Journals Forensic Science, Medicine, an...

Forensic Science, Medicine, and Pathology
Yinyu Chen, Jiaqi Liu, Tao Song, Xing Zou, Leilei Li, Qianyun Nie, Peng Zhang
Etomidate is a nonbarbiturate sedative derived from imidazole. Prolonged and excessive use of etomidate can lead to the suppression of adrenocortical function, myoclonus, and even death. This report describes a rare case of a 47-year-old man who died from acute intoxication after oral ingestion of liquid containing etomidate. The cause of death was conclusively attributed to etomidate based on a comprehensive investigation, including autopsy, histopathological examination, toxicological analysis, and biochemical analysis...
April 23, 2024: Forensic Science, Medicine, and Pathology
Jun-Jie Huang, Jia-Ying Zhuo, Qian Wang, Yue Sun, Jia-Xin Qi, Juan-Juan Wu, Yu Zhang, Gang Chen, Peng-Fei Jiang, Yan-Yan Fan
Thrombus age determination in fatal venous thromboembolism cases is an important task for forensic pathologists. In this study, we investigated the time-dependent expressions of formyl peptide receptor 2 (FPR2) and Annexin A1 (ANXA1) in a stasis-induced deep vein thrombosis (DVT) murine model, with the aim of obtaining useful information for thrombus age timing. A total of 75 ICR mice were randomly classified into thrombosis group and control group. In thrombosis group, a DVT model was established by ligating the inferior vena cava (IVC) of mice, and thrombosed IVCs were harvested at 1, 3, 5, 7, 10, 14, and 21 days after modeling...
April 23, 2024: Forensic Science, Medicine, and Pathology
Sweety Sharma, Rayshm Bhasin, Chongtham Nimi, Rajinder Singh
The escalating rates of rape and sexual assault cases underscore the essential need to analyze associative evidence of sexual assault to ensure justice. The condom, when used during the act of sexual assault/rape, leaves behind traces of lubricant that could be instrumental in establishing the link between the victim and perpetrator. This leading evidence is crucial especially when the traditional DNA analysis is challenging owing to the lack of biological evidence. The present study employs the use of ATR FTIR spectroscopy coupled with the chemometric, to discern the chemical discrimination of condom lubricants...
April 19, 2024: Forensic Science, Medicine, and Pathology
Treerat Gumpangseth, Pornhatai Komutrattananont, Patison Palee, Suree Lekawanvijit, Chaturong Kanchai, Sukon Prasitwattanaseree, Pasuk Mahakkanukrauh
The study investigated the relationship between the histological compositions of the tricuspid, pulmonary, mitral, and aortic valves, and age. All 85 fresh human hearts were obtained with an age range between 20 and 90 years. The central area of the valves was conducted to analyze the density of collagen and elastic fibers by using an image analysis program. Neural network function in MATLAB was used for classification data and accuracy test of the age predictive model. Overall, a gradual increase in the density of collagen and elastic fibers was demonstrated with age in all valve types...
April 18, 2024: Forensic Science, Medicine, and Pathology
Javiera Riquelme-Navarrete, Lourdes Gómez, María Candelaria Sánchez, Pablo Navarro, Gabriel M Fonseca
This study presents a novel conservative technique to increase oral opening and overcome rigor mortis during medicolegal autopsy (MLA). The method proposes a myotomy of the temporalis and masseter muscles, taking advantage of the incisions of the cranial opening procedures, to achieve a significant oral opening (≥ 30 mm) in fresh cadavers with established rigor mortis without altering facial aesthetics. The study was performed on 48 individuals aged between 18 and 66 years (20 males and 28 females) who were autopsied at the Instituto Nacional de Patología Forense Dr...
April 17, 2024: Forensic Science, Medicine, and Pathology
Christine Eimer, Claas Buschmann, Jonas Deeken, Thoralf Kerner
Management of severe pediatric trauma remains challenging. Injury patterns vary according to patient age and trauma mechanism. This study analyzes trauma mechanisms in deceased pediatric patients. Fatal pediatric trauma cases aged 0-18 years who underwent forensic autopsy in the Federal State of Berlin, Germany, between 2008 until 2018 were enrolled in this retrospective study. Autopsy protocols were analyzed regarding demographic characteristics, trauma mechanisms, injury patterns, resuscitation measures, survival times as well as place, and cause of death...
April 16, 2024: Forensic Science, Medicine, and Pathology
Gayan Kumarasinghe, Murugupillai Sivasubramanium, Kasun Bandara Ekanayake, Dhanushka Rambukwella, Bandarage Sanjaya
Page kidney is a condition where external compression of the renal artery and renal parenchyma leads to subsequent ischaemia and activation of renin-angiotensin-aldosterone axis. A 42-year-old female with hirsutism, hypertension and diabetes was diagnosed with a right adrenal mass and underwent laparoscopic adrenalectomy. Her hypertension worsened postoperatively and was managed medically. Subsequently she developed a right flank pain on the fifth postoperative day and died suddenly the next day. Autopsy revealed a pale body with cushingoid appearance...
April 13, 2024: Forensic Science, Medicine, and Pathology
Matheus Medeiros Nunes, Caio Rodrigues Maia, Paulo Roberto de Andrade Santos, Antônio de Lisboa Lopes Costa, Sérgio Adriane Bezerra de Moura, Pedro Paulo de Andrade Santos
Self-mutilation lesions can represent a clinical diagnosis challenge for healthcare professionals, as patients do not admit to self-mutilation. This leads to failed diagnoses due to the similarity of this condition to other diseases. Searches on the subject were carried out at the PubMed, Periódicos Capes, Scopus, Science Direct and WoS databases, according to the following inclusion criteria: articles in English, Portuguese or Spanish, published from 2018 to June 2023, encompassing case reports, case series and literature reviews...
April 13, 2024: Forensic Science, Medicine, and Pathology
Andreas G Nerlich, Stephanie Panzer, Christine Lehn, Jan Friederichs, Oliver K Peschel
The well preserved skeleton of Joseph Huber, a very well-known historical character of the 19th century Munich, also nicknamed "Finessen-Sepperl", is the starting point of the reconstruction of life and death of this historical individual. He was known as a postilion d´amour (love's messenger) of the Royal Bavarian capital with numerous comments and anecdotes and a few biographical sketches that indicate he remained well until the last few years of his life where requests for his duties lessened. The skeleton shows a small-sized male individual with almost complete loss of teeth, but otherwise very well-mineralized bone, having suffered from three episodes of trauma - an old-healed incomplete femoral neck fracture leading to severe osteoarthrosis, a clavicle fracture of the medial third with a few weeks old callus formation, and fresh serial rib fractures along with severe skull trauma with fractures of the os temporale and petrosum, presumably leading to intracranial bleeding and finally death...
April 12, 2024: Forensic Science, Medicine, and Pathology
Roger W Byard, John Gilbert
A 19-year-old male was found dead in his apartment. At autopsy he was morbidly obese (Body mass index; BMI - 40.5) with multiple areas of velvety pigmented thickening of the skin in folds around the neck, in the axillae, in the inframammary regions, over the anterior waistline and groin regions and over the dorsal aspects of the feet. These had the typical appearance of acanthosis nigricans. Internal examination revealed aspiration of gastric contents into the airways. Vitreous humour biochemistry showed markedly elevated levels of both glucose (62...
April 11, 2024: Forensic Science, Medicine, and Pathology
Lilli Stephenson, Corinna Van Den Heuvel, Melissa Humphries, Roger W Byard
PURPOSE: The most prevalent method of carbon monoxide (CO) suicide is inhalation of vehicle exhaust (VE). However, a new method of CO suicide has recently emerged involving charcoal burning (CB) in a confined space to produce fatal CO levels. This method has been reported from countries in Asia, associated with economic instability and media reporting of high-profile celebrity cases. The current study was undertaken to analyze rates and characteristics of CB suicides in South Australia (SA) for comparison with respect to their characteristics and scene, autopsy and toxicology findings...
April 11, 2024: Forensic Science, Medicine, and Pathology
Inés Sánchez-Sellero, Iván Álvarez-Freire, Pamela Cabarcos-Fernández, Lidia Janza-Candal, María Jesús Tabernero-Duque, Ana María Bermejo-Barrera
PURPOSE: Therapeutic drug monitoring of plasma lamotrigine (LTG) has customarily been carried out in order to prevent some its adverse effects. For forensic purposes, determination of LTG in plasma is an useful tool in cases of accidental overdose or suicidal attempts. Currently, there are several analytical methods available including some based on LC tandem mass spectrometry techniques, but simple and accessible LC-UV methods still can be useful for the purpose. Here we report on a new high-performance liquid chromatography method for the determination of lamotrigine in human plasma which has been developed and validated including selectivity, sensitivity, accuracy, precision and recovery studies...
April 10, 2024: Forensic Science, Medicine, and Pathology
İpek Gürel, Faruk Aşıcıoğlu, Gökhan Ersoy, Özlem Bülbül, Tülin Öztürk, Gönül Filoğlu
There may be cases where malignant tumor samples can be used for forensic DNA profiling studies. STRs are the first systems preferred in forensic science laboratories for identification purposes. However, genetic instability in tumoral tissues causes STR polymorphism to change, leading to erroneous results. On the other hand, insertion/deletion polymorphism (InDels) are used as genetic markers in forensic science, as they have features that make both STR and SNPs preferable. Although previous studies approved that STR instability is observed in many different tumors, there are only a few studies that have displayed the instability of InDels in tumoral tissues before...
April 3, 2024: Forensic Science, Medicine, and Pathology
Stephanie Baylis, Joanna F Dipnall, Richard Bassed
Reference data for dental age estimate is sparse in New Zealand (NZ), with only two contemporary studies. Te Moananui et al. (J For Sci. 53(2), 2008) presented modified Demirjian percentile curves to estimate dental age of Pasifika, Māori, and European males and females (n = 1383), while Timmins et al. (Forensic Sci Med Pathol. 8:101-8, 2012) found the Demirjian method (1973) was valid for a smaller sample (n = 200) of unknown ancestry. The study presented here sought to validate the Demirjian and the Te Moananui methods for a sample of the NZ population of unknown ancestry and a subgroup of known ancestry i...
April 3, 2024: Forensic Science, Medicine, and Pathology
Petr Handlos, Ondřej Klabal, Vladimír Vojtek, Klára Handlosová, Tomáš Krejčí, Matěj Uvíra
This case report presents a rare case of an atypical head stab wound suffered by a drug addict and inflicted with a screwdriver during drug-induced psychosis. It describes the diagnostic and treatment procedures in the hospital and the findings of the subsequent autopsy. It also analyzes the review of the interpretation of the CT scans made upon admission and the subsequent treatment by an independent medical review panel, which revealed signs of medical mismanagement. Therefore, it also discusses the legal consequences that the case may have involved for the attending physicians in addition to the consequences for the suspected perpetrator...
March 27, 2024: Forensic Science, Medicine, and Pathology
Humera Shafi Makhdoom, Ali Imran Abid, Majida Mujahid, Saira Afzal, Kishwar Sultana, Nisar Hussain, Kashif Barkat
Pheniramine is an over-the-counter antihistamine drug. Its accessibility and low cost made it more popular among drug abusers in Pakistan. In this study, pheniramine was quantified in both conventional and alternative specimens of twenty chronic drug abusers, aged 16-50 years, who were positive for pheniramine in comprehensive toxicological screening for drugs by gas chromatography with mass spectral detection in positive electron impact mode. Pheniramine was extracted from biological specimens using solid phase extraction and liquid chromatography tandem mass spectrometry was employed for quantification...
March 26, 2024: Forensic Science, Medicine, and Pathology
Daniel Preußer, Thomas Fischer, Thomas Juretzek
Protophormia terraenovae is a colonizer of decomposing bodies and is known to cause pre-mortem myiasis as the female flies lay eggs in uncleaned wounds. In this study the effects of different concentrations of antibiotics levofloxacin and ceftriaxone on maggot development, weight, length, and mortality were examined. The maggot length and weight were significantly increased by therapeutical doses of levofloxacin and ceftriaxone. The maggot development time was significantly decreased in every levofloxacin treatment compared to the control...
March 26, 2024: Forensic Science, Medicine, and Pathology
Cristina Cattaneo, Lorenzo Franceschetti
No abstract text is available yet for this article.
March 26, 2024: Forensic Science, Medicine, and Pathology
Selcuk Cetin, Nihat Akbulut, Kaan Orhan, Burak Bilecenoglu, Mert Ocak, Emre Bayram, Ahmet Altan, Bulent Eren, Serkan Silsupur, Bedirhan Sezer Oner
Determining the postmortem interval (PMI) is one of the main study subjects of forensic sciences. The main purpose of this prospective in vitro study that was the Micro-CT evaluation of teeth crown and root pulp volume versus dentin thickness in terms of PMI determination. The study involved 60 female Wistar rats, with weights ranging from 270 to 320 g. These rats were grouped into six different post-mortem period categories. Following the animals' sacrifice, they were subjected to a natural putrefaction period, with a control group, in the grounds of a sheltered garden...
March 21, 2024: Forensic Science, Medicine, and Pathology
S Plenzig, J Helmus, M Weber, M A Verhoff, V Hachmann
Irrespective of whether they are intended for collectors or for the fetish market, dolls are being produced to look more and more realistic with such a degree of life-like detail that they can be mistaken for a real person. This paper reports two cases of misidentification due to this increasing similarity: In the first case, a sex doll was mistaken for a corpse; in the second case, a corpse was mistaken for a doll. While in the latter case, only medical laypersons were at the discovery site, in the first case, an emergency doctor had issued a medical certificate of death for the purported corpse...
March 15, 2024: Forensic Science, Medicine, and Pathology
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