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Jie Kai Tee, Magdiel Inggrid Setyawati, Fei Peng, David Tai Leong, Han Kiat Ho
Nanoparticles (NPs) have been widely used in biomedical field for therapeutic treatments, drug carriers, and bio-imaging agent. Recent studies have highlighted the possibility of utilizing inorganic NPs in inducing endothelial leakiness through endothelial remodeling to promote drug transport across the barrier. However, an uncontrolled and persistent leakiness could lead to promiscuous transport of molecules and cells across the barrier, highlighting the pressing need to control the timely recovery from endothelial cell leakiness...
February 19, 2019: Nanotoxicology
Fengbang Wang, Ying Chen, Yuanyuan Wang, Yongguang Yin, Guangbo Qu, Maoyong Song, Hailin Wang
Asbestos fiber has been associated with mesothelioma and lung cancer. However, the carcinogenic risks of other fiber nanomaterials with morphological similarities to asbestos have not been fully studied. Ultra-long silver nanowires (AgNWs) are increasingly used fiber-shaped nanomaterials with a high aspect ratio, but very few studies have investigated their health risks. Here, proliferation abnormalities of lung epithelial cells induced by ultra-long AgNWs were investigated. Ultra-long AgNW treatment induced dose- and diameter-dependent increase in the ratio of multinucleated cells...
February 19, 2019: Nanotoxicology
M N Fernández, R Muñoz-Olivas, J L Luque-Garcia
Silver nanoparticles are currently one of the most widely used metallic nanoparticles. Due to their antibacterial properties, they are applied in textiles, house-holds items, and medical devices, among many other products. Understanding the potential toxicity associated with silver nanoparticles and the differential effect that nanoparticles of different size might induce is crucial, due to the increasing human and environmental exposure to this type of nanoparticles. In this work, we explored the different biomolecular mechanisms underlying the toxicity of silver nanoparticles in a size-dependent manner...
February 18, 2019: Nanotoxicology
Lisa M Rossbach, Erica Maremonti, Dag M Eide, Deborah H Oughton, Dag A Brede
Toxic effects of silver nanoparticles (Ag NPs) are, in most cases, measured within a single generation, while information regarding multigenerational exposure remains scarce. The current study assessed changes in toxic response (reproduction, fertility, and development) towards Ag NPs (NM300K; uncoated, 16.7 ± 6.5 nm) compared to AgNO3 over six generations, following chronic exposure of the model organism Caenorhabditis elegans. This revealed that AgNO3 exposure was associated with no changes in susceptibility to Ag...
February 18, 2019: Nanotoxicology
Ricky W Lewis, Paul M Bertsch, David H McNear
Deposition of engineered nanomaterials (ENMs) in various environmental compartments is projected to continue rising exponentially. Terrestrial environments are expected to be the largest repository for environmentally released ENMs. Because ENMs are enriched in biosolids during wastewater treatment, agriculturally applied biosolids facilitate ENM exposure of key soil micro-organisms, such as plant growth-promoting rhizobacteria (PGPR). The ecological ramifications of increasing levels of ENM exposure of terrestrial micro-organisms are not clearly understood, but a growing body of research has investigated the toxicity of ENMs to various soil bacteria using a myriad of toxicity end-points and experimental procedures...
February 14, 2019: Nanotoxicology
Nathalie Leynen, Frank G A J Van Bellegem, Annelies Wouters, Hannelore Bove, Jan-Pieter Ploem, Elsy Thijssen, Sabine A S Langie, Robert Carleer, Marcel Ameloot, Tom Artois, Karen Smeets
Silver nanoparticles (AgNPs) belong to the most commercialized nanomaterials, used in both consumer products and medical applications. Despite its omnipresence, in-depth knowledge on the potential toxicity of nanosilver is still lacking, especially for developing organisms. Research on vertebrates is limited due to ethical concerns, and planarians are an ideal invertebrate model to study the effects of AgNPs on stem cells and developing tissues in vivo, as regeneration mimics development by triggering massive stem cell proliferation...
February 14, 2019: Nanotoxicology
S Barillet, E Fattal, S Mura, N Tsapis, M Pallardy, H Hillaireau, S Kerdine-Römer
Modified nanoparticles (NPs) can interact with the immune system by causing its activation to fight tumors or for vaccination. During this activation, dendritic cells (DCs) are effective in generating robust immune response. However, the effect of nanomaterials on dendritic cell (DC) maturation, and the associated adjuvant effect, should be assessed as a novel biocompatibility criteria for biomaterials since immune consequences may constitute potential complications in nanomedicine. Among emerging biomaterials, poly(lactic-co-glycolic acid) NPs (PLGA NPs) are widely explored for various applications in which the degree of desired adjuvant effect may vary...
February 14, 2019: Nanotoxicology
Marzena Szwed, Tonje Sønstevold, Anders Øverbye, Nikolai Engedal, Beata Grallert, Ýrr Mørch, Einar Sulheim, Tore-Geir Iversen, Tore Skotland, Kirsten Sandvig, Maria L Torgersen
For optimal exploitation of nanoparticles (NPs) in biomedicine, and to predict nanotoxicity, detailed knowledge of the cellular responses to cell-bound or internalized NPs is imperative. The final outcome of NP-cell interaction is dictated by the type and magnitude of the NP insult and the cellular response. Here, this has been systematically studied by using poly(alkylcyanoacrylate) (PACA) particles differing only in their alkyl side chains; butyl (PBCA), ethylbutyl (PEBCA), or octyl (POCA), respectively. Surprisingly, these highly similar NPs induced different stress responses and modes of cell death in human cell lines...
February 14, 2019: Nanotoxicology
Robert A Yokel, Matthew L Hancock, Eric A Grulke, Jason M Unrine, Alan K Dozier, Uschi M Graham
Ligands that accelerate nanoceria dissolution may greatly affect its fate and effects. This project assessed the carboxylic acid contribution to nanoceria dissolution in aqueous, acidic environments. Nanoceria has commercial and potential therapeutic and energy storage applications. It biotransforms in vivo. Citric acid stabilizes nanoceria during synthesis and in aqueous dispersions. In this study, citrate-stabilized nanoceria dispersions (∼4 nm average primary particle size) were loaded into dialysis cassettes whose membranes passed cerium salts but not nanoceria particles...
February 7, 2019: Nanotoxicology
Huimin Shao, Zhongyu Han, Natalia Krasteva, Dayong Wang
The molecular response of animals to nanoplastic particles is still largely unclear. In this study, we employed a modified prolonged exposure system to investigate the molecular response of Caenorhabditis elegans to nanopolystyrene particles. Exposure to nanopolystyrene particles (1 μg/L) significantly decreased expressions of daf-2 encoding an insulin receptor, age-1 encoding a PI3K, and akt-1 encoding an Akt/PKB, and increased expression of daf-16 encoding a FOXO transcriptional factor in insulin signaling pathway...
February 7, 2019: Nanotoxicology
Lin Li, Lu Li, Xuejiao Zhou, Yang Yu, Zengqiang Li, Daiying Zuo, Yingliang Wu
Silver nanoparticles (AgNPs) are widely used for manufacturing products containing antibacterial agents, as well as food technologies such as edible films and food packaging. Routes of AgNPs exposure are principally derived by contacting with certain medical sprays, food, toothpaste, and purification products. Previously, we showed that AgNPs induce endoplasmic reticulum (ER) stress and promote apoptosis progression in SH-SY5Y cells; however, whether AgNP-induced ER stress is able to trigger autophagy in vivo and in vitro, and the role of autophagy in AgNP-induced cytotoxicity remain unclear...
February 7, 2019: Nanotoxicology
Mehulkumar Patel, Silvia H De Paoli, Oumsalama K Elhelu, Sehrish Farooq, Jan Simak
Different nanomaterials are under development for various biomedical applications in which nanoparticles contact blood and vasculature. Therefore, investigating the interactions between nanomaterials and vascular endothelial cells (ECs) is of great importance. Here, we show the effects of polyamidoamine (PAMAM) dendrimers of two different sizes, generation 2 (G2; approximately 3 nm diameter) and generation 7 (G7; 9 nm), with neutral (OH-terminated), anionic (COOH-terminated), and cationic (NH2 -terminated) surface modifications on cultured human umbilical vein ECs (HUVECs)...
February 7, 2019: Nanotoxicology
Jiaqi Tan, Qixin He, Jennifer T Pentz, Cheng Peng, Xian Yang, Meng-Hsiu Tsai, Yongsheng Chen, William C Ratcliff, Lin Jiang
Engineered nanomaterials are rapidly becoming an essential component of modern technology. Thousands of tons of nanomaterials are manufactured, used, and subsequently released into the environment annually. While the presence of these engineered nanomaterials in the environment has profound effects on various biological systems in the short term, little work has been done to understand their consequences over long, evolutionary timescales. The evolution of multicellularity is a critical step in the origin of complex life on Earth and a unique strategy for microorganisms to alleviate adverse environmental impacts, yet the selective pressures that favor the evolution of multicellular groups remain poorly understood...
February 7, 2019: Nanotoxicology
Feng Dong, Yan Zhou
Silver nanoparticles (AgNP) undergo various transformations into different Ag species in the environment, which determines their toxicity in microorganisms. In aerobic condition, AgNPs release Ag+ that causes cell inactivation. Limited information is known about the AgNP-cell interaction in oxygen-free environment. Here we compared the transformation and antibacterial effects of AgNPs in aerobic and anaerobic environment. The bacterium Pseudomonas aeruginosa was relatively not susceptible to Ag+ or AgNP in anaerobic environment, indicated by near two orders of magnitude greater of anaerobic minimum inhibitory concentration (MIC) than the aerobic counterpart...
February 7, 2019: Nanotoxicology
Henning Wigger, Bernd Nowack
Engineered nanomaterials (ENMs) are intentionally designed in different nano-forms of the same parent material in order to meet application requirements. Different grouping and read-across concepts are proposed to streamline risk assessments by pooling nano-forms in one category. Environmental grouping concepts still are in their infancy and mainly focus on grouping by hazard categories. Complete risk assessments require data on environmental release and exposure not only for ENMs but also for their nano-forms...
February 7, 2019: Nanotoxicology
M van Pomeren, W J G M Peijnenburg, R C Vlieg, S J T van Noort, M G Vijver
Important questions raised in (nano)ecotoxicology are whether biodistribution of nanoparticles (NPs) is affected by particle shape and to what extent local adverse responses are subsequently initiated. For nanomedicine, these same questions become important when the labeled NPs lose the labeling. In this study, we investigated the biodistribution patterns of gold nanoparticles (AuNPs) as well as immune-related local and systemic sublethal markers of exposure and behavioral assessment. Hatched zebrafish embryos were exposed to four differently shaped non-coated AuNPs with comparable sizes: nanospheres, nanorods, nano-urchins, and nano-bipyramids...
February 4, 2019: Nanotoxicology
Vitalii Patsula, Jana Tulinska, Štěpánka Trachtová, Miroslava Kuricova, Aurelia Liskova, Alena Španová, Fedor Ciampor, Ivo Vavra, Bohuslav Rittich, Monika Ursinyova, Mária Dusinska, Silvia Ilavska, Mira Horvathova, Vlasta Masanova, Iveta Uhnakova, Daniel Horák
Innovative nanotechnology aims to develop particles that are small, monodisperse, smart, and do not cause unintentional side effects. Uniform magnetic Fe3 O4 nanoparticles (12 nm in size) were prepared by thermal decomposition of iron(III) oleate. To make them colloidally stable and dispersible in water and cell culture medium, they were modified with phosphonic acid- (PA) and hydroxamic acid (HA)-terminated poly(ethylene glycol) yielding PA-PEG@Fe3 O4 and HA-PEG@Fe3 O4 nanoparticles; conventional γ-Fe2 O3 particles were prepared as a control...
February 1, 2019: Nanotoxicology
Songshan Wang, Jitao Lv, Shuzhen Zhang
The molecular mechanisms behind the adaptive responses for interactions between organisms and nanoparticles, such as silver nanoparticles (AgNPs), are of great concern. In this study, the transcriptome of freshwater alga Chlamydomonas reinhardtii was characterized via RNA sequencing (RNA-seq) after exposure to a nontoxic concentration of AgNPs (0.5 mg/L). The cytochrome c6 (CYC6) and ferredoxin-5 (FDX5) genes were identified with the greatest increase in expression level, which were indications of the copper deficiency in the algae...
February 1, 2019: Nanotoxicology
Chang Guo, Sarah Robertson, Ralf J M Weber, Alison Buckley, James Warren, Alan Hodgson, Joshua Z Rappoport, Konstantin Ignatyev, Kirsty Meldrum, Isabella Römer, Sameirah Macchiarulo, James Kevin Chipman, Tim Marczylo, Martin O Leonard, Timothy W Gant, Mark R Viant, Rachel Smith
Cerium oxide nanoparticles (CeO2 NPs), used in some diesel fuel additives to improve fuel combustion efficiency and exhaust filter operation, have been detected in ambient air and concerns have been raised about their potential human health impact. The majority of CeO2 NP inhalation studies undertaken to date have used aerosol particles of larger sizes than the evidence suggests are emitted from vehicles using such fuel additives. Hence, the objective of this study was to investigate the effects of inhaled CeO2 NP aerosols of a more environmentally relevant size, utilizing a combination of methods, including untargeted multi-omics to enable the broadest possible survey of molecular responses and synchrotron X-ray spectroscopy to investigate cerium speciation...
February 1, 2019: Nanotoxicology
Quincy A Hathaway, Andrya J Durr, Danielle L Shepherd, Mark V Pinti, Ashley N Brandebura, Cody E Nichols, Amina Kunovac, William T Goldsmith, Sherri A Friend, Alaeddin B Abukabda, Garrett K Fink, Timothy R Nurkiewicz, John M Hollander
Nano-titanium dioxide (nano-TiO2 ), though one of the most utilized and produced engineered nanomaterials (ENMs), diminishes cardiovascular function through dysregulation of metabolism and mitochondrial bioenergetics following inhalation exposure. The molecular mechanisms governing this cardiac dysfunction remain largely unknown. The purpose of this study was to elucidate molecular mediators that connect nano-TiO2 exposure with impaired cardiac function. Specifically, we were interested in the role of microRNA (miRNA) expression in the resulting dysfunction...
February 1, 2019: Nanotoxicology
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