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Journals Journal of Biomedical Material...

Journal of Biomedical Materials Research. Part B, Applied Biomaterials

https://read.qxmd.com/read/38533823/emulgel-based-on-fish-skin-collagen-microalgae-silver-increased-neovascularization-and-re-epithelialization-of-full-thickness-burn-in-rats
#1
JOURNAL ARTICLE
Francisco Fábio Pereira de Souza, Igor Iuco Castro-Silva, Fábia Karine Andrade, Adriano Lincoln Albuquerque Mattos, Mirrael de Sousa Lopes, Wallady da Silva Barroso, Bartolomeu Warlene Silva de Souza, Men de Sá Moreira de Souza-Filho, André Luis Coelho da Silva
Deep skin burn represents a global morbidity and mortality problem, and the limitation of topical treatment agents has motivated research to development new formulations capable of preventing infections and accelerating healing. The aim of this work was to develop and characterize an emulgel based on collagen (COL) and gelatin (GEL) extracted from fish skin associated with Chlorella vulgaris extract (CE) and silver nitrate (AgNO3 ). COL and GEL were characterized by physicochemical and thermal analyses; and CE by electrophoresis and its antioxidant capacity...
April 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38533765/albumin-suppresses-oxidation-of-ti%C3%AF-nb-alloy-in-the-simulated-inflammatory-environment
#2
JOURNAL ARTICLE
Agata Sotniczuk, Damian Kalita, Witold Chromiński, Magdalena Matczuk, Marcin Pisarek, Halina Garbacz
Literature data has shown that reactive oxygen species (ROS), generated by immune cells during post-operative inflammation, could induce corrosion of standard Ti-based biomaterials. For Ti6Al4V alloy, this process can be further accelerated by the presence of albumin. However, this phenomenon remains unexplored for Ti β-phase materials, such as TiNb alloys. These alloys are attractive due to their relatively low elastic modulus value. This study aims to address the question of how albumin influences the corrosion resistance of TiNb alloy under simulated inflammation...
April 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38520706/improving-osseointegration-and-antimicrobial-properties-of-titanium-implants-with-black-phosphorus-nanosheets-hydroxyapatite-composite-coatings-for-vascularized-bone-regeneration
#3
JOURNAL ARTICLE
Shilong Ma, Ruize Sun, Yuhui Wang, Yan Wei, Haofeng Xu, Xuanyu Liu, Ziwei Liang, Liqin Zhao, Yinchun Hu, Xiaojie Lian, Meiqing Guo, Di Huang
For decades, titanium implants have shown impressive advantages in bone repair. However, the preparation of implants with excellent antimicrobial properties as well as better osseointegration ability remains difficult for clinical application. In this study, black phosphorus nanosheets (BPNSs) were doped into hydroxyapatite (HA) coatings using electrophoretic deposition. The coatings' surface morphology, roughness, water contact angle, photothermal properties, and antibacterial properties were investigated...
April 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38520704/direct-inkjet-writing-of-polylactic-acid-%C3%AE-tricalcium-phosphate-composites-for-bone-tissue-regeneration-a-proof-of-concept-study
#4
JOURNAL ARTICLE
Vasudev Vivekanand Nayak, Vijayavenkataraman Sanjairaj, Rakesh Kumar Behera, James E Smay, Nikhil Gupta, Paulo G Coelho, Lukasz Witek
There is an ever-evolving need of customized, anatomic-specific grafting materials for bone regeneration. More specifically, biocompatible and osteoconductive materials, that may be configured dynamically to fit and fill defects, through the application of an external stimulus. The objective of this study was to establish a basis for the development of direct inkjet writing (DIW)-based shape memory polymer-ceramic composites for bone tissue regeneration applications and to establish material behavior under thermomechanical loading...
April 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38520703/photocurable-extracellular-matrix-sealant-for-cessation-of-venous-hemorrhage
#5
JOURNAL ARTICLE
Luke E Schepers, Brooke L Martindale, Alycia G Berman, Hannah L Cebull, William Van Alstine, Sydney E Hollingshead, Tyler Novak, Craig J Goergen
Hemorrhage is the second leading cause of death in patients under 46 years of age in the United States. Cessation of hemorrhage prevents hemorrhagic shock and tissue hypoxia. Controlling the bleed via direct pressure or tourniquet is often the first line of defense, but long-term care requires staples, hemostatic agents, or sealants that seal the vessel and restore blood flow. Here, we compare a new photocurable extracellular matrix sealant (pcECM) with low, medium, and high crosslink density formulations to a commercially available fibrin-based sealant, TISSEEL®...
April 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38456343/biosafety-and-chemical-solubility-studies-of-multiscale-crystal-reinforced-lithium-disilicate-glass-ceramics
#6
JOURNAL ARTICLE
Tong Zhang, Jinrong Liu, Jin Qi, Lingxiang Sun, Xiaoming Liu, Jingyu Yan, Yanjie Zhang, Xiuping Wu, Bing Li
Lithium disilicate (Li2 Si2 O5 ) glass-ceramics are currently a more widely used all-ceramic restorative material due to their good mechanical properties and excellent aesthetic properties. However, they have a series of problems such as high brittleness and low fracture toughness, which has become the main bottleneck restricting its development. Therefore, in order to compensate for these shortcomings, we propose to prepare a reinforced glass-ceramics with better mechanical properties and to test the biosafety and chemical solubility of the material...
March 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38456331/association-between-blood-markers-and-the-progression-of-osseointegration-in-percutaneous-prostheses-patients-a-pilot-study
#7
JOURNAL ARTICLE
Andrew Miller, Sujee Jeyapalina, Jayant P Agarwal, James Peter Beck
Patients implanted with osseointegrated (OI) prosthetic systems have reported vastly improved upper and lower extremity prosthetic function compared with their previous experience with socket-suspension systems. However, OI systems have been associated with superficial and deep-bone infections and implant loosening due, in part, to a failure of the osseointegration process. Although monitoring the osseointegration using circulating biomarkers has clinical relevance for understanding the progression of osseointegration with these devices, it has yet to be established...
March 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38456309/injectable-macroporous-naturally-derived-apatite-bone-cement-as-a-potential-trabecular-bone-substitute
#8
JOURNAL ARTICLE
Vimal Kumar Dewangan, T S Sampath Kumar, Mukesh Doble, Viju Daniel Varghese
In this study, we have formulated a novel apatite bone cements derived from natural sources (i.e. eggshell and fishbone) with improved qualities that is, porosity, resorbability, biological activity, and so forth. The naturally-derived apatite bone cement (i.e. FBDEAp) was prepared by mixing hydroxyapatite (synthesized from fishbone) and tricalcium phosphate (synthesized from eggshell) as a solid phase with a liquid phase (a dilute acidic blend of cement binding accelerator and biopolymers like gelatin and chitosan) with polysorbate (as liquid porogen) to get a desired bone cement paste...
March 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38433653/evaluation-of-rabbit-adipose-derived-stem-cells-fate-in-perfused-multilayered-silk-fibroin-composite-scaffold-for-osteochondral-repair
#9
JOURNAL ARTICLE
Sara Zadegan, Bahman Vahidi, Jhamak Nourmohammadi, Asiyeh Shojaee, Nooshin Haghighipour
Development of osteochondral tissue engineering approaches using scaffolds seeded with stem cells in association with mechanical stimulations has been recently considered as a promising technique for the repair of this tissue. In this study, an integrated and biomimetic trilayered silk fibroin (SF) scaffold containing SF nanofibers in each layer was fabricated. The osteogenesis and chondrogenesis of stem cells seeded on the fabricated scaffolds were investigated under a perfusion flow. 3-Dimethylthiazol-2,5-diphenyltetrazolium bromide assay showed that the perfusion flow significantly enhanced cell viability and proliferation...
March 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38433621/development-and-optimization-of-kaempferol-loaded-ethosomes-using-box-behnken-statistical-design-in-vitro-and-ex-vivo-assessments
#10
JOURNAL ARTICLE
Shraddha Singh Raghav, Bhavna Kumar, Neeraj Kumar Sethiya, Shilpa Pahwa
Kaempferol (KMP) belong to flavonoid class have developed in ethosomal formulation and were evaluated for their potential to treat diabetic foot ulcers. Even though ethosomes are highly deformable, they can pass through human skin intact. KMP ethosomes were formulated using the cold method and optimized by Box-Behnken design (BBD) (three-factor, three-level (33 )). The formulation variables used for optimization are drug concentration of KMP, soylecithin content, and ethanol percentage. The optimized formulation was examined using transmission electronic microscopy (TEM), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, in-vitro release, ex-vivo permeation studies, and storage stability...
March 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38433609/zinc-doped-hydroxyapatite-as-a-ph-responsive-drug-delivery-system-for-anticancer-drug-6-mercaptopurine
#11
JOURNAL ARTICLE
Marcel Jakubowski, Łukasz Majchrzycki, Aleksej Zarkov, Adam Voelkel, Mariusz Sandomierski
6-Mercaptopurine (6MP) is commonly used in the treatment of acute lymphoblastic leukemia as an important agent in maintenance therapy. Despite its therapeutic benefits, 6MP has some limitations during therapy. Taking into account the disadvantages during 6MP therapy, there is a great need to create an appropriate delivery system for this drug. 6MP contains in its structure nitrogen and sulfur atoms capable of forming coordination compounds with metal ions, for example zinc. Therefore, in this work, we prepared biocompatible hydroxyapatite (HAp) doped with zinc ions, and used it as a carrier for 6MP...
March 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38400798/development-of-guar-gum-reinforced-calcium-magnesium-phosphate-based-bone-biocement
#12
JOURNAL ARTICLE
Vidul Goenka, Anupama Devi V K, Ceera Manikandan, Amit Kumar Jaiswal
This study aims at developing a calcium magnesium phosphate-based bone biocement that combines a natural polymer and regenerative properties of bone bonding materials. The formulation of this biocement consists of oxidized guar gum, polydopamine, and calcium magnesium phosphate. The oxidized guar gum is easily soluble in water and has a slightly basic pH, unlike unmodified guar gum, thus allowing a homogenous paste to form in the alkaline environment of calcium magnesium phosphate. Three different oxidized degrees of guar gum were made, and the impact on the biocement properties was studied...
March 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38385983/studying-the-electrical-mechanical-and-biological-properties-of-bczt-ha-composites
#13
JOURNAL ARTICLE
Fatemeh Zare Dehnov, Raziye Hayati, Lobat Tayebi
The piezoelectric properties of natural bone and their influence on bone growth have inspired researchers to study a range of bio-piezoelectric composite materials. By exploring these materials, researchers aim to understand better, how piezoelectricity can be controlled to promote bone growth and tissue regeneration. In this work, the prominent piezoelectric material, (Ba, Zr) TiO3 -x(Ba,Ca)TiO3 , abbreviated as BCZT, was selected as a possible bone growth enhancer in hydroxyapatite (HA) scaffolds. Initially, BCZT and hydroxyapatite (HA) powders were synthesized using the sol-gel method...
March 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38385959/strontium-loaded-3d-intramedullary-nail-titanium-implant-for-critical-sized-femoral-defect-in-rabbits
#14
JOURNAL ARTICLE
Shintaro Honda, Shunsuke Fujibayashi, Takayoshi Shimizu, Seiji Yamaguchi, Yaichiro Okuzu, Yusuke Takaoka, Soichiro Masuda, Mitsuru Takemoto, Toshiyuki Kawai, Bungo Otsuki, Koji Goto, Shuichi Matsuda
The treatment of critical-sized bone defects has long been a major problem for surgeons. In this study, an intramedullary nail shaped three-dimensional (3D)-printed porous titanium implant that is capable of releasing strontium ions was developed through a simple and cost-effective surface modification technique. The feasibility of this implant as a stand-alone solution was evaluated using a rabbit's segmental diaphyseal as a defect model. The strontium-loaded implant exhibited a favorable environment for cell adhesion, and mechanical properties that were commensurate with those of a rabbit's cortical bone...
March 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38359176/s-nitroso-n-acetylpenicillamine-impregnated-latex-a-new-class-of-barrier-contraception-for-the-prevention-of-intercourse-associated-utis
#15
JOURNAL ARTICLE
Sarah N Wilson, Patrick Maffe, Jitendra Pant, Bryan M Grommersch, Hitesh Handa
Urinary tract infections (UTIs) are some of the most common infections seen in humans, affecting over half of the female population. Though easily and quickly treatable, if gone untreated for too long, UTIs can lead to narrowing of the urethra as well as bladder and kidney infections. Due to the disease potential, it is crucial to mitigate the development of UTIs throughout healthcare. Unfortunately, sexual activity and the use of condoms have been identified as common risk factors for the development of sexually acquired UTIs...
February 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38359175/cellulose-nanocrystals-reinforced-dual-crosslinked-double-network-gelma-hyaluronic-acid-injectable-nanocomposite-cryogels-with-improved-mechanical-properties-for-cartilage-tissue-regeneration
#16
JOURNAL ARTICLE
Farinaz Jonidi Shariatzadeh, Atefeh Solouk, Hamid Mirzadeh, Shahin Bonakdar, Davoud Sadeghi, Shadab Bagheri Khoulenjani
Improvement of mechanical properties of injectable tissue engineering scaffolds is a current challenge. The objective of the current study is to produce a highly porous injectable scaffold with improved mechanical properties. For this aim, cellulose nanocrystals-reinforced dual crosslinked porous nanocomposite cryogels were prepared using chemically crosslinked methacrylated gelatin (GelMA) and ionically crosslinked hyaluronic acid (HA) through the cryogelation process. The resulting nanocomposites showed highly porous structures with interconnected porosity (>90%) and mean pore size in the range of 130-296 μm...
February 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38359174/varying-material-thickness-of-silicone-rubber-for-tunable-nitric-oxide-release
#17
JOURNAL ARTICLE
Patrick Maffe, Ryan Devine, Mark Garren, Hitesh Handa
Silicone rubber (SR), a common medical-grade polymer used in medical devices, has previously been modified for nitric oxide (NO) releasing capabilities. However, the effects of material properties such as film thickness on NO release kinetics are not well explored. In this study, SR is used in the first analysis of how a polymer's thickness affects the storage and uptake of an NO donor and subsequent release properties. Observed NO release trends show that a polymer's thickness results in tunable NO release...
February 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38359173/copper-doped-magnesium-phosphate-nanopowders-for-critical-size-calvarial-bone-defect-intervention
#18
JOURNAL ARTICLE
Sara A M El-Sayed, Shaimaa ElShebiney, Hanan H Beherei, Pradeep Kumar, Yahya E Choonara, Mostafa Mabrouk
Calvarial defects of bone present difficult clinical situations, and their restoration using biocompatible materials requires special treatments that enable bone regeneration. Magnesium phosphate (MgP) is known as an osteoinductive biomaterial because it contains Mg2+ ions and P ions that enhance the activity of osteoplast cells and help in bone regeneration. In this study, MgP and CuO-doped MgP were fabricated and characterized for their physicomechanical properties, particle size, morphology, surface area, antibacterial test, and in vitro bioactivity evaluation using the following techniques: X-rays diffraction, Fourier-transformer infrared, TEM, and Brunauer, Emmett and Teller (BET) surface area, X-rays photoelectron spectroscopy (XPS), and Scanning electron microscopy (SEM)...
February 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38359172/advancements-in-3d-printed-artificial-tendon
#19
REVIEW
Ahmad Alhaskawi, Haiying Zhou, Yanzhao Dong, Xiaodi Zou, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Abdulla, Tian Tu, Olga Alenikova, Sahar Abdalbary, Hui Lu
Millions of people have been reported with tendon injuries each year. Unfortunately, Tendon injuries are increasing rapidly due to heavy exercise and a highly aging population. In addition, the introduction of 3D-printing technology in the area of tendon repair and replacement has resolved numerous issues and significantly improved the quality of artificial tendons. This advancement has also enabled us to explore and identify the most effective combinations of biomaterials that can be utilized in this field...
February 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/38359171/enzyme-functionalized-hydrogel-film-for-extracorporeal-uric-acid-reduction
#20
JOURNAL ARTICLE
Jaturavit Pantakitcharoenkul, Jad Touma, Goran Jovanovic, Matthew Coblyn
Enzyme replacement therapy for hyperuricemia treatment has been proven effective for critical state hyperuricemia patients. Still, direct administration of recombinant uricase can induce several fatal side effects. To circumvent this drawback, hydrogel protein carriers can be used in platforms for extracorporeal treatment such as microscale-based devices. In this work, calcium alginate and poly-(vinyl alcohol) hydrogel films were studied for their urate oxidase immobilization and uric acid reduction, which could be implemented in microscale-based extracorporeal devices...
February 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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