Kai Qin, Kazuhito Honjo, Scott Sherrill-Mix, Weimin Liu, Regina M Stoltz, Allisa K Oman, Lucinda A Hall, Ran Li, Sarah Sterrett, Ellen R Frederick, Jeffrey R Lancaster, Mayur Narkhede, Amitkumar Mehta, Foluso J Ogunsile, Rima B Patel, Thomas J Ketas, Victor M Cruz Portillo, Albert Cupo, Benjamin M Larimer, Anju Bansal, Paul A Goepfert, Beatrice H Hahn, Randall S Davis
BACKGROUND: Patients with chronic lymphocytic leukemia (CLL) have reduced seroconversion rates and lower binding antibody (Ab) and neutralizing antibody (NAb) titers than healthy individuals following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA vaccination. Here, we dissected vaccine-mediated humoral and cellular responses to understand the mechanisms underlying CLL-induced immune dysfunction. METHODS AND FINDINGS: We performed a prospective observational study in SARS-CoV-2 infection-naïve CLL patients (n = 95) and healthy controls (n = 30) who were vaccinated between December 2020 and June 2021...
June 2023: PLoS Medicine