Robert F Kunz, Byron J Gaskin, Qunhua Li, Sam Davanloo-Tajbakhsh, Cheng Dong
Paced by advances in high performance computing, and algorithms for multi-physics and multi-scale simulation, a number of groups have recently established numerical models of flowing blood systems, where cell-scale interactions are explicitly resolved. To be biologically representative, these models account for some or all of: (1) fluid dynamics of the carrier flow, (2) structural dynamics of the cells and vessel walls, (3) interaction and transport biochemistry, and, (4) methods for scaling to physiologically representative numbers of cells...
2015: Drug Discovery Today. Disease Models