Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine

STUDY OBJECTIVES: To report on a series of patients with narcolepsy with hypocretin-1 deficiency and absence of HLA DQB1*06:02 allele, data collected from two reference European Seep Centers. METHODS: Clinical data, HLA DQ markers, and cerebrospinal fluids (CSF) assessments have been collected retrospectively from Caucasian patients with a diagnosis of NT1 with CSF hypocretin-1 deficiency (<110 pg/ml), and absence of HLA DQB1*06:02 allele, with follow-up with at least one visit within the last 4 years, consecutively admitted to two European Sleep Centers (Lugano, Switzerland; Montpellier, France)...

STUDY OBJECTIVES: Treatment-emergent central sleep apnea (TECSA) describes the appearance or persistence of central sleep apnea while undergoing treatment for obstructive sleep apnea (OSA). TECSA is well-studied in continuous positive airway pressure (CPAP) therapy with an estimated prevalence of 8%. Based on few case reports, mandibular advancement devices (MAD) may also provoke TECSA. This study aims to gain insight into the prevalence of TECSA with MAD therapy. METHODS: This retrospective study includes a total of 129 patients with moderate to severe OSA who were treated with a custom-made titratable MAD...

No abstract text is available yet for this article.

STUDY OBJECTIVES: The treatment of obstructive sleep apnea is often impeded by intolerance of positive airway pressure therapy, which is frequently attributed to the inability to breathe through the nose. Providers caring for patients with sleep apnea need a working knowledge of nasal passage disease and available treatments to better manage this common comorbidity. METHODS: This review examines the literature connecting rhinosinusitis to adverse sleep and sleep apnea outcomes...

STUDY OBJECTIVES: This meta-analysis aimed to systematically assess the effects of continuous positive airway pressure (CPAP) in secondary prevention of major cardiovascular events (MACE) in patients with moderate-to-severe obstructive sleep apnea (OSA) and coronary artery disease (CAD). METHODS: PubMed, Embase, the Cochrane Library, and ClinicalTrials were searched for observational studies and randomized controlled trials (RCTs) that compared CPAP with usual care in moderate-to-severe OSA patients with CAD...

STUDY OBJECTIVES: Numerous studies have emphasized the significance of nutrition on the quality of sleep, but little have evaluated the effect of various coexisting dietary markers on middle-aged adults. We assessed the association between sleep quality and a large array of dietary markers among middle-aged, community-dwelling participants. METHODS: Data from the first, second and third follow-ups of CoLaus|PsyCoLaus, a population-based study in Lausanne, Switzerland, was used...

STUDY OBJECTIVES: Could HSAT using a type III portable monitor (PM) Nox-T3 detect OSA in pregnant women? METHODS: 92 pregnant women (34.5 ± 4.3 years old, gestational age 25.4 ± 8.9 weeks, BMI 29.9± 4.7 kg/m2 ) with suspected OSA underwent HSAT with the Nox-T3 PM followed by an overnight polysomnogram (PSG) and PM recording simultaneously in the laboratory within one week. PMs were scored automatically and manually using a 3% criteria, and compared to PSGs scored by following guidelines...

Growing evidence suggests that transgender individuals face a significant health disparity and are particularly vulnerable to sleep disorders. We present two patients who developed irregular sleep-wake rhythm disorder after gender reassignment and hormone replacement therapy. The growing interest in transgender health warrants further evaluation of the effects and frequency of all sleep disorders in this population. Efforts to address sleep disorders should consider assessing sleep disturbance in terms of sleep/wake patterns and schedules...

STUDY OBJECTIVES: Evaluate the quality of ChatGPT responses to questions on obstructive sleep apnea (OSA) for patient education. Assess how prompting the chatbot influences correctness, estimated grade level, and references of answers. METHODS: ChatGPT was queried four times with 24 identical questions. Queries differed by initial prompting: no prompting, patient-friendly prompting, physician-level prompting, and prompting for statistics/references. Answers were scored on a hierarchical scale: incorrect, partially correct, correct, correct with either statistic or referenced citation ("correct+"), or correct with both a statistic and citation ("perfect")...

STUDY OBJECTIVES: The relationship between time-limited eating (TLE) and sleep quality is a topic of growing interest in the field of chronobiology. Data in adult cohorts shows that TLE may improve sleep quality, but this has not been evaluated in adolescents. The aim of this secondary analysis was to (1) examine the impact of 8-hour TLE on sleep parameters in youth with obesity and (2) explore if there was any association between sleep patterns and glycemic profiles. METHODS: Adolescents with obesity were randomized into one of three groups: 8-h TLE (participants self-selected their eating window) + real-time continuous glucose monitor (CGM), 8-h TLE + blinded CGM, or a prolonged eating window...

STUDY OBJECTIVES: Our cohort study aimed to study the association between sleep duration and risk of mortality due to respiratory diseases. METHODS: We included 498,200 participants from UK Biobank (2006-2021). We classified sleep duration as short sleep duration (<7 h), long sleep duration (>9 h for adults, >8 h for older adults) and mid-range sleep duration (7~9 h). We used the cox proportional hazards model and restricted cubic spline analysis to explore the association between sleep duration and respiratory diseases mortality...

Shrinking lung syndrome (SLS) is a rare complication of systemic lupus erythematosus (SLE); its impact on sleep-disordered breathing (SDB) is not well understood. We describe a case of a 36-year-old female with SLE experiencing SLS and frequent pain crises. We review manifestations of her disease during non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. SLS with its restrictive physiology and associated diaphragmatic myopathy is expected to decrease minute ventilation during NREM and REM sleep...

Residents and fellows can play a helpful role in promoting safe and effective machine learning tools in sleep medicine. Here we highlight the importance of establishing ground truths, considering key variables, and prioritizing transparency and accountability in the development of machine learning tools within the field of artificial intelligence (AI). Through understanding, communication, and collaboration, in-training physicians have a meaningful opportunity to help progress the field towards safe machine learning tools in sleep medicine...

STUDY OBJECTIVES: Child sexual abuse (CSA) is associated with negative consequences on both physical and mental health. It has been found to influence child and adolescent sleep, which is an important developmental factor, which also influences mental and physical health. However, the literature examining this topic is plagued by methodological limitations, such as small sample sizes and unvalidated measures. METHODS: Using the Pittsburgh Sleep Quality Index, the present study examined seven subjective sleep dimensions including, sleep latency, efficiency, duration, disturbances, subjective sleep quality, daytime dysfunction, and use of sleep medication, in a sample of 707 adolescent girls aged 14-18 years old...

Combination positive airway pressure (PAP) therapy and daytime transoral neuromuscular electrical stimulation (NMES) in the treatment of sleep apnea has not been reported in the literature. We present a case of a patient with poorly controlled sleep apnea despite bilevel PAP. Adjunctive therapy with daytime NMES resulted in dramatic reduction of the apnea-hypopnea index with significant improvement in patient's symptoms.

Sleep-related sexualized behaviors occur in the parasomnia known as sexsomnia, recognized as a variant of confusional arousals in the ICSD-3. These instinctive behaviors of a sexual nature emerge from deep NREM sleep and patients often present with distinguishing features within this sleep disorder category. There are often adverse psychosocial consequences, and not uncommonly medico-legal implications. While associations to psychiatric consequences from the sexsomnia have been demonstrated and efforts to further typify this condition have been made, sexsomnia remains incompletely characterized in the more than 200 published cases to date, with male predominance...

No abstract text is available yet for this article.

STUDY OBJECTIVES: This study aimed to determine the sleep quality of in-school Nigerian adolescents and its association with their schooling and mental health outcomes. METHODS: The study was a descriptive cross-sectional study. It was conducted among adolescents attending public and private secondary schools within Ife Central Local Government, Osun State, southwestern Nigeria. A multistage sampling technique was employed to select study participants. The Pittsburgh Sleep Quality Index, Patient Health Questionnaire (PHQ) - 9 and General Anxiety Disorder (GAD) - 7 questionnaires were used to determine sleep quality, depression and anxiety respectively...

STUDY OBJECTIVES: This report gathered data to determine whether daytime assays of the autonomic nervous system (ANS) would differ between persons with nil versus modest insomnia symptoms, and would correlate with the severity of insomnia symptoms in patients. METHODS: This report is comprised of two studies. Study 1 conducted pupillary light reflex (PLR) measurements in community volunteers who were not seeking medical care. Study 2 contrasted PLR and heart rate variability (HRV) in a different sample of community volunteers and a comparison sample of adults seeking outpatient care for insomnia and psychiatric problems...

STUDY OBJECTIVES: To evaluate whether laboratory or home-based hypoglossal nerve stimulation (HNS) management would have equivalent objective and subjective obstructive sleep apnea (OSA) outcomes 6 months after activation. METHODS: Patients undergoing standard-of-care HNS implantation were randomized in a prospective, multicenter clinical trial to either a 3-month post-activation in-laboratory titration polysomnography (tPSG) or an efficacy home sleep study (eHST) with tPSG by exception for eHST non-responders at 5 months...