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Journals Journal of Zhejiang University...

Journal of Zhejiang University. Science. B

https://read.qxmd.com/read/38773879/implications-of-bacteria%C3%A2-bacteria-interactions-within-the-plant-microbiota-for-plant-health-and-productivity
#1
JOURNAL ARTICLE
Giovanni Davide Barone, Yaqi Zhou, Hongkai Wang, Sunde Xu, Zhonghua Ma, Tomislav Cernava, Yun Chen
Crop production currently relies on the widespread use of agrochemicals to ensure food security. This practice is considered unsustainable, yet has no viable alternative at present. The plant microbiota can fulfil various functions for its host, some of which could be the basis for developing sustainable protection and fertilization strategies for plants without relying on chemicals. To harness such functions, a detailed understanding of plant‒microbe and microbe‒microbe interactions is necessary...
May 22, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38772738/mir-4465-modified-mesenchymal-stem-cell-derived-small-extracellular-vesicles-inhibit-liver-fibrosis-development-via-targeting-loxl2-expression
#2
JOURNAL ARTICLE
Yanjin Wang, Yifei Chen, Fuji Yang, Xiaolong Yu, Ying Chu, Jing Zhou, Yongmin Yan, Jianbo Xi
Liver fibrosis is a significant health burden, marked by the consistent deposition of collagen. Unfortunately, the currently available treatment approaches for this condition are far from optimal. Lysyl oxidase-like protein 2 (LOXL2) secreted by hepatic stellate cells (HSCs) is a crucial player in the cross-linking of matrix collagen and is a significant target for treating liver fibrosis. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have been proposed as a potential treatment option for chronic liver disorders...
May 17, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38772736/clinical-applications-of-metagenomics-next-generation-sequencing-in-infectious-diseases
#3
JOURNAL ARTICLE
Ying Liu, Yongjun Ma
Infectious diseases are a great threat to human health. Rapid and accurate detection of pathogens is important in the diagnosis and treatment of infectious diseases. Metagenomics next-generation sequencing (mNGS) is an unbiased and comprehensive approach for detecting all RNA and DNA in a sample. With the development of sequencing and bioinformatics technologies, mNGS is moving from research to clinical application, which opens a new avenue for pathogen detection. Numerous studies have revealed good potential for the clinical application of mNGS in infectious diseases, especially in difficult-to-detect, rare, and novel pathogens...
May 17, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38772740/sialyltransferase-st3gal6-silencing-reduces-%C3%AE-2-3-sialylated-glycans-to-regulate-autophagy-by-decreasing-hspb8-bag3-in-the-brain-with-hepatic-encephalopathy
#4
JOURNAL ARTICLE
Xiaocheng Li, Yaqing Xiao, Pengfei Li, Yayun Zhu, Yonghong Guo, Huijie Bian, Zheng Li
End-stage liver diseases, such as cirrhosis and liver cancer caused by hepatitis B, are often combined with hepatic encephalopathy (HE); ammonia poisoning is posited as one of its main pathogenesis mechanisms. Ammonia is closely related to autophagy, but the molecular mechanism of ammonia's regulatory effect on autophagy in HE remains unclear. Sialylation is an essential form of glycosylation. In the nervous system, abnormal sialylation affects various physiological processes, such as neural development and synapse formation...
May 14, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38616136/input-output-specific-orchestration-of-aversive-valence-in-lateral-habenula-during-stress-dynamics
#5
JOURNAL ARTICLE
Taida Huang, Xiaonan Guo, Xiaomin Huang, Chenju Yi, Yihui Cui, Yiyan Dong
Stress has been considered as a major risk factor for depressive disorders, triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits. Among various regions across the brain, the lateral habenula (LHb) serves as a critical hub for processing aversive information during the dynamic process of stress accumulation, thus having been implicated in the pathogenesis of depression. LHb neurons integrate aversive valence conveyed by distinct upstream inputs, many of which selectively innervate the medial part (LHbM) or lateral part (LHbL) of LHb...
April 7, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38616134/energy-deprivation-induced-autophagy-and-aggrephagy-insights-from-yeast-and-mammals
#6
JOURNAL ARTICLE
Siyu Fan, Yingcong Chen, Weijing Yao, Cong Yi
Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli. Compared to research on nutrient deprivation-induced autophagy, the understanding of the molecular mechanisms and physiological/pathological significance of autophagy triggered by energy deprivation remains limited. A primary focus of our lab is to elucidate how cells sense energy deprivation and initiate autophagy. Using the model organisms Saccharomyces cerevisiae and mammalian cells, we found that cellular reactive oxygen species (ROS), DNA damage sensor Mec1, and mitochondrial aerobic respiration play essential roles in the autophagy induced by energy deprivation...
April 7, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38725342/transfer-rna-derived-fragment-trf-23-q99p9p9ndd-promotes-progression-of-gastric-cancer-by-targeting-acadsb
#7
JOURNAL ARTICLE
Yu Zhang, Xinliang Gu, Yang Li, Xun Li, Yuejiao Huang, Shaoqing Ju
Gastric cancer (GC) is one of the most common gastrointestinal tumors. As a newly discovered type of non-coding RNAs, transfer RNA (tRNA)‍-derived small RNAs (tsRNAs) play a dual biological role in cancer. Our previous studies have demonstrated the potential of tRF-23-Q99P9P9NDD as a diagnostic and prognostic biomarker for GC. In this work, we confirmed for the first time that tRF-23-Q99P9P9NDD can promote the proliferation, migration, and invasion of GC cells in vitro. The dual luciferase reporter gene assay confirmed that tRF-23-Q99P9P9NDD could bind to the 3' untranslated region (UTR) site of acyl-coenzyme A dehydrogenase short/branched chain ( ACADSB )...
May 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38725341/exosomal-let-7a-5p-derived-from-human-umbilical-cord-mesenchymal-stem-cells-alleviates-coxsackievirus-b3-induced-cardiomyocyte-ferroptosis-via-the-smad2-zfp36-signal-axis
#8
JOURNAL ARTICLE
Xin Li, Yanan Hu, Yueting Wu, Zuocheng Yang, Yang Liu, Hanmin Liu
Viral myocarditis (VMC) is one of the most common acquired heart diseases in children and teenagers. However, its pathogenesis is still unclear, and effective treatments are lacking. This study aimed to investigate the regulatory pathway by which exosomes alleviate ferroptosis in cardiomyocytes (CMCs) induced by coxsackievirus B3 (CVB3). CVB3 was utilized for inducing the VMC mouse model and cellular model. Cardiac echocardiography, left ventricular ejection fraction (LVEF), and left ventricular fractional shortening (LVFS) were implemented to assess the cardiac function...
May 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38725339/short-neuropeptide-f-in-integrated-insect-physiology
#9
REVIEW
Marcin Cholewiński, Szymon Chowański, Jan Lubawy, Arkadiusz Urbański, Karolina Walkowiak-Nowicka, Paweł Marciniak
The short neuropeptide F (sNPF) family of peptides is a multifunctional group of neurohormones involved in the regulation of various physiological processes in insects. They have been found in a broad spectrum of species, but the number of isoforms in the precursor molecule varies from one to four. The receptor for sNPF (sNPFR), which belongs to the G protein-coupled receptor family, has been characterized in various insect orders and was shown to be an ortholog of the mammalian prolactin-releasing peptide receptor (PrPR)...
May 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38725338/ceria-nanoparticles-biomedical-applications-and-toxicity
#10
REVIEW
Xiaoxuan Fu, Peng Li, Xi Chen, Yuanyuan Ma, Rong Wang, Wenxuan Ji, Jiakuo Gu, Bowen Sheng, Yizhou Wang, Zhuhong Zhang
Ceria nanoparticles (CeO2 NPs) have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation, cancer therapy, photocatalytic degradation of pollutants, sensors, etc. Many methods, including gas phase, solid phase, liquid phase, and the newly proposed green synthesis method, have been reported for the synthesis of CeO2 NPs. Due to the wide application of CeO2 NPs, concerns about their adverse impacts on human health have been raised. This review covers recent studies on the biomedical applications of CeO2 NPs, including their use in the treatment of various diseases (e...
May 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38584098/erratum-to-molecular-dynamics-simulation-reveals-dna-specific-recognition-mechanism-via-c-myb-in-pseudo-palindromic-consensus-of-mim-1-promoter
#11
JOURNAL ARTICLE
Jinru Weng, Shuo Yang, Jinkang Shen, Hongsen Liu, Yuzi Xu, Dongyun Hao, Shan Wang
The original version of this article (Weng et al., 2023) unfortunately contained a mistake. In Acknowledgments, the number (No. 226-2022-00213) of the Fundamental Research Funds for the Central Universities is wrong. The correct number should be No. 2022FZZX01-33.
April 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38584097/erratum-to-bioinformatic-analysis-for-potential-biological-processes-and-key-targets-of-heart-failure-related-stroke
#12
JOURNAL ARTICLE
Chiyu Liu, Sixu Chen, Haifeng Zhang, Yangxin Chen, Qingyuan Gao, Zhiteng Chen, Zhaoyu Liu, Jingfeng Wang
The original version of this article (Liu et al., 2021) unfortunately contained a mistake: statement of equal contribution is missing. This correction article shows that Chiyu LIU and Sixu CHEN contributed equally to this work. The original article has been corrected.
April 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38584096/seizure-as-the-main-presenting-manifestation-of-three-patients-with-acute-glufosinate-ammonium-poisoning
#13
JOURNAL ARTICLE
Ping Wang, Congying Song, Xuan Lu, Yuanqiang Lu
Glufosinate-ammonium herbicides are the most widely used broad-spectrum, non-selective herbicides in the world. Glufosinate-ammonium is a structural analogue of glutamate (Glu) which can irreversibly inhibit the activity of glutamine synthetase (GS) and Glu decarboxylase in plants, thereby blocking the synthesis of glutamine (Gln) from Glu and ammonia (Hoerlein, 1994). This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia. In humans, the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity (Watanabe and Sano, 1998)...
April 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38584095/elabela-derived-peptide-ela13-attenuates-kidney-fibrosis-by-inhibiting-the-smad-and-erk-signaling-pathways
#14
JOURNAL ARTICLE
Zhibin Yan, Ying Shi, Runling Yang, Jijun Xue, Caiyun Fu
Kidney fibrosis is an inevitable result of various chronic kidney diseases (CKDs) and significantly contributes to end-stage renal failure. Currently, there is no specific treatment available for renal fibrosis. ELA13 (amino acid sequence: RRCMPLHSRVPFP) is a conserved region of ELABELA in all vertebrates; however, its biological activity has been very little studied. In the present study, we evaluated the therapeutic effect of ELA13 on transforming growth factor-β1 (TGF-β1)-treated NRK-52E cells and unilateral ureteral occlusion (UUO) mice...
April 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38584094/large-scale-genome-wide-snp-analysis-reveals-the-rugged-and-ragged-landscape-of-global-ancestry-phylogeny-and-demographic-history-in-chicken-breeds
#15
JOURNAL ARTICLE
Natalia V Dementieva, Yuri S Shcherbakov, Olga I Stanishevskaya, Anatoly B Vakhrameev, Tatiana A Larkina, Artem P Dysin, Olga A Nikolaeva, Anna E Ryabova, Anastasiia I Azovtseva, Olga V Mitrofanova, Grigoriy K Peglivanyan, Natalia R Reinbach, Darren K Griffin, Michael N Romanov
The worldwide chicken gene pool encompasses a remarkable, but shrinking, number of divergently selected breeds of diverse origin. This study was a large-scale genome-wide analysis of the landscape of the complex molecular architecture, genetic variability, and detailed structure among 49 populations. These populations represent a significant sample of the world's chicken breeds from Europe (Russia, Czech Republic, France, Spain, UK, etc.), Asia (China), North America (USA), and Oceania (Australia). Based on the results of breed genotyping using the Illumina 60K single nucleotide polymorphism (SNP) chip, a bioinformatic analysis was carried out...
April 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38584093/nrf2-mediated-ferroptosis-of-spermatogenic-cells-involved-in-male-reproductive-toxicity-induced-by-polystyrene-nanoplastics-in-mice
#16
JOURNAL ARTICLE
Xufeng Fu, Hang Han, Hong Yang, Bo Xu, Wenjie Dai, Ling Liu, Tiantian He, Xing DU, Xiuying Pei
Microplastics (MPs) and nanoplastics (NPs) have become hazardous materials due to the massive amount of plastic waste and disposable masks, but their specific health effects remain uncertain. In this study, fluorescence-labeled polystyrene NPs (PS-NPs) were injected into the circulatory systems of mice to determine the distribution and potential toxic effects of NPs in vivo. Interestingly, whole-body imaging found that PS-NPs accumulated in the testes of mice. Therefore, the toxic effects of PS-NPs on the reproduction systems and the spermatocytes cell line of male mice, and their mechanisms, were investigated...
April 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38584092/unlocking-the-growth-potential-harnessing-the-power-of-synbiotics-to-enhance-cultivation-of-pleurotus-spp
#17
JOURNAL ARTICLE
Reshma Patil, Aizi Nor Mazila Ramli, Ang Shu Xuan, Ng Zhi Xin, Nur Izyan Wan Azelee, Prakash Bhuyar
The oyster mushroom ( Pleurotus spp.) is one of the most widely cultivated mushroom species globally. The present study investigated the effect of synbiotics on the growth and quality of Pleurotus ostreatus and Pleurotus pulmonarius . Different synbiotics formulations were applied by spraying mushroom samples daily and measuring their growth parameters, yield, biological efficiency, proximate composition, mineral content, total phenolic content (TPC), and diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity...
April 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38584091/emerging-role-of-lncrnas-as-mechanical-signaling-molecules-in-mechanotransduction-and-their-association-with-hippo-yap-signaling-a-review
#18
JOURNAL ARTICLE
Siyi Lin, Xinyu He, Ying Wang, Yu Chen, Aifu Lin
Cells within tissues are subject to various mechanical forces, including hydrostatic pressure, shear stress, compression, and tension. These mechanical stimuli can be converted into biochemical signals through mechanoreceptors or cytoskeleton-dependent response processes, shaping the microenvironment and maintaining cellular physiological balance. Several studies have demonstrated the roles of Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ) as mechanotransducers, exerting dynamic influence on cellular phenotypes including differentiation and disease pathogenesis...
April 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38584090/impacts-of-pancreatic-exocrine-insufficiency-on-gut-microbiota
#19
JOURNAL ARTICLE
Yulin Guo, Feng Cao, Fei Li
Pancreatic exocrine insufficiency (PEI) can be induced by various kinds of diseases, including chronic pancreatitis, acute pancreatitis, and post-pancreatectomy. The main pathogenetic mechanism of PEI involves the decline of trypsin synthesis, disorder of pancreatic fluid flow, and imbalance of secretion feedback. Animal studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis, with the abundance of Lactobacillus and Bifidobacterium increasing the most, which could be partially reversed by pancreatic enzyme replacement therapy...
April 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38453639/newcastle-disease-virus-suppresses-antigen-presentation-via-inhibiting-il-12-expression-in-dendritic-cells
#20
JOURNAL ARTICLE
Fulong Nan, Wenlong Nan, Xin Yan, Hui Wang, Shasha Jiang, Shuyun Zhang, Zhongjie Yu, Xianjuan Zhang, Fengjun Liu, Jun Li, Xiaoqiong Zhou, Delei Niu, Yiquan Li, Wei Wang, Ning Shi, Ningyi Jin, Changzhan Xie, Xiaoni Cui, He Zhang, Bin Wang, Huijun Lu
As a potential vectored vaccine, Newcastle disease virus (NDV) has been subject to various studies for vaccine development, while relatively little research has outlined the immunomodulatory effect of the virus in antigen presentation. To elucidate the key inhibitory factor in regulating the interaction of infected dendritic cells (DCs) and T cells, DCs were pretreated with the NDV vaccine strain LaSota as an inhibitor and stimulated with lipopolysaccharide (LPS) for further detection by enzyme-linked immunosorbent assay (ELISA), flow cytometry, immunoblotting, and quantitative real-time polymerase chain reaction (qRT-PCR)...
March 15, 2024: Journal of Zhejiang University. Science. B
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