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Manjari Kishore, Vijay Kumar, Manju Kaushal, Apoorva Gomber
No abstract text is available yet for this article.
2018: CytoJournal
Huihong Xu, Laura Bratton, Michael Nead, Donna Russell, Zhongren Zhou
Background: programmed death-ligand 1 (PD-L1) is a ligand for the inhibitory programmed cell death protein 1 (PD-L1), which are targeted by several anti-PD-1 and PD-L1 drugs for lung cancer treatment. In clinical practice, many lung cancer cases only have cytology samples available to test PD-L1. Our current study compared the PD-L1 immunohistochemistry (IHC) between paired cytological and surgical samples. Materials and Methods: Formalin-fixed lung cancer tissue microarray and paired cell blocks and surgical specimens from the same patients with a confirmed diagnosis of lung squamous cell carcinoma (SCC, n = 29) and adenocarcinoma (AC, n = 23) were sectioned for PD-L1 IHC...
2018: CytoJournal
Maya Dhanani, Aziza Nassar, Mélissa S Charles, Tri Dinh
Ovarian cancer is a heterogeneous disease having the highest gynecologic fatality in the United States with a 5-year survival rate of 46.5%. Poor overall prognosis is mostly attributed to inadequate screening tools, and the majority of diagnoses occur at late stages of the disease. Due to genetic and biological underpinnings, ovarian high-grade serous carcinomas (HGSC) have etiologic evidence in the distal fallopian tube. Fallopian tube screening modalities are aggressively investigated, but few describe cytological characteristics of benign tubal specimens to help in the comparative detection of HGSC precursor cells...
2018: CytoJournal
Shunichiro Tsuji, Kiyoshi Tsuji, Hirokuni Otsuka, Takashi Murakami
Background: Mast cells are observed in peritoneal endometriosis which causes dysmenorrhea. However, there is no report about the relationship between endocervical mast cells and dysmenorrhea. The aim of this study is to evaluate the relationship using endocervical smears. Materials and Methods: Between January 2016 and June 2016, patients filled out a questionnaire regarding dysmenorrhea and were classified into the dysmenorrhea or the control group (without dysmenorrhea)...
2018: CytoJournal
Priyadarshini Dehuri, Debasis Gochhait, Vidhyalakshmi Rangarajan, Prasath Sathiah, Neelaiah Siddaraju, Ramkumar Govindarajalou
No abstract text is available yet for this article.
2018: CytoJournal
Manjari Kishore, Manju Kaushal, Arvind Ahuja
No abstract text is available yet for this article.
2018: CytoJournal
Niveen Abdullah, Manar Hajeer, Loay Abudalu, Maher Sughayer
Background: Fine-needle aspiration (FNA) plays a fundamental role in determining the appropriate management for patients presenting with thyroid nodules. Aims: The aims of this study are to evaluate thyroid FNA test performance parameters through a cytohistological correlation. Materials and Methods: A retrospective analysis of all thyroid FNAs received over a period of 18 months was carried out. The findings were compared to their subsequent definite diagnoses on surgical specimens as well as to their follow-up repeat FNA results...
2018: CytoJournal
Katie Dennis, Maura O'Neil, Anthony Harrington
We report a case of a 65-year-old female who had a total thyroidectomy 12 years ago for papillary thyroid carcinoma (PTC) who presented with a recurrent thyroid bed mass. Fine-needle aspiration biopsy yielded malignant cells, consistent with squamous cell carcinoma (SCCa). Surgical resection was performed, and histologic evaluation of the mass showed mixed PTC and SCCa. The tumor cells were positive for BRAF V600E mutation. Thyroid carcinomas with admixed papillary carcinoma and SCCa are rare and are associated with aggressive behavior, high rates of metastasis, and poor outcomes...
2018: CytoJournal
Lester J Layfield, Magda Esebua, Leslie Dodd, Tamar Giorgadze, Robert L Schmidt
Introduction: The Papanicolaou Society of Cytopathology (PSC) has developed a set of guidelines for reporting respiratory cytology. While the malignancy risk for each category is known, the interobserver reproducibility of these diagnostic categories has not been well described. Methods: Fifty-five cytologic specimens obtained by fine needle aspiration from the pulmonary nodules were independently reviewed by four board-certified cytopathologists and assigned to the diagnostic categories described by the PSC guidelines for respiratory specimens...
2018: CytoJournal
Mariam Mir, Michelle Parmley, Kyle Molberg, Stacy Hinson, Joel Thibodeaux, Elena Lucas
No abstract text is available yet for this article.
2018: CytoJournal
Smita Chandra, Neeti Puri, Meena Harsh, Anil Kumar Juyal
Osteoblastoma is a rare bone tumor mostly affecting the young adults and commonly involving the spinal cord and long bones. Talus is the uncommon site of presentation, and if involved, then the neck is more commonly involved than the body of talus. The cytological diagnosis of osteoblastoma is limited, and to the best of our knowledge, its fine-needle aspiration (FNA) in the talus has still not been reported in the literature. The present case of osteoblastoma is, therefore, being reported due to the unusual presentation in elderly male in the body of talus and showing extensive involvement on X-ray...
2018: CytoJournal
Vijay Kumar, Poojan Agarwal, Sadhna Marwah, A S Nigam, Awantika Tiwari
Background: Leishmaniasis is the prevalent in tropical and subtropical regions of the world. Demonstration of Leishman-Donovan (LD) bodies in the bone marrow aspirates (BMA) is vital to diagnosis of visceral leishmaniasis (VL). In the present study, we studied the clinicohematological parameters encountered in VL and correlated them with parasite load on BMA. Methods: Retrospective analysis over 3 years was done; clinical details, biochemical profile, complete hemogram with peripheral smear findings, and BMA smears were reviewed and average parasite density (APD) calculated in each case...
2018: CytoJournal
Manjari Kishore, Prajwala Gupta, A K Malhotra, Vijay Kumar, Sanchit Singh, Minakshi Bhardwaj
Extramedullary hematopoiesis (EMH) usually involves reticuloendothelial system. However, it rarely may be present in the serous body effusions. In our case, the fluid cytology of both peritoneal and pleural fluid was diagnostic of the EMH in a patient with an undiagnosed underlying etiology.
2018: CytoJournal
Simon Sung, Henry D Tazelaar, John P Crapanzano, Aziza Nassar, Anjali Saqi
Background: Exogenous lipoid pneumonia (ELP) is a rare benign entity without specific clinical or imaging presentation. Although cytological studies - either bronchoalveolar lavage (BAL) or fine-needle aspiration (FNA) - may be pursued in patients with ELP, a definitive diagnosis is frequently rendered only on histology. The aim of this study is to highlight the cytological features of ELP. Methods: A search of cytopathology (CP) and surgical pathology (SP) diagnoses of ELP was conducted...
2018: CytoJournal
Neha Gupta, Kasturi Das
No abstract text is available yet for this article.
2018: CytoJournal
Vidya Monappa, Saritha M Reddy, Ranjini Kudva
Background: Hematolymphoid neoplasms (HLNs) presenting as body cavity effusions are not a common finding. They may be the first manifestation of the disease. A diagnosis on effusion cytology may provide an early breakthrough for effective clinical management. Aims: Study the cytomorphology of HLNs in effusion cytology, determine common types, sites involved and uncover useful cytomorphologic clues to subclassify them. Materials and Methods: Twenty-four biopsy-proven HLN cases with malignant body cavity effusions and 8 cases suspicious for HLN on cytology but negative on biopsy are included in this study...
2018: CytoJournal
Manjari Kishore, Prajwala Gupta, Arvind Ahuja, A S N Rao, Minakshi Bhardwaj
No abstract text is available yet for this article.
2018: CytoJournal
Ying Chen, Abha Khanna, Jie Qing Chen, Hua Zhong Zhang, Nancy P Caraway, Ruth L Katz
Background: Epithelioid hemangioendothelioma (EHE) involving serous effusion is extremely rare, and the diagnosis can be challenging. DNA ploidy quantitation of EHE in effusion fluids has not been previously described in the English-language literature. Methods: Specimens of cytological diagnosed with EHE in effusion fluids between 2002 and 2009 were retrieved from the pathology files at MD Anderson Cancer Center. A total of four cases of EHE involving or arising from effusion fluids were found, and we reviewed cytospin, smears, cell block sections, and immunostained slides...
2018: CytoJournal
Poojan Agarwal, Manju Kaushal, Shruti Dogra, Ankur Gupta, Nishi Sharma
No abstract text is available yet for this article.
2018: CytoJournal
Saniya Sharma, Nalini Gupta, Navneet Singh, Rini Chaturvedi, Digambar Behera, Arvind Rajwanshi
Background: Epidermal growth factor receptor mutation-positive ( EGFR-p ) lung adenocarcinomas are sensitive to tyrosine kinase inhibitors. Although histopathological subtype is an independent predictor of mutation status, there is a paucity of data on the cytomorphological features correlating with the EGFR mutation status. Therefore, the aim of this study was to determine whether certain cytomorphological features correlate with EGFR mutation in lung adenocarcinoma. Materials and Methods: A retrospective analysis of 48 lung adenocarcinoma cases diagnosed on fine needle aspiration cytology with known EGFR mutation status was conducted...
2018: CytoJournal
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