxis (PRO) with vWF/FVIII in the prevention of bleeding episodes in severe vWD patients to standard of care (on-demand treatment; ODT). MATERIALS AND METHODS: In this 12-month, phase III, open-label study (PRO...
February 4, 2019: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30747705/intracranial-haemorrhage-in-children-and-adults-with-haemophilia-a-and-b-a-literature-review-of-the-last-20-years
#2
REVIEW
Ezio Zanon, Samantha Pasca
Intracranial haemorrhage (ICH) is the most serious event in haemophiliacs, resulting in high rates of mortality and disability. Although the use of a prophylaxis regimen has improved outcomes, the mortality caused by ICH is still around 20%. ICH is more frequent at two different ages: in childhood (mostly in children aged ≤2 years) and in adulthood (with known risk factors such as hypertension and age ≥60 years). Our review shows how ICH remains one of the worst problems of patients with haemophilia. Greater attention to risk factors and early symptoms, together with an appropriate early prophylaxis, may reduce the risk of severe intracranial haemorrhagic events...
February 4, 2019: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30747704/increase-in-post-reperfusion-sensitivity-to-tissue-plasminogen-activator-mediated-fibrinolysis-during-liver-transplantation-is-associated-with-abnormal-metabolic-changes-and-increased-blood-product-utilisation
#3
Hunter B Moore, Angelo D'alessandro, Ernest E Moore, Matthew Wither, Peter J Lawson, Benjamin R Huebner, Kirk Hansen, Rashikh Choudhury, Trevor L Nydam
BACKGROUND: Increased systemic fibrinolytic activity can occur in liver transplant recipients after the donor graft is reperfused. However, it remains unclear whether this is related solely to tissue plasminogen activator (t-PA) levels or whether unique metabolic changes can alter t-PA activity and enhance fibrinolytic activity. We hypothesise that an increase in sensitivity to t-PA-mediated fibrinolysis (StF) following liver reperfusion is associated with specific metabolic abnormalities...
February 4, 2019: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30747703/telemedicine-and-telerehabilitation-current-and-forthcoming-applications-in-haemophilia
#4
REVIEW
Elena A Boccalandro, Giuseppe Dallari, Pier Mannuccio Mannucci
In persons with haemophilia (PWH), the importance of comprehensive disease management to prevent bleeding, joint damage and secondary diseases has been well established. However, because haemophilia is a chronic disease, intervention programmes carried out for prolonged periods of time may create problems of patient adherence. Driven by continuous technological innovation, telemedicine is being increasingly proposed as a way to provide PWH with a range of services designed to improve their health, saving the time and cost involved in going to the treatment centre, and increasing therapeutic adherence...
February 4, 2019: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30747702/position-paper-on-laboratory-testing-for-patients-with-haemophilia-a-consensus-document-from-siset-aice-sibioc-and-sipmel
#5
Armando Tripodi, Rita C Santoro, Sophie Testa, Angelo C Molinari, Sergio Bernardini, Maria Golato, Giuseppe Lippi, Walter Ageno, Elena Santagostino
No abstract text is available yet for this article.
February 4, 2019: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30747700/effects-of-in-house-cryoprecipitate-on-transfusion-usage-and-mortality-in-patients-with-multiple-trauma-with-severe-traumatic-brain-injury-a-retrospective-cohort-study
#6
Kazuhiro Sugiyama, Hiroshi Fujita, Shigeko Nishimura
BACKGROUND: Hypofibrinogenaemia is a common complication of multiple trauma with severe traumatic brain injury (Abbreviated Injury Scale score of the head ≥4; body ≥3). In Japan, neither fibrinogen concentrate nor cryoprecipitate is permitted to treat acquired hypofibrinogenaemia with the purpose of rapidly restoring a haemostatic level of fibrinogen. The aim of this study was to investigate transfusion usage and mortality in patients with multiple trauma and severe traumatic brain injury who were given a cryoprecipitate prepared in-house, comparing those administered the product early or later...
January 22, 2019: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30747706/multiple-electrode-aggregometry-and-thromboelastography-in-thrombocytopenic-patients-with-haematological-malignancies
#7
Elin N Opheim, Torunn O Apelseth, Simon J Stanworth, Geir E Eide, Tor Hervig
BACKGROUND: In thrombocytopenic patients better assessment of bleeding risk than that provided by platelet count alone is required. Multiplate® aggregometry and thromboelastography (TEG) could be used, but information on their role in such patients is limited. The primary aim of this study was to investigate the feasibility of Multiplate® analyses in patients with haematological malignancies. A secondary aim was to explore whether a multiple logistic regression model combining Multiplate® , TEG, clinical and laboratory variables was associated with risk of bleeding...
December 13, 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30747701/selective-organ-ischaemia-reperfusion-identifies-liver-as-the-key-driver-of-the-post-injury-plasma-metabolome-derangements
#8
Nathan Clendenen, Geoffrey R Nunns, Ernest E Moore, Eduardo Gonzalez, Michael Chapman, Julie A Reisz, Erik Peltz, Miguel Fragoso, Travis Nemkov, Matthew J Wither, Angela Sauaia, Christopher C Silliman, Kirk Hansen, Anirban Banerjee, Angelo D'alessandro, Hunter B Moore
BACKGROUND: Understanding the molecular mechanisms in perturbation of the metabolome following ischaemia and reperfusion is critical in developing novel therapeutic strategies to prevent the sequelae of post-injury shock. While the metabolic substrates fueling these alterations have been defined, the relative contribution of specific organs to the systemic metabolic reprogramming secondary to ischaemic or haemorrhagic hypoxia remains unclear. MATERIALS AND METHODS: A porcine model of selected organ ischaemia was employed to investigate the relative contribution of liver, kidney, spleen and small bowel ischaemia/reperfusion to the plasma metabolic phenotype, as gleaned through ultra-high performance liquid chromatography-mass spectrometry-based metabolomics...
December 13, 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30653459/red-blood-cell-storage-lesion-causes-and-potential-clinical-consequences
#9
REVIEW
Tatsuro Yoshida, Michel Prudent, Angelo D'alessandro
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen directly from ambient air via diffusion, thereby fueling oxidative phosphorylation for highly efficient energy production. RBCs have evolved to optimally serve this purpose by packing high concentrations of haemoglobin in their cytosol and shedding nuclei and other organelles. During their circulatory lifetimes in humans of approximately 120 days, RBCs are poised to transport oxygen by metabolic/redox enzymes until they accumulate damage and are promptly removed by the reticuloendothelial system...
January 2019: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30653458/red-blood-cell-alloimmunisation-in-transfusion-dependent-thalassaemia-a-systematic-review
#10
REVIEW
Massimo Franchini, Gian Luca Forni, Giuseppe Marano, Mario Cruciani, Carlo Mengoli, Valeria Pinto, Lucia De Franceschi, Donatella Venturelli, Maddalena Casale, Martina Amerini, Martina Capuzzo, Giuliano Grazzini, Francesca Masiello, Ilaria Pati, Eva Veropalumbo, Stefania Vaglio, Simonetta Pupella, Giancarlo M Liumbruno
BACKGROUND: Chronic red blood cell transfusion is the first-line treatment for severe forms of thalassaemia. This therapy is, however, hampered by a number of adverse effects, including red blood cell alloimmunisation. The aim of this systematic review was to collect the current literature data on erythrocyte alloimmunisation. MATERIALS AND METHODS: We performed a systematic search of the literature which identified 41 cohort studies involving 9,256 patients. RESULTS: The prevalence of erythrocyte alloimmunisation was 11...
January 2019: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30653457/hitchhiker-s-guide-to-the-red-blood-cell-storage-lesion
#11
EDITORIAL
Tiffany Thomas, Steven L Spitalnik
No abstract text is available yet for this article.
January 2019: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30418134/fibrinogen-measurement-in-liver-disease-validation-of-the-functional-fibrinogen-thromboelastography-assay-and-a-novel-mathematical-predictive-model
#12
Kirsty Rizzo, Kevin Vella, Daniel Zammit, Peter Gatt, Charlie Grima, Monique Borg Inguanez, Jurgen Gerada, Pierre Ellul, Mario Vassallo, Neville Azzopardi, James Pocock, Alex Gatt
BACKGROUND: Fibrinogen is produced in the liver and tends to be reduced in liver cirrhosis. Quantitative and qualitative tests exist to measure fibrinogen. We aimed to validate the functional fibrinogen thromboelastography assay (FF-TEG) and propose a new model to estimate fibrinogen levels via the Clauss method (Clauss) using data from a prothrombin time-derived fibrinogen assay (PT-Fg) in patients with liver cirrhosis. MATERIALS AND METHODS: Clauss, PT-Fg, fibrinogen antigen (Fib-Ag) and FF-TEG were studied in 55 patients with liver cirrhosis (26 with Child-Turcotte-Pugh [CTP]-A disease, 14 with CTP-B and 15 CTP-C) and 20 healthy individuals...
November 9, 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30418132/cost-of-pathogen-reduction-for-platelets-reply-to-cicchetti-et-al-blood-transfus-2018-16-483-9
#13
LETTER
Albert Farrugia
No abstract text is available yet for this article.
November 7, 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30418129/transfused-platelets-enhance-alloimmune-responses-to-transfused-kel-expressing-red-blood-cells-in-a-murine-model
#14
David J Madrid, Manjula Santhanakrishnan, Jingchun Liu, David R Gibb, Dong Liu, Prabitha Natarajan, Daniel Beitler, Zhimin Shi, Chunyan Mo, Christopher A Tormey, Seema R Patel, Sean R Stowell, Jeanne E Hendrickson
BACKGROUND: Factors influencing the development of alloantibodies against blood group antigens on transfused red blood cells are poorly defined. We hypothesised that transfused platelets may act as a danger signal to recipients and affect humoral immune responses to transfused red blood cells. MATERIALS AND METHODS: Platelet-rich plasma prepared from wild-type C57BL/6 or CD40L knockout donors was transfused into wild-type or CD40L knock-out recipients. Leucoreduced red blood cells from transgenic donors expressing high levels of the human KEL glycoprotein in an erythrocyte-specific manner (KELhi donors) were transfused after the platelets, and anti-KEL responses were measured longitudinally...
November 7, 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30412048/xxv-congresso-nazionale-della-societ%C3%A3-italiana-per-lo-studio-dell-emostasi-e-della-trombosi-siset
#15
Walter Ageno, Anna Falanga, Giancarlo Castaman
No abstract text is available yet for this article.
November 7, 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30388071/efficacy-of-platelet-rich-plasma-as-conservative-treatment-in-orthopaedics
#16
EDITORIAL
Nathan Clendenen, Adit Ginde
No abstract text is available yet for this article.
November 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30388070/the-key-role-of-tranexamic-acid-in-patient-blood-management-programmes
#17
EDITORIAL
Massimo Franchini, Giancarlo M Liumbruno
No abstract text is available yet for this article.
November 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30201084/factors-affecting-the-quality-safety-and-marketing-approval-of-clotting-factor-concentrates-for-haemophilia
#18
REVIEW
Albert Farrugia, Giancarlo M Liumbruno, Fabio Candura, Samantha Profili, Josephine Cassar
Selecting therapeutic products for the treatment of haemophilia follows the process of obtaining market approval of products submitted to the scrutiny of a regulatory agency. In well-resourced countries, key decisions on whether a product is sufficiently safe and of high quality are made by highly expert and well-resourced agencies, such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). In countries lacking such agencies, well-informed decisions can still be made through an appreciation of the key issues affecting the quality, safety and efficacy of haemophilia products...
November 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30201083/efficacy-of-topical-tranexamic-acid-within-a-blood-saving-programme-for-primary-total-hip-arthroplasty-a-pragmatic-open-label-randomised-study
#19
Nuria Pérez-Jimeno, Manuel Muñoz, Jesús Mateo, Ana P Mayoral, Antonio Herrera
BACKGROUND: Total hip arthroplasty entails considerable peri-operative blood loss, which may lead to acute post-operative anaemia and red blood cell transfusion. This study was aimed at assessing whether the addition of topical tranexamic acid to our ongoing blood-saving protocol for total hip arthroplasty was effective and safe. MATERIALS AND METHODS: A pragmatic, prospective, open-label randomised study of patients scheduled for total hip arthroplasty at a single centre was conducted...
November 2018: Blood Transfusion, Trasfusione del Sangue
https://read.qxmd.com/read/30201082/efficacy-of-platelet-rich-plasma-as-conservative-treatment-in-orthopaedics-a-systematic-review-and-meta-analysis
#20
REVIEW
Massimo Franchini, Mario Cruciani, Carlo Mengoli, Giuseppe Marano, Simonetta Pupella, Eva Veropalumbo, Francesca Masiello, Ilaria Pati, Stefania Vaglio, Giancarlo M Liumbruno
BACKGROUND: The aim of this systematic review and meta-analysis was to evaluate the benefit of platelet-rich plasma (PRP) in non-surgical orthopaedic procedures. MATERIAL AND METHODS: We searched the Cochrane Wounds Specialized Register, CENTRAL, MEDLINE (through PUBMED), Embase, and SCOPUS. We also searched clinical trials registries for ongoing and unpublished studies and checked reference lists to identify additional studies. RESULTS: We found 36 randomised controlled trials (2,073 patients) that met our inclusion criteria...
November 2018: Blood Transfusion, Trasfusione del Sangue
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