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Journal of Biomedical Materials Research. Part B, Applied Biomaterials

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https://read.qxmd.com/read/30779478/osteogenic-ability-of-rat-bone-marrow-concentrate-is-at-least-as-efficacious-as-mesenchymal-stem-cells-in-vitro
#1
Yusuke Kohno, Tzuhua Lin, Jukka Pajarinen, Monica Romero-Lopez, Masahiro Maruyama, Jhih-Fong Huang, Karthik Nathan, Zhenyu Yao, Stuart B Goodman
Cell therapy using bone marrow concentrate (BMC) or purified and expanded mesenchymal stem cells (MSCs) has been shown to have a promising osteogenic capacity. However, few studies have directly compared their relative osteogenic ability. The aim of this study was to compare the osteogenic ability of BMC isolated by density gradient centrifugation with bone marrow-derived MSCs in vitro using the cells of 3-month-old Sprague-Dawley rats. The isolated cells were seeded onto 24-well plates (1 × 105  cells/well) and cultured in control growth media, osteogenic media with dexamethasone, or media without dexamethasone (which simulated the in vivo tissue environment)...
February 19, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30779430/evaluation-of-the-mechanisms-and-effects-of-mg-ag-y-alloy-on-the-tumor-growth-and-metastasis-of-the-mg63-osteosarcoma-cell-line
#2
Yilong Dai, Yifu Tang, Xuemei Xu, Zhongwei Luo, Yu Zhang, Zhaohui Li, Zhangyuan Lin, Shushan Zhao, Min Zeng, Buhua Sun, Liang Cheng, Jianxi Zhu, Zeng Xiong, Haitao Long, Yong Zhu, Kun Yu
Osteosarcoma is a malignant primary bone tumor, which often associates with pulmonary metastasis. The radical surgery of osteosarcoma often requires internal orthopedic implants. Therefore, implants with antitumor properties should be developed. Magnesium (Mg) and its alloys possess great potential as orthopedic materials, given their biodegradable properties, superior osteogenesis performance, and antitumor features. However, problems arise with their uncontrolled degradation rates and their unknown antitumor mechanisms...
February 19, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30775847/biomechanical-characterization-of-a-novel-collagen-hyaluronan-infused-3d-printed-polymeric-device-for-partial-meniscus-replacement
#3
Salim A Ghodbane, Jay M Patel, Andrzej Brzezinski, Tyler M Lu, Charles J Gatt, Michael G Dunn
The menisci transmit load by increasing the contact area and decreasing peak contact stresses on the articular surfaces. Meniscal lesions are among the most common orthopedic injuries, and resulting meniscectomies are associated with adverse polycaprolactone contact mechanics changes and, ultimately, an increased likelihood of osteoarthritis. Meniscus scaffolds were fabricated by 3D-printing a network of circumferential and radial filaments of resorbable polymer (poly(desaminotyrosyl-tyrosine dodecyl ester dodecanoate)) and infused with collagen-hyaluronan...
February 18, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30775843/in-vivo-comparison-of-shape-memory-polymer-foam-coated-and-bare-metal-coils-for-aneurysm-occlusion-in-the-rabbit-elastase-model
#4
Scott M Herting, Yonghong Ding, Anthony J Boyle, Daying Dai, Landon D Nash, Solmaz Asnafi, Daniel R Jakaitis, Collin R Johnson, Lance M Graul, Chung Yeh, David F Kallmes, Ramanathan Kadirvel, Duncan J Maitland
Shape memory polymer (SMP) foam-coated coils (FCCs) are new embolic coils coated with porous SMP designed to expand for increased volume filling and enhanced healing after implantation. The purpose of this study was to compare chronic aneurysm healing after treatment with SMP FCCs to bare platinum coil (BPC) controls in the rabbit elastase aneurysm model. BPCs or SMP FCCs were implanted in rabbit elastase-induced aneurysms for follow-up at 30 days (n = 10), 90 days (n = 5), and 180 days (n = 12 for BPCs; n = 14 for SMP FCCs)...
February 18, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30773803/self-assembling-water-soluble-polymethacrylate-mtx-conjugates-the-significance-of-macromolecules-architecture-on-drug-conjugation-efficiency-the-final-shape-of-particles-and-drug-release
#5
Katarzyna Bernaczek, Anna Mielańczyk, Łukasz Mielańczyk, Dorota Neugebauer, Zbigniew Jan Grzywna
Water-soluble polymer-methotrexate (MTX) conjugates were obtained via efficient carbodiimide-mediated amidation (E = 17-100%). Binding abilities between water-soluble V-shaped or star-shaped copolymers and MTX were studied by isothermal titration calorimetry spectroscopic (UV-vis, NMR) and microscopic (scanning electron microscopy and transmission electron microscopy) techniques. The efficiency of the amidation reaction has depended on the amount of pendant amino alcohol groups and zeta potential (ZP) values of polymeric carries...
February 18, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30767394/effects-of-solvent-used-for-fabrication-on-drug-loading-and-release-kinetics-of-electrosprayed-temozolomide-loaded-plga-microparticles-for-the-treatment-of-glioblastoma
#6
Daniel A Rodriguez de Anda, Nareg Ohannesian, Karen S Martirosyan, Sue Anne Chew
Glioblastoma multiforme (GBM) is the most common and invasive form of malignant brain tumors and despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with GBM still remains poor. Temozolomide (TMZ) is the chemotherapy drug that is most commonly given orally after surgical resection of these tumors. In this study, the effects of solvents (i.e., dichloromethane and acetonitrile) used for the fabrication of electrosprayed TMZ-loaded poly(lactic-co-glycolic acid) (PLGA) on drug loading, loading efficiency, drug release kinetics, surface morphology, and particle size were investigated...
February 15, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30767383/ethanol-mediated-compaction-and-cross-linking-enhance-mechanical-properties-and-degradation-resistance-while-maintaining-cytocompatibility-of-a-nucleus-pulposus-scaffold
#7
Joshua D Walters, Sanjitpal S Gill, Jeremy J Mercuri
Intervertebral disc degeneration is a complex, cell-mediated process originating in the nucleus pulposus (NP) and is associated with extracellular matrix catabolism leading to disc height loss and impaired spine kinematics. Previously, we developed an acellular bovine NP (ABNP) for NP replacement that emulated human NP matrix composition and supported cell seeding; however, its mechanical properties were lower than those reported for human NP. To address this, we investigated ethanol-mediated compaction and cross-linking to enhance the ABNP's dynamic mechanical properties and degradation resistance while maintaining its cytocompatibility...
February 15, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30763463/gingipains-impair-attachment-of-epithelial-cell-to-dental-titanium-abutment-surfaces
#8
Sigrun Eick, Naida Gadzo, Manuel Tacchi, Anton Sculean, Jan Potempa, Andreas Stavropoulos
The study investigated in vitro the effect of Porphyromonas gingivalis and its cysteine proteases (gingipains) on epithelial cell adhesion to titanium-zirconium alloy surfaces. Titanium-zirconium discs with a standard machined (M) or chemically modified hydrophilic surface (modM) were coated with lamin-5 and incubated with telomerase-inactivated gingival keratinocytes (TIGK). Three P. gingivalis strains or gingipains were either added simultaneously with TIGK or after TIGK cells were already attached to the disks...
February 14, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30758129/fabrication-and-evaluation-of-bacterial-nanocellulose-poly-acrylic-acid-graphene-oxide-composite-hydrogel-characterizations-and-biocompatibility-studies-for-wound-dressing
#9
Xiang Yi Chen, Hao Ran Low, Xin Yi Loi, Laura Merel, Mohd Amin Mohd Cairul Iqbal
Graphene oxide (GO) is a potential material for wound dressing due to its excellent biocompatibility and mechanical properties. This study evaluated the effects of GO concentration on the synthesis of bacterial nanocellulose (BNC)-grafted poly(acrylic acid) (AA)-graphene oxide (BNC/P(AA)/GO) composite hydrogel and its potential as wound dressing. Hydrogels were successfully synthesized via electron-beam irradiation. The hydrogels were characterized by their mechanical properties, bioadhesiveness, water vapor transmission rates (WVTRs), water retention abilities, water absorptivity, and biocompatibility...
February 13, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30735289/topography-enhances-runx2-expression-in-outgrowing-cells-from-ips-cell-derived-embryoid-bodies
#10
Akram Al-Wahabi, Tungalag Ser-Od, Kenji Inoue, Kei Nakajima, Kenichi Matsuzaka, Takashi Inoue
The effect of differing polystyrene substrate topographies on the osteogenic potential of the outgrowing cells (OGCs) formed from mouse-induced pluripotent stem (iPS) cells (miPSCs)-derived embryoid bodies (EBs) was investigated. Polystyrene substrates were sandblasted with 25, 50, and 150 μm aluminum oxide particles to obtain topographies with average Sa values of 0.6, 1.1, and 1.8 μm, respectively. 3D-SEM was used to evaluate substrate's topographies. Examination was done by scanning electron microscopy (SEM), by immunocytofluorescence (ICF) analysis for vinculin, Runx2 and collagen type I, and by quantitative RT-PCR (qRT-PCR) analysis for Runx2 and collagen type I...
February 8, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30707487/degradation-behaviors-and-cytocompatibility-of-mg-%C3%AE-tricalcium-phosphate-composites-produced-by-spark-plasma-sintering
#11
Kai Narita, Qiaomu Tian, Ian Johnson, Chaoxing Zhang, Equo Kobayashi, Huinan Liu
Magnesium (Mg)-based materials have shown great potentials for bioresorbable implant applications. Previous studies showed that Mg with 10 and 20 vol % β-tricalcium phosphate (β-TCP) composites produced by spark plasma sintering, improved mechanical properties when compared with pure Mg. The objectives of this study were to evaluate the degradation behaviors of Mg/10% β-TCP and Mg/20% β-TCP composites in revised stimulated body fluid (rSBF), and to determine their cytocompatibility with bone marrow derived mesenchymal stem cells (BMSCs) using the direct culture method...
February 1, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30706677/sterilization-effects-on-the-handling-and-degradation-properties-of-calcium-phosphate-cements-containing-poly-d-l-lactic-co-glycolic-acid-porogens-and-carboxymethyl-cellulose
#12
Nathan W Kucko, Wenliang Li, Marcela A García Martinez, Ihtesham Ur Rehman, Ann-Sissel Teialeret Ulset, Bjørn E Christensen, Sander C G Leeuwenburgh, Ralf-Peter Herber
Injectable, self-setting calcium phosphate cements (CPCs) are synthetic bone substitutes considered favorable for the repair and regeneration of bone due to their osteocompatibility and unique handling properties. However, their clinical applicability can be compromised due to insufficient cohesion upon injection into the body coupled with poor degradation rates that restricts new bone formation. Consequently, carboxymethyl cellulose (CMC) was incorporated into CPC formulations to improve their cohesion and injectability while poly (D,L -lactic-co-glycolic acid) (PLGA) porogens were added to introduce macroporosity and improve their biodegradation rate...
February 1, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30701676/repair-of-cartilage-defects-with-devitalized-osteochondral-tissue-a-pilot-animal-study
#13
Bettina Hiemer, Berit Genz, Jürgen Ostwald, Anika Jonitz-Heincke, Andreas Wree, Tobias Lindner, Thomas Tischer, Steffen Dommerich, Rainer Bader
Devitalization using high hydrostatic pressure (HHP) treatment inactivates cells while matrix structure and biomechanical properties are maintained. Because of strong chondroinductive potential of HHP-devitalized cartilage matrix, it may be used as scaffold for reconstruction of (osteo-)chondral lesions. In this pilot study, we evaluated the feasibility of HHP-devitalized osteochondral tissue to repair osteochondral defects in a rabbit model. Removal and reimplantation of osteochondral plugs were performed in 12 female New Zealand White rabbits...
January 30, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30697956/the-optimal-incubation-time-for-in-vitro-hemocompatibility-testing-assessment-using-polymer-reference-materials-under-pulsatile-flow-with-physiological-wall-shear-stress-conditions
#14
Sjoerd Leendert Johannes Blok, Willem van Oeveren, Gerwin Erik Engels
During hemocompatibility testing, activation products may reach plateau values which can result in less distinction between hemocompatible and hemo-incompatible materials. Of concern is an underestimation of the blood activation caused by the biomaterial of interest, which may result in a false assessment of hemocompatibility. To elucidate the optimal incubation time for in vitro hemocompatibility testing, we used the Haemobile circulation model with human whole blood. Blood from healthy volunteers was in vitro incubated under pulsatile flow with physiological wall shear stress conditions at 37°C for 30, 60, 120, or 240 min...
January 29, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30697924/topical-film-prepared-with-rhus-verniciflua-extract-loaded-pullulan-hydrogel-for-atopic-dermatitis-treatment
#15
Ji Heun Jeong, Seung Keun Back, Jong Hun An, Nam-Seob Lee, Do-Kyung Kim, Chun Soo Na, Young-Gil Jeong, Seung Yun Han
Atopic dermatitis (AD) is characterized by relapsing pruritus and skin dryness. Due to the pathogenic multiplicity and the adverse effects associated with the current therapeutics, development of transdermal drug delivery system is becoming an area of interest. Here, a novel topical film prepared with Rhus verniciflua extract (RVE)-loaded pullulan hydrogel (RVE@PH) was synthesized and tested its therapeutic efficacy on the AD rats modeled by neonatal capsaicin injection method. The RVE@PH was characterized by a Fourier-transform infrared spectroscopy and an in vitro release assay...
January 29, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30690889/effect-of-the-configuration-of-poly-lactic-acid-and-content-of-poly-oxyethylene-blocks-to-the-structure-and-functional-properties-of-poly-lactic-acid-block-poly-oxirane-based-nanofibrous-electrospun-polyester-ether-urethanes-used-as-potential-drug-delivery
#16
Alena Pavelková, Pavel Kucharczyk, Zdenka Capáková, Petra Peer, Martina Pummerová, Jiří Zedník, Jiří Vohlídal, Vladimír Sedlařík
Poly(lactic acid)-block-poly(oxirane)s (PLA-b-POE) of various compositions were prepared using a one-pot approach and then extended in a reaction with l-lysine diethyl ester diisocyanate, thereby forming polyester-ether-urethanes (PEU) with prolonged chains and units with increased degradability. The PEUs are processed by electrospinning to prepare degradable nanofibrous sheet materials with and without encapsulating the antibiotic Vancomycin (VAC). PLA block isomerism and POE blocks oligomeric content (1000 g/mol) affect the thermal properties, processability, nanofibrous sheet morphology, abiotic degradation, cytocompatibility, and encapsulated antibiotic release rate of prepared PEUs...
January 28, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30690870/nanomaterials-as-potential-and-versatile-platform-for-next-generation-tissue-engineering-applications
#17
REVIEW
Rubbel Singla, Syed M S Abidi, Aqib Iqbal Dar, Amitabha Acharya
Tissue engineering (TE) is an emerging field where alternate/artificial tissues or organ substitutes are implanted to mimic the functionality of damaged or injured tissues. Earlier efforts were made to develop natural, synthetic, or semisynthetic materials for skin equivalents to treat burns or skin wounds. Nowadays, many more tissues like bone, cardiac, cartilage, heart, liver, cornea, blood vessels, and so forth are being engineered using 3-D biomaterial constructs or scaffolds that could deliver active molecules such as peptides or growth factors...
January 28, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30689292/fabrication-and-modification-of-wavy-multicomponent-vascular-grafts-with-biomimetic-mechanical-properties-antithrombogenicity-and-enhanced-endothelial-cell-affinity
#18
Hao-Yang Mi, Xin Jing, Zhu-Tong Li, Yu-Jyun Lin, James A Thomson, Lih-Sheng Turng
A mismatch of mechanical properties and a high rate of thromboses are two critical challenges of creating viable artificial small-diameter vascular grafts (SDVGs). Herein, we propose a method to fabricate wavy multicomponent vascular grafts (WMVGs) via electrospinning using an assembled rotating collector. The WMVGs consisted of a wavy silk/poly(lactic acid) (PLA) inner layer and a thermoplastic polyurethane (TPU) outer layer, which mimic the structures and properties of collagen and elastin in native blood vessels, respectively...
January 28, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30689290/anticancer-effect-of-novel-platinum-nanocomposite-beads-on-oral-squamous-cell-carcinoma-cells
#19
Mai Tanaka, Toshinori Okinaga, Kenjiro Iwanaga, Kou Matsuo, Takashi Toyono, Masaaki Sasaguri, Wataru Ariyoshi, Kazuhiro Tominaga, Yasushi Enomoto, Yasufumi Matsumura, Tatsuji Nishihara
Nanoparticles are used in industry and medicine, because of their physiochemical properties, such as size, charge, large surface area and surface reactivity. Recently, metal nanoparticles were reported to show cell toxicity on cancer cells. In this study, we focused novel platinum nanoparticles-conjugated latex beads (P2VPs), platinum nanocomposite (PtNCP) beads, and investigated the possibility to incorporate novel anti-cancer effect of these combined nanoparticles. Oral squamous cell carcinoma cell lines, HSC-3-M3 cells were injected subcutaneously into the back of nude mice to produce a xenograft model...
January 28, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/30689288/cocr-porous-scaffolds-manufactured-via-selective-laser-melting-in-orthopedics-topographical-mechanical-and-biological-characterization
#20
Paolo Caravaggi, Erica Liverani, Alberto Leardini, Alessandro Fortunato, Claudio Belvedere, Fabio Baruffaldi, Milena Fini, Annapaola Parrilli, Monica Mattioli-Belmonte, Luca Tomesani, Stefania Pagani
Over the last decade, advances in additive manufacturing have allowed to obtain complex 3D porous lattice in materials suitable for orthopedic applications. Whereas 3D-melted titanium alloys have been extensively investigated, little is the current knowledge on the feasibility of bone-replicating CoCr porous scaffolds manufactured via selective laser melting (SLM). Moreover, the effect of topography on bone cells viability and proliferation has not been fully explored yet. Small cylindrical porous lattices were modeled from micro-CT images of human trabecular bone, and from the repetition of spherical-hollow and body-centered cubic unit cells, and manufactured via SLM from CoCr powder...
January 28, 2019: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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