journal
https://read.qxmd.com/read/38006393/magnitude-and-determinants-of-intestinal-parasites-among-children-under-five-in-ethiopia-during-2010-2023-a-systematic-review-and-meta-analysis
#21
REVIEW
Abayeneh Girma, Amere Genet
Background : Intestinal parasitic infection (IPI) poses a serious public health threat across the globe, particularly in children in low- and middle-income countries like Ethiopia. This study was to provide pooled estimates for the individually available data on IPI and its predictors among children under five in Ethiopia. Methods : Cochrane's Q , I 2 , sensitivity analysis, funnel plot, Begg's, and Egger's regression tests were used to check heterogeneity and publication bias. A random-effects model was used to calculate the pooled burden of IPI among children under five...
2024: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37861408/letter-regarding-clinicopathological-analysis-of-sturge-weber-syndrome-with-focal-cortical-dysplasia-fcd-iiic
#22
JOURNAL ARTICLE
Törehan Özer, Yonca Anik
No abstract text is available yet for this article.
2024: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37800446/ectopic-salivary-glands-a-differential-diagnosis-to-a-thyroglossal-duct-cyst
#23
JOURNAL ARTICLE
Thomas Menter, Stefan Holland-Cunz
Background : Midline developmental neck lesions primarily consist of thyroglossal duct remnants. Their recurrence is uncommon following thorough resection, which includes hyoid removal (the Sistrunk procedure). Case report : A 3-year-old girl presented with mucoid secretion drainage and swelling in the anterior mid-neck region, clinically resembling a thyroglossal duct remnant. Following an initial Sistrunk procedure, the lesion recurred, prompting a subsequent resection. Histological analysis revealed a mucocele alongside acinar and mucous ectopic salivary glands...
2024: Fetal and Pediatric Pathology
https://read.qxmd.com/read/38146752/restriction-of-medically-indicated-abortions
#24
EDITORIAL
Randall Craver
No abstract text is available yet for this article.
December 26, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/38108326/placental-histopathologic-findings-in-fetal-hereditary-pyropoikilocytosis-after-undergoing-successful-intrauterine-transfusion
#25
JOURNAL ARTICLE
Anna Dar, Rachel Brancamp, Garrett S Booth, Caitlin E Hughes
Background: The available literature on intrauterine transfusion focuses largely on its application in fetal alloimmunization rather than hereditary red cell disorders, with limited illustration of its associated histopathologic findings. Case report: We present the histologic findings in a placenta associated with preterm delivery of an infant with autosomal SPTA1 mutation following multiple intrauterine transfusions, including appropriate villous maturation, subchorionic organizing hematomas, hemosiderin-laden macrophages, and dysmorphic fetal erythrocytes within villous capillaries...
December 18, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/38069499/group-b-streptococcus-and-perinatality-in-the-south-of-tunisia-epidemiology-serotype-distribution-and-antibiotic-susceptibility
#26
JOURNAL ARTICLE
Rim Kharrat, Nourelhouda Ben Ayed, Sonia Ktari, Chiraz Regaieg, Sonda Mezghani, Nedia Hmida, Faouzia Mahjoubi, Abdellatif Gargouri, Adnene Hammami
INTRODUCTION: In the lack of updated Tunisian epidemiological data, we sought to describe the epidemiology of Group B Streptococcus (GBS) in pregnant women and newborns. MATERIALS AND METHODS: A retrospective analysis of GBS neonatal invasive infections and a cross-sectional study evaluating the prevalence of maternal GBS colonization were conducted. GBS isolates were tested for antimicrobial susceptibility, serotyped, and assessed for the appurtenance to the hypervirulent ST17 clone...
December 8, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37817745/placental-histopathologic-findings-in-the-setting-of-prenatally-diagnosed-major-congenital-heart-disease
#27
JOURNAL ARTICLE
Shaimaa Rakha, Alhussein Ahmed Mohamed, Shaimaa M Yussif
Objectives: Studies suggest an association between placenta and congenital heart disease (CHD). We evaluated placental pathologies associated with major CHD. Methods: A prospective study included fetuses with major CHD, identified by fetal echocardiography. Fetal Doppler of umbilical artery (UA), middle cerebral artery (MCA), and placental histopathology were assessed. Outcome was measured by mortality at one month of age. Results: 21 cases were analyzed. Hypoplastic left heart syndrome was the commonest lesion (23...
December 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37668986/placental-syphilis-a-comprehensive-review-of-routine-histomorphology-hiv-co-infection-penicillin-treatment-immunohistochemistry-and-polymerase-chain-reaction
#28
REVIEW
Yolandi Anne Marais, Deidré Mason, Annelize Barnard, Chestley Rashaell Saaiman, Hester Christine Els, Judith Kluge, Allison Joy Glass, Colleen Anne Wright, Pawel Tomasz Schubert
Introduction: Placental examination is valuable for diagnosing congenital syphilis, but the classic histological triad is not always observed. This study aimed to identify additional morphological clues, evaluate the sensitivity of IHC and qPCR, and investigate the impact of HIV co-infection and penicillin treatment on placental morphology. Materials and methods: Two hundred and fifteen placental specimens with treponemal infection were reviewed. Morphological findings, IHC, and qPCR results were analyzed. Results: Chronic villitis (94%), acute chorioamnionitis (91...
December 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/38009306/role-of-a-pediatric-pathologist-during-and-after-a-disaster
#29
EDITORIAL
Randall Craver
No abstract text is available yet for this article.
November 27, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37975569/methylation-status-of-igf-axis-genes-in-the-placenta-of%C3%A2-south-indian-neonates-with-appropriate-and-small-for%C3%A2-gestational-age
#30
JOURNAL ARTICLE
Nithya M N, Krishnappa J, Sheela S R, Venkateswarlu Raavi
OBJECTIVE: Altered methylation patterns of insulin-like growth factor (IGF)-axis genes in small for gestational age (SGA) have been reported in different populations. In the present study, we analyzed the methylation status of IGF-axis genes in the placenta of appropriate for gestational age (AGA) and SGA neonates of South Indian women. METHODS: Placental samples were collected from AGA ( n  = 40) and SAG ( n  = 40) neonates. The methylation of IGF-axis genes promoter was analyzed using MS-PCR...
November 17, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37950513/partial-trisomy-4p-syndrome-diagnosed-prenatally
#31
JOURNAL ARTICLE
Kaouther Nasri, Nadia Ben Jamaa, Ines Ouertani, Nadia Boujelben
Introduction: Trisomy 4p is a lethal chromosomal disorder, resulting from segmental or full trisomy of the short arm of chromosome 4. Prenatal diagnosis may allow decisions on whether to continue or terminate the pregnancy. Case report: We diagnosed a fetus with partial trisomy 4p after first-trimester ultrasound detection of increased nuchal translucency, allowing the parents the opportunity to terminate the pregnancy. The partial trisomy 4p was inherited from a balanced translocation carried by the father...
November 10, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37946365/testicular-mixed-teratoma-and-yolk-sac-tumor-prepubertal-type-a-case-report-with-summary-of-prior-published-cases
#32
JOURNAL ARTICLE
Md Mohin, Soumya Dey, Raktim Ray, Firdous Wasim Sk, Oindrila Das, Uttara Chatterjee
BACKGROUND: Testicular mixed germ cell tumor is common in the post-pubertal age, less so in prepuberty. There are only 3 reports of prepubertal mixed teratoma and yolk sac tumor. Two of these cases had immature teratoma component and were in the neonatal age group. The third case in a toddler had a mature teratoma component. CASE REPORT: An 18-month-old boy presented with a testicular mass. Serum AFP was elevated (2200 ng/ml). The orchidectomy specimen contained a yolk-sac tumor and a small epidermoid cyst, indicating a mature teratomatous component...
November 9, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37906285/human-placenta-and-evolving-insights-into-pathological-changes-of-preeclampsia-a-comprehensive-review-of-the-last-decade
#33
REVIEW
Diana Maria Chiorean, Esra Cobankent Aytekin, Melinda-Ildiko Mitranovici, Sabin Gligore Turdean, Mirpooya Salehi Moharer, Ovidiu Simion Cotoi, Havva Serap Toru
The placenta, the foremost and multifaceted organ in fetal and maternal biology, is pivotal in facilitating optimal intrauterine fetal development. Remarkably, despite its paramount significance, the placenta remains enigmatic, meriting greater comprehension given its central influence on the health trajectories of both the fetus and the mother. Preeclampsia (PE) and intrauterine fetal growth restriction (IUGR), prevailing disorders of pregnancy, stem from compromised placental development. PE, characterized by heightened mortality and morbidity risks, afflicts 5-7% of global pregnancies, its etiology shrouded in ambiguity...
October 31, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37906276/assessment-of-matrix-metalloprotease-7-mmp7-immunohistochemistry-in-biliary-atresia-and-other-pediatric-cholestatic-liver-diseases
#34
JOURNAL ARTICLE
Sandhya Biswal, Dipanwita Biswas, Santosh Kumar Mahalik, Suvendu Purkait, Suvradeep Mitra
Background and aims: Biliary atresia (BA) is a progressive fibro-obliterative cholangiopathy. The histopathological diagnosis is often challenging and an immunohistochemical marker is often sought as an adjunct. We evaluated MMP7 immunohistochemistry in BA and other non-BA pediatric cholestatic liver diseases. Materials and methods: MMP7 immunohistochemistry was applied in 5 age-matched normal control, 23 cases of BA and 43 cases of non-BA pediatric cholestasis including 16 cases of choledochal cyst (CC), and a multiplication score was obtained by multiplying the intensity and percentage positivity in the cholangiocytes...
October 31, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37902221/early-diagnosis-of-46-xx-testicular-difference-of-sexual-development-unusual-presentation-with-increased-nuchal-translucency
#35
JOURNAL ARTICLE
Miguel Saraiva, Vera M F Santos, Lina Ramos, Fabiana Ramos, Joana Serra-Caetano, Rita Cardoso, Isabel Dinis, Alice Mirante
INTRODUCTION: 46,XX testicular disorder of sexual development (DSD) may present prenatally as a mismatch between phenotype and karyotype. Enlarged nuchal translucency is an abnormal sign of many disorders. We present a first trimester fetus with increased nuchal translucency that was later determined to be a 46,XX testicular DSD. CASE PRESENTATION: A first-trimester pregnancy ultrasound revealed enlarged nuchal translucency. Chorionic villous sampling documented a 46,XX karyotype...
October 30, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37818552/the-importance-of-sphingomyelin-phosphodiesterase-acid-like-3b-smpdl-3b-levels-in-kidney-biopsy-specimens-of-children-with-nephrotic-syndrome
#36
JOURNAL ARTICLE
Muhammet Kaya, İlknur Girişgen, Nagihan Yalçın, Tülay Becerir, Hande Şenol, Gülsün Gülten, Selcuk Yüksel
OBJECTIVE: It remains unclear whether the low amount of SMPDL-3b required for rituximab binding is the cause of treatment resistance in patients with treatment-resistant nephrotic syndrome with advanced podocyte injury. Given the limited number of studies on the relationship between rituximab and SMPDL-3b, this study was conducted to assess whether SMPDL-3b levels in pretreatment renal biopsy specimens can be used to predict the clinical effectiveness of immunosuppressive drugs, especially rituximab, in children with nephrotic syndrome...
October 11, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37787107/pathologist-pediatric-in-patient-genetic-stewardship
#37
JOURNAL ARTICLE
Randall Craver
Background: Costs for sendout genetic testing on in-patients are billed to the hospital. Turnaround times are several weeks, often extending past the inpatient hospitalization. Materials and Methods: We concurrently reviewed all sendout genetic in-patient test requests over an 18-month period, deferring those that could be obtained as an outpatient, directing the tests to less expensive laboratories with complementary testing profiles, and identifying no-charge sponsored tests. Results: Of 121 test requests, 25 were deferred, alternative less expensive laboratories were identified for 8, 16 requests were directed to sponsored tests, for a 42...
October 3, 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37655742/neurogenic-monodermal-teratoma-in-the-scapula-of-a-child-a-case-report
#38
JOURNAL ARTICLE
Xianping Jiang, Huan Zhang, Xifeng Du, Cailei Zhao, Qiuling Miao, Jianming Song
Background: Neurogenic monodermal teratomas (NMTs) have been reported in the ovaries but not from bone. Case Report : A 6-year-old girl had an incidentally discovered lesion in the right scapula. Upon removal, it was an NMT with predominant choroid plexus. The disease had not progressed for 31 months. Conclusion: Neurogenic monodermal teratomas can also occur in bone.
October 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37278448/chronic-myeloid-leukemia-during-pregnancy-with-placental-involvement-case-report-and-literature-review
#39
REVIEW
Esra Çobankent Aytekin, M Pooya Salehi Moharer, Ahmet Boduroglu, CemYaşar Sanhal, Havva Serap Toru
Introduction: Chronic myeloid leukemia (CML) occurrence during pregnancy is unusual due to the low prevalence of the disease in women of childbearing age, with only three reported cases. Case report: The mother was diagnosed with CML with positive BCR-ABL gene fusion in her 32nd week of gestation. The placenta showed an increased population of myelocytes and segmented neutrophils in the intervillous space and features of maternal villous malperfusion (increased perivillous fibrinoid material and distal villous hypoplasia)...
October 2023: Fetal and Pediatric Pathology
https://read.qxmd.com/read/37766589/molecular-prevalence-and-genotype-distribution-of-human-adenovirus-in-iranian-children-with-gastroenteritis
#40
JOURNAL ARTICLE
Abdulhussain Kadhim Jwaziri, Mohammad Hadi Karbalaie Niya, Pegah Khales, Atefeh Kachooei, Milad Sabaei, Soheil Rahmani Fard, Ahmad Tavakoli
OBJECTIVE: We determined the molecular prevalence and genotype distribution of human adenovirus (HAdV) among children under five years of age with gastroenteritis in Iran. METHODS: One hundred stool samples from children hospitalized were tested by PCR for adenovirus, and some of the positive samples were sequenced to determine the specific genotype. RESULTS: HAdV DNA was found in 15 samples (15%). The highest and the lowest prevalence of HAdV was observed in the age groups 24-60 months ( n  = 6; 40%) and 7-12 months ( n  = 2; 13...
September 27, 2023: Fetal and Pediatric Pathology
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