Aita Signorell, Phyllis Awor, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Manuel W Hetzel, Proscovia Athieno, Joseph Kimera, Gloria Tumukunde, Irene Angiro, Jean-Claude Kalenga, Babatunde K Akano, Kazeem Ayodeji, Charles Okon, Ocheche Yusuf, Giulia Delvento, Tristan T Lee, Nina C Brunner, Mark J Lambiris, James Okuma, Nadja Cereghetti, Valentina Buj, Theodoor Visser, Harriet G Napier, Christian Lengeler, Christian Burri
BACKGROUND: For a full treatment course of severe malaria, community-administered pre-referral rectal artesunate (RAS) should be completed by post-referral treatment consisting of an injectable antimalarial and oral artemisinin-based combination therapy (ACT). This study aimed to assess compliance with this treatment recommendation in children under 5 years. METHODS AND FINDINGS: This observational study accompanied the implementation of RAS in the Democratic Republic of the Congo (DRC), Nigeria, and Uganda between 2018 and 2020...
February 21, 2023: PLoS Medicine