Journals Molecular Nutrition & Food Res...

Molecular Nutrition & Food Research
Yike Liu, Chenlin Dai, Chendi Wang, Jiayao Wang, Weikang Yan, Maowen Luo, Juane Dong, Xiulian Li, Xuebo Liu, Ying Lan
SCOPE: Depression, a prevalent mental disorder, has significantly impacted the lives of 350 million people, yet it holds promise for amelioration through food-derived phenolics. Raspberries, renowned globally for their delectable flavor, harbor a phenolic compound known as raspberry ketone (RK). However, the impact of RK on depressive symptoms remains ambiguous. This study aims to investigate the impact of RK on lipopolysaccharide (LPS)-induced depressed mice and elucidates its potential mechanisms, focusing on the gut-brain axis...
May 17, 2024: Molecular Nutrition & Food Research
Tingting Li, Jinfeng Zhu, Qifeng Yu, Yinrui Zhu, Chao Wu, Xing Zheng, Nannan Chen, Pei Pei, Kai Yang, Kai Wang, Lin Hu
SCOPE: Active ingredients in functional foods exhibit broad-spectrum antiviral activity. The objective of this study is to investigate the protective effect of quercetin derived from bee propolis, a natural product with antiviral activity and modulating effects on the gut microbiota, against vesicular stomatitis virus (VSV) infection. METHODS AND RESULTS: Through a cellular-based study, this study demonstrates that quercetin can modulate the activity of interferon-regulating factor 3 (IRF3)...
May 16, 2024: Molecular Nutrition & Food Research
Charlotte Oliver, Vinay S N Mishra, Jessie Santoro, Anindya Mukhopadhya, Frank Buckley, Lorraine O'Driscoll, Linda Giblin, André Brodkorb
SCOPE: Milk extracellular vesicles (EVs) are nanosized particles with potential immune bioactivities. This study examines their fate during in vitro infant gastrointestinal digestion (GI). METHODS AND RESULTS: Bovine milk is digested using the in vitro INFOGEST method, adjusted for the infant. To unravel the contribution of digestive enzymes from bile, milk is treated with digestive enzymes, bile, or a combination of both. EVs are collected posttreatment using differential ultracentrifugation...
May 6, 2024: Molecular Nutrition & Food Research
Caroline R Hill, Armaghan Shafaei, Vance B Matthews, Natalie C Ward, Kevin D Croft, Joshua R Lewis, Jonathan M Hodgson, Lois Balmer, Lauren C Blekkenhorst
SCOPE: Higher intake of cruciferous and allium vegetables is associated with lower cardiometabolic risk. Little research has investigated the cardiometabolic effects of S-methyl cysteine sulfoxide (SMCSO), found abundant in these vegetables. This study hypothesizes that SMCSO will blunt development of metabolic syndrome features in mice fed high-fat feed. METHODS AND RESULTS: Fifty C57BL/6 male mice are randomly assigned to standard-chow, high-fat, or high-fat supplemented with low-SMCSO (43 mg kg-1 body weight [BW] day-1 ), medium-SMCSO (153 mg kg-1 BW day-1 ), or high-SMCSO (256 mg kg-1 BW day-1 ) for 12-weeks...
May 5, 2024: Molecular Nutrition & Food Research
Xueqin Feng, Xinying Liu, Fuling Wang, Xiaoyun Zhang, Liangxi Zhu, Hua Shu, Chunxia Wang, Liting Duan, Haixia Wang, Qinggui Ren, Fangxiang Dong, Ziteng Zhang, Dongmei Man, Miaomiao Qu
SCOPE: Prenatal nutrition imbalance correlates with developmental origin of cardiovascular diseases; however whether maternal high-sucrose diet (HS) during pregnancy causes vascular damage in renal interlobar arteries (RIA) from offspring still keeps unclear. METHODS AND RESULTS: Pregnant rats are fed with normal drinking water or 20% high-sucrose solution during the whole gestational period. Swollen mitochondria and distributed myofilaments are observed in vascular smooth muscle cells of RIA exposed to prenatal HS...
May 5, 2024: Molecular Nutrition & Food Research
Beatrice Aiuto, Simona Cirrincione, Maria Gabriella Giuffrida, Laura Cavallarin, Chiara Portesi, Andrea Mario Rossi, Giorgio Borreani, Giovanni Rolla, Massimo Geuna, Stefania Nicola, Anna Quinternetto, Lucrezia Alessi, Elena Saracco, Luisa Brussino, Cristina Lamberti
Alpha-gal syndrome (AGS) is a mammalian meat allergy associated with tick bites and specific IgE to the oligosaccharide galactose-α-1,3-galactose (α-gal). Recent studies have shown that 10-20% of AGS patients also react to the dairy proteins. Considering the already described role of the meat lipid fraction in AGS manifestations, the aim of this work has been to investigate whether the milk fat globule proteins (MFGPs) could be involved in AGS. The MFGPs are extracted and their recognition by the IgE of AGS patients is proved through immunoblotting experiments...
May 5, 2024: Molecular Nutrition & Food Research
Xiaojing Li, Jin Qian, Qinglong Liu, Min Guo, Hao Zhang, Haitao Li, Wei Chen
SCOPE: Yogurt consumption is related to a decreased risk of colorectal cancer (CRC), but whether such association is causal remains unclear. Patients with familial adenomatous polyposis (FAP) are at increased risk of CRC development. Here, the study investigates the efficacy of yogurt for intestinal polyposis chemoprevention in ApcMin/+ mice, a preclinical model for human FAP. METHODS AND RESULTS: A 10-week yogurt supplementation (15 g kg-1 ) in ApcMin/+ mice significantly reduces the intestinal polyp number (6...
May 3, 2024: Molecular Nutrition & Food Research
Alexander Montoya-Arroyo, Viola Brand, Alexander Kröpfl, Walter Vetter, Jan Frank
SCOPE: Tocomonoenols (T1) are little-known vitamin E derivatives naturally occurring in foods. Limited knowledge exists regarding the cellular uptake and metabolism of α-tocomonoenol (αT1) and none about that of γ-tocomonoenol (γT1). METHODS AND RESULTS: The study investigates the cytotoxicity, uptake, and metabolism of αT1 and γT1 in HepG2 cells compared to the α- and γ-tocopherols (T) and -tocotrienols (T3). None of the studied tocochromanols are cytotoxic up to 100 µmol L-1 ...
May 3, 2024: Molecular Nutrition & Food Research
Bart G J Moerings, Jurriaan J Mes, Jeroen van Bergenhenegouwen, Coen Govers, Miriam van Dijk, Renger F Witkamp, Klaske van Norren, Suzanne Abbring
Beta-glucans and arabinoxylans are known for their immunostimulatory properties. However, in vivo these have been documented almost exclusively following parenteral administration, underemphasizing oral intake. C57BL/6 mice are fed either a control diet or a diet supplemented with yeast-derived whole β-glucan particle (yWGP) or with rice-derived arabinoxylan (rice bran-1) at a concentration of 1%, 2.5%, or 5% weight/weight (w/w) for 2 weeks. Thereafter, cells from blood, bone marrow, and spleen are collected for ex vivo stimulation with various microbial stimuli...
April 29, 2024: Molecular Nutrition & Food Research
Qian Li, Weixin Ke, Shuai Jiang, Miao Zhang, Kai Shan, Chunbao Li
SCOPE: Epidemiological studies have linked excessive red and processed meat intake to gut disorders. Under laboratory conditions, high heme content is considered the primary health risk factor for red meat. However, heme in meat is present in myoglobin, which is an indigestible protein, suggesting the different functions between myoglobin and heme. This study aims to explore how dietary myoglobin and heme affect gut health and microbiota differently. METHODS AND RESULTS: Histological and biochemical assessments as well as 16S rRNA sequencing are performed...
April 27, 2024: Molecular Nutrition & Food Research
Taiwo Bankole, Tianzhou Ma, Itika Arora, Zhentian Lei, Murugesan Raju, Zhenhai Li, Yuanyuan Li
SCOPE: Obesity and its metabolic comorbidities pose a major global challenge for public health. Glucoraphanin (GRN) is a natural bioactive compound enriched in broccoli that is known to have potential health benefits against various human chronic diseases. METHODS AND RESULTS: This study investigats the effects of broccoli GRN supplementation on body weight, metabolic parameters, gut microbiome and metabolome associated with obesity. The study is conducted on an obese-related C57BL/6J mouse model through the treatment of normal control diet, high-fat diet (HFD)and GRN-supplemented HFD (HFD-GRN) to determine the metabolic protection of GRN...
April 27, 2024: Molecular Nutrition & Food Research
Shannon L Kelleher, Serena Burkinshaw, Seun Elizabeth Kuyooro
Botanicals and herbal supplements contain a diverse array of polyphenols that may affect mammary gland function and promote galactagogue activity. This scoping review is conducted to identify scientific literature elucidating how polyphenols affect mammary gland biology and cellular mechanisms critical for lactation. A literature search of PubMed and Medline reviews relevant studies in dairy animals, rodent models, and cultured mammary epithelial cells that are published from January 2010 until July 2023, to ascertain effects of polyphenols on mechanisms regulating milk production and composition...
April 26, 2024: Molecular Nutrition & Food Research
Nanhai Xiao, Wen He, Shuping Chen, Yao Yao, Na Wu, Mingsheng Xu, Huaying Du, Yan Zhao, Yonggang Tu
Egg yolk lipids significantly alleviate dextran sulfate sodium (DSS)-induced colitis by inhibiting NLRP3 inflammasome, reversing gut microbiota dysbiosis, and increasing short chain fatty acids (SCFAs) concentrations. However, the role of gut microbiota and the relationship between SCFAs and NLRP3 inflammasome are still unknown. Here, this study confirms that antibiotic treatment abolishes the protective effect of egg yolk lipids on DSS-induced colonic inflammation, intestinal barrier damage, and lipopolysaccharide translocation...
April 24, 2024: Molecular Nutrition & Food Research
Tianxu Liu, Ismail Muhammad Asif, Yan Chen, Meixue Zhang, Bin Li, Ling Wang
Gut fungi are important parts of intestinal microbes. Dietary ingredients have the potential to regulate the structure of gut fungi in different directions and modulate mycobiome composition by changing dietary patterns, which have been applied to neurological disorders. Emerging pieces of evidence have revealed the regulatory functions of gut mycobiome in gastrointestinal diseases, but the relationships between gut fungi and functional gastrointestinal disorders (FGIDs) are ignored in the past. This review discusses the impact of dietary nutrients and patterns on mycobiome, and the possible ways in which gut fungi are involved in the pathogenesis of FGIDs...
April 24, 2024: Molecular Nutrition & Food Research
Ya-Ru Kuo, Cheng-Hung Lin, Wei-Sheng Lin, Min-Hsiung Pan
SCOPE: This study investigates the potential of glutamine to mitigate intestinal mucositis and dysbiosis caused by the chemotherapeutic agent 5-fluorouracil (5-FU). METHODS AND RESULTS: Over twelve days, Institute of Cancer Research (ICR) mice are given low (0.5 mg kg-1 ) or high (2 mg kg-1 ) doses of L-Glutamine daily, with 5-FU (50 mg kg-1 ) administered between days six and nine. Mice receiving only 5-FU exhibited weight loss, diarrhea, abnormal cell growth, and colonic inflammation, correlated with decreased mucin proteins, increased endotoxins, reduced fecal short-chain fatty acids, and altered gut microbiota...
April 24, 2024: Molecular Nutrition & Food Research
Mingjian Bai, Xiaolong Wang, Dongyang Liu, Aofeng Xu, Hao Cheng, Lin Li, Chunjing Zhang
SCOPE: Tolypocladium sinense is a fungus isolated from Cordyceps. Cordyceps has some medicinal value and is also a daily health care product. This study explores the preventive effects of T. sinense mycelium polysaccharide (TSMP) on high-fat diet-induced obesity and chronic inflammation in mice. METHODS AND RESULTS: Here, the study establishes an obese mouse model induced by high-fat diet. In this study, the mice are administered TSMP daily basis to evaluate its effect on alleviating obesity...
April 23, 2024: Molecular Nutrition & Food Research
Ling Ma, Yanyan Huo, Qingyuan Tang, Xiulian Wang, Weiqin Wang, Dan Wu, Yicheng Li, Lingyan Chen, Shasha Wang, Yiwen Zhu, Wenli Wang, Yuan Liu, Nanjie Xu, Li Chen, Guangjun Yu, Jinjin Chen
SCOPE: This study investigates the exosomal microRNA (miRNA) profiles of term and preterm breast milk, including the most abundant and differentially expressed (DE) miRNAs, and their impact on neurodevelopment in infants. METHODS AND RESULTS: Mature milk is collected from the mothers of term and preterm infants. Using high-throughput sequencing and subsequent data analysis, exosomal miRNA profiles of term and preterm human breast milk (HBM) are acquired and it is found that the let-7 and miR-148 families are the most abundant miRNAs...
April 21, 2024: Molecular Nutrition & Food Research
Mengcheng Jin, Tangbin Zou, Hairong Huang, Ming Chen, Haoqi Zou, Baoyan Chen, Chengze Lai, Huawen Li, Peiwen Zhang
SCOPE: Bile acids play a crucial role in lipid absorption and the regulation of lipid, glucose, and energy homeostasis. Coenzyme Q10 (CoQ10), a lipophilic antioxidant, has been recognized for its positive effects on obesity and related glycolipid metabolic disorders. However, the relationship between CoQ10 and bile acids has not yet been evaluated. METHODS AND RESULTS: This study assesses the impact of CoQ10 treatment on bile acid metabolism in mice on a high-fat diet using Ultra-Performance Liquid Chromatography-tandem Mass Spectrometry...
April 21, 2024: Molecular Nutrition & Food Research
Junki Miyamoto, Yuna Ando, Akari Nishida, Mayu Yamano, Shunsuke Suzuki, Hiromi Takada, Ikuo Kimura
SCOPE: Obesity and metabolic diseases are closely associated, and individuals who become obese are also prone to type 2 diabetes and cardiovascular disorders. Gut microbiota is mediated by diet and can influence host metabolism and the incidence of metabolic disorders. Recent studies have suggested that improving gut microbiota through a fructooligosaccharide (FOS)-supplemented diet may ameliorate obesity and other metabolic disorders. Although accumulating evidence supports the notion of the developmental origins of health and disease, the underlying mechanisms remain obscure...
April 19, 2024: Molecular Nutrition & Food Research
Yue Li, Yuwei Lai, Tingting Geng, Peng-Fei Xia, Jun-Xiang Chen, Zhou-Zheng Tu, Kun Yang, Yun-Fei Liao, Gang Liu, An Pan
SCOPE: Among patients with diabetes, who have modified nutritional behavior and a higher risk of cardiovascular disease (CVD), the influence of ultraprocessed foods (UPFs) on CVD remains unknown. The study aims to evaluate the association between UPF intake and the risk of CVD among individuals with type 2 diabetes (T2D) and further examine the potential biological pathways linking the association. METHODS AND RESULTS: This study includes 5405 participants with T2D who provided at least one 24-h dietary recall from the UK Biobank study...
April 19, 2024: Molecular Nutrition & Food Research
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