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Nutrition & Metabolism

Fan Qiu, Yu-Qing Zhang
Background: Mulberry ( Morus multicaulis ) branch bark powder have showed effective hypoglycemic activity in our previous research. This study aims to explore the mechanism of protect effect on diabetes mice of mulberry branch bark as food supplement based on non-targeted GC-MS metabolomics' platform. Methods: Animal model of double diabetes was established with high fat diet and Streptozotocin injection. Mice were fed with mulberry branch bark powder (MBBP) for five weeks to study its therapeutic effect...
2019: Nutrition & Metabolism
Jining Yang, Xi Zhou, Xianglong Zeng, Ou Hu, Long Yi, Mantian Mi
Background/aims: Oxidative stress-induced damage in endothelial cells is a crucial initiator of atherosclerosis (AS), which is highly related to excessive reactive oxygen species (ROS) and mitochondrial dynamics. Resveratrol (RSV) exerts beneficial effects against endothelial oxidative injury, while the underlying mechanisms have not been fully elucidated. Thus, we aimed to explore the role of mitochondria dynamics during the anti-oxidative activities of RSV in palmitic acid (PA)-stimulated human umbilical vein endothelial cells (HUVECs) and to verify whether tyrosyl transfer- RNA synthetase (TyrRS) and poly (ADP-ribose) polymerase 1 (PARP1) are targeted during this process...
2019: Nutrition & Metabolism
Seyed Ali Jazayeri-Tehrani, Seyed Mahdi Rezayat, Siavash Mansouri, Mostafa Qorbani, Seyed Moayed Alavian, Milad Daneshi-Maskooni, Mohammad-Javad Hosseinzadeh-Attar
Background: Since lifestyle changes are main therapies for non-alcoholic fatty liver disease (NAFLD), changing dietary components (nutritional or bioactive) may play a parallel important role. Few studies have assessed the effects of curcumin on NAFLD (mainly antioxidant and anti-inflammatory effects). We aimed to determine the effects of nano-curcumin (NC) on overweight/obese NAFLD patients by assessing glucose, lipids, inflammation, insulin resistance, and liver function indices, especially through nesfatin...
2019: Nutrition & Metabolism
Jiahua Fan, Yangqing Liu, Songping Yin, Nixuan Chen, Xinxiu Bai, Qiuyi Ke, Jia Shen, Min Xia
Background: Small dense LDL cholesterol (sdLDL-c) has been established to be highly associated with metabolic disorder. However, the relationship between circulating sdLDL-c and the presence of metabolic syndrome (MetS) has not been fully established. Methods: A total of 1065 Chinese males (45.07 ± 11.08 years old) without diabetes and general obesity was recruited into a population-based, cross-sectional study. The MetS was defined based on the updated National Cholesterol Education Program/ Adult Treatment Panel III criteria for Asian Americans...
2019: Nutrition & Metabolism
Licong Yang, Yan Zhao, Yongfang Pan, Dongming Li, Guodong Zheng
Background: Obesity has become a public health concern worldwide because it is linked to numerous metabolic disorders, such as hyperlipidemia, hypertension and cardiovascular disease. Therefore, there is an urgent need to develop new therapeutic strategies that are efficacious and have minimal side effects in obesity treatment. This study examined the effect of dietary supplement of Smilax china L. ethanol extract (SCLE) on high-fat diet (HFD) induced obesity. Methods: Fifty ICR mice were fed a normal diet, high-fat diet (HFD) or HFD supplemented with 0...
2019: Nutrition & Metabolism
Ji-Chang Zhou, Yumei Zhu, Chunmei Gong, Xiongshun Liang, Xiaoying Zhou, Yuanfei Xu, Deliang Lyu, Junluan Mo, Jian Xu, Jinping Song, Xiaoling Che, Shiqiang Sun, Changhua Huang, Xiao-Li Liu
Background: The GC haplotype of the vitamin D binding protein (encoded by the GC gene) might be a risk factor to the vitamin D (VD) nutritional status for many populations, while evidences from the Chinese Han population are sparse. We test the association between vitamin D binding protein genotypes and VD status as well as the metabolic parameters of glucose and lipids in a Han Chinese population. Methods: In a cross-sectional study conducted at a health examination centre (registered in ClinicalTrials...
2019: Nutrition & Metabolism
Dominik Saul, Marie Weber, Marc Hendrik Zimmermann, Robyn Laura Kosinsky, Daniel Bernd Hoffmann, Björn Menger, Stefan Taudien, Wolfgang Lehmann, Marina Komrakova, Stephan Sehmisch
Background: Osteoporosis is one of the world's major medical burdens in the twenty-first century. Pharmaceutical intervention currently focusses on decelerating bone loss, but phytochemicals such as baicalein, which is a lipoxygenase inhibitor, may rescue bone loss. Studies evaluating the effect of baicalein in vivo are rare. Methods: We administered baicalein to sixty-one three-month-old female Sprague-Dawley rats. They were divided into five groups, four of which were ovariectomized (OVX) and one non-ovariectomized (NON-OVX)...
2019: Nutrition & Metabolism
Yeli Wang, Liang Sun, Xu Lin, Jian-Min Yuan, Woon-Puay Koh, An Pan
Background: Although retinol binding protein 4 (RBP4) has been implicated in insulin resistance in experimental studies, the association between RBP4 and risk of type 2 diabetes remains unclear. We assessed this association in a Chinese population, and pooled our results with those from two prior studies. Methods: Plasma RBP4 levels were measured among 571 incident type 2 diabetes cases and 571 controls nested within the Singapore Chinese Health Study. All participants were free of diabetes, cancer and cardiovascular disease at blood collection (1999-2004)...
2019: Nutrition & Metabolism
Fang-Ying Xia, Li Zhu, Chao Xu, Qing-Qing Wu, Wan-Jia Chen, Rong Zeng, Yue-Yi Deng
Background: Effective evaluation or prediction of therapy response could be helpful for treatment of chronic kidney disease (CKD), which may rely on accurate biomarkers. Acylcarnitines are involved with lipid metabolism and mitochondrial function. The relation of acylcarnitines with treatment response in patients with CKD is unknown. The purpose of this study is to investigate the association of plasma acylcarnitines with renal function and its alteration by intervention in patients with IgA nephropathy (IgAN)...
2019: Nutrition & Metabolism
Sally A V Draycott, Ge Liu, Zoe C Daniel, Matthew J Elmes, Beverly S Muhlhausler, Simon C Langley-Evans
Background: Increased consumption of linoleic acid (LA, omega-6) in Western diets coupled with the pro-inflammatory and adipogenic properties of its derivatives has led to suggestions that fetal exposure to this dietary pattern could be contributing to the intergenerational cycle of obesity. Method: This study aimed to evaluate the effects of maternal consumption of a LA to alpha-linolenic acid (ALA) ratio similar to modern Western diets (9:1) compared to a lower ratio (1:1...
2019: Nutrition & Metabolism
Yanislava Karusheva, Lejla Kunstein, Alessandra Bierwagen, Bettina Nowotny, Stefan Kabisch, Jan B Groener, Ann Kristin Fleitmann, Christian Herder, Giovanni Pacini, Klaus Strassburger, Hans-Ulrich Häring, Peter P Nawroth, Andreas F H Pfeiffer, Volker Burkart, Karsten Müssig, Michael Roden, Julia Szendroedi
Background: Higher dietary intake of fibers and coffee, but lower red meat intake is associated with reduced risk for type 2 diabetes in epidemiological studies. We hypothesized that a calorie-restricted diet, which is high in fiber and coffee, but free of red meat, improves beta-cell function in patients with T2D. Methods: In a randomized parallel-group pilot trial, obese type 2 diabetes patients were randomly allocated to consume either a diet high in cereal fiber and coffee, but free of red meat ( n  = 17) (L-RISK) or a diet low in fiber, free of coffee but high in red meat ( n  = 20) (H-RISK) for 8 weeks...
2018: Nutrition & Metabolism
Xianghui Li, Liang Sun, Wenduo Zhang, Hongxia Li, Siming Wang, Hongna Mu, Qi Zhou, Ying Zhang, Yueming Tang, Yu Wang, Wenxiang Chen, Ruiyue Yang, Jun Dong
Background: Several studies have identified a negative association between serum glycine (Gly) levels and metabolic syndrome (MetS). However, this association has not been fully established in the elderly. Methods: A total of 472 Chinese individuals (272 males and 200 females, 70.1 ± 6.6 years old) participated in a population-based, cross-sectional survey in Beijing Hospital. The MetS and its components were defined based on the 2006 International Diabetes Federation (IDF) standard for Asians...
2018: Nutrition & Metabolism
Golaleh Asghari, Mehrnaz Momenan, Emad Yuzbashian, Parvin Mirmiran, Fereidoun Azizi
Background & Aims: Although dietary patterns have been linked to chronic diseases such as cardiovascular disease, sparse data are available for a relationship between dietary patterns and incident chronic kidney disease (CKD) in West Asian populations. The aim of this study was to evaluate the association of population-based dietary pattern with the risk of incident CKD after 6.1 years of follow-up. Methods: At baseline, habitual dietary intakes of 1630 participants of the Tehran Lipid and Glucose Study (TLGS) who were free of CKD was assessed by a valid and reliable food-frequency questionnaire...
2018: Nutrition & Metabolism
Adam J Black, Rudolf J Schilder, Scot R Kimball
Background: In a previous study, we showed that consumption of diets enriched in saturated fatty acids causes changes in alternative splicing of pre-mRNAs encoding a number of proteins in rat skeletal muscle, including the one encoding skeletal muscle Troponin T ( Tnnt3 ). However, whether saturated fatty acids act directly on muscle cells to modulate alternative pre-mRNA splicing was not assessed. Moreover, the signaling pathway through which saturated fatty acids act to promote changes in alternative splicing is unknown...
2018: Nutrition & Metabolism
Ning Jia, Xiaoyan Lin, Shizhan Ma, Shujian Ge, Shumin Mu, Chongbo Yang, Shulong Shi, Ling Gao, Jin Xu, Tao Bo, Jiajun Zhao
Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic and progressive liver disease with an increased risk of morbidity and mortality. However, so far no specific pharmacotherapy has been approved. Gynostemma pentaphylla (Thunb.) Makino (GP) is a traditional Chinese medicine that is widely used against hyperlipemia as well as hyperglycemia. This study aims to evaluate the effect of GP on NAFLD and explore the possible mechanism. Methods: High-fat-diet induced NAFLD mice model were orally administrated with GP at dose of 11...
2018: Nutrition & Metabolism
Reza Tabrizi, Maryam Akbari, Kamran B Lankarani, Seyed Taghi Heydari, Fariba Kolahdooz, Zatollah Asemi
Background and objective: The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on endothelial activation among patients with metabolic syndrome and related disorders. Methods: Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related RCTs published before 30th April 2018. The heterogeneity among the included studies was assessed using Cochran's Q test and I-square (I2 ) statistic...
2018: Nutrition & Metabolism
Fei Gao, Yinan Zhang, Sheng Ge, Huijuan Lu, Ruihua Chen, Pingyan Fang, Yixie Shen, Congrong Wang, Weiping Jia
Background: It has been proved that coffee consumption was associated with a lower risk of type 2 diabetes mellitus. But the benefit effect of coffee on hyperglycemia in Chinese population was largely unknown. Besides, the relationship of coffee intake and diabetic pathogenesis was still unclear. Methods: The study population was selected from the Shanghai High-Risk Diabetic Screen (SHiDS) project. A total of 1328 individuals over 18 years of age who have the information of coffee intake were enrolled in the study from 2012 to 2016...
2018: Nutrition & Metabolism
Cristiane Freitas Rodrigues, Willian Salgueiro, Matheus Bianchini, Juliana Cristina Veit, Robson Luiz Puntel, Tatiana Emanuelli, Cristiane Casagrande Dernadin, Daiana Silva Ávila
Background: Salvia hispanica seeds have been commonly used by people that seek healthy habits through natural foods to reduce cholesterol and triacylglycerides levels, however, the evidences that support this assumption are still scarce in literature. Here, we aimed to evaluate the lipid lowering effects of chia by using Caenorhabditis elegans as animal model, a nematode that has proven its usefulness for lipid metabolism studies. Methods: We prepared hexane (HE) and Bligh-Dyer (BDE) extracts, evaluated and compared their safety, antioxidant potential and their lipid-lowering activity in the worms...
2018: Nutrition & Metabolism
Trevor T Nyakudya, Emmanuel Mukwevho, Kennedy H Erlwanger
Background: Consumption of fructose-rich diets has been implicated in the increasing global prevalence of metabolic syndrome (MetS). Interventions during periods of early ontogenic developmental plasticity can cause epigenetic changes which program metabolism for positive or negative health benefits later in life. The phytochemical oleanolic acid (OA) possesses anti-diabetic and anti-obesity effects. We investigated the potential protective effects of neonatal administration of OA on the subsequent development of high fructose diet-induced metabolic dysfunction in rats...
2018: Nutrition & Metabolism
Zhao-Yan Liu, Xu-Ying Tan, Qi-Jiong Li, Gong-Cheng Liao, Ai-Ping Fang, Dao-Ming Zhang, Pei-Yan Chen, Xiao-Yan Wang, Yun Luo, Jing-An Long, Rong-Huan Zhong, Hui-Lian Zhu
Background: Evidence has suggested a potential link exists between trimethylamine-N-oxide (TMAO), a choline-derived metabolite produced by gut microbiota, and some cancers, but little is known for primary liver cancer (PLC). Methods: A case-control study was designed including 671 newly diagnosed PLC patients and 671 control subjects frequency-matched by age (±5 years) and sex, in Guangdong province, China. High-performance liquid chromatography with online electrospray ionization tandem mass spectrometry (HPLC-MS/MS) was used to measure serum TMAO and choline...
2018: Nutrition & Metabolism
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