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Journal of Inflammation

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https://read.qxmd.com/read/30728752/inhibition-of-pstat1-by-tofacitinib-accounts-for-the-early-improvement-of-experimental-chronic-synovitis
#1
Sandra Pérez-Baos, Paula Gratal, Juan I Barrasa, Ana Lamuedra, Olga Sánchez-Pernaute, Gabriel Herrero-Beaumont, Raquel Largo
Background: In order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial activation of STATs and their end-products, along with their modification with tofacitinib (TOFA), at flare-up in antigen induced arthritis (AIA). New Zealand rabbits were randomly assigned to four groups -healthy controls, AIA, TOFA-treated AIA, or TOFA-treated controls-. AIA was induced with 4 weekly intra-articular ovalbumin injections in sensitized animals...
2019: Journal of Inflammation
https://read.qxmd.com/read/30675131/biomarkers-for-acute-respiratory-distress-syndrome-and-prospects-for-personalised-medicine
#2
REVIEW
Savino Spadaro, Mirae Park, Cecilia Turrini, Tanushree Tunstall, Ryan Thwaites, Tommaso Mauri, Riccardo Ragazzi, Paolo Ruggeri, Trevor T Hansel, Gaetano Caramori, Carlo Alberto Volta
Acute lung injury (ALI) affects over 10% of patients hospitalised in critical care, with acute respiratory distress syndrome (ARDS) being the most severe form of ALI and having a mortality rate in the region of 40%. There has been slow but incremental progress in identification of biomarkers that contribute to the pathophysiology of ARDS, have utility in diagnosis and monitoring, and that are potential therapeutic targets (Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA, Thompson T, Ware LB, Matthay MA, Lancet Respir Med 2014, 2:611--620)...
2019: Journal of Inflammation
https://read.qxmd.com/read/30574022/the-role-of-n-glycosylation-of-cd200-cd200r1-interaction-in-classical-microglial-activation
#3
Chao Liu, Yifen Shen, Ying Tang, Yongchun Gu
Background: Microglial inflammatory activation is the common feature of the central nervous system (CNS) diseases. Microglia can be activated and particularly polarized toward a dual role in the injured CNS. The CD200 receptor 1 (CD200R1) inhibits inflammatory microglia activation as illustrated by studies. Publications show abnormal activation of microglia secondary to the deficient inhibit of CD200-CD200R interaction. In the present study, we established a neuronal-microglia co-culture system to investigate the association between CD200R1 engagement and classical microglial activation...
2018: Journal of Inflammation
https://read.qxmd.com/read/30564065/transient-receptor-potential-ankyrin-1-trpa1-mediates-il-1%C3%AE-induced-apoptosis-in-rat-chondrocytes-via-calcium-overload-and-mitochondrial-dysfunction
#4
Songjiang Yin, Li Zhang, Liang Ding, Zhengquan Huang, Bo Xu, XiaoChen Li, Peimin Wang, Jun Mao
Background: Chondrocyte apoptosis is a central feature in the progression of osteoarthritis (OA), and would be triggered by sustained elevation of intracellular calcium ion (Ca2+ ), also known as a cellular second messenger. Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, and the activation of which causes an influx of cation ions, in particularly Ca2+ , into the activated cells. Therefore, we investigate the potential role of TRPA1 in mediating Ca2+ influx to promote chondrocyte apoptosis in OA...
2018: Journal of Inflammation
https://read.qxmd.com/read/30534004/dynamics-of-soluble-vascular-endothelial-growth-factor-receptors-and-their-ligands-in-aqueous-humour-during-ranibizumab-for-age-related-macular-degeneration
#5
Ryosuke Motohashi, Hidetaka Noma, Kanako Yasuda, Osamu Kotake, Hiroshi Goto, Masahiko Shimura
Background: Intravitreal ranibizumab injection (IRI) is effective for patients with exudative age-related macular degeneration (AMD) and decreases intraocular levels of vascular endothelial growth factor (VEGF), but VEGF receptor intraocular dynamics after IRI are unclear. Therefore, we evaluated changes in the aqueous humor levels of soluble vascular endothelial growth factor receptor (sVEGFR)-1, sVEGFR-2, and their ligands for these receptors (VEGF) patients with AMD receiving IRI. Methods: The subjects were 24 patients with AMD (24 eyes) who received 3 doses of IRI at monthly intervals...
2018: Journal of Inflammation
https://read.qxmd.com/read/30534003/cannabinoid-2-receptor-attenuates-inflammation-during-skin-wound-healing-by-inhibiting-m1-macrophages-rather-than-activating-m2-macrophages
#6
Yu Du, Peng Ren, Qi Wang, Shu-Kun Jiang, Miao Zhang, Jiao-Yong Li, Lin-Lin Wang, Da-Wei Guan
Background: The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by regulating macrophage polarisation. Several research findings suggested that the activation of CB2R could attenuate inflammation by reducing pro-inflammatory M1 macrophage polarisation and promoting anti-inflammatory M2 polarisation. However, considering CB2R inhibits fibrosis and M2 promotes fibrosis, that the activation of CB2R may lead to an increase in M2 macrophages seems contradictory...
2018: Journal of Inflammation
https://read.qxmd.com/read/30498399/suppression-of-hyperexcitability-of-trigeminal-nociceptive-neurons-associated-with-inflammatory-hyperalgesia-following-systemic-administration-of-lutein-via-inhibition-of-cyclooxygenase-2-cascade-signaling
#7
Yumiko Syoji, Ryota Kobayashi, Nako Miyamura, Tsukasa Hirohara, Yoshiko Kubota, Nobuo Uotsu, Kei Yui, Yoshihito Shimazu, Mamoru Takeda
Introduction: Lutein is a dietary constituent known to inhibit inflammation; however, its effect on nociceptive neuron-associated hyperalgesia remains to be determined. The present study therefore investigated under in vivo conditions whether administration of lutein attenuates the inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) neurons that is associated with mechanical hyperalgesia. Results: Complete Freund's adjuvant (CFA) was injected into the whisker pads of rats to induce inflammation, and then mechanical stimulation was applied to the orofacial area to assess the threshold of escape...
2018: Journal of Inflammation
https://read.qxmd.com/read/30479572/circulating-natural-antibodies-to-inflammatory-cytokines-are-potential-biomarkers-for-atherosclerosis
#8
Peng Wang, Huan Zhao, Zhenqi Wang, Xuan Zhang
Background: Inflammatory cytokines contribute to the development of atherosclerosis. Natural antibodies in the circulation have protective effects on common diseases including atherosclerosis-related conditions. Purpose: The present study aimed to investigate the possible involvement of circulating IgG antibodies against inflammatory cytokines in atherosclerosis. Methods: A total of 220 patients with diagnosis of atherosclerosis and 200 healthy controls were recruited...
2018: Journal of Inflammation
https://read.qxmd.com/read/30473634/contribution-of-the-inflammasome-to-inflammaging
#9
Nancy H Mejias, Camila C Martinez, Marisa E Stephens, Juan Pablo de Rivero Vaccari
Background: Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer's disease and Parkinson's disease. The inflammasome is a multi-protein complex of the innate immune response involved in the activation of caspase-1 and the processing of the inflammatory cytokines interleukin (IL)-1β and IL-18. We have previously shown that the inflammasome plays a role in the aging process in the brain...
2018: Journal of Inflammation
https://read.qxmd.com/read/30473633/the-severity-of-lps-induced-inflammatory-injury-is-negatively-associated-with-the-functional-liver-mass-after-lps-injection-in-rat-model
#10
Haoshu Fang, Anding Liu, Xulin Chen, Wenhui Cheng, Olaf Dirsch, Uta Dahmen
Background: High levels of serum lipopolysaccharide (LPS) were observed in sepsis patients with liver injury and high mortality. However, the role of liver in modulation LPS induced inflammatory injury was ill investigated. In the present study, the severity of LPS induced inflammatory response was observed after liver resection or portal branch occlusion to decreasing functional liver mass. The local and systemic damage was observed to investigate the role of liver in modulation inflammatory injury...
2018: Journal of Inflammation
https://read.qxmd.com/read/30386182/znf580-a-brake-on-interleukin-6
#11
Philipp Stenzel, Kaj Nagorsen, Jonathan Bernd, Ulrike Leppert, Andreas Zakrzewicz, Janine Berkholz
Background: Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis, endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However, it is unknown if ZNF580 could play a role during inflammation. The aim of this study was to find out if ZNF580 affects the expression of IL-6, if it occurs in monocytic cells and responds to inflammatory mediators. Results: Overexpression of ZNF580 reduced LPS-induced promotor activity of IL-6...
2018: Journal of Inflammation
https://read.qxmd.com/read/30250404/the-roles-of-il-19-and-il-20-in-the-inflammation-of-degenerative-lumbar-spondylolisthesis
#12
Kuo-Yuan Huang, Yu-Hsiang Hsu, Wei-Yu Chen, Hui-Ling Tsai, Jing-Jou Yan, Jung-Der Wang, Wen-Lung Liu, Ruey-Mo Lin
Background: Degenerative lumbar spondylolisthesis (DLS) is a major cause of spinal canal stenosis and is often related to lower back pain. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory bone disorders likes intervertebral disc herniation, rheumatoid arthritis (RA), osteoporosis, and bone fracture. IL-19 also acts as a proinflammatory cytokine in RA. The aim of the present study was to investigate whether IL-19 and IL-20 are involved in DLS and compare three different tissues including disc, facet joint, and ligamentum flavum of patients with DLS to verify which tissue is affected more by inflammation...
2018: Journal of Inflammation
https://read.qxmd.com/read/30214382/contribution-of-diminished-kidney-transplant-gfr-to-increased-circulating-chemokine-ligand-27-level
#13
Ahmed Zahran, Ahmed Attia, Holly Mansell, Ahmed Shoker
Background: Inflammatory chemokine ligands (CCLs) play an important role in cardiovascular disease and allograft injury. CCLs may independently associate with diminished estimated glomerular filtration rate (eGFR) in stable renal transplant recipients (RTR). Methods: Plasma levels of 19 CCLs (1, 2, 3, 4, 5, 8, 11, 13, 15, 17, 21, 24, 26, 27, CXCL5, 8, 10, 12 and 13) were measured in a cohort of 101 RTR. The cohort was divided according to CKD-EPI equation into three groups; group 1: eGFR ≥ 60 ml/min, group 2: eGFR 30-59...
2018: Journal of Inflammation
https://read.qxmd.com/read/30214381/in-vitro-suppression-of-inflammatory-cytokine-response-by-methionine-sulfoximine
#14
Tyler J Peters, Amruta A Jambekar, William S A Brusilow
Background: The glutamine synthetase inhibitor methionine sulfoximine (MSO), shown previously to prevent death caused by an inflammatory liver response in mice, was tested on in vitro production of cytokines by mouse peritoneal macrophages triggered with lipopolysaccharide (LPS). Results: MSO significantly reduced the production of Interleukin 6 (IL-6) and Tumor Necrosis Factor Alpha (TNFα) at 4 and 6 h after LPS-treatment. This reduction did not result from decreased transcription of IL-6 and TNFα genes, and therefore appeared to result from post-transcriptional inhibition of synthesis of these cytokines...
2018: Journal of Inflammation
https://read.qxmd.com/read/30202244/expression-and-clinical-significance-of-the-nek7-nlrp3-inflammasome-signaling-pathway-in-patients-with-systemic-lupus-erythematosus
#15
Zhen-Zhen Ma, Hong-Sheng Sun, Ji-Cai Lv, Lei Guo, Qing-Rui Yang
Background: The aim of the study was to investigate the expression of the NEK7-NLRP3 inflammasome signaling pathway in the peripheral blood mononuclear cells (PBMCs) of patients with systemic lupus erythematosus (SLE), as well as its clinical significance. Methods: A total of 38 SLE patients and 33 healthy volunteers were recruited. Real time PCR and western blotting were performed to determine mRNA and protein levels of NEK7 , NLRP3 inflammasome components ( NLRP3 , ASC , and Caspase-1 ), and downstream cytokines ( IL-1b and IL-18 ) in PBMCs from the two groups...
2018: Journal of Inflammation
https://read.qxmd.com/read/30150897/mbd2-regulates-differentiation-and-function-of-th17-cells-in-neutrophils-dominant-asthma-via-hif-1%C3%AE
#16
Li Xu, Wen J Sun, Ai J Jia, Lu L Qiu, Bing Xiao, Lin Mu, Jian M Li, Xiu F Zhang, Yan Wei, Cong Peng, Dong S Zhang, Xu D Xiang
Background: T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies indicated that Methtyl-CpG binding domain protein 2 (MBD2) expression was increased in asthma patients. The aim of the present study is to understand how MBD2 interacts with HIF-1α to regulate Th17 cell differentiation and IL-17 expression in neutrophils-dominant asthma...
2018: Journal of Inflammation
https://read.qxmd.com/read/30038551/anti-inflammatory-effect-of-hesperidin-enhances-chondrogenesis-of-human-mesenchymal-stem-cells-for-cartilage-tissue-repair
#17
Shipeng Xiao, Wenguang Liu, Jianqiang Bi, Shenghou Liu, Heng Zhao, Ningji Gong, Deguo Xing, Hongwei Gao, Mingzhi Gong
Background: Articular cartilage diseases are considered a major health problem, and tissue engineering using human mesenchymal stem cells (MSCs) have been shown as a promising solution for cartilage tissue repair. Hesperidin is a flavonoid extract from citrus fruits with anti-inflammatory properties. We aimed to investigate the effect of hesperidin on MSCs for cartilage tissue repair. MSCs were treated by hesperidin, and colony formation and proliferation assays were performed to evaluate self-renewal ability of MSCs...
2018: Journal of Inflammation
https://read.qxmd.com/read/30008619/caspase-recruitment-domain-card-family-card9-card10-card11-card14-and-card15-are-increased-during-active-inflammation-in-patients-with-inflammatory-bowel-disease
#18
Jesús K Yamamoto-Furusho, Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Andrea Sarmiento-Aguilar, Rafael Barreto-Zuñiga, Braulio Martínez-Benitez, Montserrat A Lara-Velazquez
Background: The CARD family plays an important role in innate immune response by the activation of NF-κB. The aim of this study was to determine the gene expression and to enumerate the protein-expressing cells of some members of the CARD family (CARD9, CARD10, CARD11, CARD14 and CARD15) in patients with IBD and normal controls without colonic inflammation. Methods: We included 48 UC patients, 10 Crohn's disease (CD) patients and 18 non-inflamed controls. Gene expression was performed by RT-PCR and protein expression by immunohistochemistry...
2018: Journal of Inflammation
https://read.qxmd.com/read/29946226/experimental-murine-acute-lung-injury-induces-increase-of-pulmonary-tie2-expressing-macrophages
#19
Heidi Ehrentraut, Christina Weisheit, Marcel Scheck, Stilla Frede, Tobias Hilbert
Background: Breakdown of the alveolo-capillary wall is pathognomonic for Acute Lung Injury (ALI). Angiopoietins, vascular-specific growth factors, are linked to endothelial barrier dysfunction, and elevated Angiopoietin-2 (ANG2) levels are associated with poor outcome of ALI patients. Specialized immune cells, referred to as 'TIE2-expressing monocytes and macrophages' (TEM), were shown to specifically respond to ANG2 binding. However, their involvement in acute inflammatory processes is so far completely undescribed...
2018: Journal of Inflammation
https://read.qxmd.com/read/29849508/the-impact-of-septic-stimuli-on-the-systemic-inflammatory-response-and-physiologic-insult-in-a-preclinical-non-human-primate-model-of-polytraumatic-injury
#20
Diego A Vicente, Matthew J Bradley, Benjamin Bograd, Crystal Leonhardt, Eric A Elster, Thomas A Davis
Background: Established animal trauma models are limited in recapitulating the pathophysiology of human traumatic injury. Herein, we characterize the physiologic insult and inflammatory response in two clinically relevant non-human primate (NHP) trauma models. Methods: Mauritian Cynomolgus Macaques underwent either a laparoscopic closed abdomen liver injury (laparoscopic 60% left-lobe hepatectomy) in an established uncontrolled severe hemorrhage model (THM), or a polytrauma hemorrhage model (PHM) involving combined liver and bowel injury, uncontrolled severe hemorrhage as well as an open full-thickness cutaneous flank wound...
2018: Journal of Inflammation
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