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Immunity & Ageing: I & A

Albino Carrizzo, Claudio Procaccini, Paola Lenzi, Clorinda Fusco, Francesco Villa, Serena Migliarino, Massimiliano De Lucia, Francesco Fornai, Giuseppe Matarese, Annibale A Puca, Carmine Vecchione
Background: Pentraxin 3 (PTX3), an acute-phase inflammation protein produced by several cell types, has long been described as a possible biomarker for age-related cardiovascular and cerebrovascular diseases. Although several mechanisms of action have been identified to date in the vascular and immune systems, the direct effects of PTX3 on isolated endothelial cells at morphological and metabolic levels remain unknown. Findings: PTX3 induced cytoplasmic vacuolization and dilution of mitochondrial matrix in isolated, human endothelial cells...
2019: Immunity & Ageing: I & A
Brandt D Pence, Johnathan R Yarbro
Background: Inflammaging is a condition of chronic low-grade inflammation due to the aging process and is associated with a variety of chronic diseases. Monocytes are innate immune cells which contribute to inflammation and are dysregulated during aging, demonstrated reduced phagocytosis, increased inflammation, and alterations in subset proportions. Metabolism is known to determine immune cell function, with quiescent and anti-inflammatory cells primarily relying on fatty acid oxidation, while activated and inflammatory cells primarily rely on glycolysis...
2019: Immunity & Ageing: I & A
Lihang Zhang, Juan Xu, Jinchao Gao, Peiqing Chen, Ming Yin, Wenjuan Zhao
Background: Apolipoprotein E4 (APOE4) and ageing are the most important known risk factors for late-onset Alzheimer's disease (AD). In the present study, we determined the alterations of IgG, CD19, and Aβ in various brain regions of uninfected male and female APOE3- and APOE4-TR mice at the age of 3 and 10 months to elucidate impacts of AD risk factors on alterations of brain IgG. Results: Positive staining for IgG was distributed across the brain, including neocortex, entorhinal cortex, hippocampus, thalamus and cerebellum...
2019: Immunity & Ageing: I & A
Thomas Huneck Haupt, Line Jee Hartmann Rasmussen, Thomas Kallemose, Steen Ladelund, Ove Andersen, Charlotta Pisinger, Jesper Eugen-Olsen
Background: The plasma level of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is a strong predictor of disease development and premature mortality in the general population. Unhealthy lifestyle habits such as smoking or unhealthy eating is known to elevate the suPAR level. We aimed to investigate whether change in lifestyle habits impact on the suPAR level, and whether the resultant levels are associated with mortality. Results: Paired suPAR measurements from baseline- and the 5-year visit of the population-based Inter99 study were compared with the habits of diet, smoking, alcohol consumption, and physical activity...
2019: Immunity & Ageing: I & A
Xufeng Li, Jiren Zhang, Chen Sun, Yuanyuan Zhang, Rui Cai, Shilin Fu, Jingfen Zheng, Dehai Huang
Background: This study aimed to construct a biological age assessment formula for the Chinese population and to explore the effectiveness of double filtration plasmapheresis for anti-ageing and longevity. Methods: 915 subjects were recruited, including 584 (63.8%) males and 331 females (36.2%). Male age was 50.94±10.60 (mean±SD), and female age was 51.20±11.84 (mean±SD). 34 blood markers were detected in the laboratory. The ageing biomarkers were determined by statistical correlation analysis and redundancy analysis, and the biological age assessment formula was established by multiple linear regression analysis...
2018: Immunity & Ageing: I & A
Lucyna Kaszubowska, Jerzy Foerster, Daria Schetz, Zbigniew Kmieć
Background: NK cells are cytotoxic lymphocytes of innate immunity composed of: cytotoxic CD56dim and immunoregulatory CD56bright cells. The study aimed to analyze the expression of cellular protective proteins: sirtuin 1 (SIRT1), heat shock protein 70 (HSP70) and manganese superoxide dismutase (SOD2) in CD56dim and CD56bright NK cells of the young, seniors aged under 85 ('the old') and seniors aged over 85 ('the oldest'). We studied both non-stimulated NK cells and cells stimulated by IL-2, LPS or PMA with ionomycin...
2018: Immunity & Ageing: I & A
Adriaan A van Beek, Floris Fransen, Ben Meijer, Paul de Vos, Edward F Knol, Huub F J Savelkoul
Background: The influence of age on basophils is poorly understood, as well as the effect of aging-associated microbiota on basophils. Therefore, we studied the influence of aging and aging-associated microbiota on basophil frequency and phenotype, and differentiation from basophil precursors. Results: Basophils became more abundant in bone marrow (BM) and spleens of 19-month-old mice compared with 4-month-old mice. Aged basophils tended to express less CD200R3 and more CD123, both in BM and spleen...
2018: Immunity & Ageing: I & A
Roberta Esposito, Regina Sorrentino, Giuseppe Giugliano, Marisa Avvedimento, Roberta Paolillo, Ciro Santoro, Maria Scalamogna, Mafalda Esposito, Federica Ilardi, Francesco Rozza, Giovanni Esposito, Maurizio Galderisi, Valentina Trimarco
Background: Some components of Nutraceuticals (NUT) such as red yeast rice and Morus alba have demonstrated positive effects on the endothelial function in hypercholesterolemic subjects. Our aim was to compare the effects of two different NUT combinations on cold pressure test (CPT) derived coronary flow reserve (CFR) assessed by transthoracic echo-Doppler. Results: In a randomized, single-blind study, 28 consecutive patients with a variety of cardiovascular risk factors received NUT A (LopiGLIK®: berberine, red yeast rice powder, and leaf extract of Morus alba ) or B (Armolipid Plus®: policosanol, red yeast rice, berberine, astaxantine, folic acidandcoenzyme Q10)...
2018: Immunity & Ageing: I & A
Reiko Kuroda, Hiroaki Higuchi, Keishirou Yoshida, Yasunori Yonejima, Keiko Hisa, Masanori Utsuyama, Kenji Osawa, Katsuiku Hirokawa
Background: Previous reports showed that oral administration of Leuconostoc mesenteroides strain NTM048 increases IgA levels and CD4+ T cell population in feces and mice, respectively, as revealed by flow cytometric analysis of splenocytes. This study aimed to evaluate the effect of chocolate supplemented with L. mesenteroides strain NTM048 (> 1.00 × 109  CFU/day, NTM048) on the immune parameters of healthy subjects, using a randomized, placebo-controlled, double-blinded study design...
2018: Immunity & Ageing: I & A
Xavier Camous, Lucian Visan, Crystal Tan Tze Ying, Brian Abel, Ma Shwe Zin Nyunt, Vipin Narang, Michael Poidinger, Christophe Carre, Sanie Sesay, Nabil Bosco, Nicolas Burdin, Paul Anantharajah Tambyah, Ng Tze Pin, Anis Larbi
Abstract: Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influenza vaccination in older adults. Sustaining health in aging could be an important player in maintaining immune responses to influenza vaccination. Trial registration: NCT03266237. Registered 30 August 2017,
2018: Immunity & Ageing: I & A
Yen-Ling Chiu, Kai-Hsiang Shu, Feng-Jung Yang, Tzu-Ying Chou, Ping-Min Chen, Fang-Yun Lay, Szu-Yu Pan, Cheng-Jui Lin, Nicolle H R Litjens, Michiel G H Betjes, Selma Bermudez, Kung-Chi Kao, Jean-San Chia, George Wang, Yu-Sen Peng, Yi-Fang Chuang
Background: Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of the immune system. Nevertheless, the etiology and impact of these changes in ESRD patients remain unknown. Results: Compared to healthy individuals, ESRD patients exhibit accelerated immunosenescence in both T cell and monocyte compartments, characterized by a dramatic reduction in naïve CD4+ and CD8+ T cell numbers but increase in CD8+ TEMRA cell and proinflammatory monocyte numbers...
2018: Immunity & Ageing: I & A
Annibale A Puca, Anna Ferrario, Anna Maciag, Giulia Accardi, Anna Aiello, Caterina Maria Gambino, Giuseppina Candore, Calogero Caruso, Aryan M Namboodiri, Janardan P Pandey
Background: The aim of this study was to analyse the role of GM allotypes, i.e. the hereditary antigenic determinants expressed on immunoglobulin polypeptide chains, in the attainment of longevity. The role played by immunoglobulin allotypes in the control of immune responses is well known as well as the role of an efficient immune response in longevity achievement. So, it is conceivable that particular GM allotypes may contribute to the generation of an efficient immune response that supports successful ageing, hence longevity...
2018: Immunity & Ageing: I & A
Calogero Caruso, Janardan P Pandey, Annibale A Puca
No abstract text is available yet for this article.
2018: Immunity & Ageing: I & A
Jin Zhang, Yuchao Wang, Xueshuang Dong, Jianghua Liu
Background: Crocetin, an agent derived from saffron, has multiple pharmacological properties, such as neuroprotective, anti-oxidant, and anti-inflammatory actions. These properties might benefit the treatment of Alzheimer's disease (AD). In the present study, we tested whether crocetin attenuates inflammation and amyloid-β (Aβ) accumulation in APPsw transgenic mice, AD mouse models. Cell viability and the levels of Aβ40 and Aβ42 in HeLa cells stably transfected with Swedish mutant APP751 were evaluated...
2018: Immunity & Ageing: I & A
Yang Zhang, Ling Wang, Lei Meng, Guang-Ke Cao, Yu-Liang Zhao, Yu Wu
Background: Sepsis is one of the common death factors in intensive care unit, which refers to the systemic inflammatory response syndrome caused by infection. It has many complications such as acute renal injury, shock, multiple organ dysfunction, and failure. The mortality of acute renal injury is the highest among the complications, which is a serious threat to the safety of patients and affects the quality of life. This study aimed to observe the changes in autophagy-related protein expressions in patients with acute kidney injury (AKI) after continuous renal replacement therapy (CRRT) and their impacts on prognosis...
2018: Immunity & Ageing: I & A
Salvatrice Mancuso, Melania Carlisi, Marco Santoro, Mariasanta Napolitano, Simona Raso, Sergio Siragusa
One of the most important determinants of aging-related changes is a complex biological process emerged recently and called "immunosenescence". Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysregulation may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. At present, the relationship between immunosenescence and lymphoma in elderly patients is not defined in a satisfactory way...
2018: Immunity & Ageing: I & A
Ying Tang, Peifen Liang, Junzhe Chen, Sha Fu, Bo Liu, Min Feng, Baojuan Lin, Ben Lee, Anping Xu, Hui Y Lan
Background: Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. Methods: Serum levels of high sensitive C-reactive protein (hs-CRP), glucose (Glu), triglyceride (TG), cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), superoxide dismutase (SOD), serum creatinine (SCr), serum uric acid (SUA) were measured in 6060healthy subjects (3672 male and 2388 female, mean age:45...
2018: Immunity & Ageing: I & A
Anja Manig, Sandra Ribes, Catharina Diesselberg, Stephanie Bunkowski, Roland Nau, Sandra Schütze
In order to elucidate the causes for the increased mortality of aged patients with bacterial central nervous system (CNS) infections, we compared the course of Streptococcus pneumoniae ( S. pneumoniae ) meningitis in aged and young mice. Aged (21.2 ± 3.1 months, n  = 40) and young (3.2 ± 0.9 months, n  = 42) C57BL/6N and B6/SJL mice were infected by intracerebral injection of 50-70 CFU  S. pneumoniae serotype 3 and monitored for 15 days. Aged and young mice did not differ concerning mortality (35% versus 38%), weight loss, development of clinical symptoms, bacterial concentrations in cerebellum and spleen as well as the number of leukocytes infiltrating the CNS...
2018: Immunity & Ageing: I & A
Divyansh Agarwal, Kenneth E Schmader, Andrew V Kossenkov, Susan Doyle, Raj Kurupati, Hildegund C J Ertl
Background: The elderly patient population is the most susceptible to influenza virus infection and its associated complications. Polypharmacy is common in the aged, who often have multiple co-morbidities. Previous studies have demonstrated that commonly used prescription drugs can have extensive impact on immune defenses and responses to vaccination. In this study, we examined how the dynamics of immune responses to the two influenza A virus strains of the trivalent inactivated influenza vaccine (TIV) can be affected by patient's history of using the prescription drugs Metformin, NSAIDs or Statins...
2018: Immunity & Ageing: I & A
Kathleen G Lanzer, Tres Cookenham, William W Reiley, Marcia A Blackman
[This corrects the article DOI: 10.1186/s12979-018-0122-y.].
2018: Immunity & Ageing: I & A
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